{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where in_cev_map = 0, surface_class = \"A2_pm_peripheral\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P25054", "APC", "Adenomatous polyposis coli protein", "Tier 1", 0.644, 1, "A2_pm_peripheral", 31, null, 0, 0, null, null, 1, 39, "41471356,40788329,40207978,39796151,39335496,39189513,38710049,38509823,37199793,37185533,36894782,36882463,36827736,36252203,35544380,35490167,34837173,34708097,34240523,34008621,32486960,32429721,32386347,31937772,31295701,31249960,30609568,29886066,29666278,27736370,27427891,26552824,26552816,25059182,24681393,22236082,19389630,19029139,9546673", 0, "familial adenomatous polyposis 1", 0.8462165290909345], ["Q4FZB7", "KMT5B", "Histone-lysine N-methyltransferase KMT5B", "Tier 1", 0.628, 1, "A2_pm_peripheral", 10, 54.91, 1, 0, null, null, 0, 0, null, 0, "intellectual disability, autosomal dominant 51", 0.7943209483524042], ["Q5JVL4", "EFHC1", "EF-hand domain-containing protein 1", "Tier 1", 0.626, 1, "A2_pm_peripheral", 2, 83.88, 1, 0, null, null, 0, 0, null, 0, "juvenile myoclonic epilepsy", 0.7858434985198706], ["O75800", "ZMYND10", "Zinc finger MYND domain-containing protein 10", "Tier 1", 0.625, 1, "A2_pm_peripheral", 2, 88.75, 0, 0, null, null, 0, 0, null, 0, "primary ciliary dyskinesia", 0.7822239837882315], ["Q86SQ9", "DHDDS", "Dehydrodolichyl diphosphate synthase complex subunit DHDDS", "Tier 1", 0.624, 1, "A2_pm_peripheral", 9, 94.75, 0, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa 59", 0.7786578489187141], ["O43586", "PSTPIP1", "Proline-serine-threonine phosphatase-interacting protein 1", "Tier 1", 0.624, 1, "A2_pm_peripheral", 4, 85.75, 0, 0, null, null, 0, 0, null, 0, "pyogenic arthritis-pyoderma gangrenosum-acne syndrome", 0.7793785829807485], ["Q8NFD5", "ARID1B", "AT-rich interactive domain-containing protein 1B", "Tier 1", 0.624, 1, "A2_pm_peripheral", 2, 46.19, 0, 0, null, null, 0, 0, null, 0, "Coffin-Siris syndrome 1", 0.7813407475430133], ["Q9NPP4", "NLRC4", "NLR family CARD domain-containing protein 4", "Tier 1", 0.619, 1, "A2_pm_peripheral", 6, 85.12, 1, 0, null, null, 0, 0, null, 0, "periodic fever-infantile enterocolitis-autoinflammatory syndrome", 0.7635956406357429], ["P10636", "MAPT", "Microtubule-associated protein tau", "Tier 1", 0.618, 1, "A2_pm_peripheral", 100, 49.22, 1, 0, null, null, 1, 9, "40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187", 0, "Pick disease", 0.7600399335134378], ["P35716", "SOX11", "Transcription factor SOX-11", "Tier 1", 0.614, 1, "A2_pm_peripheral", 4, 56.41, 1, 0, null, null, 0, 0, null, 0, "intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism", 0.7470288070793535], ["O15350", "TP73", "Tumor protein p73", "Tier 1", 0.612, 1, "A2_pm_peripheral", 28, 65.19, 0, 0, null, null, 0, 0, null, 0, "ciliary dyskinesia, primary, 47, and lissencephaly", 0.7409037542174439], ["P12643", "BMP2", "Bone morphogenetic protein 2", "Tier 1", 0.611, 1, "A2_pm_peripheral", 21, 79.56, 0, 0, null, null, 1, 10, "41144653,38542880,37231465,35591468,35195734,34067593,33997500", 0, "short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1", 0.7361833785834584], ["P41159", "LEP", "Leptin", "Tier 1", 0.606, 1, "A2_pm_peripheral", 10, 81.12, 1, 0, null, null, 1, 14, "40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164", 0, "obesity due to congenital leptin deficiency", 0.7197450249224271], ["Q8N136", "DAW1", "Dynein assembly factor with WD repeat domains 1", "Tier 1", 0.596, 1, "A2_pm_peripheral", 1, 96.62, 0, 0, null, null, 0, 0, null, 0, "ciliary dyskinesia, primary, 52", 0.6876653910907874], ["Q9H6P5", "TASP1", "Threonine aspartase 1", "Tier 1", 0.594, 1, "A2_pm_peripheral", 10, 86.81, 0, 0, null, null, 0, 0, null, 0, "Suleiman-El-Hattab syndrome", 0.6801464403674466], ["Q9UQC2", "GAB2", "GRB2-associated-binding protein 2", "Tier 1", 0.572, 1, "A2_pm_peripheral", 10, 51.91, 0, 