{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, surface_class = \"A2_pm_peripheral\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P15056", "BRAF", "Serine/threonine-protein kinase B-raf", "Tier 1", 0.803, 1, "A2_pm_peripheral", 100, 66.38, 0, 0, null, null, 1, 6, "39624124,34874026,33497198,31726389,24486214,11856330", 1, "cardiofaciocutaneous syndrome", 0.8764542776642054], ["P04049", "RAF1", "RAF proto-oncogene serine/threonine-protein kinase", "Tier 1", 0.799, 1, "A2_pm_peripheral", 75, 67.5, 0, 0, null, null, 1, 4, "15112994,12173045,11856330,9883908", 1, "Noonan syndrome", 0.8625147809861142], ["Q06187", "BTK", "Tyrosine-protein kinase BTK", "Tier 1", 0.794, 1, "A2_pm_peripheral", 100, 84.44, 0, 0, null, null, 1, 1, "41951939", 1, "X-linked agammaglobulinemia", 0.8454716106068291], ["Q02750", "MAP2K1", "Dual specificity mitogen-activated protein kinase kinase 1", "Tier 1", 0.788, 1, "A2_pm_peripheral", 94, 83.25, 0, 0, null, null, 1, 1, "29580944", 1, "cardiofaciocutaneous syndrome", 0.825549979325162], ["P01111", "NRAS", "GTPase NRas", "Tier 1", 0.783, 1, "A2_pm_peripheral", 35, 92.06, 0, 0, null, null, 1, 2, "39952900,39371477", 1, "Noonan syndrome 6", 0.8087775198380727], ["O60674", "JAK2", "Tyrosine-protein kinase JAK2", "Tier 1", 0.78, 1, "A2_pm_peripheral", 100, 86.88, 0, 0, null, null, 1, 8, "41455398,34121564,32985358,31279934,30415442,25809097,22411871,20711698", 1, "polycythemia vera", 0.8000866241942614], ["P01137", "TGFB1", "Transforming growth factor beta-1 proprotein", "Tier 1", 0.78, 1, "A2_pm_peripheral", 20, 79.56, 1, 0, null, null, 1, 4, "38132522,32370304,16775010,11856769", 1, "Camurati-Engelmann disease", 0.7995305374459716], ["P98170", "XIAP", "E3 ubiquitin-protein ligase XIAP", "Tier 1", 0.78, 1, "A2_pm_peripheral", 74, 74.25, 0, 0, null, null, 1, 4, "35383192,29864441,27514505,26318819", 1, "X-linked lymphoproliferative disease", 0.8013347966323413], ["Q9UHD9", "UBQLN2", "Ubiquilin-2", "Tier 1", 0.778, 1, "A2_pm_peripheral", 4, 61.03, 0, 0, null, null, 1, 2, "23541532", 1, "amyotrophic lateral sclerosis type 15", 0.7942015735994536], ["O15294", "OGT", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit", "Tier 1", 0.77, 1, "A2_pm_peripheral", 44, 93.06, 0, 0, null, null, 1, 2, "36868188,36626902", 1, "intellectual disability, X-linked 106", 0.7660009745204424], ["Q92743", "HTRA1", "Serine protease HTRA1", "Tier 1", 0.768, 1, "A2_pm_peripheral", 18, 83.25, 1, 0, null, null, 1, 1, "31988066", 1, "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2", 0.7611877816680132], ["P35221", "CTNNA1", "Catenin alpha-1", "Tier 1", 0.765, 1, "A2_pm_peripheral", 10, 82.94, 1, 0, null, null, 1, 2, "40265971", 1, "Butterfly-shaped pigment dystrophy", 0.7487735496199569], ["P26038", "MSN", "Moesin", "Tier 1", 0.755, 1, "A2_pm_peripheral", 10, 86.38, 0, 0, null, null, 1, 65, "41813080,41784619,41611946,40904334,40886652,40258621,40222299,39454415,39053429,38856817,38759442,38687941,38561432,38446130,38349197,38295649,38266273,37869770,37806507,37423650,37353120,37062561,37058944,36982925,36843953,36700559,36562728,36179642,35026109,34893239,34538325,33960345,33727809,33528465,33149582,32882423,32291531,32170403,31872318,31792209,31213813,31072481,30985076,30865739,32254866,29955964,29568450,29136862,28917759,28832225", 1, "combined immunodeficiency due to moesin deficiency", 0.7157135146765757], ["P84077", "ARF1", "ADP-ribosylation