{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, surface_class = \"B_cargo\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P06280", "GLA", "Alpha-galactosidase A", "Tier 1", 0.768, 1, "B_cargo", 31, 94.31, 0, 0, null, null, 1, 15, "41930712,41508958,41143454,38347795,38230795,37459647,37423441,37288783,36593537,36197710,35362383,31433757,31112933,29793133,17461758", 1, "Fabry disease", 0.8939694636235022], ["P51608", "MECP2", "Methyl-CpG-binding protein 2", "Tier 1", 0.765, 1, "B_cargo", 9, 56.59, 0, 0, null, null, 1, 4, "40894892,25934574", 1, "Rett syndrome", 0.8836154777062162], ["P10253", "GAA", "Lysosomal alpha-glucosidase", "Tier 1", 0.763, 1, "B_cargo", 19, 91.88, 0, 0, null, null, 1, 9, "41639270,38804293,36935137,36290911,33674421,34122904,31657561,28477231,8756406", 1, "Glycogen storage disease due to acid maltase deficiency", 0.8766674295528372], ["P01130", "LDLR", "Low-density lipoprotein receptor", "Tier 1", 0.763, 1, "B_cargo", 36, 75.44, 0, 0, null, null, 1, 18, "41707385,38796450,37351166,37175248,33177004,32415571,31841991,31493779,42031715,41599761,41276911,38996211,30269613,25855589", 1, "hypercholesterolemia, familial, 1", 0.8776305284554387], ["P04637", "TP53", "Cellular tumor antigen p53", "Tier 1", 0.763, 1, "B_cargo", 100, 75.06, 0, 0, null, null, 1, 13, "38811338,36591491,36364157,34375633,32370304,32161460,29737162,29610332,29323871,26413153,26406332,21324664,19734942", 1, "Li-Fraumeni syndrome", 0.876069213988417], ["Q06124", "PTPN11", "Tyrosine-protein phosphatase non-receptor type 11", "Tier 1", 0.762, 1, "B_cargo", 100, 85.94, 0, 0, null, null, 1, 1, "35821507", 1, "Noonan syndrome", 0.8741645623918622], ["P00441", "SOD1", "Superoxide dismutase [Cu-Zn]", "Tier 1", 0.761, 1, "B_cargo", 100, 97.94, 0, 0, null, null, 1, 7, "37671010,35052634,34208092,32592467,28771197,41325160", 1, "amyotrophic lateral sclerosis", 0.8701480663155676], ["P04424", "ASL", "Argininosuccinate lyase", "Tier 1", 0.76, 1, "B_cargo", 2, 96.31, 0, 0, null, null, 1, 7, "41897330,36768220,35926421,35123334,32157125,31942851,25825978", 1, "argininosuccinic aciduria", 0.8658097399401212], ["P35520", "CBS", "Cystathionine beta-synthase", "Tier 1", 0.76, 1, "B_cargo", 19, 90.06, 1, 0, null, null, 1, 6, "41780400,40454747,39984441,39541715,30792407,8650546", 1, "classic homocystinuria", 0.8675045223052872], ["P07902", "GALT", "Galactose-1-phosphate uridylyltransferase", "Tier 1", 0.758, 1, "B_cargo", 2, 91.69, 0, 0, null, null, 1, 1, "25483705", 1, "classic galactosemia", 0.8596600028722636], ["P02545", "LMNA", "Prelamin-A/C", "Tier 1", 0.758, 1, "B_cargo", 27, 76.38, 1, 0, null, null, 1, 1, "37565451", 1, "dilated cardiomyopathy", 0.8593312064339074], ["P11413", "G6PD", "Glucose-6-phosphate 1-dehydrogenase", "Tier 1", 0.755, 1, "B_cargo", 25, 94.38, 1, 0, null, null, 1, 3, "41935727,20811084", 1, "anemia, nonspherocytic hemolytic, due to G6PD deficiency", 0.8516109113701843], ["P04181", "OAT", "Ornithine aminotransferase, mitochondrial", "Tier 1", 0.754, 1, "B_cargo", 25, 94.06, 0, 0, null, null, 1, 5, "36610257,36010442,35744448,31883987,30847660", 1, "Gyrate atrophy of choroid and retina", 0.8467230038335781], ["P42336", "PIK3CA", "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "Tier 1", 0.754, 1, "B_cargo", 100, 