{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where in_cev_map = 0, surface_class = \"A_assoc\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P15884", "TCF4", "Transcription factor 4", "Tier 1", 0.705, 1, "A_assoc", 5, 51.12, 0, 0, null, null, 1, 4, "36252203,17909039,41851110,37805109", 0, "Pitt-Hopkins syndrome", 0.8490531860867685], ["Q9NZK5", "ADA2", "Adenosine deaminase 2", "Tier 1", 0.699, 1, "A_assoc", 2, 95.81, 0, 0, null, null, 0, 0, null, 0, "deficiency of adenosine deaminase 2", 0.8291292532404531], ["Q99972", "MYOC", "Myocilin", "Tier 1", 0.699, 1, "A_assoc", 24, 78.94, 0, 0, null, null, 0, 0, null, 0, "glaucoma 1, open angle, A", 0.8294483747483756], ["Q9UBH0", "IL36RN", "Interleukin-36 receptor antagonist protein", "Tier 1", 0.695, 1, "A_assoc", 3, 92.44, 0, 0, null, null, 0, 0, null, 0, "psoriasis 14, pustular", 0.8155144873787125], ["P20062", "TCN2", "Transcobalamin-2", "Tier 1", 0.694, 1, "A_assoc", 11, 91.5, 0, 0, null, null, 1, 3, "41935727,39493449", 0, "transcobalamin II deficiency", 0.8116989428679681], ["Q96MK3", "FAM20A", "Pseudokinase FAM20A", "Tier 1", 0.693, 1, "A_assoc", 4, 85.25, 0, 0, null, null, 0, 0, null, 0, "amelogenesis imperfecta type 1G", 0.8106031517056754], ["P55000", "SLURP1", "Secreted Ly-6/uPAR-related protein 1", "Tier 1", 0.692, 1, "A_assoc", 2, 84.19, 0, 0, null, null, 0, 0, null, 0, "mal de Meleda", 0.8064330379723671], ["P45452", "MMP13", "Collagenase 3", "Tier 1", 0.691, 1, "A_assoc", 49, 88.62, 0, 0, null, null, 1, 4, "41754778,40893365,38471488,38750696", 0, "spondyloepimetaphyseal dysplasia, Missouri type", 0.8032079813035149], ["P29460", "IL12B", "Interleukin-12 subunit beta", "Tier 1", 0.687, 1, "A_assoc", 20, 91.12, 1, 0, null, null, 0, 0, null, 0, "psoriasis", 0.7914863943708039], ["Q96S42", "NODAL", "Nodal homolog", "Tier 1", 0.684, 1, "A_assoc", 1, 75.44, 0, 0, null, null, 1, 3, "38155321,24146916,23918801", 0, "heterotaxy, visceral, 5, autosomal", 0.7788051667024423], ["P00797", "REN", "Renin", "Tier 1", 0.68, 1, "A_assoc", 91, 85.44, 0, 0, null, null, 1, 456, "42025056,42000159,41992303,41979049,41942404,41934998,41909751,41904852,41851110,41849890,41794534,41780402,41770936,41718462,41711853,41698160,41671930,41659919,41629318,41545413,41538945,41529264,41519163,41454539,41443106,41386094,41330678,41327249,41249026,41234744,41207040,41205456,41175848,41172349,41171135,41164194,41161441,41148632,41118515,41089000,41067030,41024479,41002305,40994449,40968863,40963922,40893365,40891676,40870790,40801503,41906877,40832436,39923730,39263947,39129649,38811951,36190914,35983901,35907639,35187107,34619249,34248841,32981365,32838280,32527800,31988066,26746799,21147843", 0, "familial juvenile hyperuricemic nephropathy type 2", 0.7657976389758877], ["P05019", "IGF1", "Insulin-like growth factor 1", "Tier 1", 0.68, 1, "A_assoc", 32, 59.53, 1, 0, null, null, 1, 23, "38384162,35859339,35591468,33977395,33467925,32511241,31930684,26245346,24832383,23933187,23373648,16019422,41283885,39263947,38497478,33888746,15231297", 0, "growth delay due to insulin-like growth factor type 1 deficiency", 0.7650418939376437], ["Q9GZV9", "FGF23", "Fibroblast growth factor 23", "Tier 1", 0.679, 1, "A_assoc", 6, 76.62, 1, 0, null, null, 1, 11, "39007037,38079395,35415885,32065590,30297602,30197987,41226313,36705086", 0, "autosomal dominant hypophosphatemic rickets", 0.762326334964193], ["P20849", "COL9A1", "Collagen alpha-1(IX) chain", "Tier 1", 0.678, 1, "A_assoc", 5, 61.5, 0, 0, null, null, 0, 0, null, 0, "Stickler syndrome", 0.7594904923903256], ["P35225", "IL13", "Interleukin-13", "Tier 1", 0.669, 1, "A_assoc", 13, 85.62, 1, 0, null, null, 1, 9, "41463156,35356877,33742062,32784904,27640094,29949702,21793788", 0, "atopic eczema", 0.7297489019498119], ["Q2MKA7", "RSPO1", "R-spondin-1", "Tier 1", 0.669, 1, "A_assoc", 12, 74.69, 1, 0, null, null, 0, 0, null, 0, "palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome", 0.7285342885472184], ["Q9BQB4", "SOST", "Sclerostin", "Tier 1", 0.666, 1, "A_assoc", 3, 70.81, 