0, null, null, 0, 0, null, 0, "cancer", 0.6072358553557748], ["Q8IWB6", "TEX14", "Inactive serine/threonine-protein kinase TEX14", "Tier 1", 0.571, 1, "A2_pm_peripheral", 2, 50.47, 0, 0, null, null, 0, 0, null, 0, "spermatogenic failure 23", 0.603775324929283], ["Q13882", "PTK6", "Protein-tyrosine kinase 6", "Tier 1", 0.56, 1, "A2_pm_peripheral", 9, 88.81, 0, 0, null, null, 0, 0, null, 0, "medullary thyroid gland carcinoma", 0.5657289152364859], ["P51813", "BMX", "Cytoplasmic tyrosine-protein kinase BMX", "Tier 1", 0.555, 1, "A2_pm_peripheral", 6, 75.75, 0, 0, null, null, 1, 1, "34962102", 0, "alopecia areata", 0.5491699656070116], ["O76083", "PDE9A", "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A", "Tier 1", 0.553, 1, "A2_pm_peripheral", 25, 81.0, 0, 0, null, null, 0, 0, null, 0, "coronary artery disease", 0.5429744031742744], ["Q96RU8", "TRIB1", "Tribbles homolog 1", "Tier 1", 0.552, 1, "A2_pm_peripheral", 5, 76.56, 0, 0, null, null, 1, 1, "36579647", 0, "neurodegenerative disease", 0.5397808385585621], ["Q9BVS4", "RIOK2", "Serine/threonine-protein kinase RIO2", "Tier 1", 0.552, 1, "A2_pm_peripheral", 10, 67.38, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.539818754658029], ["Q86T24", "ZBTB33", "Transcriptional regulator Kaiso", "Tier 1", 0.551, 1, "A2_pm_peripheral", 19, 54.78, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5355170277816887], ["Q9NXF7", "DCAF16", "DDB1- and CUL4-associated factor 16", "Tier 1", 0.548, 1, "A2_pm_peripheral", 2, 38.19, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5251061120759617], ["Q14678", "KANK1", "KN motif and ankyrin repeat domain-containing protein 1", "Tier 1", 0.546, 1, "A2_pm_peripheral", 5, 53.97, 0, 0, null, null, 0, 0, null, 0, "basal cell carcinoma", 0.5204468359739138], ["Q5TC82", "RC3H1", "Roquin-1", "Tier 1", 0.545, 1, "A2_pm_peripheral", 6, 61.12, 0, 0, null, null, 1, 2, "27010430", 0, "hemophagocytic lymphohistiocytosis, familial, 6", 0.5161798637096334], ["O43663", "PRC1", "Protein regulator of cytokinesis 1", "Tier 1", 0.544, 1, "A2_pm_peripheral", 6, 78.94, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5139662839321523], ["P49789", "FHIT", "Bis(5'-adenosyl)-triphosphatase", "Tier 1", 0.542, 1, "A2_pm_peripheral", 9, 95.25, 0, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.505651828927915], ["P48775", "TDO2", "Tryptophan 2,3-dioxygenase", "Tier 1", 0.541, 1, "A2_pm_peripheral", 22, 90.06, 0, 0, null, null, 0, 0, null, 0, "Hypertryptophanemia", 0.5037265368575525], ["Q96AT9", "RPE", "Ribulose-phosphate 3-epimerase", "Tier 1", 0.54, 1, "A2_pm_peripheral", 4, 96.56, 0, 0, null, null, 1, 19, "37958909,31080896,26923800,25270019,23539459,22913867,22710369,22281826,21701525,21546514,21448811,21137477,20623466,19197318,18628724,18441313,17891009,17369776,16815269", 0, "neurodegenerative disease", 0.4992627094132485], ["P11712", "CYP2C9", "Cytochrome P450 2C9", "Tier 1", 0.536, 1, "A2_pm_peripheral", 15, 92.94, 0, 0, null, null, 0, 0, null, 0, "cholesterol embolism", 0.4868290635834234], ["Q15788", "NCOA1", "Nuclear receptor coactivator 1", "Tier 1", 0.536, 1, "A2_pm_peripheral", 100, 46.72, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.48697450901885614], ["Q96MU7", "YTHDC1", "YTH domain-containing protein 1", "Tier 1", 0.533, 1, "A2_pm_peripheral", 100, 60.34, 0, 0, null, null, 1, 1, "41430607", 0, "neurodegenerative disease", 0.47698771849556626], ["O14733", "MAP2K7", "Dual specificity mitogen-activated protein kinase kinase 7", "Tier 1", 0.529, 1, "A2_pm_peripheral", 37, 77.25, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.4624505042962164], ["P43351", "RAD52", "DNA repair protein RAD52 homolog", "Tier 1", 0.528, 1, "A2_pm_peripheral", 11, 69.62, 1, 0, null, null, 1, 6, "37288783,32945515,31495919,26784987,24500205,23836560", 0, "Abnormality of the skeletal system", 0.45994164258033876], ["Q9BX66", "SORBS1", "Sorbin