{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, surface_class = \"A_assoc\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P07225", "PROS1", "Vitamin K-dependent protein S", "Tier 1.5", 0.847, 1, "A_assoc", 3, 82.94, 1, 0, null, null, 1, 2, "36859809,33674695", 1, "thrombophilia due to protein S deficiency, autosomal dominant", 0.8240418292042652], ["P39060", "COL18A1", "Collagen alpha-1(XVIII) chain", "Tier 1.5", 0.836, 1, "A_assoc", 9, 50.62, 1, 0, null, null, 1, 2, "36707842,23679916", 1, "Knobloch syndrome 1", 0.7867122552672962], ["P35625", "TIMP3", "Metalloproteinase inhibitor 3", "Tier 1.5", 0.831, 1, "A_assoc", 1, 87.0, 0, 0, null, null, 1, 3, "42105605,36768220", 1, "Sorsby fundus dystrophy", 0.7684253675298044], ["P02748", "C9", "Complement component C9", "Tier 1.5", 0.829, 1, "A_assoc", 9, 78.75, 1, 0, null, null, 1, 10, "41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383", 1, "Immunodeficiency due to a late component of complements deficiency", 0.761965409699055], ["P36955", "SERPINF1", "Pigment epithelium-derived factor", "Tier 1.5", 0.811, 1, "A_assoc", 3, 90.12, 0, 0, null, null, 1, 17, "41503480,40965986,24311895,21546514,19668729,17628122,16787141,16724865,16136393,15947805", 1, "osteogenesis imperfecta", 0.701995723393119], ["O00187", "MASP2", "Mannan-binding lectin serine protease 2", "Tier 1.5", 0.81, 1, "A_assoc", 10, 89.44, 0, 0, null, null, 1, 1, "40371468", 1, "immunodeficiency due to MASP-2 deficiency", 0.6996393077218865], ["Q16270", "IGFBP7", "Insulin-like growth factor-binding protein 7", "Tier 1.5", 0.785, 1, "A_assoc", 1, 84.44, 0, 0, null, null, 1, 4, "41192243,27679852,41280530", 1, "familial retinal arterial macroaneurysm", 0.6182241349863704], ["Q99988", "GDF15", "Growth/differentiation factor 15", "Tier 1.5", 0.775, 1, "A_assoc", 4, 75.69, 1, 0, null, null, 1, 29, "41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547", 1, "hyperemesis gravidarum", 0.5821658682742563], ["P10451", "SPP1", "Osteopontin", "Tier 1.5", 0.772, 1, "A_assoc", 3, 53.41, 0, 0, null, null, 1, 62, "41690559,41223977,39422353,38600327,32943056,32042311,31603904,30307407,28916037,28453726,25278703,21147843,42136308,42108056,40845664,40479828,39677448,39340832,38834269,37162508,36508319,36284815,35433114,35190123,34420232,32166466,31987218,31879964,31806966,31301870,30135425,29441346,28988933,28706912,26529285,25949891,25930003,25713073,24902765,24491763,24438228,23889968,23619316,22880609,22241292,21962803,21801960,20967826,19570203,18985031", 1, "osteoporosis", 0.5729473764531288], ["P10646", "TFPI", "Tissue factor pathway inhibitor", "Tier 1.5", 0.768, 1, "A_assoc", 9, 73.62, 1, 0, null, null, 1, 28, "32366845,32224381,30994257,30302740,27563744,27196067,24263002,23528042,22951415,22658294,22632032,22239993,21696535,21389323,8578509,25521966,24319161", 1, "hemophilia A", 0.5591056672248635], ["P10909", "CLU", "Clusterin", "Tier 1.5", 0.766, 1, "A_assoc", 2, 77.31, 0, 0, null, null, 1, 5, "42041411,37179603,36980195,35383192,26061649", 1, "Alzheimer disease", 0.5545645077431476], ["P13497", "BMP1", "Bone morphogenetic protein 1", "Tier 1.5", 0.766, 1, "A_assoc", 8, 81.44, 0, 0, null, null, 1, 1, "39939919", 