{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1 and surface_class = \"A2_pm_peripheral\" sorted by evidence_priority descending", "rows": [["P15056", "BRAF", "Serine/threonine-protein kinase B-raf", "Tier 1", 0.803, 1, "A2_pm_peripheral", 100, 66.38, 0, 0, null, null, 1, 6, "39624124,34874026,33497198,31726389,24486214,11856330", 1, "cardiofaciocutaneous syndrome", 0.8764542776642054], ["P04049", "RAF1", "RAF proto-oncogene serine/threonine-protein kinase", "Tier 1", 0.799, 1, "A2_pm_peripheral", 75, 67.5, 0, 0, null, null, 1, 4, "15112994,12173045,11856330,9883908", 1, "Noonan syndrome", 0.8625147809861142], ["Q06187", "BTK", "Tyrosine-protein kinase BTK", "Tier 1", 0.794, 1, "A2_pm_peripheral", 100, 84.44, 0, 0, null, null, 1, 1, "41951939", 1, "X-linked agammaglobulinemia", 0.8454716106068291], ["O60315", "ZEB2", "Zinc finger E-box-binding homeobox 2", "Tier 1.5", 0.789, 1, "A2_pm_peripheral", 1, 48.16, 0, 0, null, null, 1, 3, "27719642,24146916,18698484", 1, "Mowat-Wilson syndrome", 0.8313744323041312], ["Q02750", "MAP2K1", "Dual specificity mitogen-activated protein kinase kinase 1", "Tier 1", 0.788, 1, "A2_pm_peripheral", 94, 83.25, 0, 0, null, null, 1, 1, "29580944", 1, "cardiofaciocutaneous syndrome", 0.825549979325162], ["P11274", "BCR", "Breakpoint cluster region protein", "Tier 1.5", 0.785, 1, "A2_pm_peripheral", 5, 64.81, 0, 0, null, null, 1, 20, "41951939,41535871,40882628,37937247,37103734,32929022,32507237,31825964,31650445,31295447,29299123,28686804,25809097,23836560,22411871,21810089,21653319,21030439,16990253,11713794", 1, "chronic myelogenous leukemia", 0.8183048540102864], ["P01111", "NRAS", "GTPase NRas", "Tier 1", 0.783, 1, "A2_pm_peripheral", 35, 92.06, 0, 0, null, null, 1, 2, "39952900,39371477", 1, "Noonan syndrome 6", 0.8087775198380727], ["O60674", "JAK2", "Tyrosine-protein kinase JAK2", "Tier 1", 0.78, 1, "A2_pm_peripheral", 100, 86.88, 0, 0, null, null, 1, 8, "41455398,34121564,32985358,31279934,30415442,25809097,22411871,20711698", 1, "polycythemia vera", 0.8000866241942614], ["P01137", "TGFB1", "Transforming growth factor beta-1 proprotein", "Tier 1", 0.78, 1, "A2_pm_peripheral", 20, 79.56, 1, 0, null, null, 1, 4, "38132522,32370304,16775010,11856769", 1, "Camurati-Engelmann disease", 0.7995305374459716], ["P98170", "XIAP", "E3 ubiquitin-protein ligase XIAP", "Tier 1", 0.78, 1, "A2_pm_peripheral", 74, 74.25, 0, 0, null, null, 1, 4, "35383192,29864441,27514505,26318819", 1, "X-linked lymphoproliferative disease", 0.8013347966323413], ["Q9UHD9", "UBQLN2", "Ubiquilin-2", "Tier 1", 0.778, 1, "A2_pm_peripheral", 4, 61.03, 0, 0, null, null, 1, 2, "23541532", 1, "amyotrophic lateral sclerosis type 15", 0.7942015735994536], ["Q9ULC3", "RAB23", "Ras-related protein Rab-23", "Tier 1.5", 0.776, 1, "A2_pm_peripheral", 6, 79.56, 1, 0, null, null, 1, 1, "23618401", 1, "RAB23-related Carpenter syndrome", 0.7879955689930709], ["O15294", "OGT", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit", "Tier 1", 0.77, 1, "A2_pm_peripheral", 44, 93.06, 0, 0, null, null, 1, 2, "36868188,36626902", 1, "intellectual disability, X-linked 106", 0.7660009745204424], ["P55263", "ADK", "Adenosine kinase", "Tier 1.5", 0.769, 1, "A2_pm_peripheral", 