{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, surface_class = \"A_surface\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P21359", "NF1", "Neurofibromin", "Tier 1.5", 0.965, 1, "A_surface", 26, 87.19, 1, 0, null, null, 1, 2, "32980430,22617876", 1, "neurofibromatosis type 1", 0.8844735398780649], ["P00813", "ADA", "Adenosine deaminase", "Tier 1.5", 0.957, 1, "A_surface", 2, 96.56, 0, 0, null, null, 1, 72, "42012076,41877526,41762796,41635914,40403280,40189053,39856849,39847085,36796307,33998617,32043202,30876536,30060448,27589406,26606306,25597304,25521724,25360869,24976151,24893272,24682016,24035856,23462984,23202335,23037591,22944024,22613226,41910181,41791686,41267360,39673485,39396299,38583236,36855421,34241023,33147453,32546280,30926472,26605646,24624989,23373863,22543727,20345118,19381549,19378312,18293985,17440909,17000903,16856187,16619330", 1, "Severe combined immunodeficiency due to adenosine deaminase deficiency", 0.8556816060494579], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.949, 1, "A_surface", 11, 75.94, 0, 0, null, null, 1, 6, "41733039,34364920,31434881,30237882,29299123,22411871", 1, "acute myeloid leukemia", 0.8313389209288576], ["P16234", "PDGFRA", "Platelet-derived growth factor receptor alpha", "Tier 1.5", 0.945, 1, "A_surface", 14, 72.69, 1, 0, null, null, 1, 4, "33334063,32127469,28010895,30594071", 1, "gastrointestinal stromal tumor", 0.8167494524079806], ["P04626", "ERBB2", "Receptor tyrosine-protein kinase erbB-2", "Tier 1.5", 0.934, 1, "A_surface", 63, 74.0, 0, 0, null, null, 1, 119, "41836728,41744190,41540559,41494763,41413339,41321156,41297941,40851486,40761795,40494827,40403699,40382399,40223744,40220375,40120226,40080161,40056884,39873777,39809083,39756158,39748051,39643321,39609809,39539244,39263860,39233482,39177424,38901393,38813974,38789508,38693181,38679242,38604040,38409854,38066021,37729138,37659641,37591183,37522239,37392577,37038354,36272296,36255496,36001395,35504229,34952586,34476602,34236165,33876310,33627408", 1, "non-small cell lung carcinoma", 0.7789523142843545], ["P15529", "CD46", "Membrane cofactor protein", "Tier 1.5", 0.934, 1, "A_surface", 7, 82.12, 1, 0, null, null, 1, 9, "35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032", 1, "atypical hemolytic-uremic syndrome with MCP/CD46 anomaly", 0.7798469882597787], ["P24394", "IL4R", "Interleukin-4 receptor subunit alpha", "Tier 1.5", 0.923, 1, "A_surface", 10, 54.75, 0, 0, null, null, 1, 3, "32751068,27819142,22282665", 1, "asthma", 0.742115080702623], ["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.921, 1, "A_surface", 7, 77.88, 1, 0, null, null, 1, 17, "40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027", 1, "autoimmune lymphoproliferative syndrome type 1", 0.7377210386590284], ["P16671", "CD36", "Platelet glycoprotein 4", "Tier 1.5", 0.921, 1, "A_surface", 1, 93.94, 0, 0, null, null, 1, 6, "41713143,41140242,39762152,33596054,33291667,31904170", 1, "platelet-type bleeding disorder 10", 0.7360571429413174], ["P09758", "TACSTD2", "Tumor-associated calcium signal transducer 2", "Tier 1.5", 0.919, 1, "A_surface", 7, 82.69, 0, 0, null, null, 1, 4, "41384307,41241473,40050871,39250993", 1, "gelatinous drop-like corneal dystrophy", 0.7293087728162646], ["P08637", "FCGR3A", "Low affinity immunoglobulin gamma Fc region receptor III-A", "Tier 1.5", 0.912, 