{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where in_cev_map = 1, surface_class = \"A2_pm_peripheral\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P35555", "FBN1", "Fibrillin-1", "Tier 1", 0.809, 1, "A2_pm_peripheral", 11, null, 0, 0, null, null, 0, 0, null, 1, "Marfan syndrome", 0.8969300970597663], ["P15056", "BRAF", "Serine/threonine-protein kinase B-raf", "Tier 1", 0.803, 1, "A2_pm_peripheral", 100, 66.38, 0, 0, null, null, 1, 6, "39624124,34874026,33497198,31726389,24486214,11856330", 1, "cardiofaciocutaneous syndrome", 0.8764542776642054], ["P04049", "RAF1", "RAF proto-oncogene serine/threonine-protein kinase", "Tier 1", 0.799, 1, "A2_pm_peripheral", 75, 67.5, 0, 0, null, null, 1, 4, "15112994,12173045,11856330,9883908", 1, "Noonan syndrome", 0.8625147809861142], ["P51531", "SMARCA2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2", "Tier 1", 0.797, 1, "A2_pm_peripheral", 31, 65.06, 0, 0, null, null, 0, 0, null, 1, "intellectual disability-sparse hair-brachydactyly syndrome", 0.85547142397368], ["P62873", "GNB1", "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "Tier 1", 0.794, 1, "A2_pm_peripheral", 100, 97.06, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 42", 0.8462216225099116], ["P52333", "JAK3", "Tyrosine-protein kinase JAK3", "Tier 1", 0.794, 1, "A2_pm_peripheral", 42, 85.69, 0, 0, null, null, 0, 0, null, 1, "T-B+ severe combined immunodeficiency due to JAK3 deficiency", 0.8450717197794638], ["Q06187", "BTK", "Tyrosine-protein kinase BTK", "Tier 1", 0.794, 1, "A2_pm_peripheral", 100, 84.44, 0, 0, null, null, 1, 1, "41951939", 1, "X-linked agammaglobulinemia", 0.8454716106068291], ["Q02750", "MAP2K1", "Dual specificity mitogen-activated protein kinase kinase 1", "Tier 1", 0.788, 1, "A2_pm_peripheral", 94, 83.25, 0, 0, null, null, 1, 1, "29580944", 1, "cardiofaciocutaneous syndrome", 0.825549979325162], ["O75369", "FLNB", "Filamin-B", "Tier 1", 0.788, 1, "A2_pm_peripheral", 23, 76.25, 0, 0, null, null, 0, 0, null, 1, "Larsen syndrome", 0.826975893141549], ["P06737", "PYGL", "Glycogen phosphorylase, liver form", "Tier 1", 0.787, 1, "A2_pm_peripheral", 19, 92.69, 1, 0, null, null, 0, 0, null, 1, "glycogen storage disease VI", 0.8220063508118274], ["P49770", "EIF2B2", "Translation initiation factor eIF2B subunit beta", "Tier 1", 0.787, 1, "A2_pm_peripheral", 25, 86.56, 1, 0, null, null, 0, 0, null, 1, "CACH syndrome", 0.824634396744653], ["P21333", "FLNA", "Filamin-A", "Tier 1", 0.786, 1, "A2_pm_peripheral", 26, 76.56, 1, 0, null, null, 0, 0, null, 1, "Melnick-Needles syndrome", 0.8200516896124751], ["O43175", "PHGDH", "D-3-phosphoglycerate dehydrogenase", "Tier 1", 0.784, 1, "A2_pm_peripheral", 21, 92.94, 0, 0, null, null, 0, 0, null, 1, "PHGDH deficiency", 0.8128323162948055], ["P01111", "NRAS", "GTPase NRas", "Tier 1", 0.783, 1, "A2_pm_peripheral", 35, 92.06, 0, 0, null, null, 1, 2, "39952900,39371477", 1, "Noonan syndrome 6", 0.8087775198380727], ["Q9Y3Z3", "SAMHD1", "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1", "Tier 