and SH3 domain-containing protein 1", "Tier 1", 0.527, 1, "A2_pm_peripheral", 11, 46.94, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.45582260952481995], ["Q9UK80", "USP21", "Ubiquitin carboxyl-terminal hydrolase 21", "Tier 1", 0.524, 1, "A2_pm_peripheral", 4, 69.75, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.44616960950164986], ["O00757", "FBP2", "Fructose-1,6-bisphosphatase isozyme 2", "Tier 1", 0.523, 1, "A2_pm_peripheral", 14, 93.75, 0, 0, null, null, 0, 0, null, 0, "leukodystrophy, childhood-onset, remitting", 0.44205857063120163], ["O15519", "CFLAR", "CASP8 and FADD-like apoptosis regulator", "Tier 1", 0.523, 1, "A2_pm_peripheral", 17, 78.31, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.4419421569940659], ["Q12923", "PTPN13", "Tyrosine-protein phosphatase non-receptor type 13", "Tier 1", 0.519, 1, "A2_pm_peripheral", 12, 60.03, 0, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.43005634671382553], ["P29475", "NOS1", "Nitric oxide synthase 1", "Tier 1", 0.514, 1, "A2_pm_peripheral", 100, 79.31, 0, 0, null, null, 0, 0, null, 0, "cervical carcinoma", 0.41359915410428943], ["Q7Z6G8", "ANKS1B", "Ankyrin repeat and sterile alpha motif domain-containing protein 1B", "Tier 1", 0.511, 1, "A2_pm_peripheral", 4, 56.94, 0, 0, null, null, 0, 0, null, 0, "alcohol drinking", 0.4042006937895571], ["Q15700", "DLG2", "Disks large homolog 2", "Tier 1", 0.51, 1, "A2_pm_peripheral", 2, 69.94, 0, 0, null, null, 0, 0, null, 0, "alcohol drinking", 0.40008157091117924], ["P33260", "CYP2C18", "Cytochrome P450 2C18", "Tier 1", 0.507, 1, "A2_pm_peripheral", 2, 93.81, 0, 0, null, null, 0, 0, null, 0, "response to anticoagulant", 0.3915927978813387], ["Q9UQF2", "MAPK8IP1", "C-Jun-amino-terminal kinase-interacting protein 1", "Tier 1", 0.506, 1, "A2_pm_peripheral", 27, 54.03, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.3877056074053897], ["O00451", "GFRA2", "GDNF family receptor alpha-2", "Tier 1", 0.487, 1, "A2_pm_peripheral", 5, 75.0, 1, 0, null, null, 0, 0, null, 0, "poisoning", 0.32401333746089783], ["Q5SZJ8", "BEND6", "BEN domain-containing protein 6", "Tier 1", 0.486, 1, "A2_pm_peripheral", 2, 71.81, 0, 0, null, null, 0, 0, null, 0, "muscle cramp", 0.3185460431293047], ["Q8N5Z0", "AADAT", "Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial", "Tier 1", 0.485, 1, "A2_pm_peripheral", 17, 97.31, 0, 0, null, null, 0, 0, null, 0, "retinopathy", 0.31774809840020035], ["P59768", "GNG2", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2", "Tier 1", 0.485, 1, "A2_pm_peripheral", 100, 89.56, 1, 0, null, null, 0, 0, null, 0, "multiple sclerosis", 0.3157760490336847], ["Q6ZSG1", "ARK2C", "E3 ubiquitin-protein ligase ARK2C", "Tier 1", 0.482, 1, "A2_pm_peripheral", 9, 57.0, 0, 0, null, null, 0, 0, null, 0, "protozoa infectious disease", 0.30575954222879614]], "truncated": false, "filtered_table_rows_count": 69, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"in_cev_map\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "A2_pm_peripheral", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 67, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 2, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 69, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 69, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 51, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 18, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 69, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 69, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 55, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 14, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1&_facet=aptamer_count_pubmed"}, {"name": "aptamer_pmids", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1&_facet=aptamer_pmids"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1169.8530968278646, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}