{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where in_cev_map = 0, surface_class = \"B_cargo\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P00439", "PAH", "Phenylalanine-4-hydroxylase", "Tier 1", 0.618, 1, "B_cargo", 20, 88.69, 0, 0, null, null, 1, 11, "39435559,35394406,35081018,34973551,33386219,32587339,31349094,26043089,24749544,23583275,16914451", 0, "phenylketonuria", 0.892702971437507], ["P40337", "VHL", "von Hippel-Lindau disease tumor suppressor", "Tier 1", 0.616, 1, "B_cargo", 100, 84.44, 0, 0, null, null, 1, 5, "39437434,36250201,34549489,23142634,17290195", 0, "von Hippel-Lindau disease", 0.8883247767048489], ["Q13315", "ATM", "Serine-protein kinase ATM", "Tier 1", 0.613, 1, "B_cargo", 14, null, 1, 0, null, null, 1, 9, "41867498,39253616,37656667,34733968,28838608,28706912,26176230,17386435,15181173", 0, "ataxia telangiectasia", 0.8759719859489208], ["O00255", "MEN1", "Menin", "Tier 1", 0.61, 1, "B_cargo", 61, 84.44, 0, 0, null, null, 0, 0, null, 0, "multiple endocrine neoplasia type 1", 0.8653255032429027], ["P35670", "ATP7B", "Copper-transporting ATPase 2", "Tier 1", 0.61, 1, "B_cargo", 13, 71.69, 1, 0, null, null, 1, 1, "39737993", 0, "Wilson disease", 0.8657500553466239], ["P35557", "GCK", "Hexokinase-4", "Tier 1", 0.609, 1, "B_cargo", 35, 93.69, 0, 0, null, null, 0, 0, null, 0, "MODY", 0.8633086470947097], ["O43602", "DCX", "Neuronal migration protein doublecortin", "Tier 1", 0.609, 1, "B_cargo", 18, 66.5, 1, 0, null, null, 0, 0, null, 0, "lissencephaly type 1 due to doublecortin gene mutation", 0.864453842605602], ["P21549", "AGXT", "Alanine--glyoxylate aminotransferase", "Tier 1", 0.607, 1, "B_cargo", 17, 98.31, 0, 0, null, null, 0, 0, null, 0, "primary hyperoxaluria type 1", 0.8572717660798254], ["O14746", "TERT", "Telomerase reverse transcriptase", "Tier 1", 0.607, 1, "B_cargo", 23, 80.19, 1, 0, null, null, 1, 13, "41104418,40347637,40062394,39513874,39441744,37427434,36005058,35658460,33476148,28004350,24176970,22013508", 0, "dyskeratosis congenita, autosomal dominant 2", 0.8577919827748599], ["P04629", "NTRK1", "High affinity nerve growth factor receptor", "Tier 1", 0.607, 1, "B_cargo", 65, 78.25, 0, 0, null, null, 1, 1, "38604287", 0, "hereditary sensory and autonomic neuropathy type 4", 0.8579248191890114], ["Q9BZS1", "FOXP3", "Forkhead box protein P3", "Tier 1", 0.606, 1, "B_cargo", 2, 56.72, 0, 0, null, null, 1, 8, "40448637,34457999,32892748,26999456,24460675,22323540,18698484,18319343", 0, "immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome", 0.8516802661294931], ["P19544", "WT1", "Wilms tumor protein", "Tier 1", 0.606, 1, "B_cargo", 28, 50.78, 0, 0, null, null, 1, 3, "27417971,19123921,11329270", 0, "Denys-Drash syndrome", 0.8525486743466777], ["P37231", "PPARG", "Peroxisome proliferator-activated receptor gamma", "Tier 1", 0.605, 1, "B_cargo", 100, 76.12, 0, 0, null, null, 1, 3, "37203464,33671292,28206680", 0, "type 2 diabetes mellitus", 0.8486094742593474], ["Q9Y6K1", "DNMT3A", "DNA (cytosine-5)-methyltransferase 3A", "Tier 1", 0.605, 1, "B_cargo", 43, 72.94, 1, 0, null, null, 1, 3, "39079576,31733056,23179556", 0, "acute myeloid leukemia", 0.8505245588442946], ["Q3T906", "GNPTAB", "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta", "Tier 1", 0.605, 1, "B_cargo", 5, 71.62, 1, 0, null, null, 0, 0, null, 0, "mucolipidosis type III, alpha/beta", 0.8490445308315259], ["P23760", "PAX3", "Paired box protein Pax-3", "Tier 1", 0.605, 1, "B_cargo", 1, 63.94, 0, 0, null, null, 0, 0, null, 0, "Waardenburg syndrome type 1", 0.8500072027894306], ["P54132", "BLM", "RecQ-like DNA helicase BLM", "Tier 1", 0.605, 1, "B_cargo", 15, 60.53, 0, 0, null, null, 1, 9, "40700985,38959435,34973563,33571410,33050386,31563064,30343567,27332117,19146404", 0, "Bloom