1, "A_surface", 15, 85.69, 0, 0, null, null, 1, 2, "41249026,21531729", 1, "autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity", 0.7061437347032623], ["P02786", "TFRC", "Transferrin receptor protein 1", "Tier 1.5", 0.887, 1, "A_surface", 22, 86.69, 1, 0, null, null, 1, 3, "39831311,29046922,32527800", 1, "TFRC-related combined immunodeficiency", 0.623449899069336], ["P15260", "IFNGR1", "Interferon gamma receptor 1", "Tier 1.5", 0.862, 1, "A_surface", 5, 66.0, 0, 0, null, null, 1, 2, "33667716", 1, "disseminated atypical mycobacterial infection", 0.5414012388034828], ["P21926", "CD9", "CD9 antigen", "Tier 1.5", 0.858, 1, "A_surface", 5, 88.56, 0, 0, null, null, 1, 17, "41999228,41625383,40618375,39266887,38866706,38057814,37585601,37351166,37019008,36704890,34647460,34505435,33304477,32730952,32207293,28959386", 1, "diphtheria", 0.5261379875719714], ["P13591", "NCAM1", "Neural cell adhesion molecule 1", "Tier 1.5", 0.852, 1, "A_surface", 7, 79.5, 0, 0, null, null, 1, 1, "36649818", 1, "smoking initiation", 0.5071020926446286], ["Q92633", "LPAR1", "Lysophosphatidic acid receptor 1", "Tier 1.5", 0.843, 1, "A_surface", 16, 83.62, 1, 0, null, null, 1, 1, "32065590", 1, "Epiretinal membrane", 0.4757255248053499], ["Q9P121", "NTM", "Neurotrimin", "Tier 1.5", 0.824, 1, "A_surface", 2, 82.38, 0, 0, null, null, 1, 2, "35699468,26194558", 1, "smoking initiation", 0.41382172436739945], ["Q14242", "SELPLG", "P-selectin glycoprotein ligand 1", "Tier 1.5", 0.82, 1, "A_surface", 1, 50.38, 0, 0, null, null, 1, 1, "25979951", 1, "glaucoma", 0.40058604767334977], ["P08571", "CD14", "Monocyte differentiation antigen CD14", "Tier 1.5", 0.818, 1, "A_surface", 1, 84.75, 0, 0, null, null, 1, 14, "41636061,41542672,41140242,38477735,38280803,37162508,36716100,36475636,32589412,32515246,30900705,30563044,25483705,12498773", 1, "dengue disease", 0.39219972762611355], ["P31785", "IL2RG", "Cytokine receptor common subunit gamma", "Tier 1.5", 0.804, 1, "A_surface", 14, 75.5, 1, 0, null, null, 1, 2, "30800133,33869115", 0, "gamma chain deficiency", 0.8469997000418428], ["Q5ZPR3", "CD276", "CD276 antigen", "Tier 1.5", 0.804, 1, "A_surface", 3, 83.31, 1, 0, null, null, 1, 1, "38866941", 1, "response to statin", 0.3471917147958521], ["P08100", "RHO", "Rhodopsin", "Tier 1.5", 0.804, 1, "A_surface", 4, 88.75, 1, 0, null, null, 1, 45, "41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760", 0, "retinitis pigmentosa", 0.8481942240861982], ["O95342", "ABCB11", "Bile salt export pump", "Tier 1.5", 0.801, 1, "A_surface", 8, 83.12, 1, 0, null, null, 1, 1, "36313979", 0, "progressive familial intrahepatic cholestasis type 2", 0.8372060401943777], ["P10912", "GHR", "Growth hormone receptor", "Tier 1.5", 0.799, 1, "A_surface", 9, 58.69, 0, 0, null, null, 1, 5, "38811951,38477735,31603904", 0, "Laron syndrome", 0.8304020079647765], ["Q13308", "PTK7", "Inactive tyrosine-protein kinase 7", "Tier 1.5", 0.796, 1, "A_surface", 1, 82.69, 0, 0, null, null, 1, 110, "41949051,41786503,41782379,41780252,41473803,41172349,41097888,41065179,41047832,40987771,40652441,40618375,40556592,40488675,40479736,40415219,40388621,40274545,40033943,39933564,39583320,39468753,39405917,39315658,39226482,39211579,39161311,39127174,38985770,38922365,38889444,38773263,38708542,38695582,38642044,38466380,38359901,38148412,38064592,37974961,37480788,37473438,37458448,37247456,37105082,37003060,36765879,36722904,36722696,36471380", 