{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where in_cev_map = 0, surface_class = \"A_surface\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P13569", "CFTR", "Cystic fibrosis transmembrane conductance regulator", "Tier 1", 0.824, 1, "A_surface", 58, 75.62, 1, 0, null, null, 1, 10, "41148207,31029337,30595527,22483890,15657417", 0, "cystic fibrosis", 0.9133535862571094], ["Q14654", "KCNJ11", "ATP-sensitive inward rectifier potassium channel 11", "Tier 1", 0.81, 1, "A_surface", 9, 83.81, 1, 0, null, null, 0, 0, null, 0, "type 2 diabetes mellitus", 0.8651421397012851], ["P07949", "RET", "Proto-oncogene tyrosine-protein kinase receptor Ret", "Tier 1", 0.809, 1, "A_surface", 34, 78.81, 1, 0, null, null, 1, 83, "41962371,41744190,41636718,41526122,41406741,41171123,41082837,41060784,41027166,40932619,40815127,40711581,40633058,40602121,40410423,40285964,40252505,40222299,39344894,39288589,39190775,38953438,38876068,38852325,38718747,38604287,38354543,38282384,38237282,37851382,37774402,37757695,37437453,37245460,36952259,36315022,35550937,35420408,34342436,34132907,34016094,33513536,33462661,33119785,33011620,32760976,32527800,32212604,32138930,31897454", 0, "medullary thyroid gland carcinoma", 0.8617460262224842], ["Q12809", "KCNH2", "Voltage-gated inwardly rectifying potassium channel KCNH2", "Tier 1", 0.806, 1, "A_surface", 23, 62.75, 1, 0, null, null, 1, 1, "22617876", 0, "Romano-Ward syndrome", 0.8549238933917284], ["P82251", "SLC7A9", "b(0,+)-type amino acid transporter 1", "Tier 1", 0.805, 1, "A_surface", 4, 85.44, 1, 0, null, null, 0, 0, null, 0, "cystinuria", 0.8484952668941285], ["Q695T7", "SLC6A19", "Sodium-dependent neutral amino acid transporter B(0)AT1", "Tier 1", 0.804, 1, "A_surface", 19, 90.0, 1, 0, null, null, 0, 0, null, 0, "Hartnup disease", 0.8464240093600148], ["P41180", "CASR", "Extracellular calcium-sensing receptor", "Tier 1", 0.804, 1, "A_surface", 31, 75.69, 1, 0, null, null, 0, 0, null, 0, "familial hypocalciuric hypercalcemia 1", 0.8460848589627423], ["Q05586", "GRIN1", "Glutamate receptor ionotropic, NMDA 1", "Tier 1", 0.803, 1, "A_surface", 84, 82.88, 1, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant", 0.8446685494288694], ["P07911", "UMOD", "Uromodulin", "Tier 1", 0.803, 1, "A_surface", 10, 82.94, 1, 0, null, null, 1, 4, "37533140,35446786", 0, "familial juvenile hyperuricemic nephropathy type 1", 0.8446536377993564], ["O43526", "KCNQ2", "Potassium voltage-gated channel subfamily KQT member 2", "Tier 1", 0.803, 1, "A_surface", 24, 58.19, 1, 0, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.8423358217314708], ["P07333", "CSF1R", "Macrophage colony-stimulating factor 1 receptor", "Tier 1", 0.802, 1, "A_surface", 26, 77.81, 0, 0, null, null, 1, 1, "29277631", 0, "leukoencephalopathy, diffuse hereditary, with spheroids 1", 0.8391971566583056], ["Q9HBA0", "TRPV4", "Transient receptor potential cation channel subfamily V member 4", "Tier 1", 0.801, 1, "A_surface", 19, 71.62, 1, 0, null, null, 0, 0, null, 0, "metatropic dysplasia", 0.8356240344517467], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.8, 1, "A_surface", 16, 84.94, 0, 0, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138], ["P16473", "TSHR", "Thyrotropin receptor", "Tier 1", 0.8, 1, "A_surface", 9, 74.0, 1, 0, null, null, 1, 6, "41054857,40997970,40588369,38650837", 0, "hypothyroidism due to TSH receptor mutations", 0.8327127196409464], ["Q92736", "RYR2", "Ryanodine receptor 2", "Tier 1", 0.8, 1, "A_surface", 26, null, 1, 0, null, null, 1, 1, "24130701", 0, "catecholaminergic polymorphic ventricular tachycardia 1", 0.8338648743498255], ["Q8IZF0", "NALCN", "Sodium leak channel NALCN", "Tier 1", 0.796, 1, "A_surface", 5, 76.69, 1, 0, null, null, 0, 0, null, 0, "congenital contractures of the limbs and face, hypotonia, and developmental delay", 0.8198033442161259], ["P41181", "AQP2", "Aquaporin-2", "Tier 1", 0.795, 1, "A_surface", 7, 91.75, 1, 