{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1 and tier = \"Tier 1.5\" sorted by priority_score descending", "rows": [["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.914, 7, 77.88, 1, 0, null, null, null, 1, 17, "40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027", 1, "autoimmune lymphoproliferative syndrome type 1", 0.7377210386590284], ["P21583", "KITLG", "Kit ligand", "Tier 1.5", 0.848, 6, 71.88, 1, 0, null, null, null, 1, 2, "36579647,23967247", 0, "hyperpigmentation with or without hypopigmentation, familial progressive", 0.6756727302967072], ["Q00975", "CACNA1B", "Voltage-dependent N-type calcium channel subunit alpha-1B", "Tier 1.5", 0.807, 7, 59.91, 1, 0, null, null, null, 1, 2, "31118475,25782368", 0, "Seizure", 0.7217241968702018], ["P15260", "IFNGR1", "Interferon gamma receptor 1", "Tier 1.5", 0.804, 5, 66.0, 0, 0, null, null, null, 1, 2, "33667716", 1, "disseminated atypical mycobacterial infection", 0.5414012388034828], ["P02748", "C9", "Complement component C9", "Tier 1.5", 0.796, 9, 78.75, 1, 0, null, null, null, 1, 10, "41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383", 1, "Immunodeficiency due to a late component of complements deficiency", 0.761965409699055], ["Q13085", "ACACA", "Acetyl-CoA carboxylase 1", "Tier 1.5", 0.79, 10, 82.81, 1, 0, null, null, null, 1, 1, "41854184", 1, null, null], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.788, 11, 75.94, 0, 0, null, null, null, 1, 6, "41733039,34364920,31434881,30237882,29299123,22411871", 1, "acute myeloid leukemia", 0.8313389209288576], ["Q92633", "LPAR1", "Lysophosphatidic acid receptor 1", "Tier 1.5", 0.785, 16, 83.62, 1, 0, null, null, null, 1, 1, "32065590", 1, "Epiretinal membrane", 0.4757255248053499], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.783, 3, 68.62, 1, 0, null, null, null, 1, 2, "41101154,27364573", 0, "persistent Mullerian duct syndrome", 0.7847328444470535], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.775, 3, 80.19, 0, 0, null, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["P02776", "PF4", "Platelet factor 4", "Tier 1.5", 0.77, 10, 75.06, 0, 0, null, null, null, 1, 10, "33859620,32366845,31967847,23847186,23673861,34248840,32022468", 1, "systemic scleroderma", 0.11523541376593864], ["P39060", "COL18A1", "Collagen alpha-1(XVIII) chain", "Tier 1.5", 0.769, 9, 50.62, 1, 0, null, null, null, 1, 2, "36707842,23679916", 1, "Knobloch syndrome 1", 0.7867122552672962], ["P43007", "SLC1A4", "Neutral amino acid transporter A", "Tier 1.5", 0.75, 1, 80.56, 1, 0, null, null, null, 1, 6, "36219068,31989939,27571928,26811678,19046328,16139842", 1, "spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome", 0.8025684205131692], ["Q9GZU2", "PEG3", "Paternally-expressed gene 3 protein", "Tier 1.5", 0.75, 1, 44.53, 0, 0, null, null, null, 1, 1, "16595502", 0, "neurodegenerative disease", 0.34815912577489827], ["P18075", "BMP7", "Bone morphogenetic protein 7", "Tier 1.5", 0.749, 4, 76.19, 0, 0, null, null, null, 1, 1, "30537181", 0, "Inguinal hernia", 0.4420059023371716], ["P08648", "ITGA5", "Integrin alpha-5", "Tier 1.5", 0.748, 14, 85.25, 1, 0, null, null, null, 1, 2, "32174798,38258032", 1, "skin disease", 0.28465651599598124], ["O60884", "DNAJA2", "DnaJ homolog subfamily A member 2", "Tier 1.5", 0.73, 1, 83.38, 1, 0, null, null, null, 1, 2, "41935727,33879515", 1, "dengue disease", 0.37068859424875583], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "Tier 1.5", 0.727, 1, 79.62, 0, 0, null, null, null, 1, 1, "23770039", 0, "familial hypobetalipoproteinemia 2", 