1, "osteogenesis imperfecta", 0.5547577676549571], ["P02771", "AFP", "Alpha-fetoprotein", "Tier 1.5", 0.765, 1, "A_assoc", 5, 88.94, 1, 0, null, null, 1, 195, "41849903,41732103,41688234,41327249,41051792,40839965,40750207,40684729,40578247,40383027,40381048,40347636,40262341,40216053,39982565,39942588,39890683,39771616,39479488,39383727,39305942,39167423,39140150,39082193,39067928,39007743,38904836,38852341,38356334,37836778,37709445,37606762,37366993,37303825,37295202,37284243,37228865,37104032,36989661,36979562,36842207,36693188,36512161,36389169,36290918,36240195,36130652,35969067,35793076,35747812,41637558,41575587,41123957,41103270,40349714,40286895,38899396,37325361", 1, "Congenital deficiency in alpha-fetoprotein", 0.5500580170557311], ["P55145", "MANF", "Mesencephalic astrocyte-derived neurotrophic factor", "Tier 1.5", 0.761, 1, "A_assoc", 3, 81.69, 0, 0, null, null, 1, 1, "12698297", 1, "diabetes, deafness, developmental delay, and short stature syndrome", 0.5377386885662411], ["P24593", "IGFBP5", "Insulin-like growth factor-binding protein 5", "Tier 1.5", 0.711, 1, "A_assoc", 3, 76.06, 1, 0, null, null, 1, 4, "39317671,31930684", 1, "hypothyroidism", 0.3702458751451027], ["Q00604", "NDP", "Norrin", "Tier 1.5", 0.707, 1, "A_assoc", 11, 83.56, 1, 0, null, null, 1, 2, "39057719,11352723", 0, "Norrie disease", 0.8566451682188412], ["O43866", "CD5L", "CD5 antigen-like", "Tier 1.5", 0.706, 1, "A_assoc", 4, 85.88, 1, 0, null, null, 1, 3, "40215752,37100807", 1, "functional neutrophil defect", 0.3529395470693119], ["P10145", "CXCL8", "Interleukin-8", "Tier 1.5", 0.706, 1, "A_assoc", 21, 88.06, 1, 0, null, null, 1, 15, "39564692,35821507,31985806,29268188,41866852,37732574,37016361,36037714,35197258,34884636,25998051,24129312", 1, "coronary artery disease", 0.35357870191996843], ["P22692", "IGFBP4", "Insulin-like growth factor-binding protein 4", "Tier 1.5", 0.706, 1, "A_assoc", 4, 77.25, 0, 0, null, null, 1, 6, "35323639,32515246,31930684", 1, "allergic rhinitis", 0.35214760515440524], ["P12273", "PIP", "Prolactin-inducible protein", "Tier 1.5", 0.701, 1, "A_assoc", 1, 89.69, 0, 0, null, null, 1, 7, "41440247,36179084,35726753,35336001,28107930,26297462,21559755", 1, "neurodegenerative disease", 0.3382059336442212], ["P80162", "CXCL6", "C-X-C motif chemokine 6", "Tier 1.5", 0.699, 1, "A_assoc", 2, 81.0, 1, 0, null, null, 1, 3, "40008515,36649818,32628701", 1, "neurodegenerative disease", 0.3309117033683961], ["P98066", "TNFAIP6", "Tumor necrosis factor-inducible gene 6 protein", "Tier 1.5", 0.693, 1, "A_assoc", 5, 81.12, 0, 0, null, null, 1, 1, "39263947", 1, "type 2 diabetes mellitus", 0.30862220597837015], ["Q13253", "NOG", "Noggin", "Tier 1.5", 0.685, 1, "A_assoc", 2, 86.06, 0, 0, null, null, 1, 2, "38397086", 0, "proximal symphalangism 1A", 0.7844136456463046], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.685, 1, "A_assoc", 3, 68.62, 1, 0, null, null, 1, 2, "41101154,27364573", 0, "persistent Mullerian duct syndrome", 0.7847328444470535], ["P01138", "NGF", "Beta-nerve growth factor", "Tier 1.5", 0.684, 1, "A_assoc", 8, 73.25, 0, 0, null, null, 1, 6, "42015870,38780008,32982626,21216401,7545283,29754498", 0, "hereditary sensory