0, 0, null, null, 1, 32, "42031715,41736700,41545413,41276911,41242313,40464222,40429697,34361085,33717084,33334063,21204783,42030934,41450662,41226313,39470582,39007037,38444701,38074899,37481136,35966595,35869074,35646527", 0, "sclerosteosis 1", 0.7184345506579789], ["P05305", "EDN1", "Endothelin-1", "Tier 1", 0.666, 1, "A_assoc", 17, 65.19, 1, 0, null, null, 1, 2, "40438585,37198662", 0, "auriculocondylar syndrome", 0.7193561828311311], ["P12272", "PTHLH", "Parathyroid hormone-related protein", "Tier 1", 0.666, 1, "A_assoc", 11, 62.88, 1, 0, null, null, 0, 0, null, 0, "brachydactyly type E", 0.7203484375635054], ["Q99574", "SERPINI1", "Neuroserpin", "Tier 1", 0.665, 1, "A_assoc", 3, 88.12, 0, 0, null, null, 0, 0, null, 0, "familial encephalopathy with neuroserpin inclusion bodies", 0.7162803151916303], ["P01270", "PTH", "Parathyroid hormone", "Tier 1", 0.664, 1, "A_assoc", 26, 72.12, 1, 0, null, null, 1, 9, "40464222,40108760,39880691,38079395,25901535,41303575,41226313", 0, "hypoparathyroidism, familial isolated 1", 0.7147450451832739], ["O43323", "DHH", "Desert hedgehog protein", "Tier 1", 0.657, 1, "A_assoc", 5, 84.38, 0, 0, null, null, 1, 1, "18698484", 0, "46,XY gonadal dysgenesis-motor and sensory neuropathy syndrome", 0.6912706692651148], ["Q9Y5K2", "KLK4", "Kallikrein-4", "Tier 1", 0.65, 1, "A_assoc", 18, 90.12, 0, 0, null, null, 1, 2, "30114962,35323639", 0, "Hypomaturation amelogenesis imperfecta", 0.6659029046455642], ["Q8N300", "SVBP", "Small vasohibin-binding protein", "Tier 1", 0.649, 1, "A_assoc", 24, 85.06, 1, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder with ataxia, hypotonia, and microcephaly", 0.6640118055835142], ["P05113", "IL5", "Interleukin-5", "Tier 1", 0.642, 1, "A_assoc", 5, 86.69, 1, 0, null, null, 1, 12, "40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585", 0, "asthma", 0.6399821251487101], ["Q16552", "IL17A", "Interleukin-17A", "Tier 1", 0.641, 1, "A_assoc", 44, 84.31, 1, 0, null, null, 1, 30, "42017161,41754778,41482938,41477217,40410820,39376102,38091227,38031342,37879125,37238999,36517803,36375248,36326540,35724603,32784904,32387307,31316164,27827561,24056860,21524680,20967861,37563071,34531951", 0, "psoriasis", 0.6367521314106471], ["O95390", "GDF11", "Growth/differentiation factor 11", "Tier 1", 0.636, 1, "A_assoc", 5, 73.12, 0, 0, null, null, 1, 7, "40664633,39909827,31638376,23663781,32408813", 0, "vertebral hypersegmentation and orofacial anomalies", 0.6207007733160915], ["P05230", "FGF1", "Fibroblast growth factor 1", "Tier 1", 0.633, 1, "A_assoc", 96, 90.69, 0, 0, null, null, 1, 3, "35415885,33536494,27663888", 0, "cancer", 0.6088477966360052], ["P22894", "MMP8", "Neutrophil collagenase", "Tier 1", 0.631, 1, "A_assoc", 25, 90.38, 0, 0, null, null, 1, 4, "35821507,34183667,33534888,30197987", 0, "acne", 0.603247809982021], ["P09237", "MMP7", "Matrilysin", "Tier 1", 0.631, 1, "A_assoc", 16, 87.81, 0, 0, null, null, 1, 9, "41890985,37022120,36508319,33742062,31844116,30553167,28738067,27836219", 0, "acne", 0.603247809982021], ["Q9UHF0", "TAC3", "Tachykinin-3", "Tier 1", 0.63, 1, "A_assoc", 2, 64.88, 1, 0, null, null, 0, 0, null, 0, "hypogonadotropic hypogonadism 10 with or without anosmia", 0.5995324402695232], ["P35247", "SFTPD", "Pulmonary surfactant-associated protein D", "Tier 1", 0.624, 1, "A_assoc", 31, 65.5, 0, 0, null, null, 1, 1, "39884764", 0, "COVID-19", 0.5808114412785164], ["P07492", "GRP", "Gastrin-releasing peptide", "Tier 1", 0.619, 1, "A_assoc", 9, 63.94, 1, 0, null, null, 1, 6, "38890976,38659329,37500079,29027923,41810845,23179274", 0, "type 2 diabetes mellitus", 0.5648167305980163], ["O95150", "TNFSF15", "Tumor necrosis factor ligand superfamily member 15", "Tier 1", 0.618, 1, "A_assoc", 7, 81.06, 0, 0, null, null, 1, 2, "35026285", 0, "leprosy", 0.5605330843692238], ["Q9UNA0", "ADAMTS5", "A disintegrin and metalloproteinase with thrombospondin motifs 5", "Tier 1", 0.613, 1, "A_assoc", 7, 77.56, 0, 0, null, null, 1, 3, "35700850,26594036", 0, "Abnormality of the skeletal system", 