4, 93.31, 0, 0, null, null, 1, 2, "26051465", 1, "adenosine kinase deficiency", 0.7617058236708037], ["Q92743", "HTRA1", "Serine protease HTRA1", "Tier 1", 0.768, 1, "A2_pm_peripheral", 18, 83.25, 1, 0, null, null, 1, 1, "31988066", 1, "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2", 0.7611877816680132], ["P35221", "CTNNA1", "Catenin alpha-1", "Tier 1", 0.765, 1, "A2_pm_peripheral", 10, 82.94, 1, 0, null, null, 1, 2, "40265971", 1, "Butterfly-shaped pigment dystrophy", 0.7487735496199569], ["P26038", "MSN", "Moesin", "Tier 1", 0.755, 1, "A2_pm_peripheral", 10, 86.38, 0, 0, null, null, 1, 65, "41813080,41784619,41611946,40904334,40886652,40258621,40222299,39454415,39053429,38856817,38759442,38687941,38561432,38446130,38349197,38295649,38266273,37869770,37806507,37423650,37353120,37062561,37058944,36982925,36843953,36700559,36562728,36179642,35026109,34893239,34538325,33960345,33727809,33528465,33149582,32882423,32291531,32170403,31872318,31792209,31213813,31072481,30985076,30865739,32254866,29955964,29568450,29136862,28917759,28832225", 1, "combined immunodeficiency due to moesin deficiency", 0.7157135146765757], ["P84077", "ARF1", "ADP-ribosylation factor 1", "Tier 1", 0.755, 1, "A2_pm_peripheral", 36, 85.94, 1, 0, null, null, 1, 3, "30965174,11320245", 1, "periventricular nodular heterotopia 8", 0.7173626622431929], ["Q13153", "PAK1", "Serine/threonine-protein kinase PAK 1", "Tier 1", 0.753, 1, "A2_pm_peripheral", 41, 73.69, 0, 0, null, null, 1, 2, "32636813,20564698", 1, "intellectual developmental disorder with macrocephaly, seizures, and speech delay", 0.7110292416229067], ["Q13546", "RIPK1", "Receptor-interacting serine/threonine-protein kinase 1", "Tier 1", 0.749, 1, "A2_pm_peripheral", 39, 69.75, 1, 0, null, null, 1, 2, "41290466,35919280", 1, "immunodeficiency 57", 0.698121745966467], ["P35241", "RDX", "Radixin", "Tier 1.5", 0.749, 1, "A2_pm_peripheral", 2, 86.56, 0, 0, null, null, 1, 2, "33253235,30700648", 1, "hearing loss, autosomal recessive", 0.6973070672344621], ["P50148", "GNAQ", "Guanine nucleotide-binding protein G(q) subunit alpha", "Tier 1", 0.748, 1, "A2_pm_peripheral", 30, 93.0, 1, 0, null, null, 1, 1, "40015005", 1, "Sturge-Weber syndrome", 0.6941111530708174], ["P61586", "RHOA", "Transforming protein RhoA", "Tier 1", 0.744, 1, "A2_pm_peripheral", 100, 93.56, 0, 0, null, null, 1, 4, "25645980,19389625,12927206,12123800", 1, "ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies", 0.6804889074382072], ["Q00535", "CDK5", "Cyclin-dependent kinase 5", "Tier 1", 0.744, 1, "A2_pm_peripheral", 10, 91.56, 0, 0, null, null, 1, 4, "33291667,33200349", 1, "Alzheimer disease", 0.6800338890220147], ["O95786", "RIGI", "Antiviral innate immune response receptor RIG-I", "Tier 1", 0.735, 1, "A2_pm_peripheral", 44, 85.19, 1, 0, null, null, 1, 6, "34487794,33253193,32946572,31600868,26018150,22127865", 1, "Singleton-Merten dysplasia", 0.6485708110478319], ["P26196", "DDX6", "Probable ATP-dependent RNA helicase DDX6", "Tier 1", 0.734, 1, "A2_pm_peripheral", 9, 84.06, 0, 0, null, null, 1, 2, "34132569", 1, "intellectual developmental disorder with impaired language and dysmorphic facies", 0.6482686715821397], ["P12931", "SRC", "Proto-oncogene