{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, surface_class = \"B_cargo\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P14136", "GFAP", "Glial fibrillary acidic protein", "Tier 1.5", 0.761, 1, "B_cargo", 1, 80.0, 0, 0, null, null, 1, 4, "42022738,40983220,27924617,27399849", 1, "Alexander disease", 0.8713727112153956], ["P00480", "OTC", "Ornithine transcarbamylase, mitochondrial", "Tier 1.5", 0.76, 1, "B_cargo", 4, 92.19, 0, 0, null, null, 1, 71, "42031033,41819402,41207276,41033028,40970979,40801924,40719766,40644866,40602786,40187287,40064103,40015047,39904249,39644528,39571486,39275399,39030014,38504447,38193253,37459789,37364386,37103619,36891736,36618689,36454704,36403375,35884270,35672499,35006795,34973550,34821674,34684942,34152736,33812186,33035887,32862845,32768827,32674777,31673790,31580049,31325751,31016392,30837641,30778448,30594079,30426224,30202432,30128033,29937498,28578167", 1, "ornithine carbamoyltransferase deficiency", 0.8675763935672858], ["P11532", "DMD", "Dystrophin", "Tier 1.5", 0.76, 1, "B_cargo", 6, 76.38, 0, 0, null, null, 1, 32, "41983899,41503480,41083485,40396427,39910928,39469668,38050701,37765072,37261868,34876524,34693888,34440571,34075115,33617542,32592467,28315675,28252048,27530235,27173731,26594036,26163061,26039989,21838691,20962041,17011811,38448545", 1, "Duchenne muscular dystrophy", 0.865885140119287], ["P05165", "PCCA", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Tier 1.5", 0.756, 1, "B_cargo", 25, 87.44, 1, 0, null, null, 1, 1, "36578103", 1, "propionic acidemia", 0.8530542602972598], ["P35475", "IDUA", "Alpha-L-iduronidase", "Tier 1.5", 0.755, 1, "B_cargo", 11, 94.75, 0, 0, null, null, 1, 1, "18838694", 1, "Scheie syndrome", 0.8500187612858606], ["P26440", "IVD", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Tier 1.5", 0.754, 1, "B_cargo", 5, 93.38, 1, 0, null, null, 1, 2, "41230502,26946282", 1, "isovaleric acidemia", 0.8480603595890895], ["P48637", "GSS", "Glutathione synthetase", "Tier 1.5", 0.754, 1, "B_cargo", 2, 94.94, 0, 0, null, null, 1, 1, "24296062", 1, "Glutathione synthetase deficiency", 0.8480115629745476], ["P50897", "PPT1", "Palmitoyl-protein thioesterase 1", "Tier 1.5", 0.752, 1, "B_cargo", 1, 91.69, 0, 0, null, null, 1, 2, "33112630", 1, "neuronal ceroid lipofuscinosis 1", 0.8400332147230634], ["P50416", "CPT1A", "Carnitine O-palmitoyltransferase 1, liver isoform", "Tier 1.5", 0.751, 1, "B_cargo", 1, 92.44, 0, 0, null, null, 1, 1, "29325019", 1, "carnitine palmitoyl transferase 1A deficiency", 0.8360102017303558], ["P48728", "AMT", "Aminomethyltransferase, mitochondrial", "Tier 1.5", 0.749, 1, "B_cargo", 2, 93.69, 0, 0, null, null, 1, 6, "41360349,38751431,36935143,32969502,32779681,32062632", 1, "glycine encephalopathy", 0.8307194416875259], ["P55157", "MTTP", "Microsomal triglyceride transfer protein large subunit", "Tier 1.5", 0.748, 1, "B_cargo", 2, 86.56, 1, 0, null, null, 1, 1, "23770039", 1, "abetalipoproteinemia", 0.8281089516017405], ["Q53H12", "AGK", "Acylglycerol kinase, mitochondrial", "Tier 1.5", 0.747, 1, "B_cargo", 1, 87.0, 1, 