and autonomic neuropathy type 5", 0.7785402119369383], ["P18510", "IL1RN", "Interleukin-1 receptor antagonist protein", "Tier 1.5", 0.682, 1, "A_assoc", 5, 87.06, 0, 0, null, null, 1, 1, "38928037", 0, "sterile multifocal osteomyelitis with periostitis and pustulosis", 0.7734282711738736], ["O15520", "FGF10", "Fibroblast growth factor 10", "Tier 1.5", 0.67, 1, "A_assoc", 2, 80.0, 0, 0, null, null, 1, 1, "35415885", 0, "Lacrimoauriculodentodigital syndrome", 0.7344198619465704], ["O00300", "TNFRSF11B", "Tumor necrosis factor receptor superfamily member 11B", "Tier 1.5", 0.666, 1, "A_assoc", 1, 86.5, 0, 0, null, null, 1, 1, "15562003", 0, "juvenile Paget disease", 0.7184894548525037], ["P19835", "CEL", "Bile salt-activated lipase", "Tier 1.5", 0.658, 1, "A_assoc", 7, 82.56, 0, 0, null, null, 1, 2, "39653009,34940276", 0, "MODY", 0.6940743944678538], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "Tier 1.5", 0.652, 1, "A_assoc", 1, 79.62, 0, 0, null, null, 1, 1, "23770039", 0, "familial hypobetalipoproteinemia 2", 0.6739043862507132], ["O75594", "PGLYRP1", "Peptidoglycan recognition protein 1", "Tier 1.5", 0.649, 1, "A_assoc", 1, 91.0, 0, 0, null, null, 1, 2, "35821507,33534888", 1, "dementia", 0.16478389504231422], ["P02776", "PF4", "Platelet factor 4", "Tier 1.5", 0.635, 1, "A_assoc", 10, 75.06, 0, 0, null, null, 1, 10, "33859620,32366845,31967847,23847186,23673861,34248840,32022468", 1, "systemic scleroderma", 0.11523541376593864], ["O76093", "FGF18", "Fibroblast growth factor 18", "Tier 1.5", 0.631, 1, "A_assoc", 1, 87.56, 0, 0, null, null, 1, 1, "35415885", 0, "cancer", 0.6028027301556572], ["P08620", "FGF4", "Fibroblast growth factor 4", "Tier 1.5", 0.631, 1, "A_assoc", 1, 81.5, 0, 0, null, null, 1, 3, "35415885,33536494,7547864", 0, "cancer", 0.6026669167438079], ["O95445", "APOM", "Apolipoprotein M", "Tier 1.5", 0.631, 1, "A_assoc", 3, 89.44, 0, 0, null, null, 1, 10, "38238732,36980195,35120890,32237898,30771967,37425696,37400771,34796696", 1, "type 2 diabetes mellitus", 0.10169659060091507], ["Q9GZX6", "IL22", "Interleukin-22", "Tier 1.5", 0.619, 1, "A_assoc", 6, 88.12, 0, 0, null, null, 1, 7, "34208021,33869115,28942363,26792955,37041650", 0, "atopic eczema", 0.5627493881195745], ["Q15726", "KISS1", "Metastasis-suppressor KiSS-1", "Tier 1.5", 0.618, 1, "A_assoc", 2, 59.41, 1, 0, null, null, 1, 1, "35026192", 0, "hypogonadotropic hypogonadism", 0.5608645918536114], ["P22466", "GAL", "Galanin peptides", "Tier 1.5", 0.613, 1, "A_assoc", 10, 66.56, 1, 0, null, null, 1, 27, "40382399,40371468,39772541,39705316,39681229,39430968,39329806,39263318,38487245,38314707,37737989,37610431,37512948,36795559,36194889,34944985,34635237,33769582,33006019,32502344,31778957,31173420,30650243,29808997,25940316,21850727,9546673", 0, "temporal lobe epilepsy", 0.5442263564708273], ["P02766", "TTR", "Transthyretin", "Tier 1.5", 0.609, 0, "A_assoc", 0, 88.0, 0, 0, null, null, 1, 11, "39737993,32616928,23770039,21875107,21314458,39596348,38399458,36881759,33572452", 1, "amyloidosis, hereditary systemic 1", 0.846421986844374], ["P56703", "WNT3", "Proto-oncogene Wnt-3", "Tier 1.5", 0.608, 1, "A_assoc", 1, 88.25, 0, 0, null, null, 1, 2, "40168709,18673242", 