{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1 and surface_class = \"A_surface\" sorted by evidence_priority descending", "rows": [["P21359", "NF1", "Neurofibromin", "Tier 1.5", 0.965, 1, "A_surface", 26, 87.19, 1, 0, null, null, 1, 2, "32980430,22617876", 1, "neurofibromatosis type 1", 0.8844735398780649], ["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.959, 1, "A_surface", 6, 90.25, 1, 0, null, null, 1, 2, "24635113", 1, "chronic granulomatous disease", 0.8633132852459866], ["P21802", "FGFR2", "Fibroblast growth factor receptor 2", "Tier 1", 0.959, 1, "A_surface", 62, 73.94, 0, 0, null, null, 1, 5, "41786503,39759879,31357131,24242861,19212647", 1, "Crouzon syndrome", 0.8637438969881663], ["P78504", "JAG1", "Protein jagged-1", "Tier 1", 0.958, 1, "A_surface", 7, 73.12, 0, 0, null, null, 1, 4, "37338014,37052638,23341879,18673242", 1, "Alagille syndrome due to a JAG1 point mutation", 0.8586542923232751], ["P00813", "ADA", "Adenosine deaminase", "Tier 1.5", 0.957, 1, "A_surface", 2, 96.56, 0, 0, null, null, 1, 72, "42012076,41877526,41762796,41635914,40403280,40189053,39856849,39847085,36796307,33998617,32043202,30876536,30060448,27589406,26606306,25597304,25521724,25360869,24976151,24893272,24682016,24035856,23462984,23202335,23037591,22944024,22613226,41910181,41791686,41267360,39673485,39396299,38583236,36855421,34241023,33147453,32546280,30926472,26605646,24624989,23373863,22543727,20345118,19381549,19378312,18293985,17440909,17000903,16856187,16619330", 1, "Severe combined immunodeficiency due to adenosine deaminase deficiency", 0.8556816060494579], ["P11166", "SLC2A1", "Solute carrier family 2, facilitated glucose transporter member 1", "Tier 1", 0.956, 1, "A_surface", 5, 90.25, 0, 0, null, null, 1, 2, "39627234,33184583", 1, "encephalopathy due to GLUT1 deficiency", 0.8521823225896756], ["P29965", "CD40LG", "CD40 ligand", "Tier 1", 0.954, 1, "A_surface", 8, 82.62, 1, 0, null, null, 1, 6, "37331977,36203210,26504624", 1, "hyper-IgM syndrome type 1", 0.8451678829647167], ["P11362", "FGFR1", "Fibroblast growth factor receptor 1", "Tier 1", 0.954, 1, "A_surface", 82, 73.88, 0, 0, null, null, 1, 13, "41873087,41820318,40092750,39759879,39249203,37336759,33536494,31583159,31357131,30297602,28442904", 1, "hypogonadotropic hypogonadism 2 with or without anosmia", 0.8472925100660907], ["P08581", "MET", "Hepatocyte growth factor receptor", "Tier 1", 0.953, 1, "A_surface", 100, 79.25, 0, 0, null, null, 1, 149, "42012469,41992303,41973478,41873087,41861669,41858296,41848278,41601428,41462891,41391726,41234744,41123956,41084363,41065179,41024479,40954195,40938088,40923343,40840349,40740738,40728393,40640119,40388621,40189053,40116812,40041032,39930702,39853766,39852082,39744222,39735310,39674868,39631842,39586988,39527480,39513807,39355222,39348183,39288204,39087949,38925633,38923378,38876234,38829176,38697444,38515622,38298092,38277932,38230289,38225704,30237882,29416033,26131766", 1, "papillary renal cell carcinoma", 0.84195976263742], ["P06213", "INSR", "Insulin receptor", "Tier 1", 0.953, 1, "A_surface", 87, 77.62, 0, 0, null, null, 1, 14, "33410883,24768638,40603733,37779149,36310231,35478209,29262294,27648925,26387957,26245346,19396447,17167487", 1, "Leprechaunism", 0.8448849372402896], ["Q8WZ42", "TTN", "Titin", "Tier 1", 0.953, 1, "A_surface", 64, null, 0, 0, null, null, 1, 1, "29952259", 1, "dilated cardiomyopathy", 0.8419847660466327], ["P37173", "TGFBR2", "TGF-beta receptor type-2", "Tier 1", 0.952, 1, "A_surface", 22, 81.0, 1, 0, null, null, 1, 8, "32452828,30595527,29522674,29375127,26284552,23999222,22899759,11856769", 1, "Loeys-Dietz syndrome", 0.8390072008866913], ["P19438", "TNFRSF1A", "Tumor necrosis factor receptor superfamily member 1A", "Tier 1", 0.951, 1, "A_surface", 13, 