0, null, null, 1, 1, "35763566", 1, "Sengers syndrome", 0.8231275438888749], ["P42224", "STAT1", "Signal transducer and activator of transcription 1-alpha/beta", "Tier 1.5", 0.744, 1, "B_cargo", 10, 87.25, 1, 0, null, null, 1, 5, "41290466,38569854,31879964,31702021,21433395", 1, "Chronic mucocutaneous candidosis", 0.8147374964880533], ["P09936", "UCHL1", "Ubiquitin carboxyl-terminal hydrolase isozyme L1", "Tier 1.5", 0.741, 1, "B_cargo", 14, 93.62, 0, 0, null, null, 1, 2, "30863411", 1, "early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome", 0.8048623975346616], ["P43007", "SLC1A4", "Neutral amino acid transporter A", "Tier 1.5", 0.741, 1, "B_cargo", 1, 80.56, 1, 0, null, null, 1, 6, "36219068,31989939,27571928,26811678,19046328,16139842", 1, "spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome", 0.8025684205131692], ["Q6NUK1", "SLC25A24", "Mitochondrial adenyl nucleotide antiporter SLC25A24", "Tier 1.5", 0.74, 1, "B_cargo", 3, 81.31, 0, 0, null, null, 1, 1, "41871245", 1, "Fontaine progeroid syndrome", 0.7984507086824493], ["P98155", "VLDLR", "Very low-density lipoprotein receptor", "Tier 1.5", 0.737, 1, "B_cargo", 27, 75.69, 1, 0, null, null, 1, 1, "19188685", 1, "Dysequilibrium syndrome", 0.790164037509625], ["P21397", "MAOA", "Amine oxidase [flavin-containing] A", "Tier 1.5", 0.733, 1, "B_cargo", 4, 97.0, 0, 0, null, null, 1, 2, "36795559,26841904", 1, "Brunner syndrome", 0.7777423430063588], ["Q15813", "TBCE", "Tubulin-specific chaperone E", "Tier 1.5", 0.732, 1, "B_cargo", 6, 89.19, 1, 0, null, null, 1, 1, "34448574", 1, "hypoparathyroidism-retardation-dysmorphism syndrome", 0.7744447925917005], ["Q01105", "SET", "Protein SET", "Tier 1.5", 0.73, 1, "B_cargo", 3, 77.62, 0, 0, null, null, 1, 556, "42039565,41993416,41969971,41928908,41902675,41898181,41881226,41770599,41761637,41666037,41644952,41542672,41498743,41486176,41405351,41226313,41207276,41169591,41135899,41099717,41020397,40892043,40808600,40710098,40706113,40656531,40618375,40598898,40394224,40362575,40333723,40313273,40306472,40270429,40259434,40245514,40243681,40220375,40215752,40212654,40209705,40083221,39971069,39959072,39954262,39939919,39865031,39832878,39803439,39744100,30485711", 1, "intellectual disability, autosomal dominant 58", 0.7663060887583324], ["P50461", "CSRP3", "Cysteine and glycine-rich protein 3", "Tier 1.5", 0.728, 1, "B_cargo", 2, 73.44, 0, 0, null, null, 1, 1, "29222138", 1, "dilated cardiomyopathy 1M", 0.7615568697921314], ["Q13043", "STK4", "Serine/threonine-protein kinase 4", "Tier 1.5", 0.728, 1, "B_cargo", 16, 75.94, 1, 0, null, null, 1, 1, "31707227", 1, "combined immunodeficiency due to STK4 deficiency", 0.7613382040802787], ["Q16719", "KYNU", "Kynureninase", "Tier 1.5", 0.726, 1, "B_cargo", 3, 95.44, 0, 0, null, null, 1, 2, "39045230", 1, "vertebral, cardiac, renal, and limb defects syndrome 2", 0.7538237163234831], ["P07237", "P4HB", "Protein disulfide-isomerase", "Tier 1.5", 0.723, 1, "B_cargo", 14, 88.5, 1, 0, null, null, 1, 2, "31625090,28952381", 1, "Cole-Carpenter syndrome", 0.7447295842045853], ["Q15796", "SMAD2", "SMAD