{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, surface_class = \"A_surface\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.959, 1, "A_surface", 6, 90.25, 1, 0, null, null, 1, 2, "24635113", 1, "chronic granulomatous disease", 0.8633132852459866], ["P21802", "FGFR2", "Fibroblast growth factor receptor 2", "Tier 1", 0.959, 1, "A_surface", 62, 73.94, 0, 0, null, null, 1, 5, "41786503,39759879,31357131,24242861,19212647", 1, "Crouzon syndrome", 0.8637438969881663], ["P78504", "JAG1", "Protein jagged-1", "Tier 1", 0.958, 1, "A_surface", 7, 73.12, 0, 0, null, null, 1, 4, "37338014,37052638,23341879,18673242", 1, "Alagille syndrome due to a JAG1 point mutation", 0.8586542923232751], ["P11166", "SLC2A1", "Solute carrier family 2, facilitated glucose transporter member 1", "Tier 1", 0.956, 1, "A_surface", 5, 90.25, 0, 0, null, null, 1, 2, "39627234,33184583", 1, "encephalopathy due to GLUT1 deficiency", 0.8521823225896756], ["P29965", "CD40LG", "CD40 ligand", "Tier 1", 0.954, 1, "A_surface", 8, 82.62, 1, 0, null, null, 1, 6, "37331977,36203210,26504624", 1, "hyper-IgM syndrome type 1", 0.8451678829647167], ["P11362", "FGFR1", "Fibroblast growth factor receptor 1", "Tier 1", 0.954, 1, "A_surface", 82, 73.88, 0, 0, null, null, 1, 13, "41873087,41820318,40092750,39759879,39249203,37336759,33536494,31583159,31357131,30297602,28442904", 1, "hypogonadotropic hypogonadism 2 with or without anosmia", 0.8472925100660907], ["P08581", "MET", "Hepatocyte growth factor receptor", "Tier 1", 0.953, 1, "A_surface", 100, 79.25, 0, 0, null, null, 1, 149, 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"Tier 1", 0.952, 1, "A_surface", 22, 81.0, 1, 0, null, null, 1, 8, "32452828,30595527,29522674,29375127,26284552,23999222,22899759,11856769", 1, "Loeys-Dietz syndrome", 0.8390072008866913], ["P19438", "TNFRSF1A", "Tumor necrosis factor receptor superfamily member 1A", "Tier 1", 0.951, 1, "A_surface", 13, 71.38, 1, 0, null, null, 1, 1, "35197258", 1, "TNF receptor 1-associated periodic fever syndrome", 0.8352778213184682], ["P06744", "GPI", "Glucose-6-phosphate isomerase", "Tier 1", 0.949, 1, "A_surface", 13, 97.94, 1, 0, null, null, 1, 19, "41911185,41329468,41232387,35821507,34953205,32730952,29501157,27419372,25919296,25483705,24334484,23656757,23578283,23018995,22116094,20967861,17574575,27380815", 1, "hemolytic anemia due to glucophosphate isomerase deficiency", 0.8306909118751346], ["P36897", "TGFBR1", "TGF-beta receptor type-1", "Tier 1", 0.948, 1, "A_surface", 44, 84.19, 1, 0, null, null, 1, 1, "41089000", 1, "Loeys-Dietz syndrome 1", 0.8275292516338373], ["P36894", "BMPR1A", "Bone morphogenetic protein receptor type-1A", "Tier 1", 0.948, 1, "A_surface", 11, 82.62, 0, 0, null, null, 1, 1, "30537181", 1, "juvenile polyposis syndrome", 0.8278395086688584], ["P22607", "FGFR3", "Fibroblast growth factor receptor 3", "Tier 1", 0.948, 1, "A_surface", 13, 74.19, 1, 0, null, null, 1, 6, "38569854,37704353,34864168,33952673,31357131", 1, "achondroplasia", 0.8270702096931246], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.947, 1, "A_surface", 70, 64.19, 1, 0, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["P08069", "IGF1R", "Insulin-like growth factor 1 receptor", "Tier 1", 0.945, 1, "A_surface", 46, 78.0, 1, 