factor 1", "Tier 1", 0.755, 1, "A2_pm_peripheral", 36, 85.94, 1, 0, null, null, 1, 3, "30965174,11320245", 1, "periventricular nodular heterotopia 8", 0.7173626622431929], ["Q13153", "PAK1", "Serine/threonine-protein kinase PAK 1", "Tier 1", 0.753, 1, "A2_pm_peripheral", 41, 73.69, 0, 0, null, null, 1, 2, "32636813,20564698", 1, "intellectual developmental disorder with macrocephaly, seizures, and speech delay", 0.7110292416229067], ["Q13546", "RIPK1", "Receptor-interacting serine/threonine-protein kinase 1", "Tier 1", 0.749, 1, "A2_pm_peripheral", 39, 69.75, 1, 0, null, null, 1, 2, "41290466,35919280", 1, "immunodeficiency 57", 0.698121745966467], ["P50148", "GNAQ", "Guanine nucleotide-binding protein G(q) subunit alpha", "Tier 1", 0.748, 1, "A2_pm_peripheral", 30, 93.0, 1, 0, null, null, 1, 1, "40015005", 1, "Sturge-Weber syndrome", 0.6941111530708174], ["P61586", "RHOA", "Transforming protein RhoA", "Tier 1", 0.744, 1, "A2_pm_peripheral", 100, 93.56, 0, 0, null, null, 1, 4, "25645980,19389625,12927206,12123800", 1, "ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies", 0.6804889074382072], ["Q00535", "CDK5", "Cyclin-dependent kinase 5", "Tier 1", 0.744, 1, "A2_pm_peripheral", 10, 91.56, 0, 0, null, null, 1, 4, "33291667,33200349", 1, "Alzheimer disease", 0.6800338890220147], ["O95786", "RIGI", "Antiviral innate immune response receptor RIG-I", "Tier 1", 0.735, 1, "A2_pm_peripheral", 44, 85.19, 1, 0, null, null, 1, 6, "34487794,33253193,32946572,31600868,26018150,22127865", 1, "Singleton-Merten dysplasia", 0.6485708110478319], ["P26196", "DDX6", "Probable ATP-dependent RNA helicase DDX6", "Tier 1", 0.734, 1, "A2_pm_peripheral", 9, 84.06, 0, 0, null, null, 1, 2, "34132569", 1, "intellectual developmental disorder with impaired language and dysmorphic facies", 0.6482686715821397], ["P12931", "SRC", "Proto-oncogene tyrosine-protein kinase Src", "Tier 1", 0.73, 1, "A2_pm_peripheral", 78, 83.44, 0, 1, "1Y57", "2SRC", 1, 19, "40569566,39664567,38471488,35928129,35859339,34757788,34083659,33530373,32668060,30970280,28701145,26458993,25645980,23842900,22693611,22323540,18985031,18682833,12842895", 1, "cancer", 0.6343904000453656], ["P61769", "B2M", "Beta-2-microglobulin", "Tier 1", 0.725, 1, "A2_pm_peripheral", 100, 94.06, 0, 0, null, null, 1, 15, "41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167", 1, "Immunodeficiency by defective expression of HLA class 1", 0.6180318849819645], ["P23921", "RRM1", "Ribonucleoside-diphosphate reductase large subunit", "Tier 1", 0.724, 1, "A2_pm_peripheral", 12, 92.25, 1, 0, null, null, 1, 1, "21955496", 1, "non-small cell lung carcinoma", 0.6122881671315019], ["P43405", "SYK", "Tyrosine-protein kinase SYK", "Tier 1", 0.723, 1, "A2_pm_peripheral", 93, 84.0, 0, 0, null, null, 1, 2, "35782912,31825964", 1, "immunodeficiency 82 with systemic inflammation", 0.608506293550361], ["P06241", "FYN", "Tyrosine-protein kinase Fyn", "Tier 1", 0.721, 1, "A2_pm_peripheral", 53, 80.81, 0, 0, null, null, 1, 5, "38559166,37149826,34757788,32668060,29754498", 1, "chronic myelogenous leukemia", 0.6018224074412558], ["P07947", "YES1", "Tyrosine-protein kinase Yes", "Tier 1", 0.716, 1, "A2_pm_peripheral", 1, 81.88, 0, 0, null, null, 1, 1, "34757788", 1, "chronic myelogenous leukemia", 0.5851678597856559], ["P45984", "MAPK9", "Mitogen-activated protein kinase 9", "Tier 1", 0.707, 1, "A2_pm_peripheral", 