family member 2", "Tier 1.5", 0.72, 1, "B_cargo", 10, 77.62, 0, 0, null, null, 1, 7, "37415558,35356877,33124760,22899759,21266541,16775010,11856769", 1, "Loeys-Dietz syndrome 6", 0.7333699386757103], ["Q9NXG6", "P4HTM", "Transmembrane prolyl 4-hydroxylase", "Tier 1.5", 0.717, 1, "B_cargo", 1, 81.06, 0, 0, null, null, 1, 1, "28685750", 1, "hypotonia, hypoventilation, impaired intellectual development, dysautonomia, epilepsy, and eye abnormalities", 0.7218110110850424], ["Q13158", "FADD", "FAS-associated death domain protein", "Tier 1.5", 0.708, 1, "B_cargo", 18, 72.12, 1, 0, null, null, 1, 3, "36309655,30594071,26318819", 1, "FADD-related immunodeficiency", 0.6932338529214827], ["P23458", "JAK1", "Tyrosine-protein kinase JAK1", "Tier 1.5", 0.706, 1, "B_cargo", 51, 85.56, 0, 0, null, null, 1, 2, "41290466,20711698", 1, "rheumatoid arthritis", 0.6871251698480906], ["Q9H082", "RAB33B", "Ras-related protein Rab-33B", "Tier 1.5", 0.702, 1, "B_cargo", 2, 80.62, 0, 0, null, null, 1, 3, "34248841,32838280,29754498", 1, "Smith-McCort dysplasia 2", 0.6718069684124652], ["P06401", "PGR", "Progesterone receptor", "Tier 1.5", 0.701, 1, "B_cargo", 20, 56.16, 0, 0, null, null, 1, 11, "31226842,25461163,41716468,41535871,41318995,39719189,39028987,38802696,38512151,36001395,30428522", 1, "endometriosis", 0.669096724339783], ["Q05655", "PRKCD", "Protein kinase C delta type", "Tier 1.5", 0.7, 1, "B_cargo", 2, 80.69, 0, 0, null, null, 1, 2, "29961347,29754498", 1, "autoimmune lymphoproliferative syndrome", 0.6669954888212556], ["Q13423", "NNT", "NAD(P) transhydrogenase, mitochondrial", "Tier 1.5", 0.692, 1, "B_cargo", 3, 90.88, 0, 0, null, null, 1, 3, "40903908,36413497,18425911", 1, "familial glucocorticoid deficiency", 0.638839481734631], ["P35354", "PTGS2", "Prostaglandin G/H synthase 2", "Tier 1.5", 0.69, 1, "B_cargo", 7, 93.0, 0, 0, null, null, 1, 7, "39503504,38959476,33230429,22544606,19723884,17909039,31482734", 1, "rheumatoid arthritis", 0.6335569514731725], ["P17096", "HMGA1", "High mobility group protein HMG-I/HMG-Y", "Tier 1.5", 0.674, 1, "B_cargo", 5, 65.0, 0, 0, null, null, 1, 4, "41871245,31538905,20961861,19956671", 1, "HIV infection", 0.5809402815127065], ["Q01518", "CAP1", "Adenylyl cyclase-associated protein 1", "Tier 1.5", 0.668, 1, "B_cargo", 5, 81.75, 1, 0, null, null, 1, 1, "37614296", 1, "neurodegenerative disease", 0.5608927359093832], ["P57075", "UBASH3A", "Ubiquitin-associated and SH3 domain-containing protein A", "Tier 1.5", 0.667, 1, "B_cargo", 2, 82.25, 0, 0, null, null, 1, 1, "41680500", 1, "rheumatoid arthritis", 0.5578057740717796], ["P09668", "CTSH", "Pro-cathepsin H", "Tier 1.5", 0.664, 1, "B_cargo", 2, 93.88, 0, 0, null, null, 1, 1, "38811951", 1, "type 1 diabetes mellitus", 0.5481319551898879], ["Q7Z3B1", "NEGR1", "Neuronal growth regulator 1", "Tier 1.5", 0.663, 1, "B_cargo", 2, 81.62, 0, 0, null, null, 1, 1, "29754498", 1, "intelligence", 0.544218102469465], ["P12270", "TPR", "Nucleoprotein TPR", "Tier 1.5", 0.663, 1, "B_cargo", 4, 60.5, 0, 0, null, null, 1, 1, "33217386", 1, "HIV infection", 