tyrosine-protein kinase Src", "Tier 1", 0.73, 1, "A2_pm_peripheral", 78, 83.44, 0, 1, "1Y57", "2SRC", 1, 19, "40569566,39664567,38471488,35928129,35859339,34757788,34083659,33530373,32668060,30970280,28701145,26458993,25645980,23842900,22693611,22323540,18985031,18682833,12842895", 1, "cancer", 0.6343904000453656], ["P61769", "B2M", "Beta-2-microglobulin", "Tier 1", 0.725, 1, "A2_pm_peripheral", 100, 94.06, 0, 0, null, null, 1, 15, "41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167", 1, "Immunodeficiency by defective expression of HLA class 1", 0.6180318849819645], ["P23921", "RRM1", "Ribonucleoside-diphosphate reductase large subunit", "Tier 1", 0.724, 1, "A2_pm_peripheral", 12, 92.25, 1, 0, null, null, 1, 1, "21955496", 1, "non-small cell lung carcinoma", 0.6122881671315019], ["P43405", "SYK", "Tyrosine-protein kinase SYK", "Tier 1", 0.723, 1, "A2_pm_peripheral", 93, 84.0, 0, 0, null, null, 1, 2, "35782912,31825964", 1, "immunodeficiency 82 with systemic inflammation", 0.608506293550361], ["P06241", "FYN", "Tyrosine-protein kinase Fyn", "Tier 1", 0.721, 1, "A2_pm_peripheral", 53, 80.81, 0, 0, null, null, 1, 5, "38559166,37149826,34757788,32668060,29754498", 1, "chronic myelogenous leukemia", 0.6018224074412558], ["P32121", "ARRB2", "Beta-arrestin-2", "Tier 1.5", 0.719, 1, "A2_pm_peripheral", 1, 83.81, 1, 0, null, null, 1, 4, "24736311,40652239,29054528", 1, "cancer", 0.5962458729823639], ["P07947", "YES1", "Tyrosine-protein kinase Yes", "Tier 1", 0.716, 1, "A2_pm_peripheral", 1, 81.88, 0, 0, null, null, 1, 1, "34757788", 1, "chronic myelogenous leukemia", 0.5851678597856559], ["P09769", "FGR", "Tyrosine-protein kinase Fgr", "Tier 1.5", 0.716, 1, "A2_pm_peripheral", 3, 82.19, 0, 0, null, null, 1, 1, "39564692", 1, "chronic myelogenous leukemia", 0.5869168331059803], ["P45984", "MAPK9", "Mitogen-activated protein kinase 9", "Tier 1", 0.707, 1, "A2_pm_peripheral", 5, 81.44, 0, 0, null, null, 1, 1, "41505229", 1, "cancer", 0.5569349147269519], ["P04406", "GAPDH", "Glyceraldehyde-3-phosphate dehydrogenase", "Tier 1", 0.706, 1, "A2_pm_peripheral", 21, 98.12, 1, 0, null, null, 1, 11, "39832592,39429683,35821507,28131717,26310631,23215008,37500700,16115199", 1, "neurodegenerative disease", 0.55307368855439], ["P42680", "TEC", "Tyrosine-protein kinase Tec", "Tier 1.5", 0.705, 1, "A2_pm_peripheral", 1, 85.0, 0, 0, null, null, 1, 13, "39352470,39329798,36414190,36105684,35624657,35462326,35006795,30578658,30398689,27548775,26843427,25016253,24875764", 1, "alopecia areata", 0.5491699656070116], ["O75534", "CSDE1", "Cold shock domain-containing protein E1", "Tier 1", 0.704, 1, "A2_pm_peripheral", 5, 79.56, 0, 0, null, null, 1, 1, "10101203", 1, "neurodegenerative disease", 0.5472997885061864], ["P17252", "PRKCA", "Protein kinase C alpha type", "Tier 1.5", 0.704, 1, "A2_pm_peripheral", 6, 86.38, 0, 0, null, null, 1, 1, "41505229", 1, "acute myeloid leukemia", 0.547429504944985], ["P67809", "YBX1", "Y-box-binding protein 1", "Tier 1", 0.703, 1, "A2_pm_peripheral", 11, 61.84, 0, 0, null, null, 1, 9, "31989173,31160337,22730292,21245151,16093451", 1, "dengue disease", 0.5435698373845997], ["P34947", "GRK5", "G protein-coupled receptor kinase 