{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where in_cev_map = 0, surface_class = \"A_surface\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["O95255", "ABCC6", "ATP-binding cassette sub-family C member 6", "Tier 1.5", 0.809, 1, "A_surface", 4, 80.94, 0, 0, null, null, 0, 0, null, 0, "Pseudoxanthoma elasticum", 0.864631668818611], ["P21439", "ABCB4", "Phosphatidylcholine translocator ABCB4", "Tier 1.5", 0.806, 1, "A_surface", 4, 83.25, 1, 0, null, null, 0, 0, null, 0, "progressive familial intrahepatic cholestasis type 3", 0.851728159166962], ["P31785", "IL2RG", "Cytokine receptor common subunit gamma", "Tier 1.5", 0.804, 1, "A_surface", 14, 75.5, 1, 0, null, null, 1, 2, "30800133,33869115", 0, "gamma chain deficiency", 0.8469997000418428], ["Q9UM01", "SLC7A7", "Y+L amino acid transporter 1", "Tier 1.5", 0.804, 1, "A_surface", 5, 83.81, 1, 0, null, null, 0, 0, null, 0, "lysinuric protein intolerance", 0.8450026270275782], ["P08100", "RHO", "Rhodopsin", "Tier 1.5", 0.804, 1, "A_surface", 4, 88.75, 1, 0, null, null, 1, 45, "41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760", 0, "retinitis pigmentosa", 0.8481942240861982], ["P48029", "SLC6A8", "Sodium- and chloride-dependent creatine transporter 1", "Tier 1.5", 0.804, 1, "A_surface", 6, 84.62, 1, 0, null, null, 0, 0, null, 0, "creatine transporter deficiency", 0.847268393806457], ["Q9UQD0", "SCN8A", "Sodium channel protein type 8 subunit alpha", "Tier 1.5", 0.803, 1, "A_surface", 4, 68.38, 1, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 13", 0.8437707419548253], ["O95342", "ABCB11", "Bile salt export pump", "Tier 1.5", 0.801, 1, "A_surface", 8, 83.12, 1, 0, null, null, 1, 1, "36313979", 0, "progressive familial intrahepatic cholestasis type 2", 0.8372060401943777], ["P78508", "KCNJ10", "ATP-sensitive inward rectifier potassium channel 10", "Tier 1.5", 0.801, 1, "A_surface", 4, 82.44, 1, 0, null, null, 0, 0, null, 0, "EAST syndrome", 0.8357483559927158], ["P30968", "GNRHR", "Gonadotropin-releasing hormone receptor", "Tier 1.5", 0.799, 1, "A_surface", 1, 84.19, 0, 0, null, null, 0, 0, null, 0, "hypogonadotropic hypogonadism", 0.83100005285263], ["Q16281", "CNGA3", "Cyclic nucleotide-gated channel alpha-3", "Tier 1.5", 0.799, 1, "A_surface", 10, 74.44, 1, 0, null, null, 0, 0, null, 0, "achromatopsia", 0.8315799021867489], ["P10912", "GHR", "Growth hormone receptor", "Tier 1.5", 0.799, 1, "A_surface", 9, 58.69, 0, 0, null, null, 1, 5, "38811951,38477735,31603904", 0, "Laron syndrome", 0.8304020079647765], ["P13866", "SLC5A1", "Sodium/glucose cotransporter 1", "Tier 1.5", 0.797, 1, "A_surface", 4, 84.38, 1, 0, null, null, 0, 0, null, 0, "glucose-galactose malabsorption", 0.8220991027793896], ["Q04844", "CHRNE", "Acetylcholine receptor subunit epsilon", "Tier 1.5", 0.797, 1, "A_surface", 13, 80.69, 1, 0, null, null, 0, 0, null, 0, "Congenital myasthenic syndromes", 0.8223287249629152], ["P23942", "PRPH2", "Peripherin-2", "Tier 1.5", 0.796, 1, "A_surface", 1, 87.0, 1, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.8194208847382956], ["Q9BZV2", "SLC19A3", "Thiamine transporter 2", "Tier 1.5", 0.796, 1, "A_surface", 19, 81.56, 1, 0, null, null, 0, 0, null, 0, "biotin-responsive basal ganglia disease", 0.8189646480334981], ["Q5JUK3", "KCNT1", "Potassium channel subfamily T member 1", "Tier 1.5", 0.795, 1, "A_surface", 6, 73.88, 1, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 14", 0.8165232785825526], ["Q9NQW8", "CNGB3", "Cyclic nucleotide-gated channel beta-3", "Tier 1.5", 0.791, 1, "A_surface", 9, 68.12, 1, 0, null, null, 0, 0, null, 0, "achromatopsia", 0.8033348000666748], ["Q01718", "MC2R", "Adrenocorticotropic hormone receptor", "Tier 1.5", 0.79, 1, "A_surface", 2, 85.38, 1, 0, null, null, 0, 0, null, 