71.38, 1, 0, null, null, 1, 1, "35197258", 1, "TNF receptor 1-associated periodic fever syndrome", 0.8352778213184682], ["P06744", "GPI", "Glucose-6-phosphate isomerase", "Tier 1", 0.949, 1, "A_surface", 13, 97.94, 1, 0, null, null, 1, 19, "41911185,41329468,41232387,35821507,34953205,32730952,29501157,27419372,25919296,25483705,24334484,23656757,23578283,23018995,22116094,20967861,17574575,27380815", 1, "hemolytic anemia due to glucophosphate isomerase deficiency", 0.8306909118751346], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.949, 1, "A_surface", 11, 75.94, 0, 0, null, null, 1, 6, "41733039,34364920,31434881,30237882,29299123,22411871", 1, "acute myeloid leukemia", 0.8313389209288576], ["P36897", "TGFBR1", "TGF-beta receptor type-1", "Tier 1", 0.948, 1, "A_surface", 44, 84.19, 1, 0, null, null, 1, 1, "41089000", 1, "Loeys-Dietz syndrome 1", 0.8275292516338373], ["P36894", "BMPR1A", "Bone morphogenetic protein receptor type-1A", "Tier 1", 0.948, 1, "A_surface", 11, 82.62, 0, 0, null, null, 1, 1, "30537181", 1, "juvenile polyposis syndrome", 0.8278395086688584], ["P22607", "FGFR3", "Fibroblast growth factor receptor 3", "Tier 1", 0.948, 1, "A_surface", 13, 74.19, 1, 0, null, null, 1, 6, "38569854,37704353,34864168,33952673,31357131", 1, "achondroplasia", 0.8270702096931246], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.947, 1, "A_surface", 70, 64.19, 1, 0, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["P05106", "ITGB3", "Integrin beta-3", "Positive Control", 0.946, 1, "A_surface", 123, 87.0, 1, 1, "8T2U", "8T2V", 1, 2, "22133781,23544955", 1, "Glanzmann thrombasthenia 1", 0.8208115968652424], ["P08069", "IGF1R", "Insulin-like growth factor 1 receptor", "Tier 1", 0.945, 1, "A_surface", 46, 78.0, 1, 0, null, null, 1, 10, "40997970,39263947,33410883,30041514,23373648,16019422,15231297", 1, "growth delay due to insulin-like growth factor I resistance", 0.8166352227841136], ["P16234", "PDGFRA", "Platelet-derived growth factor receptor alpha", "Tier 1.5", 0.945, 1, "A_surface", 14, 72.69, 1, 0, null, null, 1, 4, "33334063,32127469,28010895,30594071", 1, "gastrointestinal stromal tumor", 0.8167494524079806], ["Q13563", "PKD2", "Polycystin-2", "Tier 1", 0.943, 1, "A_surface", 31, 70.12, 1, 0, null, null, 1, 3, "41315228,36126144", 1, "polycystic kidney disease 2", 0.810960823768978], ["O75844", "ZMPSTE24", "CAAX prenyl protease 1 homolog", "Tier 1", 0.942, 1, "A_surface", 4, 89.44, 0, 0, null, null, 1, 1, "37565451", 1, "mandibuloacral dysplasia with type B lipodystrophy", 0.8071967390737101], ["P25942", "CD40", "Tumor necrosis factor receptor superfamily member 5", "Tier 1", 0.941, 1, "A_surface", 14, 81.19, 0, 0, null, null, 1, 8, "41982466,37331977,36203210,33335251,26504624,26231918,23460531,12828856", 1, "hyper-IgM syndrome type 3", 0.8038021669520221], ["P58335", "ANTXR2", "Anthrax toxin receptor 2", "Tier 1", 0.941, 1, "A_surface", 14, 71.81, 1, 0, null, null, 1, 4, "41503480,41083485,41020397,40313273", 1, "hyaline fibromatosis syndrome", 0.8028849863986661], ["P61073", "CXCR4", "C-X-C chemokine receptor type 4", "Tier 1", 0.94, 1, "A_surface", 33, 82.25, 1, 0, null, null, 1, 17, "40671676,40401615,39865939,39778270,37052638,35157940,33739080,31737891,31267721,31097627,28670693,26265085,25329893,22811524,22376154,12498773,41543187", 1, "WHIM syndrome", 0.8009225456235435], ["Q16832", "DDR2", "Discoidin domain-containing receptor 2", "Tier 1", 0.936, 1, "A_surface", 5, 75.81, 0, 0, null, null, 1, 1, "26067556", 1, "spondyloepimetaphyseal dysplasia-short limb-abnormal calcification syndrome", 0.7854778386444168], ["P04626", "ERBB2", "Receptor tyrosine-protein kinase erbB-2", "Tier 1.5", 0.934, 1, "A_surface", 63, 74.0, 0, 0, null, null, 1, 