{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where in_cev_map = 0, surface_class = \"B_cargo\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P22304", "IDS", "Iduronate 2-sulfatase", "Tier 1.5", 0.613, 1, "B_cargo", 2, 93.06, 0, 0, null, null, 1, 9, "41791433,41521476,41396069,40394224,37948569,31273548,30529550,28420169,20842131", 0, "mucopolysaccharidosis type 2", 0.8781523206667287], ["Q8NCM8", "DYNC2H1", "Cytoplasmic dynein 2 heavy chain 1", "Tier 1.5", 0.608, 1, "B_cargo", 4, 83.44, 1, 0, null, null, 0, 0, null, 0, "asphyxiating thoracic dystrophy 3", 0.8610362911667925], ["O76039", "CDKL5", "Cyclin-dependent kinase-like 5", "Tier 1.5", 0.605, 1, "B_cargo", 3, 53.12, 0, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 2", 0.8510325653635987], ["Q9UIF7", "MUTYH", "Adenine DNA glycosylase", "Tier 1.5", 0.605, 1, "B_cargo", 3, 78.94, 0, 0, null, null, 0, 0, null, 0, "familial adenomatous polyposis 2", 0.8483469680730393], ["Q2M1P5", "KIF7", "Kinesin-like protein KIF7", "Tier 1.5", 0.603, 1, "B_cargo", 5, 67.19, 1, 0, null, null, 0, 0, null, 0, "acrocallosal syndrome", 0.8424257475739304], ["O60931", "CTNS", "Cystinosin", "Tier 1.5", 0.603, 1, "B_cargo", 6, 89.44, 1, 0, null, null, 0, 0, null, 0, "nephropathic cystinosis", 0.841818398377195], ["P58012", "FOXL2", "Forkhead box protein L2", "Tier 1.5", 0.603, 1, "B_cargo", 2, 60.12, 0, 0, null, null, 1, 1, "37933840", 0, "blepharophimosis, ptosis, and epicanthus inversus syndrome", 0.841709236718747], ["P20823", "HNF1A", "Hepatocyte nuclear factor 1-alpha", "Tier 1.5", 0.602, 1, "B_cargo", 6, 56.97, 0, 0, null, null, 1, 4, "15781225,15629461", 0, "MODY", 0.8405262466243777], ["P38935", "IGHMBP2", "DNA-binding protein SMUBP-2", "Tier 1.5", 0.602, 1, "B_cargo", 4, 77.38, 0, 0, null, null, 0, 0, null, 0, "autosomal recessive distal spinal muscular atrophy 1", 0.8396147647161344], ["Q9HBG6", "IFT122", "Intraflagellar transport protein 122 homolog", "Tier 1.5", 0.602, 1, "B_cargo", 5, 82.88, 1, 0, null, null, 0, 0, null, 0, "cranioectodermal dysplasia", 0.8402296001002503], ["O43435", "TBX1", "T-box transcription factor TBX1", "Tier 1.5", 0.602, 1, "B_cargo", 1, 68.19, 0, 0, null, null, 1, 1, "24797903", 0, "22q11.2 deletion syndrome", 0.8406035626999856], ["P82279", "CRB1", "Protein crumbs homolog 1", "Tier 1.5", 0.602, 1, "B_cargo", 1, 75.06, 0, 0, null, null, 0, 0, null, 0, "Leber congenital amaurosis 8", 0.8398871782775204], ["Q8N159", "NAGS", "N-acetylglutamate synthase, mitochondrial", "Tier 1.5", 0.601, 1, "B_cargo", 1, 79.75, 0, 0, null, null, 0, 0, null, 0, "hyperammonemia due to N-acetylglutamate synthase deficiency", 0.8382373711482316], ["Q2TBA0", "KLHL40", "Kelch-like protein 40", "Tier 1.5", 0.6, 1, "B_cargo", 1, 89.44, 0, 0, null, null, 0, 0, null, 0, "nemaline myopathy 8", 0.8348979900805442], ["Q9BXW9", "FANCD2", "Fanconi anemia group D2 protein", "Tier 1.5", 0.6, 1, "B_cargo", 13, 76.75, 1, 0, null, null, 0, 0, null, 0, "Fanconi anemia complementation group D2", 0.8319139646572291], ["Q05066", "SRY", "Sex-determining region Y protein", "Tier 1.5", 0.599, 1, "B_cargo", 10, 67.62, 1, 0, null, null, 1, 1, "40082426", 0, "46,XY sex reversal 1", 0.8290523705747719], ["P31271", "HOXA13", "Homeobox protein Hox-A13", "Tier 1.5", 0.598, 1, "B_cargo", 1, 54.28, 0, 0, null, null, 0, 0, null, 0, "hand-foot-genital syndrome", 0.8270145658663097], ["Q13485", "SMAD4", "SMAD family member 4", "Tier 1.5", 0.598, 1, "B_cargo", 12, 73.38, 0, 0, null, null, 1, 10, "39602246,35356877,33124760,32456365,31876518,29632714,27843907,21266541,17132729,16775010", 0, "juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome", 0.8277625447220475], ["Q99593", "TBX5", "T-box transcription factor TBX5", "Tier 1.5", 0.598, 1, "B_cargo", 4, 62.66, 0, 0, null, null, 0, 0, null, 0, "Holt-Oram syndrome", 0.827317913681364], ["P13686", "ACP5", "Tartrate-resistant acid phosphatase type 5", "Tier 1.5", 0.597, 1, "B_cargo", 2, 94.62, 