1, "neurodegenerative disease", 0.3194172724024113], ["P16410", "CTLA4", "Cytotoxic T-lymphocyte protein 4", "Tier 1.5", 0.787, 1, "A_surface", 22, 80.12, 0, 0, null, null, 1, 26, "41907643,40972397,40870970,40811947,40536609,39417693,38473398,38158454,36966395,36831533,36603108,36015348,33970170,32929022,32840510,32280743,32024070,31405808,28918052,28082399,26030229,25565435,24892807,23460536,23460531,14612549", 0, "autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency", 0.7906408646569979], ["P08648", "ITGA5", "Integrin alpha-5", "Tier 1.5", 0.785, 1, "A_surface", 14, 85.25, 1, 0, null, null, 1, 2, "32174798,38258032", 1, "skin disease", 0.28465651599598124], ["P32942", "ICAM3", "Intercellular adhesion molecule 3", "Tier 1.5", 0.785, 1, "A_surface", 1, 87.12, 0, 0, null, null, 1, 3, "40650261,34730968,17660953", 1, "lymphatic system disease", 0.28331776251399693], ["Q96MS0", "ROBO3", "Roundabout homolog 3", "Tier 1.5", 0.784, 1, "A_surface", 3, 63.69, 0, 0, null, null, 1, 2, "32369590", 0, "horizontal gaze palsy with progressive scoliosis", 0.7813306356858872], ["P51654", "GPC3", "Glypican-3", "Tier 1.5", 0.779, 1, "A_surface", 4, 75.06, 1, 0, null, null, 1, 65, "42083729,41790019,41653459,41045695,40825648,40722645,39998646,39874791,39608318,39427046,38910291,38787447,38621313,38368644,37665421,36903516,36457288,36317566,36072763,35788872,35699181,35477501,35051745,34974867,34306031,33254049,33080969,32356075,30347351,30122918,29675356,29605994,29277631,27601357,28263753", 0, "Simpson-Golabi-Behmel syndrome type 1", 0.762708583613362], ["P20023", "CR2", "Complement receptor type 2", "Tier 1.5", 0.776, 1, "A_surface", 9, 74.94, 1, 0, null, null, 1, 1, "33235290", 0, "immunodeficiency, common variable, 7", 0.7543125403898414], ["P40126", "DCT", "L-dopachrome tautomerase", "Tier 1.5", 0.774, 1, "A_surface", 1, 89.12, 0, 0, null, null, 1, 1, "27245069", 0, "oculocutaneous albinism type 8", 0.7468868816172217], ["P08887", "IL6R", "Interleukin-6 receptor subunit alpha", "Tier 1.5", 0.768, 1, "A_surface", 10, 77.88, 1, 0, null, null, 1, 18, "40853309,38152968,37034659,36579647,35890412,33590853,33340765,32515246,29211023,28929152,26552813,26383776,24481022,24440854,23235494,22503683,22258147,22094809", 0, "rheumatoid arthritis", 0.7269057706798291], ["Q00975", "CACNA1B", "Voltage-dependent N-type calcium channel subunit alpha-1B", "Tier 1.5", 0.767, 1, "A_surface", 7, 59.91, 1, 0, null, null, 1, 2, "31118475,25782368", 0, "Seizure", 0.7217241968702018], ["P01732", "CD8A", "T-cell surface glycoprotein CD8 alpha chain", "Tier 1.5", 0.761, 1, "A_surface", 8, 78.19, 0, 0, null, null, 1, 2, "38487531,36979667", 1, "progressive supranuclear palsy", 0.2036023725502463], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.76, 1, "A_surface", 3, 80.19, 0, 0, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["P15391", "CD19", "B-lymphocyte antigen CD19", "Tier 1.5", 0.755, 1, "A_surface", 4, 62.22, 1, 0, null, null, 1, 13, "41079126,40652441,38661725,38148412,36095289,35829681,34680368,34364920,32401486,31912987,29928472,21127492", 0, "immunodeficiency, common variable, 3", 0.6821072538733047], ["P32970", "CD70", "CD70 antigen", "Tier 1.5", 0.75, 1, "A_surface", 1, 83.19, 0, 0, null, null, 1, 1, "30609550", 0, "severe combined