0, "familial glucocorticoid deficiency", 0.8001007686411645], ["O43525", "KCNQ3", "Potassium voltage-gated channel subfamily KQT member 3", "Tier 1.5", 0.789, 1, "A_surface", 1, 56.72, 0, 0, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.7961763561533409], ["P37023", "ACVRL1", "Activin receptor type-1-like", "Tier 1.5", 0.789, 1, "A_surface", 7, 82.0, 0, 0, null, null, 0, 0, null, 0, "telangiectasia, hereditary hemorrhagic, type 2", 0.7951167515831324], ["P16410", "CTLA4", "Cytotoxic T-lymphocyte protein 4", "Tier 1.5", 0.787, 1, "A_surface", 22, 80.12, 0, 0, null, null, 1, 26, "41907643,40972397,40870970,40811947,40536609,39417693,38473398,38158454,36966395,36831533,36603108,36015348,33970170,32929022,32840510,32280743,32024070,31405808,28918052,28082399,26030229,25565435,24892807,23460536,23460531,14612549", 0, "autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency", 0.7906408646569979], ["Q13698", "CACNA1S", "Voltage-dependent L-type calcium channel subunit alpha-1S", "Tier 1.5", 0.786, 1, "A_surface", 2, 71.81, 0, 0, null, null, 0, 0, null, 0, "hypokalemic periodic paralysis, type 1", 0.7869997029542154], ["O95622", "ADCY5", "Adenylate cyclase type 5", "Tier 1.5", 0.785, 1, "A_surface", 2, 73.19, 1, 0, null, null, 0, 0, null, 0, "dyskinesia with orofacial involvement, autosomal dominant", 0.7830401650561951], ["Q96MS0", "ROBO3", "Roundabout homolog 3", "Tier 1.5", 0.784, 1, "A_surface", 3, 63.69, 0, 0, null, null, 1, 2, "32369590", 0, "horizontal gaze palsy with progressive scoliosis", 0.7813306356858872], ["P51168", "SCNN1B", "Epithelial sodium channel subunit beta", "Tier 1.5", 0.783, 1, "A_surface", 5, 82.44, 1, 0, null, null, 0, 0, null, 0, "bronchiectasis with or without elevated sweat chloride 1", 0.775668400727201], ["O43497", "CACNA1G", "Voltage-dependent T-type calcium channel subunit alpha-1G", "Tier 1.5", 0.783, 1, "A_surface", 2, 58.22, 1, 0, null, null, 0, 0, null, 0, "Spinocerebellar ataxia type 42", 0.7770459773037601], ["P43004", "SLC1A2", "Excitatory amino acid transporter 2", "Tier 1.5", 0.783, 1, "A_surface", 7, 77.75, 1, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 41", 0.7772658651722512], ["Q8TDI8", "TMC1", "Transmembrane channel-like protein 1", "Tier 1.5", 0.781, 1, "A_surface", 1, 76.88, 0, 0, null, null, 0, 0, null, 0, "autosomal recessive nonsyndromic hearing loss 7", 0.7694318181814068], ["P48547", "KCNC1", "Voltage-gated potassium channel KCNC1", "Tier 1.5", 0.78, 1, "A_surface", 10, 78.56, 1, 0, null, null, 0, 0, null, 0, "Progressive myoclonic epilepsy", 0.7675090944252294], ["Q13255", "GRM1", "Metabotropic glutamate receptor 1", "Tier 1.5", 0.779, 1, "A_surface", 4, 70.94, 1, 0, null, null, 0, 0, null, 0, "autosomal recessive spinocerebellar ataxia 13", 0.7631507286490296], ["P51654", "GPC3", "Glypican-3", "Tier 1.5", 0.779, 1, "A_surface", 4, 75.06, 1, 0, null, null, 1, 65, "42083729,41790019,41653459,41045695,40825648,40722645,39998646,39874791,39608318,39427046,38910291,38787447,38621313,38368644,37665421,36903516,36457288,36317566,36072763,35788872,35699181,35477501,35051745,34974867,34306031,33254049,33080969,32356075,30347351,30122918,29675356,29605994,29277631,27601357,28263753", 0, "Simpson-Golabi-Behmel syndrome type 1", 0.762708583613362], ["Q9NUN7", "ACER3", "Alkaline ceramidase 3", "Tier 1.5", 0.777, 1, "A_surface", 2, 93.19, 0, 0, null, null, 0, 0, null, 0, "alkaline ceramidase 3 deficiency", 0.7575827142824458], ["P20023", "CR2", "Complement receptor type 2", "Tier 1.5", 0.776, 1, "A_surface", 9, 74.94, 1, 0, null, null, 1, 1, "33235290", 0, "immunodeficiency, common variable, 7", 0.7543125403898414], ["P40126", "DCT", "L-dopachrome tautomerase", "Tier 1.5", 0.774, 1, "A_surface", 1, 89.12, 0, 0, null, null, 1, 1, "27245069", 