0.5442996355354548], ["Q9HCB6", "SPON1", "Spondin-1", "Tier 1", 0.613, 1, "A_assoc", 4, 77.25, 0, 0, null, null, 1, 2, "31640794,27640094", 0, "atrial fibrillation", 0.5420224587351377], ["Q8IU60", "DCP2", "m7GpppN-mRNA hydrolase", "Tier 1", 0.613, 1, "A_assoc", 33, 66.81, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5442061583114092], ["P56704", "WNT3A", "Protein Wnt-3a", "Tier 1", 0.608, 1, "A_assoc", 4, 88.31, 1, 0, null, null, 1, 1, "37231925", 0, "neurodegenerative disease", 0.5271953966006525], ["O00585", "CCL21", "C-C motif chemokine 21", "Tier 1", 0.608, 1, "A_assoc", 5, 72.69, 1, 0, null, null, 1, 2, "36314402,29733244", 0, "rheumatoid arthritis", 0.5266345093424485], ["Q4VCS5", "AMOT", "Angiomotin", "Tier 1", 0.608, 1, "A_assoc", 18, 56.75, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5261379875719714], ["O14793", "MSTN", "Growth/differentiation factor 8", "Tier 1", 0.602, 1, "A_assoc", 5, 78.75, 0, 0, null, null, 1, 4, "41020397,40664633,40313273,33334063", 0, "myostatin-related muscle hypertrophy", 0.5055829543398623], ["P78556", "CCL20", "C-C motif chemokine 20", "Tier 1", 0.6, 1, "A_assoc", 6, 88.69, 1, 0, null, null, 1, 1, "36375248", 0, "inflammatory bowel disease", 0.4987938599485985], ["P60568", "IL2", "Interleukin-2", "Tier 1", 0.6, 1, "A_assoc", 37, 84.12, 1, 0, null, null, 1, 45, "41754959,40972397,40761795,40447990,38081519,37805109,37141264,37110712,37074914,34511903,34386332,32784904,32574155,32280743,31383650,31270926,30800133,29556342,29055191,28129128,27959341,27878687,27819142,27529794,27179422,26048585,25919090,24682172,35756119,30883749,29244152,24968026,24418663,18319343,12900522", 0, "asthma", 0.5009876866575907], ["Q6IQ23", "PLEKHA7", "Pleckstrin homology domain-containing family A member 7", "Tier 1", 0.599, 1, "A_assoc", 3, 56.69, 0, 0, null, null, 0, 0, null, 0, "open-angle glaucoma", 0.49623877592982996], ["O15496", "PLA2G10", "Group 10 secretory phospholipase A2", "Tier 1", 0.597, 1, "A_assoc", 7, 88.0, 0, 0, null, null, 1, 1, "9526554", 0, "neurodegenerative disease", 0.48857112988743956], ["P19801", "AOC1", "Diamine oxidase [copper-containing]", "Tier 1", 0.596, 1, "A_assoc", 5, 95.0, 0, 0, null, null, 1, 1, "29978265", 0, "Abnormality of the skeletal system", 0.4879067570517193], ["Q9BW91", "NUDT9", "ADP-ribose pyrophosphatase", "Tier 1", 0.596, 1, "A_assoc", 2, 84.62, 0, 0, null, null, 1, 1, "15303967", 0, "gout", 0.48671248625701], ["Q8NI35", "PATJ", "InaD-like protein", "Tier 1", 0.596, 1, "A_assoc", 10, 60.97, 0, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.4853816860727928], ["P15085", "CPA1", "Carboxypeptidase A1", "Tier 1", 0.594, 1, "A_assoc", 6, 95.19, 0, 0, null, null, 0, 0, null, 0, "type 2 diabetes mellitus", 0.480064090634254], ["P39900", "MMP12", "Macrophage metalloelastase", "Tier 1", 0.594, 1, "A_assoc", 86, 86.94, 0, 0, null, null, 1, 8, "41861669,38477735,38296402,37015819,35120890,34183667,27530235", 0, "atopic eczema", 0.4795677061208266]], "truncated": false, "filtered_table_rows_count": 119, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"in_cev_map\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "A_assoc", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 119, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 119, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 119, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 72, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1&has_known_aptamer=1", "selected": false}, {"value": 0, "label": 0, "count": 47, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1&has_known_aptamer=0", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 119, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 119, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_assoc&tier=Tier+1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 74, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 45, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 794.930421281606, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}