0, null, null, 1, 10, "40997970,39263947,33410883,30041514,23373648,16019422,15231297", 1, "growth delay due to insulin-like growth factor I resistance", 0.8166352227841136], ["Q13563", "PKD2", "Polycystin-2", "Tier 1", 0.943, 1, "A_surface", 31, 70.12, 1, 0, null, null, 1, 3, "41315228,36126144", 1, "polycystic kidney disease 2", 0.810960823768978], ["O75844", "ZMPSTE24", "CAAX prenyl protease 1 homolog", "Tier 1", 0.942, 1, "A_surface", 4, 89.44, 0, 0, null, null, 1, 1, "37565451", 1, "mandibuloacral dysplasia with type B lipodystrophy", 0.8071967390737101], ["P25942", "CD40", "Tumor necrosis factor receptor superfamily member 5", "Tier 1", 0.941, 1, "A_surface", 14, 81.19, 0, 0, null, null, 1, 8, "41982466,37331977,36203210,33335251,26504624,26231918,23460531,12828856", 1, "hyper-IgM syndrome type 3", 0.8038021669520221], ["P58335", "ANTXR2", "Anthrax toxin receptor 2", "Tier 1", 0.941, 1, "A_surface", 14, 71.81, 1, 0, null, null, 1, 4, "41503480,41083485,41020397,40313273", 1, "hyaline fibromatosis syndrome", 0.8028849863986661], ["P61073", "CXCR4", "C-X-C chemokine receptor type 4", "Tier 1", 0.94, 1, "A_surface", 33, 82.25, 1, 0, null, null, 1, 17, "40671676,40401615,39865939,39778270,37052638,35157940,33739080,31737891,31267721,31097627,28670693,26265085,25329893,22811524,22376154,12498773,41543187", 1, "WHIM syndrome", 0.8009225456235435], ["Q16832", "DDR2", "Discoidin domain-containing receptor 2", "Tier 1", 0.936, 1, "A_surface", 5, 75.81, 0, 0, null, null, 1, 1, "26067556", 1, "spondyloepimetaphyseal dysplasia-short limb-abnormal calcification syndrome", 0.7854778386444168], ["P13987", "CD59", "CD59 glycoprotein", "Tier 1", 0.932, 1, "A_surface", 17, 79.31, 1, 0, null, null, 1, 1, "19915929", 1, "primary CD59 deficiency", 0.7738276843579196], ["Q13554", "CAMK2B", "Calcium/calmodulin-dependent protein kinase type II subunit beta", "Tier 1", 0.932, 1, "A_surface", 4, 70.56, 0, 0, null, null, 1, 2, "29784938,26594036", 1, "intellectual disability, autosomal dominant 54", 0.7745713380655789], ["P29317", "EPHA2", "Ephrin type-A receptor 2", "Tier 1", 0.931, 1, "A_surface", 100, 82.25, 0, 0, null, null, 1, 16, "40563410,40408544,39259047,37251690,35700603,35397426,32169805,34541193,28235049,24586375,21902173,21793789", 1, "Total congenital cataract", 0.7690993612962792], ["P12821", "ACE", "Angiotensin-converting enzyme", "Tier 1", 0.93, 1, "A_surface", 97, 90.94, 0, 0, null, null, 1, 108, "41505229,41326371,41315058,41027166,40975918,40578246,40549055,40494268,40394224,40157106,39796148,39643350,39638470,39368201,39326115,39277931,38989925,38783134,38559166,38454949,38189917,37692001,37526583,37422510,37385465,37231283,37191170,36924636,36327903,36128975,36069206,35985229,35831655,34248841,34227370,34213110,34109445,33362222,32981365,32969502,31542417,30707214,29367662,29244716,28507681,25035238,24861783,24125636,20373790,20119964,41716474,41274248,40642289,40333723,40321580,40227272,39964138,39923730,38553521,37932762,37808754,37375202,36822303,36714461,36581924,36288301,36170362,36073793,35972202,35910791,35748608,35542182,34953639,34876524,34855379,34798263,34696413,34619249,34458322,34282416,34230708,34230707,34166652,33684258,33683787,33629859,33561300,32838280,32551560,21147843,18209324,16607776", 