0, "neurodegenerative disease", 0.5272184953415704], ["P43251", "BTD", "Biotinidase", "Tier 1.5", 0.607, 0, "A_assoc", 0, 86.19, 0, 0, null, null, 1, 1, "27628341", 1, "biotinidase deficiency", 0.8394965674633185], ["P02654", "APOC1", "Apolipoprotein C-I", "Tier 1.5", 0.6, 1, "A_assoc", 8, 70.69, 0, 0, null, null, 1, 4, "41316897,40501769,35415203,15132764", 1, null, null], ["P24855", "DNASE1", "Deoxyribonuclease-1", "Tier 1.5", 0.591, 1, "A_assoc", 1, 94.25, 0, 0, null, null, 1, 1, "36838023", 0, "systemic lupus erythematosus", 0.4692224712894944], ["P41271", "NBL1", "Neuroblastoma suppressor of tumorigenicity 1", "Tier 1.5", 0.585, 1, "A_assoc", 2, 75.75, 0, 0, null, null, 1, 2, "35026285,29281176", 0, "nontoxic goiter", 0.44859094265791405], ["P18075", "BMP7", "Bone morphogenetic protein 7", "Tier 1.5", 0.583, 1, "A_assoc", 4, 76.19, 0, 0, null, null, 1, 1, "30537181", 0, "Inguinal hernia", 0.4420059023371716], ["P01031", "C5", "Complement C5", "Tier 1.5", 0.58, 0, "A_assoc", 0, 81.56, 0, 0, null, null, 1, 58, "41407269,41159487,40915733,40683108,40479828,40243681,39831626,39318191,39263947,39073397,38694318,38179195,37566081,35442665,35056853,34637287,33398182,33039563,32882310,32784904,32463617,31862877,31460550,31301466,31184617,30810582,30633241,29850750,29846697,29341876,29294056,28918528,28104543,26947566,26838458,26221631,26057195,23887360,23662585,23595830,19843610,19469583,17263432,16518777,15745996,14980623,14552769,12903182,12490703,10408383", 1, "Immunodeficiency due to a late component of complements deficiency", 0.7500698741801265], ["Q8NEV9", "IL27", "Interleukin-27 subunit alpha", "Tier 1.5", 0.573, 1, "A_assoc", 4, 75.62, 1, 0, null, null, 1, 2, "35859339,32784904", 0, "Crohn's disease", 0.40963715551754365], ["P41221", "WNT5A", "Protein Wnt-5a", "Tier 1.5", 0.572, 0, "A_assoc", 0, 87.69, 0, 0, null, null, 1, 4, "40855286,32693649,22363130,18673242", 1, "Robinow syndrome", 0.7220360983378594], ["O95750", "FGF19", "Fibroblast growth factor 19", "Tier 1.5", 0.566, 1, "A_assoc", 4, 79.81, 0, 0, null, null, 1, 4, "35415885,31967847,27679852", 0, "cancer", 0.38540691230511315], ["P35443", "THBS4", "Thrombospondin-4", "Tier 1.5", 0.559, 0, "A_assoc", 0, 84.56, 0, 0, null, null, 1, 3, "28252048,38045440,32527800", 1, "Abnormality of the skeletal system", 0.6783866364728552]], "truncated": false, "filtered_table_rows_count": 96, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A_assoc", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5", "results": 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0, "label": 0, "count": 96, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 96, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_assoc&tier=Tier+1.5", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 96, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 60, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 36, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 75, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 21, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_assoc&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 340.05119279026985, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}