92.38, 0, 0, null, null, 1, 2, "40560578,36801760", 1, "megalencephaly-capillary malformation-polymicrogyria syndrome", 0.846936627407075], ["P16278", "GLB1", "Beta-galactosidase", "Tier 1", 0.754, 1, "B_cargo", 8, 90.12, 0, 0, null, null, 1, 31, "41235448,40569566,40411663,37893383,36795559,36194889,34635237,34597992,34282923,29089431,28115631,27873255,25826571,25549616,24581444,24581443,24404773,23274138,21908397,21676871,21115656,18682034,17526692,17391960,17317571,17299271,23495909,12166645,11513587,11075346,11024283", 1, "mucopolysaccharidosis type 4B", 0.847874266091269], ["P10619", "CTSA", "Lysosomal protective protein", "Tier 1", 0.753, 1, "B_cargo", 12, 94.5, 0, 0, null, null, 1, 3, "41325160,10660541,41226313", 1, "galactosialidosis", 0.8421773206603207], ["P22830", "FECH", "Ferrochelatase, mitochondrial", "Tier 1", 0.753, 1, "B_cargo", 25, 86.56, 0, 0, null, null, 1, 2, "24561613,24481979", 1, "autosomal erythropoietic protoporphyria", 0.8424032706667833], ["Q8NBK3", "SUMF1", "Formylglycine-generating enzyme", "Tier 1", 0.753, 1, "B_cargo", 18, 83.56, 0, 0, null, null, 1, 1, "38467937", 1, "Multiple sulfatase deficiency", 0.8444446120971877], ["Q15465", "SHH", "Sonic hedgehog protein", "Tier 1", 0.753, 1, "B_cargo", 20, 78.38, 1, 0, null, null, 1, 4, "33257185,32867229,18698484,38462144", 1, "holoprosencephaly 3", 0.8433062137163501], ["Q14376", "GALE", "UDP-glucose 4-epimerase", "Tier 1", 0.752, 1, "B_cargo", 11, 97.06, 0, 0, null, null, 1, 1, "37486460", 1, "galactose epimerase deficiency", 0.8407417123376392], ["P55265", "ADAR", "Double-stranded RNA-specific adenosine deaminase", "Tier 1", 0.752, 1, "B_cargo", 24, 68.38, 1, 0, null, null, 1, 8, "41910181,41791686,41772759,41497668,41267360,39673485,38583236,17000903", 1, "Aicardi-Goutieres syndrome 6", 0.8388797454328872], ["P35270", "SPR", "Sepiapterin reductase", "Tier 1", 0.751, 1, "B_cargo", 14, 96.69, 0, 0, null, null, 1, 368, "42010751,41791433,41759131,41646885,41572478,41547223,41524709,41522607,41330132,41294718,41248478,41231675,41185944,41035145,40897008,40839967,40821668,40801924,40558441,40516427,40331775,40277558,40251423,40207094,40191889,40174668,40163419,40130277,40113339,39954411,39927773,39894103,39852074,39808989,39742443,39644990,39584594,39206405,38934238,38870828,38829419,38742926,38732912,38682836,38645339,38613992,38606503,38552466,38444705,38342787,32456943", 1, "dopa-responsive dystonia due to sepiapterin reductase deficiency", 0.8362323603565402], ["P43235", "CTSK", "Cathepsin K", "Tier 1", 0.751, 1, "B_cargo", 70, 94.88, 0, 0, null, null, 1, 3, "32603599,32693649,29263412", 1, "pycnodysostosis", 0.8370793964210973], ["P07954", "FH", "Fumarate hydratase, mitochondrial", "Tier 1", 0.751, 1, "B_cargo", 7, 92.69, 0, 0, null, null, 1, 4, "37351166,32190730,28211680,21396765", 1, "hereditary leiomyomatosis and renal cell cancer", 0.8372834886646517], ["P53634", "CTSC", "Dipeptidyl peptidase 1", "Tier 1", 0.751, 1, "B_cargo", 18, 90.12, 0, 0, null, null, 1, 1, "37052638", 1, "Papillon-Lef\u00e8vre syndrome", 0.8373137649306006], ["P19429", "TNNI3", "Troponin I, cardiac muscle", "Tier 1", 0.75, 1, "B_cargo", 39, 78.62, 1, 0, null, null, 1, 1, "26594036", 1, "hypertrophic cardiomyopathy", 0.8340329164680969], ["Q99714", "HSD17B10", "3-hydroxyacyl-CoA