0.5418451313960712], ["Q96RS0", "TGS1", "Trimethylguanosine synthase", "Tier 1.5", 0.661, 1, "B_cargo", 2, 59.94, 0, 0, null, null, 1, 1, "27572987", 1, "neurodegenerative disease", 0.5358070245955443], ["P37802", "TAGLN2", "Transgelin-2", "Tier 1.5", 0.658, 1, "B_cargo", 1, 88.12, 0, 0, null, null, 1, 3, "41358073,32527800", 1, "neurodegenerative disease", 0.5261379875719714], ["Q13794", "PMAIP1", "Phorbol-12-myristate-13-acetate-induced protein 1", "Tier 1.5", 0.658, 1, "B_cargo", 1, 81.94, 0, 0, null, null, 1, 1, "21616931", 1, "neurodegenerative disease", 0.527389679534353], ["Q16798", "ME3", "NADP-dependent malic enzyme, mitochondrial", "Tier 1.5", 0.658, 1, "B_cargo", 5, 91.69, 1, 0, null, null, 1, 1, "39602246", 1, "open-angle glaucoma", 0.5259955902523525], ["O15067", "PFAS", "Phosphoribosylformylglycinamidine synthase", "Tier 1.5", 0.656, 1, "B_cargo", 3, 92.31, 1, 0, null, null, 1, 10, "41934998,41928580,40936959,40862935,40772729,40658928,39110961,38202993,37051269,34991260", 1, "dyskeratosis congenita", 0.5199677146803817], ["Q6FI81", "CIAPIN1", "Anamorsin", "Tier 1.5", 0.654, 1, "B_cargo", 3, 80.19, 0, 0, null, null, 1, 1, "40506465", 1, "neurodegenerative disease", 0.5125028552204193], ["P32119", "PRDX2", "Peroxiredoxin-2", "Tier 1.5", 0.654, 1, "B_cargo", 7, 97.75, 0, 0, null, null, 1, 2, "41097770", 1, "neurodegenerative disease", 0.5148660529122818], ["Q7L7L0", "H2AC25", "Histone H2A type 3", "Tier 1.5", 0.651, 1, "B_cargo", 2, 90.94, 1, 0, null, null, 1, 2, "38045440,37593997", 1, "infectious disease", 0.5030392466541774], ["O15021", "MAST4", "Microtubule-associated serine/threonine-protein kinase 4", "Tier 1.5", 0.649, 1, "B_cargo", 1, 42.53, 0, 0, null, null, 1, 1, "18376136", 1, "Neurodevelopmental disorder", 0.4951959408492021], ["P16455", "MGMT", "Methylated-DNA--protein-cysteine methyltransferase", "Tier 1.5", 0.647, 1, "B_cargo", 21, 85.12, 1, 0, null, null, 1, 4, "41951573,38806504,31601097,28499389", 1, "Abnormality of the skeletal system", 0.49129662019672776], ["P84090", "ERH", "Enhancer of rudimentary homolog", "Tier 1.5", 0.646, 1, "B_cargo", 4, 95.94, 0, 0, null, null, 1, 1, "41785608", 1, "neurodegenerative disease", 0.48655131342191105]], "truncated": false, "filtered_table_rows_count": 260, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "B_cargo", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 164, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 96, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 260, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 260, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 260, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=B_cargo&tier=Tier+1.5", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 260, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 140, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 120, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 219, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 41, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 398.9911740645766, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}