0, 0, null, null, 1, 2, "30537181", 0, "Spondyloenchondrodysplasia with immune dysregulation", 0.8234579245679164], ["Q96GM8", "TOE1", "Target of EGR1 protein 1", "Tier 1.5", 0.597, 1, "B_cargo", 1, 77.75, 0, 0, null, null, 0, 0, null, 0, "pontocerebellar hypoplasia type 7", 0.824632140055663], ["Q9BYX4", "IFIH1", "Interferon-induced helicase C domain-containing protein 1", "Tier 1.5", 0.597, 1, "B_cargo", 9, 79.44, 1, 0, null, null, 1, 1, "18983163", 0, "Aicardi-Goutieres syndrome 7", 0.8235229759148853], ["Q9UH77", "KLHL3", "Kelch-like protein 3", "Tier 1.5", 0.597, 1, "B_cargo", 3, 90.5, 0, 0, null, null, 0, 0, null, 0, "pseudohypoaldosteronism type 2D", 0.8246213773832068], ["P28069", "POU1F1", "Pituitary-specific positive transcription factor 1", "Tier 1.5", 0.596, 1, "B_cargo", 1, 67.75, 0, 0, null, null, 0, 0, null, 0, "pituitary hormone deficiency, combined, 1", 0.8206947239178665], ["Q99453", "PHOX2B", "Paired mesoderm homeobox protein 2B", "Tier 1.5", 0.596, 1, "B_cargo", 5, 59.78, 0, 0, null, null, 0, 0, null, 0, "central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease", 0.8208322275185037], ["Q9H334", "FOXP1", "Forkhead box protein P1", "Tier 1.5", 0.596, 1, "B_cargo", 1, 57.94, 0, 0, null, null, 0, 0, null, 0, "intellectual disability-severe speech delay-mild dysmorphism syndrome", 0.8203183311387787], ["O15259", "NPHP1", "Nephrocystin-1", "Tier 1.5", 0.594, 1, "B_cargo", 2, 75.88, 0, 0, null, null, 0, 0, null, 0, "nephronophthisis 1", 0.8140254888983035], ["Q53S33", "BOLA3", "BolA-like protein 3", "Tier 1.5", 0.594, 1, "B_cargo", 1, 80.94, 0, 0, null, null, 0, 0, null, 0, "multiple mitochondrial dysfunctions syndrome 2", 0.8146596253409263], ["P41229", "KDM5C", "Lysine-specific demethylase 5C", "Tier 1.5", 0.594, 1, "B_cargo", 2, 71.94, 0, 0, null, null, 0, 0, null, 0, "syndromic X-linked intellectual disability Claes-Jensen type", 0.8149829731199962], ["P04198", "MYCN", "N-myc proto-oncogene protein", "Tier 1.5", 0.593, 1, "B_cargo", 2, 60.16, 0, 0, null, null, 1, 3, "38074684,34703655,23243020", 0, "Feingold syndrome type 1", 0.8115451687313872], ["Q8IXJ9", "ASXL1", "Polycomb group protein ASXL1", "Tier 1.5", 0.592, 1, "B_cargo", 4, 42.22, 1, 0, null, null, 0, 0, null, 0, "Bohring-Opitz syndrome", 0.8082443730060624], ["Q9BSI4", "TINF2", "TERF1-interacting nuclear factor 2", "Tier 1.5", 0.592, 1, "B_cargo", 3, 60.56, 0, 0, null, null, 0, 0, null, 0, "dyskeratosis congenita, autosomal dominant 3", 0.8076730158243078], ["Q9NW38", "FANCL", "E3 ubiquitin-protein ligase FANCL", "Tier 1.5", 0.592, 1, "B_cargo", 8, 91.31, 1, 0, null, null, 0, 0, null, 0, "Fanconi anemia complementation group L", 0.8062585405338945], ["P51530", "DNA2", "DNA replication ATP-dependent helicase/nuclease DNA2", "Tier 1.5", 0.591, 1, "B_cargo", 1, 87.81, 0, 0, null, null, 1, 79, "41919953,40756646,40549055,40280078,40067128,39933341,39701233,39400726,39339485,39263860,39196429,38844882,38240894,38219326,38057050,38015452,37991343,37955623,37604608,37499488,37470836,36958207,36809725,36242904,36178489,36150338,35491044,35384954,35176850,35093773,33676715,33496853,33415103,33217231,32800122,32601890,32475386,32200901,31706177,31561796,31278549,31276907,31159934,30952252,30904620,30862445,30609356,30209628,30172325,29884355", 0, "mitochondrial DNA deletion syndrome with progressive myopathy", 0.8039462281320306], ["Q9NRG9", "AAAS", "Aladin", "Tier 1.5", 0.59, 1, "B_cargo", 2, 75.25, 1, 0, null, null, 1, 2, "39798364,30768874", 0, "triple-A syndrome", 0.8009946434571534], ["P17735", "TAT", "Tyrosine aminotransferase", "Tier 1.5", 0.59, 1, "B_cargo", 1, 91.75, 0, 0, null, null, 1, 116, "42052694,41392711,41107360,41026857,40789888,40681131,40125796,40063097,39876991,39558155,39335496,39318271,39167715,38924638,38501479,38054213,37240414,36879476,36832059,36642821,36576612,36475447,36277654,36209487,36198145,35654302,35364795,33981364,33909408,33155468,33149582,32976590,32250590,32147886,32100315,32061015,32051269,31975549,31881749,31880928,31707021,35345244,31243610,30976173,30540162,30529550,30350592,30285239,30198708,29464116", 