119, "41836728,41744190,41540559,41494763,41413339,41321156,41297941,40851486,40761795,40494827,40403699,40382399,40223744,40220375,40120226,40080161,40056884,39873777,39809083,39756158,39748051,39643321,39609809,39539244,39263860,39233482,39177424,38901393,38813974,38789508,38693181,38679242,38604040,38409854,38066021,37729138,37659641,37591183,37522239,37392577,37038354,36272296,36255496,36001395,35504229,34952586,34476602,34236165,33876310,33627408", 1, "non-small cell lung carcinoma", 0.7789523142843545], ["P15529", "CD46", "Membrane cofactor protein", "Tier 1.5", 0.934, 1, "A_surface", 7, 82.12, 1, 0, null, null, 1, 9, "35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032", 1, "atypical hemolytic-uremic syndrome with MCP/CD46 anomaly", 0.7798469882597787], ["P13987", "CD59", "CD59 glycoprotein", "Tier 1", 0.932, 1, "A_surface", 17, 79.31, 1, 0, null, null, 1, 1, "19915929", 1, "primary CD59 deficiency", 0.7738276843579196], ["Q13554", "CAMK2B", "Calcium/calmodulin-dependent protein kinase type II subunit beta", "Tier 1", 0.932, 1, "A_surface", 4, 70.56, 0, 0, null, null, 1, 2, "29784938,26594036", 1, "intellectual disability, autosomal dominant 54", 0.7745713380655789], ["P29317", "EPHA2", "Ephrin type-A receptor 2", "Tier 1", 0.931, 1, "A_surface", 100, 82.25, 0, 0, null, null, 1, 16, "40563410,40408544,39259047,37251690,35700603,35397426,32169805,34541193,28235049,24586375,21902173,21793789", 1, "Total congenital cataract", 0.7690993612962792], ["P12821", "ACE", "Angiotensin-converting enzyme", "Tier 1", 0.93, 1, "A_surface", 97, 90.94, 0, 0, null, null, 1, 108, "41505229,41326371,41315058,41027166,40975918,40578246,40549055,40494268,40394224,40157106,39796148,39643350,39638470,39368201,39326115,39277931,38989925,38783134,38559166,38454949,38189917,37692001,37526583,37422510,37385465,37231283,37191170,36924636,36327903,36128975,36069206,35985229,35831655,34248841,34227370,34213110,34109445,33362222,32981365,32969502,31542417,30707214,29367662,29244716,28507681,25035238,24861783,24125636,20373790,20119964,41716474,41274248,40642289,40333723,40321580,40227272,39964138,39923730,38553521,37932762,37808754,37375202,36822303,36714461,36581924,36288301,36170362,36073793,35972202,35910791,35748608,35542182,34953639,34876524,34855379,34798263,34696413,34619249,34458322,34282416,34230708,34230707,34166652,33684258,33683787,33629859,33561300,32838280,32551560,21147843,18209324,16607776", 1, "diabetic nephropathy", 0.7656590329495216], ["P02511", "CRYAB", "Alpha-crystallin B chain", "Tier 1", 0.925, 1, "A_surface", 21, 75.75, 1, 0, null, null, 1, 2, "28720498,23530262", 1, "myofibrillar myopathy 2", 0.7505030087389963], ["Q14432", "PDE3A", "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A", "Tier 1", 0.924, 1, "A_surface", 9, 60.25, 1, 0, null, null, 1, 1, "34456709", 1, "Brachydactyly - arterial hypertension", 0.7468849549430213], ["P24394", "IL4R", "Interleukin-4 receptor subunit alpha", "Tier 1.5", 0.923, 1, "A_surface", 10, 54.75, 0, 0, null, null, 1, 3, "32751068,27819142,22282665", 1, "asthma", 0.742115080702623], ["P01019", "AGT", "Angiotensinogen", "Tier 1", 0.921, 1, "A_surface", 22, 86.44, 0, 0, null, null, 1, 16, "35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235", 1, "renal tubular dysgenesis", 0.7354947364860083], ["P01730", "CD4", "T-cell surface glycoprotein CD4", "Tier 1", 0.921, 1, "A_surface", 85, 85.25, 0, 0, null, null, 1, 96, "41889731,41761629,41654945,41542672,41395530,41338305,41206244,40972397,40877519,40788329,40448637,39920212,39269432,38744189,38661725,37895096,37881079,37836456,37170724,37141264,37110712,36352911,36149728,34386332,33389440,32786336,32567629,32157125,31778957,31707227,31434881,31316164,30393236,29881374,29556342,29375127,29277631,29145483,28934318,28800954,28290464,27959341,27529508,28955932,26792955,25757623,25754473,25241192,25189099,24661998", 