0, null, null, 0, 0, null, 0, "diabetes insipidus, nephrogenic, autosomal", 0.817870726313342], ["Q9ULV1", "FZD4", "Frizzled-4", "Tier 1", 0.795, 1, "A_surface", 11, 84.31, 1, 0, null, null, 1, 1, "18673242", 0, "Familial exudative vitreoretinopathy", 0.8152111103672746], ["Q13651", "IL10RA", "Interleukin-10 receptor subunit alpha", "Tier 1", 0.795, 1, "A_surface", 7, 62.0, 1, 0, null, null, 1, 2, "25870409,25558474", 0, "Autosomal recessive early-onset inflammatory bowel disease", 0.8151052076044897], ["Q01974", "ROR2", "Tyrosine-protein kinase transmembrane receptor ROR2", "Tier 1", 0.794, 1, "A_surface", 6, 68.31, 0, 0, null, null, 1, 2, "41782379,18673242", 0, "autosomal recessive Robinow syndrome", 0.8145559265435566], ["Q9H222", "ABCG5", "ATP-binding cassette sub-family G member 5", "Tier 1", 0.793, 1, "A_surface", 8, 85.06, 1, 0, null, null, 0, 0, null, 0, "sitosterolemia", 0.810555184820483], ["Q9UM73", "ALK", "ALK tyrosine kinase receptor", "Tier 1", 0.791, 1, "A_surface", 79, 68.19, 0, 0, null, null, 1, 6, "40347134,38604287,32218299,29205808,24116381,21281497", 0, "neuroblastoma", 0.8016889264946979], ["Q12866", "MERTK", "Tyrosine-protein kinase Mer", "Tier 1", 0.79, 1, "A_surface", 42, 72.25, 0, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7985580877708576], ["Q4KMG0", "CDON", "Cell adhesion molecule-related/down-regulated by oncogenes", "Tier 1", 0.79, 1, "A_surface", 3, 62.03, 0, 0, null, null, 1, 3, "36333824,24629635,18698484", 0, "holoprosencephaly", 0.800378039564866], ["Q9H1D0", "TRPV6", "Transient receptor potential cation channel subfamily V member 6", "Tier 1", 0.789, 1, "A_surface", 24, 80.56, 1, 0, null, null, 0, 0, null, 0, "hyperparathyroidism, transient neonatal", 0.7964821997780153], ["P16871", "IL7R", "Interleukin-7 receptor subunit alpha", "Tier 1", 0.789, 1, "A_surface", 8, 67.44, 0, 0, null, null, 0, 0, null, 0, "immunodeficiency 104", 0.7983119488718231], ["P15509", "CSF2RA", "Granulocyte-macrophage colony-stimulating factor receptor subunit alpha", "Tier 1", 0.788, 1, "A_surface", 2, 82.0, 0, 0, null, null, 0, 0, null, 0, "Congenital pulmonary alveolar proteinosis", 0.7922592394513138], ["Q14028", "CNGB1", "Cyclic nucleotide-gated channel beta-1", "Tier 1", 0.788, 1, "A_surface", 11, 57.66, 1, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7931901344765326], ["P22223", "CDH3", "Cadherin-3", "Tier 1", 0.786, 1, "A_surface", 19, 76.75, 0, 0, null, null, 1, 1, "41304780", 0, "EEM syndrome", 0.7851776755128059], ["P24530", "EDNRB", "Endothelin receptor type B", "Tier 1", 0.786, 1, "A_surface", 17, 75.0, 1, 0, null, null, 0, 0, null, 0, "Waardenburg syndrome type 4A", 0.7874601728728147], ["Q03431", "PTH1R", "Parathyroid hormone/parathyroid hormone-related peptide receptor", "Tier 1", 0.786, 1, "A_surface", 52, 70.94, 1, 0, null, null, 0, 0, null, 0, "metaphyseal chondrodysplasia, Jansen type", 0.7859378587442476], ["O60741", "HCN1", "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1", "Tier 1", 0.786, 1, "A_surface", 12, 68.94, 1, 0, null, null, 0, 0, null, 0, "Generalized epilepsy with febrile seizures-plus", 0.7853938745545654], ["O43909", "EXTL3", "Exostosin-like 3", "Tier 1", 0.785, 1, "A_surface", 4, 83.69, 1, 0, null, null, 0, 0, null, 0, "immunoskeletal dysplasia with neurodevelopmental abnormalities", 0.7837827977649315], ["P22888", "LHCGR", "Lutropin-choriogonadotropic hormone receptor", "Tier 1", 0.785, 1, "A_surface", 4, 80.12, 1, 0, null, null, 0, 0, null, 0, "Leydig cell hypoplasia, type 1", 0.783461117057047], ["P23416", "GLRA2", "Glycine receptor subunit alpha-2", "Tier 1", 0.784, 1, "A_surface", 13, 83.81, 1, 0, null, null, 0, 0, null, 0, "intellectual developmental disorder, X-linked, syndromic, Pilorge type", 0.7805605973560554], ["P56696", "KCNQ4", "Potassium voltage-gated channel subfamily KQT member 4", "Tier 1", 0.783, 1, "A_surface", 13, 65.25, 1, 0, null, null, 0, 0, null, 0, "autosomal