dehydrogenase type-2", "Tier 1", 0.749, 1, "B_cargo", 15, 96.88, 1, 0, null, null, 1, 1, "17917077", 1, "HSD10 mitochondrial disease", 0.828877258137219], ["P38117", "ETFB", "Electron transfer flavoprotein subunit beta", "Tier 1", 0.749, 1, "B_cargo", 4, 96.12, 0, 0, null, null, 1, 4, "40102450,37599631", 1, "multiple acyl-CoA dehydrogenase deficiency", 0.8299661865891321], ["Q9Y6K9", "IKBKG", "NF-kappa-B essential modulator", "Tier 1", 0.749, 1, "B_cargo", 17, 82.0, 0, 0, null, null, 1, 2, "27802394,16891465", 1, "incontinentia pigmenti", 0.8297700299216089], ["P42345", "MTOR", "Serine/threonine-protein kinase mTOR", "Tier 1", 0.749, 1, "B_cargo", 70, 78.0, 1, 0, null, null, 1, 27, "41951939,41924451,41819327,41563473,40316188,39728786,37574619,35356877,34638443,34362425,33319976,33124760,32521684,32245065,32170897,31840081,33455222,28945233,28471660,25751060,25057446,24292708,24242861,22363130,22239618,19878313,17495522", 1, "Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome", 0.8296449565554538], ["P20936", "RASA1", "Ras GTPase-activating protein 1", "Tier 1", 0.749, 1, "B_cargo", 15, 75.44, 0, 0, null, null, 1, 1, "25778421", 1, "capillary malformation-arteriovenous malformation 1", 0.8306926057172873], ["P01116", "KRAS", "GTPase KRas", "Tier 1", 0.748, 1, "B_cargo", 100, 91.5, 0, 1, "6GOD", "6MNX", 1, 21, "41132421,40824107,40766128,40148451,39215101,38784467,38784452,38604287,37637206,36229679,35473857,34097885,32871244,32370304,32010971,31583159,28639199,28514850,27936442,20565241,17461759", 1, "Noonan syndrome 3", 0.8263697027313498], ["Q99707", "MTR", "Methionine synthase", "Tier 1", 0.748, 1, "B_cargo", 9, 87.5, 1, 0, null, null, 1, 1, "25964329", 1, "methylcobalamin deficiency type cblG", 0.8253271986114175], ["Q9Y3A5", "SBDS", "Ribosome maturation protein SBDS", "Tier 1", 0.748, 1, "B_cargo", 6, 74.06, 1, 0, null, null, 1, 1, "19454024", 1, "Shwachman-Diamond syndrome", 0.8282172244212194], ["P27986", "PIK3R1", "Phosphatidylinositol 3-kinase regulatory subunit alpha", "Tier 1", 0.747, 1, "B_cargo", 100, 83.19, 0, 0, null, null, 1, 1, "40560578", 1, "SHORT syndrome", 0.8239278567344643], ["P00519", "ABL1", "Tyrosine-protein kinase ABL1", "Tier 1", 0.747, 1, "B_cargo", 85, 63.38, 0, 1, "2GQG", "1OPL", 1, 5, "31295447,23836560,22411871,21810089,21653319", 1, "chronic myelogenous leukemia", 0.8219762968845584], ["P11498", "PC", "Pyruvate carboxylase, mitochondrial", "Tier 1", 0.746, 1, "B_cargo", 10, 90.38, 1, 0, null, null, 1, 607, "42025735,42015877,41963040,41956254,41946336,41942404,41940259,41852458,41850902,41813080,41806728,41801682,41791686,41786503,41742365,41713118,41686726,41679186,41671824,41621292,41586771,41570502,41545126,41519040,41453347,41447218,41444487,41422636,41401493,41328792,41294729,41275818,41275550,41268823,41207524,41167900,41155928,41149351,41135241,41103270,41061457,41030495,41002305,40992058,40978513,40974925,40968085,40952515,40942102,40936186", 1, "pyruvate carboxylase deficiency disease", 0.8195584644258792], ["Q13148", "TARDBP", "TAR DNA-binding protein 43", "Tier 1", 0.746, 1, "B_cargo", 44, 65.19, 1, 0, null, null, 1, 7, "39548508,34469713,26915990,37671010,35739092,23264567", 1, "amyotrophic lateral sclerosis", 0.8196962822149189], ["P46531", "NOTCH1", "Neurogenic locus