0.6739043862507132], ["Q99988", "GDF15", "Growth/differentiation factor 15", "Tier 1.5", 0.718, 4, 75.69, 1, 0, null, null, null, 1, 29, "41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547", 1, "hyperemesis gravidarum", 0.5821658682742563], ["Q00604", "NDP", "Norrin", "Tier 1.5", 0.716, 11, 83.56, 1, 0, null, null, null, 1, 2, "39057719,11352723", 0, "Norrie disease", 0.8566451682188412], ["P46094", "XCR1", "Chemokine XC receptor 1", "Tier 1.5", 0.715, 1, 84.94, 1, 0, null, null, null, 1, 1, "35212764", 0, "COVID-19", 0.459103766220463], ["P32239", "CCKBR", "Gastrin/cholecystokinin type B receptor", "Tier 1.5", 0.713, 5, 75.75, 1, 0, null, null, null, 1, 2, "33776434,27754762", 0, "gastroesophageal reflux disease", 0.4256110167566802], ["P25106", "ACKR3", "Atypical chemokine receptor 3", "Tier 1.5", 0.71, 14, 82.44, 1, 0, null, null, null, 1, 2, "40401615,28670693", 0, "oculomotor-abducens synkinesis", 0.49893280382434735], ["P41221", "WNT5A", "Protein Wnt-5a", "Tier 1.5", 0.71, 0, 87.69, 0, 0, null, null, null, 1, 4, "40855286,32693649,22363130,18673242", 1, "Robinow syndrome", 0.7220360983378594], ["A0A0C5B5G6", "MT-RNR1", "Mitochondrial-derived peptide MOTS-c", "Tier 1.5", 0.7, 0, 72.06, 0, 0, null, null, null, 1, 1, "35311942", 0, null, null], ["P08620", "FGF4", "Fibroblast growth factor 4", "Tier 1.5", 0.7, 1, 81.5, 0, 0, null, null, null, 1, 3, "35415885,33536494,7547864", 0, "cancer", 0.6026669167438079], ["P07225", "PROS1", "Vitamin K-dependent protein S", "Tier 1.5", 0.7, 3, 82.94, 1, 0, null, null, null, 1, 2, "36859809,33674695", 1, "thrombophilia due to protein S deficiency, autosomal dominant", 0.8240418292042652], ["P19021", "PAM", "Peptidyl-glycine alpha-amidating monooxygenase", "Tier 1.5", 0.695, 0, 71.69, 0, 0, null, null, null, 1, 25, "41855944,41500123,41384307,41285544,41222440,40607956,39929897,39472107,38867016,38846799,37977804,37977780,37906116,37127012,36905684,35478209,33911033,33516855,32315032,32307868,30399413,30124431,26406332,22954359,14965210", 1, "type 2 diabetes mellitus", 0.5754371880839976], ["P21359", "NF1", "Neurofibromin", "Tier 1.5", 0.695, 26, 87.19, 1, 0, null, null, null, 1, 2, "32980430,22617876", 1, "neurofibromatosis type 1", 0.8844735398780649], ["P21781", "FGF7", "Fibroblast growth factor 7", "Tier 1.5", 0.695, 0, 82.44, 0, 0, null, null, null, 1, 5, "35415885,15719578,7547864,16462265", 0, "cancer", 0.5963369026823151], ["P10586", "PTPRF", "Receptor-type tyrosine-protein phosphatase F", "Tier 1.5", 0.69, 13, 82.0, 0, 0, null, null, null, 1, 4, "42101929,39087949,36594741", 1, "smoking initiation", 0.4641111755355386], ["O00501", "CLDN5", "Claudin-5", "Tier 1.5", 0.685, 0, 83.75, 0, 0, null, null, null, 1, 1, "18951306", 1, "genetic disorder", 0.40861362787778505], ["Q96RJ3", "TNFRSF13C", "Tumor necrosis factor receptor superfamily member 13C", "Tier 1.5", 0.681, 8, 63.03, 1, 0, null, null, null, 1, 1, "23470998", 0, "immunodeficiency, common variable, 4", 0.660711678987284], ["P14384", "CPM", "Carboxypeptidase M", "Tier 1.5", 0.68, 1, 90.31, 0, 0, null, null, null, 1, 3, "38876068,38060303,36768220", 1, "hydronephrosis", 0.3163273148871551], ["P26718", "KLRK1", "NKG2-D type II integral membrane protein", "Tier 1.5", 0.679, 22, 79.19, 0, 0, null, null, null, 1, 1, "24629635", 0, "Behcet's syndrome", 0.18614538678991077], ["P09758", "TACSTD2", "Tumor-associated calcium signal transducer 2", "Tier 1.5", 0.673, 7, 82.69, 0, 0, null, null, null, 1, 4, "41384307,41241473,40050871,39250993", 1, "gelatinous drop-like corneal dystrophy", 