0, "tyrosinemia type II", 0.7986496109306669], ["P46020", "PHKA1", "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform", "Tier 1.5", 0.589, 1, "B_cargo", 10, 81.69, 1, 0, null, null, 0, 0, null, 0, "glycogen storage disease IXd", 0.7957863874816654], ["Q8WX94", "NLRP7", "NACHT, LRR and PYD domains-containing protein 7", "Tier 1.5", 0.589, 1, "B_cargo", 3, 82.25, 1, 0, null, null, 0, 0, null, 0, "hydatidiform mole, recurrent, 1", 0.7978415742308576], ["Q9ULV5", "HSF4", "Heat shock factor protein 4", "Tier 1.5", 0.589, 1, "B_cargo", 2, 59.59, 0, 0, null, null, 0, 0, null, 0, "cataract 5 multiple types", 0.7953462784936949], ["O60281", "ZNF292", "Zinc finger protein 292", "Tier 1.5", 0.588, 1, "B_cargo", 2, 46.91, 0, 0, null, null, 0, 0, null, 0, "intellectual developmental disorder, autosomal dominant 64", 0.7931698496364843], ["Q9UBR1", "UPB1", "Beta-ureidopropionase", "Tier 1.5", 0.588, 1, "B_cargo", 2, 97.0, 1, 0, null, null, 0, 0, null, 0, "beta-ureidopropionase deficiency", 0.7918900848494692], ["O14770", "MEIS2", "Homeobox protein Meis2", "Tier 1.5", 0.588, 1, "B_cargo", 4, 61.97, 0, 0, null, null, 1, 2, "41495882", 0, "cardiac malformation, cleft lip/palate, microcephaly, and digital anomalies", 0.7938323593532864], ["Q00973", "B4GALNT1", "Beta-1,4 N-acetylgalactosaminyltransferase 1", "Tier 1.5", 0.588, 1, "B_cargo", 3, 88.69, 0, 0, null, null, 0, 0, null, 0, "hereditary spastic paraplegia 26", 0.7949291425747776], ["P19532", "TFE3", "Transcription factor E3", "Tier 1.5", 0.587, 1, "B_cargo", 1, 58.66, 0, 0, null, null, 0, 0, null, 0, "intellectual developmental disorder, X-linked, syndromic, with pigmentary mosaicism and coarse facies", 0.7894865093321197], ["Q9Y2M0", "FAN1", "Fanconi-associated nuclease 1", "Tier 1.5", 0.587, 1, "B_cargo", 18, 69.88, 1, 0, null, null, 0, 0, null, 0, "karyomegalic interstitial nephritis", 0.7887103269780822], ["P81274", "GPSM2", "G-protein-signaling modulator 2", "Tier 1.5", 0.587, 1, "B_cargo", 7, 66.94, 0, 0, null, null, 0, 0, null, 0, "Chudley-McCullough syndrome", 0.7892319521351122], ["A6NGG8", "PCARE", "Photoreceptor cilium actin regulator", "Tier 1.5", 0.586, 1, "B_cargo", 1, 43.78, 0, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7851829492847434], ["O15119", "TBX3", "T-box transcription factor TBX3", "Tier 1.5", 0.586, 1, "B_cargo", 1, 54.91, 0, 0, null, null, 1, 1, "34873487", 0, "ulnar-mammary syndrome", 0.7856453214934344], ["Q6PJG6", "BRAT1", "Integrator complex assembly factor BRAT1", "Tier 1.5", 0.586, 1, "B_cargo", 5, 84.81, 1, 0, null, null, 0, 0, null, 0, "Lethal neonatal spasticity-epileptic encephalopathy syndrome", 0.7870801460315344], ["O15409", "FOXP2", "Forkhead box protein P2", "Tier 1.5", 0.585, 1, "B_cargo", 2, 59.22, 0, 0, null, null, 0, 0, null, 0, "childhood apraxia of speech", 0.7839103460347123]], "truncated": false, "filtered_table_rows_count": 1200, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"in_cev_map\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "B_cargo", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 747, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 453, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 1200, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1200, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1080, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 120, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 1200, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1200, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=B_cargo&tier=Tier+1.5", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1076, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 124, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 685.0844244472682, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}