5", "Tier 1", 0.702, 1, "A2_pm_peripheral", 23, 90.38, 0, 0, null, null, 1, 1, "18230760", 1, "venous thromboembolism", 0.5394311062516939], ["Q92888", "ARHGEF1", "Rho guanine nucleotide exchange factor 1", "Tier 1", 0.695, 1, "A2_pm_peripheral", 7, 73.19, 0, 0, null, null, 1, 6, "25645980,23757206,25033804,22689339,19389625,12123800", 1, "immunodeficiency 62", 0.5170912094162261], ["Q96PY5", "FMNL2", "Formin-like protein 2", "Tier 1.5", 0.695, 1, "A2_pm_peripheral", 1, 76.44, 0, 0, null, null, 1, 1, "41149482", 1, "open-angle glaucoma", 0.5157968177633478], ["P09543", "CNP", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "Tier 1.5", 0.689, 1, "A2_pm_peripheral", 1, 87.25, 0, 0, null, null, 1, 9, "40034273,38569854,37704353,35528922,31171207,30089209,27192549,19021295", 1, "myopia 2, autosomal dominant", 0.49606855995054094], ["P31948", "STIP1", "Stress-induced-phosphoprotein 1", "Tier 1.5", 0.689, 1, "A2_pm_peripheral", 8, 89.75, 1, 0, null, null, 1, 7, "41406518,38012811,34831332,32614006,27681499,24654750,24013070", 1, "neurodegenerative disease", 0.4967711525222825], ["P21980", "TGM2", "Protein-glutamine gamma-glutamyltransferase 2", "Tier 1.5", 0.688, 1, "A2_pm_peripheral", 17, 92.88, 1, 0, null, null, 1, 1, "35980938", 1, "neurodegenerative disease", 0.49455272812698803], ["P49327", "FASN", "Fatty acid synthase", "Tier 1", 0.68, 1, "A2_pm_peripheral", 34, 85.44, 1, 0, null, null, 1, 1, "41854184", 1, "dengue disease", 0.46815584653391107], ["Q07812", "BAX", "Apoptosis regulator BAX", "Tier 1", 0.679, 1, "A2_pm_peripheral", 37, 85.94, 0, 0, null, null, 1, 21, "41323565,41237573,40761795,40148451,39946362,39318128,37301952,36907299,36843953,36309655,32987067,32486412,31747745,30005287,27843907,26325285,24481451,23582862,23528042,21563784,21362508", 1, "T-cell acute lymphoblastic leukemia", 0.4626258720529755], ["P09104", "ENO2", "Gamma-enolase", "Tier 1", 0.676, 1, "A2_pm_peripheral", 16, 97.06, 0, 0, null, null, 1, 1, "36384120", 1, "neurodegenerative disease", 0.4533558777394424], ["P07355", "ANXA2", "Annexin A2", "Tier 1", 0.673, 1, "A2_pm_peripheral", 41, 94.25, 0, 0, null, null, 1, 12, "40685636,31029658,29906496,24489826,35211356,29982617,27890659,27777972,26061649", 1, "neurodegenerative disease", 0.4424399692174707]], "truncated": false, "filtered_table_rows_count": 118, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A2_pm_peripheral"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 99, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 19, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 78, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 40, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 116, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 2, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 118, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 118, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 82, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 36, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 95, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 23, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 356.34129121899605, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}