1, "HIV infection", 0.7364522622142639], ["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.921, 1, "A_surface", 7, 77.88, 1, 0, null, null, 1, 17, "40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027", 1, "autoimmune lymphoproliferative syndrome type 1", 0.7377210386590284], ["P16671", "CD36", "Platelet glycoprotein 4", "Tier 1.5", 0.921, 1, "A_surface", 1, 93.94, 0, 0, null, null, 1, 6, "41713143,41140242,39762152,33596054,33291667,31904170", 1, "platelet-type bleeding disorder 10", 0.7360571429413174], ["P07204", "THBD", "Thrombomodulin", "Tier 1", 0.92, 1, "A_surface", 13, 78.62, 1, 0, null, null, 1, 5, "41988704,34708097,28549218,21526769,7622501", 1, "thrombomodulin-related bleeding disorder", 0.7323266135403641], ["Q9H244", "P2RY12", "P2Y purinoceptor 12", "Tier 1", 0.919, 1, "A_surface", 5, 84.44, 1, 0, null, null, 1, 2, "32679592,19509485", 1, "platelet-type bleeding disorder 8", 0.7304079345653686], ["P09758", "TACSTD2", "Tumor-associated calcium signal transducer 2", "Tier 1.5", 0.919, 1, "A_surface", 7, 82.69, 0, 0, null, null, 1, 4, "41384307,41241473,40050871,39250993", 1, "gelatinous drop-like corneal dystrophy", 0.7293087728162646], ["P21589", "NT5E", "5'-nucleotidase", "Tier 1", 0.916, 1, "A_surface", 50, 91.88, 0, 0, null, null, 1, 3, "38689291,30472954,25720604", 1, "hereditary arterial and articular multiple calcification syndrome", 0.7199342086353593], ["P08575", "PTPRC", "Receptor-type tyrosine-protein phosphatase C", "Tier 1", 0.916, 1, "A_surface", 6, 76.06, 1, 0, null, null, 1, 1, "25251012", 1, "immunodeficiency 104", 0.7200430416648742], ["Q9UNQ0", "ABCG2", "Broad substrate specificity ATP-binding cassette transporter ABCG2", "Tier 1", 0.915, 1, "A_surface", 29, 85.25, 1, 0, null, null, 1, 8, "40873307,36807620,35544739,33833512,31180052,31085078,26176230,24319544", 1, "gout", 0.7158028003520317], ["P22455", "FGFR4", "Fibroblast growth factor receptor 4", "Tier 1", 0.915, 1, "A_surface", 52, 73.62, 0, 0, null, null, 1, 2, "39759879,30297602", 1, "cancer", 0.7150377661800104], ["P13612", "ITGA4", "Integrin alpha-4", "Tier 1", 0.914, 1, "A_surface", 7, 84.44, 1, 0, null, null, 1, 3, "30065768,28670693,26504766", 1, "Crohn's disease", 0.7134551179424343], ["P08637", "FCGR3A", "Low affinity immunoglobulin gamma Fc region receptor III-A", "Tier 1.5", 0.912, 1, "A_surface", 15, 85.69, 0, 0, null, null, 1, 2, "41249026,21531729", 1, "autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity", 0.7061437347032623]], "truncated": false, "filtered_table_rows_count": 286, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A_surface"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 255, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 31, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 183, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 102, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5", "selected": false}, {"value": "Positive Control", "label": "Positive Control", "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Positive+Control", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 284, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 2, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 286, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface", "results": [{"value": "A_surface", "label": "A_surface", "count": 286, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 144, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 142, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 166, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 120, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 594.0071647055447, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}