0, "oculocutaneous albinism type 8", 0.7468868816172217], ["Q86YC3", "NRROS", "Transforming growth factor beta activator LRRC33", "Tier 1.5", 0.773, 1, "A_surface", 1, 83.31, 1, 0, null, null, 0, 0, null, 0, "seizures, early-onset, with neurodegeneration and brain calcifications", 0.744630610851649], ["Q9Y6J6", "KCNE2", "Potassium voltage-gated channel subfamily E member 2", "Tier 1.5", 0.772, 1, "A_surface", 1, 78.25, 0, 0, null, null, 0, 0, null, 0, "Romano-Ward syndrome", 0.739531738338193], ["O75899", "GABBR2", "Gamma-aminobutyric acid type B receptor subunit 2", "Tier 1.5", 0.771, 1, "A_surface", 26, 77.75, 1, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 59", 0.7356789732167734], ["O43914", "TYROBP", "TYRO protein tyrosine kinase-binding protein", "Tier 1.5", 0.77, 1, "A_surface", 5, 64.62, 0, 0, null, null, 0, 0, null, 0, "Nasu-Hakola disease", 0.7323368313860329], ["Q16572", "SLC18A3", "Vesicular acetylcholine transporter", "Tier 1.5", 0.77, 1, "A_surface", 7, 76.19, 1, 0, null, null, 0, 0, null, 0, "Congenital myasthenic syndromes", 0.7324174860789537], ["P08887", "IL6R", "Interleukin-6 receptor subunit alpha", "Tier 1.5", 0.768, 1, "A_surface", 10, 77.88, 1, 0, null, null, 1, 18, "40853309,38152968,37034659,36579647,35890412,33590853,33340765,32515246,29211023,28929152,26552813,26383776,24481022,24440854,23235494,22503683,22258147,22094809", 0, "rheumatoid arthritis", 0.7269057706798291], ["P30542", "ADORA1", "Adenosine receptor A1", "Tier 1.5", 0.767, 1, "A_surface", 5, 92.44, 1, 0, null, null, 0, 0, null, 0, "asthma", 0.7232344154541454], ["Q00975", "CACNA1B", "Voltage-dependent N-type calcium channel subunit alpha-1B", "Tier 1.5", 0.767, 1, "A_surface", 7, 59.91, 1, 0, null, null, 1, 2, "31118475,25782368", 0, "Seizure", 0.7217241968702018], ["Q9Y5Y9", "SCN10A", "Sodium channel protein type 10 subunit alpha", "Tier 1.5", 0.764, 1, "A_surface", 8, 67.31, 1, 0, null, null, 0, 0, null, 0, "atrial fibrillation", 0.7126293968222049], ["Q13705", "ACVR2B", "Activin receptor type-2B", "Tier 1.5", 0.763, 1, "A_surface", 9, 83.31, 1, 0, null, null, 0, 0, null, 0, "Heterotaxia", 0.7109733260300651], ["Q2M385", "MPEG1", "Macrophage-expressed gene 1 protein", "Tier 1.5", 0.761, 1, "A_surface", 5, 82.75, 1, 0, null, null, 0, 0, null, 0, "immunodeficiency 77", 0.7043238859467001], ["Q9NPI9", "KCNJ16", "Inward rectifier potassium channel 16", "Tier 1.5", 0.761, 1, "A_surface", 4, 78.12, 1, 0, null, null, 0, 0, null, 0, "hypokalemic tubulopathy and deafness", 0.7018965238443493], ["Q9H2X9", "SLC12A5", "Solute carrier family 12 member 5", "Tier 1.5", 0.76, 1, "A_surface", 2, 78.44, 1, 0, null, null, 0, 0, null, 0, "genetic developmental and epileptic encephalopathy", 0.6993945840545625], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.76, 1, "A_surface", 3, 80.19, 0, 0, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["Q8IWU4", "SLC30A8", "Proton-coupled zinc antiporter SLC30A8", "Tier 1.5", 0.759, 1, "A_surface", 3, 82.12, 1, 0, null, null, 0, 0, null, 0, "type 2 diabetes mellitus", 0.6974093822415375]], "truncated": false, "filtered_table_rows_count": 417, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": 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"has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 355, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 62, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": "A_surface", "label": "A_surface", "count": 417, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 417, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 305, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 112, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 377.4029277265072, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}