5, 81.44, 0, 0, null, null, 1, 1, "41505229", 1, "cancer", 0.5569349147269519], ["P04406", "GAPDH", "Glyceraldehyde-3-phosphate dehydrogenase", "Tier 1", 0.706, 1, "A2_pm_peripheral", 21, 98.12, 1, 0, null, null, 1, 11, "39832592,39429683,35821507,28131717,26310631,23215008,37500700,16115199", 1, "neurodegenerative disease", 0.55307368855439], ["O75534", "CSDE1", "Cold shock domain-containing protein E1", "Tier 1", 0.704, 1, "A2_pm_peripheral", 5, 79.56, 0, 0, null, null, 1, 1, "10101203", 1, "neurodegenerative disease", 0.5472997885061864], ["P67809", "YBX1", "Y-box-binding protein 1", "Tier 1", 0.703, 1, "A2_pm_peripheral", 11, 61.84, 0, 0, null, null, 1, 9, "31989173,31160337,22730292,21245151,16093451", 1, "dengue disease", 0.5435698373845997], ["P34947", "GRK5", "G protein-coupled receptor kinase 5", "Tier 1", 0.702, 1, "A2_pm_peripheral", 23, 90.38, 0, 0, null, null, 1, 1, "18230760", 1, "venous thromboembolism", 0.5394311062516939], ["Q92888", "ARHGEF1", "Rho guanine nucleotide exchange factor 1", "Tier 1", 0.695, 1, "A2_pm_peripheral", 7, 73.19, 0, 0, null, null, 1, 6, "25645980,23757206,25033804,22689339,19389625,12123800", 1, "immunodeficiency 62", 0.5170912094162261], ["P49327", "FASN", "Fatty acid synthase", "Tier 1", 0.68, 1, "A2_pm_peripheral", 34, 85.44, 1, 0, null, null, 1, 1, "41854184", 1, "dengue disease", 0.46815584653391107], ["Q07812", "BAX", "Apoptosis regulator BAX", "Tier 1", 0.679, 1, "A2_pm_peripheral", 37, 85.94, 0, 0, null, null, 1, 21, "41323565,41237573,40761795,40148451,39946362,39318128,37301952,36907299,36843953,36309655,32987067,32486412,31747745,30005287,27843907,26325285,24481451,23582862,23528042,21563784,21362508", 1, "T-cell acute lymphoblastic leukemia", 0.4626258720529755], ["P09104", "ENO2", "Gamma-enolase", "Tier 1", 0.676, 1, "A2_pm_peripheral", 16, 97.06, 0, 0, null, null, 1, 1, "36384120", 1, "neurodegenerative disease", 0.4533558777394424], ["P07355", "ANXA2", "Annexin A2", "Tier 1", 0.673, 1, "A2_pm_peripheral", 41, 94.25, 0, 0, null, null, 1, 12, "40685636,31029658,29906496,24489826,35211356,29982617,27890659,27777972,26061649", 1, "neurodegenerative disease", 0.4424399692174707], ["Q15828", "CST6", "Cystatin-M", "Tier 1", 0.673, 1, "A2_pm_peripheral", 5, 90.44, 0, 0, null, null, 1, 1, "27679852", 1, "autosomal recessive hypohidrotic ectodermal dysplasia", 0.44403998062712996], ["P52209", "PGD", "6-phosphogluconate dehydrogenase, decarboxylating", "Tier 1", 0.666, 1, "A2_pm_peripheral", 4, 96.81, 0, 0, null, null, 1, 1, "31557732", 1, "neurodegenerative disease", 0.4205455366275092], ["Q8NB16", "MLKL", "Mixed lineage kinase domain-like protein", "Tier 1", 0.665, 1, "A2_pm_peripheral", 22, 83.12, 0, 0, null, null, 1, 5, "42019750,38744189,35919280", 1, "chronic recurrent multifocal osteomyelitis", 0.41771763075738416], ["P08238", "HSP90AB1", "Heat shock protein HSP 90-beta", "Tier 1", 0.661, 1, "A2_pm_peripheral", 32, 84.31, 1, 0, null, null, 1, 1, "35921069", 1, "multiple myeloma", 0.40496963397728575], ["P02686", "MBP", "Myelin basic protein", "Tier 1", 0.658, 1, "A2_pm_peripheral", 6, 54.12, 0, 0, null, null, 1, 21, "42058742,39442496,38852383,38217663,38070612,37500079,33676686,33195056,32365011,29484603,26686919,25202925,23998713,22736004,10848986,30982509,24512542,19457263", 1, "alcohol drinking", 0.391844482483692], ["P24941", "CDK2", "Cyclin-dependent kinase 2", "Tier 1", 