1, "diabetic nephropathy", 0.7656590329495216], ["P02511", "CRYAB", "Alpha-crystallin B chain", "Tier 1", 0.925, 1, "A_surface", 21, 75.75, 1, 0, null, null, 1, 2, "28720498,23530262", 1, "myofibrillar myopathy 2", 0.7505030087389963], ["Q14432", "PDE3A", "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A", "Tier 1", 0.924, 1, "A_surface", 9, 60.25, 1, 0, null, null, 1, 1, "34456709", 1, "Brachydactyly - arterial hypertension", 0.7468849549430213], ["P01019", "AGT", "Angiotensinogen", "Tier 1", 0.921, 1, "A_surface", 22, 86.44, 0, 0, null, null, 1, 16, "35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235", 1, "renal tubular dysgenesis", 0.7354947364860083], ["P01730", "CD4", "T-cell surface glycoprotein CD4", "Tier 1", 0.921, 1, "A_surface", 85, 85.25, 0, 0, null, null, 1, 96, "41889731,41761629,41654945,41542672,41395530,41338305,41206244,40972397,40877519,40788329,40448637,39920212,39269432,38744189,38661725,37895096,37881079,37836456,37170724,37141264,37110712,36352911,36149728,34386332,33389440,32786336,32567629,32157125,31778957,31707227,31434881,31316164,30393236,29881374,29556342,29375127,29277631,29145483,28934318,28800954,28290464,27959341,27529508,28955932,26792955,25757623,25754473,25241192,25189099,24661998", 1, "HIV infection", 0.7364522622142639], ["P07204", "THBD", "Thrombomodulin", "Tier 1", 0.92, 1, "A_surface", 13, 78.62, 1, 0, null, null, 1, 5, "41988704,34708097,28549218,21526769,7622501", 1, "thrombomodulin-related bleeding disorder", 0.7323266135403641], ["Q9H244", "P2RY12", "P2Y purinoceptor 12", "Tier 1", 0.919, 1, "A_surface", 5, 84.44, 1, 0, null, null, 1, 2, "32679592,19509485", 1, "platelet-type bleeding disorder 8", 0.7304079345653686], ["P21589", "NT5E", "5'-nucleotidase", "Tier 1", 0.916, 1, "A_surface", 50, 91.88, 0, 0, null, null, 1, 3, "38689291,30472954,25720604", 1, "hereditary arterial and articular multiple calcification syndrome", 0.7199342086353593], ["P08575", "PTPRC", "Receptor-type tyrosine-protein phosphatase C", "Tier 1", 0.916, 1, "A_surface", 6, 76.06, 1, 0, null, null, 1, 1, "25251012", 1, "immunodeficiency 104", 0.7200430416648742], ["Q9UNQ0", "ABCG2", "Broad substrate specificity ATP-binding cassette transporter ABCG2", "Tier 1", 0.915, 1, "A_surface", 29, 85.25, 1, 0, null, null, 1, 8, "40873307,36807620,35544739,33833512,31180052,31085078,26176230,24319544", 1, "gout", 0.7158028003520317], ["P22455", "FGFR4", "Fibroblast growth factor receptor 4", "Tier 1", 0.915, 1, "A_surface", 52, 73.62, 0, 0, null, null, 1, 2, "39759879,30297602", 1, "cancer", 0.7150377661800104], ["P13612", "ITGA4", "Integrin alpha-4", "Tier 1", 0.914, 1, "A_surface", 7, 84.44, 1, 0, null, null, 1, 3, "30065768,28670693,26504766", 1, "Crohn's disease", 0.7134551179424343], ["O75581", "LRP6", "Low-density lipoprotein receptor-related protein 6", "Tier 1", 0.911, 1, "A_surface", 27, 79.19, 1, 0, null, null, 1, 5, "42031715,37175248,18673242", 1, "tooth agenesis, selective, 7", 0.7022725510765017], ["P40189", "IL6ST", "Interleukin-6 receptor subunit beta", "Tier 1", 0.911, 1, "A_surface", 20, 74.62, 1, 0, null, null, 1, 2, "39571081,22258147", 1, "Autosomal recessive hyper-IgE syndrome", 0.7027634038262931], ["P09601", "HMOX1", "Heme oxygenase 1", "Tier 1", 0.905, 1, "A_surface", 