0.7293087728162646], ["P98066", "TNFAIP6", "Tumor necrosis factor-inducible gene 6 protein", "Tier 1.5", 0.671, 5, 81.12, 0, 0, null, null, null, 1, 1, "39263947", 1, "type 2 diabetes mellitus", 0.30862220597837015], ["O95750", "FGF19", "Fibroblast growth factor 19", "Tier 1.5", 0.668, 4, 79.81, 0, 0, null, null, null, 1, 4, "35415885,31967847,27679852", 0, "cancer", 0.38540691230511315], ["O00744", "WNT10B", "Protein Wnt-10b", "Tier 1.5", 0.668, 0, 80.06, 0, 0, null, null, null, 1, 2, "32810272,18673242", 0, "Split hand-split foot malformation", 0.7755225395358214], ["Q9HCK4", "ROBO2", "Roundabout homolog 2", "Tier 1.5", 0.665, 6, 67.38, 0, 0, null, null, null, 1, 2, "40616090,31640794", 0, "familial vesicoureteral reflux", 0.6460375744556555], ["Q6PCB0", "VWA1", "von Willebrand factor A domain-containing protein 1", "Tier 1.5", 0.664, 0, 78.38, 0, 0, null, null, null, 1, 4, "41906877,41693575,38904251,38299345", 0, "neuronopathy, distal hereditary motor, autosomal recessive 7", 0.7420531156755253], ["A2RU14", "TMEM218", "Transmembrane protein 218", "Tier 1.5", 0.663, 0, 87.62, 0, 0, null, null, null, 1, 6, "41360349,34861273,31349094,29277631,26580576,26248137", 0, "Joubert syndrome 39", 0.7308441626389979], ["P16870", "CPE", "Carboxypeptidase E", "Tier 1.5", 0.66, 0, 90.38, 0, 0, null, null, null, 1, 16, "39863729,39793371,38861005,36832010,36773630,27886773,27219679,25738486,28706644,24768847,23875581,22280349,21419619,20949139,20491465,19174227", 1, "BDV syndrome", 0.7029731914682913], ["P18510", "IL1RN", "Interleukin-1 receptor antagonist protein", "Tier 1.5", 0.66, 5, 87.06, 0, 0, null, null, null, 1, 1, "38928037", 0, "sterile multifocal osteomyelitis with periostitis and pustulosis", 0.7734282711738736], ["P98155", "VLDLR", "Very low-density lipoprotein receptor", "Tier 1.5", 0.66, 27, 75.69, 1, 0, null, null, null, 1, 1, "19188685", 1, "Dysequilibrium syndrome", 0.790164037509625], ["Q86YL7", "PDPN", "Podoplanin", "Tier 1.5", 0.66, 6, 57.97, 0, 0, null, null, null, 1, 4, "41304780,41292412,39451677", 0, "Microscopic hematuria", 0.41183796492083136], ["P22692", "IGFBP4", "Insulin-like growth factor-binding protein 4", "Tier 1.5", 0.66, 4, 77.25, 0, 0, null, null, null, 1, 6, "35323639,32515246,31930684", 1, "allergic rhinitis", 0.35214760515440524], ["Q13433", "SLC39A6", "Zinc transporter ZIP6", "Tier 1.5", 0.66, 0, 60.44, 0, 0, null, null, null, 1, 1, "40132409", 1, "breast cancer", 0.11188167100061543], ["O15389", "SIGLEC5", "Sialic acid-binding Ig-like lectin 5", "Tier 1.5", 0.656, 3, 77.75, 0, 0, null, null, null, 1, 3, "33584010,27678199,24405684", 0, "dentures", 0.15815607474115415], ["Q9Y625", "GPC6", "Glypican-6", "Tier 1.5", 0.655, 0, 82.0, 0, 0, null, null, null, 1, 1, "40093223", 1, "autosomal recessive omodysplasia", 0.7503216726357611]], "truncated": false, "filtered_table_rows_count": 499, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"tier\" = :p1 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "Tier 1.5"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 499, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 498, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 499, "toggle_url": "https://apt-scout.org/scout/v_targets.json?tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 261, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 238, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 397, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 102, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 229.1717710031662, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}