0.652, 1, "A2_pm_peripheral", 100, 88.44, 0, 1, "1QMZ", "1HCK", 1, 24, "33981223,26972431,21616931,21059336,20394401,19320493,18495468,18186614,11071782,11106396,9826690,9826689,8606778,11566434", 1, "neurodegenerative disease", 0.37316884263655814], ["P06702", "S100A9", "Protein S100-A9", "Tier 1", 0.651, 1, "A2_pm_peripheral", 13, 94.31, 1, 0, null, null, 1, 9, "41924874,41505229,41477217,40215752,39317671,37879125,35724603,33534888,32478041", 1, "inborn error of immunity", 0.36994943453938645], ["Q99418", "CYTH2", "Cytohesin-2", "Tier 1", 0.651, 1, "A2_pm_peripheral", 11, 84.62, 0, 0, null, null, 1, 2, "23757206,15277685", 1, "neurodegenerative disease", 0.3695798546847018], ["P43652", "AFM", "Afamin", "Tier 1", 0.649, 1, "A2_pm_peripheral", 3, 90.5, 0, 0, null, null, 1, 181, "41981590,41644987,41639270,41592438,41405386,41252929,41187335,41065720,41003495,40817942,40487293,40430051,40279903,40200829,39916299,39863729,39852074,39772502,39421963,39349658,39299186,39282756,39167342,39131199,39032299,38925633,38646165,38224944,38136647,38094082,38074684,37975892,37678120,37630325,37611441,37444259,37442003,37329944,37232893,37166710,37144950,37127843,36861067,36819738,36759615,36694259,36587435,36551097,36340178,36227568,37400771,27530235", 1, "Abnormality of the skeletal system", 0.3630438694285995], ["Q86UW9", "DTX2", "Probable E3 ubiquitin-protein ligase DTX2", "Tier 1", 0.645, 1, "A2_pm_peripheral", 4, 71.81, 0, 0, null, null, 1, 3, "36623457,35569274,24164310", 1, "neurodegenerative disease", 0.34889093978477204], ["P25054", "APC", "Adenomatous polyposis coli protein", "Tier 1", 0.644, 1, "A2_pm_peripheral", 31, null, 0, 0, null, null, 1, 39, "41471356,40788329,40207978,39796151,39335496,39189513,38710049,38509823,37199793,37185533,36894782,36882463,36827736,36252203,35544380,35490167,34837173,34708097,34240523,34008621,32486960,32429721,32386347,31937772,31295701,31249960,30609568,29886066,29666278,27736370,27427891,26552824,26552816,25059182,24681393,22236082,19389630,19029139,9546673", 0, "familial adenomatous polyposis 1", 0.8462165290909345], ["P07996", "THBS1", "Thrombospondin-1", "Tier 1", 0.641, 1, "A2_pm_peripheral", 11, 84.25, 0, 0, null, null, 1, 6, "35990694,34248840,31640794,30884317,24434496,22314602", 1, "autism spectrum disorder", 0.3356118729017016], ["P28676", "GCA", "Grancalcin", "Tier 1", 0.641, 1, "A2_pm_peripheral", 4, 81.31, 0, 0, null, null, 1, 7, "40480702,39153834,35029036,24818254,22915350,17673982,11058113", 1, "intelligence", 0.33779315817113664]], "truncated": false, "filtered_table_rows_count": 78, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A2_pm_peripheral", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 75, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 3, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 78, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 76, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 2, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 78, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 78, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 60, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 18, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 63, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 15, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 933.1610859371722, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}