26, 82.88, 0, 0, null, null, 1, 6, "37533140,40526855,40509588,39812275,37457170", 1, "heme oxygenase 1 deficiency", 0.6838783130237968], ["P35968", "KDR", "Vascular endothelial growth factor receptor 2", "Tier 1", 0.904, 1, "A_surface", 54, 71.12, 0, 0, null, null, 1, 22, "29608400,27490795,26125598,10548435,9685413,41572478,41187655,39225423,33191671,32199927,30626772,21970900,21907194,20237249,19135441,18499900,17347807,16842232,16787141", 1, "neoplasm", 0.681272749535704], ["Q9NZQ7", "CD274", "Programmed cell death 1 ligand 1", "Tier 1", 0.903, 1, "A_surface", 74, 88.25, 0, 0, null, null, 1, 67, "41855853,41830812,41781380,41770936,41629133,41479885,41205458,41195987,41173800,40972397,40811947,40789156,40758411,40682599,40581004,40516668,40209314,40188671,40119836,40016918,40012368,39929085,39916963,39824759,39805944,39532409,39454136,39440615,39417693,39352679,39344385,39332044,39222892,39003918,38940673,38859589,38763821,38636085,38621341,38446717,37944524,37923412,37531891,37364303,36484532,35972912,35624582,35268583,34523014,34156677", 1, "non-small cell lung carcinoma", 0.6769230776549127], ["Q15303", "ERBB4", "Receptor tyrosine-protein kinase erbB-4", "Tier 1", 0.903, 1, "A_surface", 14, 73.12, 1, 0, null, null, 1, 3, "32592467,30697465,23990977", 1, "non-small cell lung carcinoma", 0.6754899662390331], ["P17181", "IFNAR1", "Interferon alpha/beta receptor 1", "Tier 1", 0.901, 1, "A_surface", 5, 78.0, 0, 0, null, null, 1, 1, "27068091", 1, "immunodeficiency 106, susceptibility to viral infections", 0.6703994774055272], ["Q07075", "ENPEP", "Glutamyl aminopeptidase", "Tier 1", 0.9, 1, "A_surface", 7, 93.5, 0, 0, null, null, 1, 2, "38467937", 1, "hypertension", 0.6677707312760746], ["O15455", "TLR3", "Toll-like receptor 3", "Tier 1", 0.899, 1, "A_surface", 20, 90.62, 1, 0, null, null, 1, 7, "26018150,25528762,17150912,17150911", 1, "Herpetic encephalitis", 0.6617401048830444], ["P27487", "DPP4", "Dipeptidyl peptidase 4", "Tier 1", 0.893, 1, "A_surface", 100, 96.25, 0, 0, null, null, 1, 4, "30056058,26605646", 1, "type 2 diabetes mellitus", 0.6432827162361505], ["P07550", "ADRB2", "Beta-2 adrenergic receptor", "Tier 1", 0.89, 1, "A_surface", 100, 79.12, 1, 0, null, null, 1, 2, "41637639,32376022", 1, "asthma", 0.634300392456126], ["P27338", "MAOB", "Amine oxidase [flavin-containing] B", "Tier 1", 0.889, 1, "A_surface", 56, 95.62, 0, 0, null, null, 1, 1, "26841904", 1, "Parkinson disease", 0.6302940908016386]], "truncated": false, "filtered_table_rows_count": 183, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A_surface", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 182, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 183, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 183, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 183, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": "A_surface", "label": "A_surface", "count": 183, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 101, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 82, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 96, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 87, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 358.36739372462034, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}