syndrome", 0.8491084997646711], ["Q96RY7", "IFT140", "Intraflagellar transport protein 140 homolog", "Tier 1", 0.604, 1, "B_cargo", 4, 80.12, 1, 0, null, null, 0, 0, null, 0, "short-rib thoracic dysplasia 9 with or without polydactyly", 0.8464676938353167], ["P54098", "POLG", "DNA polymerase subunit gamma-1", "Tier 1", 0.604, 1, "B_cargo", 36, 78.94, 1, 0, null, null, 0, 0, null, 0, "mitochondrial DNA depletion syndrome 4a", 0.8474167021250057], ["P40692", "MLH1", "DNA mismatch repair protein Mlh1", "Tier 1", 0.604, 1, "B_cargo", 7, 77.31, 0, 0, null, null, 0, 0, null, 0, "Lynch syndrome", 0.8472183133029993], ["O15360", "FANCA", "Fanconi anemia group A protein", "Tier 1", 0.604, 1, "B_cargo", 6, 74.88, 1, 0, null, null, 0, 0, null, 0, "Fanconi anemia complementation group A", 0.8469248580955555], ["Q92574", "TSC1", "Hamartin", "Tier 1", 0.604, 1, "B_cargo", 5, 62.06, 1, 0, null, null, 1, 1, "18974095", 0, "tuberous sclerosis", 0.8476796313298992], ["Q2NKJ3", "CTC1", "CST complex subunit CTC1", "Tier 1", 0.603, 1, "B_cargo", 7, 77.5, 1, 0, null, null, 0, 0, null, 0, "Coats plus syndrome", 0.8438631461095314], ["Q92793", "CREBBP", "CREB-binding protein", "Tier 1", 0.603, 1, "B_cargo", 100, 52.53, 0, 0, null, null, 1, 1, "39429683", 0, "Rubinstein-Taybi syndrome due to CREBBP mutations", 0.8442311239876018], ["Q12879", "GRIN2A", "Glutamate receptor ionotropic, NMDA 2A", "Tier 1", 0.602, 1, "B_cargo", 37, 60.84, 1, 0, null, null, 0, 0, null, 0, "Landau-Kleffner syndrome", 0.8407159711916629], ["P38398", "BRCA1", "Breast cancer type 1 susceptibility protein", "Tier 1", 0.602, 1, "B_cargo", 33, 41.59, 1, 0, null, null, 1, 13, "40251554,37288783,36858016,32945515,32245065,29737162,28841982,26784987,24734899,23836560,21800393,16825284", 0, "breast cancer", 0.839035109761358], ["P20807", "CAPN3", "Calpain-3", "Tier 1", 0.601, 1, "B_cargo", 5, 78.25, 0, 0, null, null, 0, 0, null, 0, "autosomal recessive limb-girdle muscular dystrophy type 2A", 0.8360959201056175], ["O60260", "PRKN", "E3 ubiquitin-protein ligase parkin", "Tier 1", 0.601, 1, "B_cargo", 21, 78.06, 0, 0, null, null, 0, 0, null, 0, "Young adult-onset Parkinsonism", 0.8361755700457273], ["Q02127", "DHODH", "Dihydroorotate dehydrogenase (quinone), mitochondrial", "Tier 1", 0.6, 1, "B_cargo", 100, 96.12, 0, 0, null, null, 1, 1, "29626096", 0, "postaxial acrofacial dysostosis", 0.8330628404263816], ["Q7Z2E3", "APTX", "Aprataxin", "Tier 1", 0.6, 1, "B_cargo", 11, 80.75, 0, 0, null, null, 0, 0, null, 0, "ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia", 0.832110422501825], ["Q5S007", "LRRK2", "Leucine-rich repeat serine/threonine-protein kinase 2", "Tier 1", 0.6, 1, "B_cargo", 44, 77.5, 1, 0, null, null, 1, 4, "38467937,37586882,37422510,36774388", 0, "Hereditary late-onset Parkinson disease", 0.8349742982582067], ["Q13402", "MYO7A", "Unconventional myosin-VIIa", "Tier 1", 0.6, 1, "B_cargo", 1, 77.25, 0, 0, null, null, 0, 0, null, 0, "Usher syndrome type 1B", 0.8326791560829035], ["Q15910", "EZH2", "Histone-lysine N-methyltransferase EZH2", "Tier 1", 0.6, 1, "B_cargo", 38, 76.25, 1, 0, null, null, 1, 8, "41574287,41223251,40931580,39853766,36626902,32884286,30795863,27719642", 0, "Weaver syndrome", 0.8324078192564933], ["P49715", "CEBPA", "CCAAT/enhancer-binding protein alpha", "Tier 1", 0.6, 1, "B_cargo", 2, 61.69, 0, 0, null, null, 1, 7, "38965606,30909853,31546149,30795863,28639199,26983359", 0, "acute myeloid leukemia", 0.8336701187896877], ["Q9BY41", "HDAC8", "Histone deacetylase 8", "Tier 1", 0.599, 1, "B_cargo", 53, 95.31, 0, 0, null, null, 0, 0, null, 0, "Cornelia de Lange syndrome", 0.8312421317616957], ["O14832", "PHYH", "Phytanoyl-CoA dioxygenase, peroxisomal", "Tier 1", 0.598, 1, "B_cargo", 1, 85.44, 0, 0, null, null, 0, 0, null, 