immunodeficiency due to CD70 deficiency", 0.6651491980619259], ["Q96RJ3", "TNFRSF13C", "Tumor necrosis factor receptor superfamily member 13C", "Tier 1.5", 0.748, 1, "A_surface", 8, 63.03, 1, 0, null, null, 1, 1, "23470998", 0, "immunodeficiency, common variable, 4", 0.660711678987284], ["Q9HCK4", "ROBO2", "Roundabout homolog 2", "Tier 1.5", 0.744, 1, "A_surface", 6, 67.38, 0, 0, null, null, 1, 2, "40616090,31640794", 0, "familial vesicoureteral reflux", 0.6460375744556555], ["Q8NER1", "TRPV1", "Transient receptor potential cation channel subfamily V member 1", "Tier 1.5", 0.738, 1, "A_surface", 8, 71.94, 1, 0, null, null, 1, 2, "40855286,28604222", 0, "migraine disorder", 0.6269329225883602], ["P42658", "DPP6", "A-type potassium channel modulatory protein DPP6", "Tier 1.5", 0.737, 1, "A_surface", 8, 86.69, 1, 0, null, null, 1, 1, "41313574", 0, "Autosomal dominant microcephaly", 0.6225938492787458], ["P01876", "IGHA1", "Immunoglobulin heavy constant alpha 1", "Tier 1.5", 0.736, 1, "A_surface", 14, 81.88, 1, 0, null, null, 1, 2, "37325361", 1, "IGA glomerulonephritis", 0.12053726815801102], ["Q8N126", "CADM3", "Cell adhesion molecule 3", "Tier 1.5", 0.735, 1, "A_surface", 1, 84.38, 0, 0, null, null, 1, 2, "39263947", 0, "Charcot-Marie-Tooth disease, axonal, type 2FF", 0.6157861516342734], ["P01877", "IGHA2", "Immunoglobulin heavy constant alpha 2", "Tier 1.5", 0.726, 1, "A_surface", 4, 83.0, 1, 0, null, null, 1, 2, "37325361", 1, "Chronic mucocutaneous candidosis", 0.08794784007807564], ["P21709", "EPHA1", "Ephrin type-A receptor 1", "Tier 1.5", 0.724, 1, "A_surface", 4, 80.38, 0, 0, null, null, 1, 4, "35283197,24629635,41325160", 0, "Alzheimer disease", 0.5784090512493305], ["P31358", "CD52", "CAMPATH-1 antigen", "Tier 1.5", 0.723, 1, "A_surface", 1, 67.19, 0, 0, null, null, 1, 1, "39865939", 0, "chronic lymphocytic leukemia", 0.5770414699711784], ["P18627", "LAG3", "Lymphocyte activation gene 3 protein", "Tier 1.5", 0.72, 1, "A_surface", 6, 78.38, 1, 0, null, null, 1, 6, "40761795,38158454,36603108,28934318", 0, "melanoma", 0.5672649687930189], ["P55259", "GP2", "Pancreatic secretory granule membrane major glycoprotein GP2", "Tier 1.5", 0.707, 1, "A_surface", 4, 78.62, 1, 0, null, null, 1, 3, "36902059,25483705,24334484", 0, "type 2 diabetes mellitus", 0.5235291484788168], ["O43653", "PSCA", "Prostate stem cell antigen", "Tier 1.5", 0.706, 1, "A_surface", 1, 81.31, 0, 0, null, null, 1, 2, "41911185", 0, "duodenal ulcer", 0.5197329863180171]], "truncated": false, "filtered_table_rows_count": 102, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A_surface", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 72, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 30, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 102, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 101, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 102, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": "A_surface", "label": "A_surface", "count": 102, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 62, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 40, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 70, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 32, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 403.38152600452304, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}