notch homolog protein 1", "Tier 1", 0.746, 1, "B_cargo", 29, 59.59, 1, 0, null, null, 1, 4, "38559166,34431568,33614227,28685750", 1, "Adams-Oliver syndrome", 0.8199672000988557], ["P22681", "CBL", "E3 ubiquitin-protein ligase CBL", "Tier 1", 0.745, 1, "B_cargo", 33, 62.84, 0, 0, null, null, 1, 4, "39759445,37013991,30216975,25306351", 1, "Noonan syndrome-like disorder with juvenile myelomonocytic leukemia", 0.8150104416646294], ["P04062", "GBA1", "Lysosomal acid glucosylceramidase", "Tier 1", 0.744, 1, "B_cargo", 58, 93.25, 0, 0, null, null, 1, 1, "37586882", 1, "Gaucher disease type 1", 0.8135519187294226], ["P16435", "POR", "NADPH--cytochrome P450 reductase", "Tier 1", 0.744, 1, "B_cargo", 9, 91.06, 0, 0, null, null, 1, 11, "40318334,39697550,38684113,36979536,36768220,34770519,32486489,32290083,31636244,30478720,19384756", 1, "Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis", 0.8147489131213279], ["P26358", "DNMT1", "DNA (cytosine-5)-methyltransferase 1", "Tier 1", 0.744, 1, "B_cargo", 27, 77.81, 1, 0, null, null, 1, 12, "41635784,39079576,38762976,36609400,31733056,29554483,23179556", 1, "autosomal dominant cerebellar ataxia, deafness and narcolepsy", 0.8134195803175972], ["P35637", "FUS", "RNA-binding protein FUS", "Tier 1", 0.744, 1, "B_cargo", 23, 53.59, 1, 0, null, null, 1, 8, "40394046,35592098,28701145,15132764,12927206", 1, "sporadic amyotrophic lateral sclerosis", 0.8117088043931799], ["P32754", "HPD", "4-hydroxyphenylpyruvate dioxygenase", "Tier 1", 0.743, 1, "B_cargo", 4, 95.69, 0, 0, null, null, 1, 2, "38093483,28912094", 1, "Tyrosinemia type 3", 0.8084143670720506], ["P52788", "SMS", "Spermine synthase", "Tier 1", 0.743, 1, "B_cargo", 2, 94.81, 0, 0, null, null, 1, 3, "37384557,36558901,31606878", 1, "syndromic X-linked intellectual disability Snyder type", 0.8110331779507982], ["P00491", "PNP", "Purine nucleoside phosphorylase", "Tier 1", 0.743, 1, "B_cargo", 41, 93.81, 0, 0, null, null, 1, 3, "38377562,31510048,30264075", 1, "purine nucleoside phosphorylase deficiency", 0.8112966864301248], ["P07602", "PSAP", "Prosaposin", "Tier 1", 0.743, 1, "B_cargo", 20, 73.75, 1, 0, null, null, 1, 1, "41889102", 1, "Gaucher disease due to saposin C deficiency", 0.8100495894070405], ["Q13501", "SQSTM1", "Sequestosome-1", "Tier 1", 0.743, 1, "B_cargo", 26, 67.25, 1, 0, null, null, 1, 4, "40413753,32225060", 1, "amyotrophic lateral sclerosis", 0.809360678421687], ["Q9UHD2", "TBK1", "Serine/threonine-protein kinase TBK1", "Tier 1", 0.742, 1, "B_cargo", 25, 89.69, 1, 0, null, null, 1, 1, "40413753", 1, "frontotemporal dementia and/or amyotrophic lateral sclerosis 4", 0.8079405505675022]], "truncated": false, "filtered_table_rows_count": 529, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "B_cargo", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": 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"/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 529, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 339, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 190, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 369, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 160, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 999.1329130716622, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}