0, "Refsum disease", 0.8265474775217052], ["P22557", "ALAS2", "5-aminolevulinate synthase, erythroid-specific, mitochondrial", "Tier 1", 0.598, 1, "B_cargo", 27, 82.19, 0, 0, null, null, 0, 0, null, 0, "X-linked sideroblastic anemia 1", 0.8266521651625864], ["P41235", "HNF4A", "Hepatocyte nuclear factor 4-alpha", "Tier 1", 0.598, 1, "B_cargo", 8, 73.88, 0, 0, null, null, 1, 1, "37016361", 0, "MODY", 0.8258786338560885], ["Q96SD1", "DCLRE1C", "Protein artemis", "Tier 1", 0.598, 1, "B_cargo", 14, 69.44, 1, 0, null, null, 0, 0, null, 0, "severe combined immunodeficiency due to DCLRE1C deficiency", 0.826513936982479], ["Q14191", "WRN", "Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN", "Tier 1", 0.598, 1, "B_cargo", 42, 68.62, 0, 0, null, null, 1, 1, "27332117", 0, "Werner syndrome", 0.8278730962406992], ["O94761", "RECQL4", "ATP-dependent DNA helicase Q4", "Tier 1", 0.598, 1, "B_cargo", 2, 67.38, 0, 0, null, null, 1, 1, "31495919", 0, "Rothmund-Thomson syndrome type 2", 0.8261878622968941], ["Q9H3D4", "TP63", "Tumor protein 63", "Tier 1", 0.598, 1, "B_cargo", 26, 63.19, 0, 0, null, null, 1, 1, "17563751", 0, "ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3", 0.8281511708882607], ["P48431", "SOX2", "Transcription factor SOX-2", "Tier 1", 0.598, 1, "B_cargo", 13, 59.84, 1, 0, null, null, 1, 13, "41377018,40082426,37891174,37370863,36284815,34405338,31991109,31301870,28988933,26176230,23892456,18490265,15863505", 0, "anophthalmia/microphthalmia-esophageal atresia syndrome", 0.8263477268235936], ["Q9UMN6", "KMT2B", "Histone-lysine N-methyltransferase 2B", "Tier 1", 0.598, 1, "B_cargo", 4, null, 0, 0, null, null, 0, 0, null, 0, "dystonia 28, childhood-onset", 0.8253090908207902], ["P11473", "VDR", "Vitamin D3 receptor", "Tier 1", 0.597, 1, "B_cargo", 52, 83.56, 0, 0, null, null, 0, 0, null, 0, "Hypocalcemic vitamin D-resistant rickets", 0.8226576498848421], ["Q9Y253", "POLH", "DNA polymerase eta", "Tier 1", 0.597, 1, "B_cargo", 100, 76.88, 1, 0, null, null, 0, 0, null, 0, "xeroderma pigmentosum variant type", 0.8236705244099821], ["Q8IWS0", "PHF6", "PHD finger protein 6", "Tier 1", 0.597, 1, "B_cargo", 2, 73.44, 0, 0, null, null, 0, 0, null, 0, "Borjeson-Forssman-Lehmann syndrome", 0.8219833984621376], ["P40879", "SLC26A3", "Chloride anion exchanger", "Tier 1", 0.596, 1, "B_cargo", 13, 85.06, 1, 0, null, null, 0, 0, null, 0, "congenital secretory chloride diarrhea 1", 0.8189631913308207], ["Q8NB91", "FANCB", "Fanconi anemia group B protein", "Tier 1", 0.596, 1, "B_cargo", 6, 71.0, 1, 0, null, null, 1, 1, "23836560", 0, "Fanconi anemia", 0.8195998375932156], ["Q7Z4S6", "KIF21A", "Kinesin-like protein KIF21A", "Tier 1", 0.595, 1, "B_cargo", 5, 70.56, 0, 0, null, null, 0, 0, null, 0, "congenital fibrosis of the extraocular muscles", 0.8179974657616618]], "truncated": false, "filtered_table_rows_count": 832, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"in_cev_map\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "B_cargo", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 739, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 93, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 832, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 832, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 642, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 190, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 832, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 832, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=B_cargo&tier=Tier+1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 573, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 259, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1606.8090898916125, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}