dominant nonsyndromic hearing loss 2A", 0.7765455627642878], ["Q13224", "GRIN2B", "Glutamate receptor ionotropic, NMDA 2B", "Tier 1", 0.783, 1, "A_surface", 36, 60.69, 1, 0, null, null, 0, 0, null, 0, "intellectual disability, autosomal dominant 6", 0.7771650025965382], ["P30531", "SLC6A1", "Sodium- and chloride-dependent GABA transporter 1", "Tier 1", 0.782, 1, "A_surface", 5, 87.94, 1, 0, null, null, 0, 0, null, 0, "epilepsy with myoclonic atonic seizures", 0.7729414443362785], ["Q9H251", "CDH23", "Cadherin-23", "Tier 1", 0.781, 1, "A_surface", 6, 76.75, 0, 0, null, null, 0, 0, null, 0, "Usher syndrome type 1", 0.7713456285400272], ["Q9NY46", "SCN3A", "Sodium channel protein type 3 subunit alpha", "Tier 1", 0.781, 1, "A_surface", 2, 68.25, 1, 0, null, null, 0, 0, null, 0, "familial focal epilepsy with variable foci", 0.7708874082891223], ["P43220", "GLP1R", "Glucagon-like peptide 1 receptor", "Tier 1", 0.78, 1, "A_surface", 70, 81.5, 1, 0, null, null, 1, 2, "40691365,30957581", 0, "type 2 diabetes mellitus", 0.7667004144705459], ["Q07699", "SCN1B", "Sodium channel regulatory subunit beta-1", "Tier 1", 0.779, 1, "A_surface", 36, 87.06, 1, 0, null, null, 0, 0, null, 0, "Generalized epilepsy with febrile seizures-plus", 0.7638796221342504], ["P21579", "SYT1", "Synaptotagmin-1", "Tier 1", 0.779, 1, "A_surface", 24, 81.81, 0, 0, null, null, 0, 0, null, 0, "infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome", 0.7640586502824556], ["Q01668", "CACNA1D", "Voltage-dependent L-type calcium channel subunit alpha-1D", "Tier 1", 0.777, 1, "A_surface", 6, 64.31, 1, 0, null, null, 0, 0, null, 0, "aldosterone-producing adenoma with seizures and neurological abnormalities", 0.7565859403082721], ["P30518", "AVPR2", "Vasopressin V2 receptor", "Tier 1", 0.776, 1, "A_surface", 38, 76.0, 1, 0, null, null, 0, 0, null, 0, "nephrogenic syndrome of inappropriate antidiuresis", 0.7522383646690638], ["O15399", "GRIN2D", "Glutamate receptor ionotropic, NMDA 2D", "Tier 1", 0.776, 1, "A_surface", 13, 63.22, 1, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 46", 0.7529662497608808], ["P26678", "PLN", "Phospholamban", "Tier 1", 0.775, 1, "A_surface", 7, 81.88, 0, 0, null, null, 1, 9, "39536855,32382487,30777430,25240642,21848510,19158349", 0, "hypertrophic cardiomyopathy", 0.750557685745381], ["P48167", "GLRB", "Glycine receptor subunit beta", "Tier 1", 0.775, 1, "A_surface", 12, 78.06, 1, 0, null, null, 0, 0, null, 0, "hyperekplexia 2", 0.7488854563756028], ["P08588", "ADRB1", "Beta-1 adrenergic receptor", "Tier 1", 0.775, 1, "A_surface", 7, 75.31, 1, 0, null, null, 0, 0, null, 0, "hypertension", 0.7498467911536156], ["Q9HBE5", "IL21R", "Interleukin-21 receptor", "Tier 1", 0.775, 1, "A_surface", 6, 64.12, 0, 0, null, null, 1, 2, "30800133,29244152", 0, "Cryptosporidiosis - chronic cholangitis - liver disease", 0.7501392499286187]], "truncated": false, "filtered_table_rows_count": 291, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"in_cev_map\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "A_surface", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 287, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 4, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 291, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 291, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 209, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 82, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": "A_surface", "label": "A_surface", "count": 291, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 291, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 164, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1&has_cryoEM=1", "selected": false}, {"value": 0, "label": 0, "count": 127, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1&has_cryoEM=0", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 497.3794361576438, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}