1", 0.783, 1, "A2_pm_peripheral", 76, 88.19, 0, 0, null, null, 0, 0, null, 1, "Aicardi-Gouti\u00e8res syndrome", 0.8101030032946703], ["Q8TD16", "BICD2", "Protein bicaudal D homolog 2", "Tier 1", 0.782, 1, "A2_pm_peripheral", 2, 78.0, 0, 0, null, null, 0, 0, null, 1, "autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures", 0.8072433385790271], ["Q08499", "PDE4D", "3',5'-cyclic-AMP phosphodiesterase 4D", "Tier 1", 0.782, 1, "A2_pm_peripheral", 100, 67.44, 0, 0, null, null, 0, 0, null, 1, "acrodysostosis 2 with or without hormone resistance", 0.8053064772512085], ["Q01831", "XPC", "DNA repair protein complementing XP-C cells", "Tier 1", 0.782, 1, "A2_pm_peripheral", 14, 66.56, 1, 0, null, null, 0, 0, null, 1, "Xeroderma pigmentosum complementation group C", 0.8056391472748724], ["Q96BN8", "OTULIN", "Ubiquitin thioesterase otulin", "Tier 1", 0.781, 1, "A2_pm_peripheral", 12, 83.81, 0, 0, null, null, 0, 0, null, 1, "autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive", 0.804614072482804], ["O60674", "JAK2", "Tyrosine-protein kinase JAK2", "Tier 1", 0.78, 1, "A2_pm_peripheral", 100, 86.88, 0, 0, null, null, 1, 8, "41455398,34121564,32985358,31279934,30415442,25809097,22411871,20711698", 1, "polycythemia vera", 0.8000866241942614], ["P01137", "TGFB1", "Transforming growth factor beta-1 proprotein", "Tier 1", 0.78, 1, "A2_pm_peripheral", 20, 79.56, 1, 0, null, null, 1, 4, "38132522,32370304,16775010,11856769", 1, "Camurati-Engelmann disease", 0.7995305374459716], ["P98170", "XIAP", "E3 ubiquitin-protein ligase XIAP", "Tier 1", 0.78, 1, "A2_pm_peripheral", 74, 74.25, 0, 0, null, null, 1, 4, "35383192,29864441,27514505,26318819", 1, "X-linked lymphoproliferative disease", 0.8013347966323413], ["Q9UHD9", "UBQLN2", "Ubiquilin-2", "Tier 1", 0.778, 1, "A2_pm_peripheral", 4, 61.03, 0, 0, null, null, 1, 2, "23541532", 1, "amyotrophic lateral sclerosis type 15", 0.7942015735994536], ["P49773", "HINT1", "Adenosine 5'-monophosphoramidase HINT1", "Tier 1", 0.777, 1, "A2_pm_peripheral", 59, 96.19, 0, 0, null, null, 0, 0, null, 1, "Autosomal recessive axonal neuropathy with neuromyotonia", 0.7895184274923306], ["O15294", "OGT", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit", "Tier 1", 0.77, 1, "A2_pm_peripheral", 44, 93.06, 0, 0, null, null, 1, 2, "36868188,36626902", 1, "intellectual disability, X-linked 106", 0.7660009745204424], ["Q9Y263", "PLAA", "Phospholipase A-2-activating protein", "Tier 1", 0.77, 1, "A2_pm_peripheral", 5, 84.0, 0, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies", 0.7656265019633831], ["Q9NWZ3", "IRAK4", "Interleukin-1 receptor-associated kinase 4", "Tier 1", 0.768, 1, "A2_pm_peripheral", 96, 83.94, 0, 0, null, null, 0, 0, null, 1, "immunodeficiency 67", 0.7593923638641371], ["Q92743", "HTRA1", "Serine protease HTRA1", "Tier 1", 0.768, 1, "A2_pm_peripheral", 18, 83.25, 1, 0, null, null, 1, 1, "31988066", 1, "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2", 0.7611877816680132], ["Q9BYI3", "HYCC1", "Hyccin", "Tier 1", 0.766, 1, "A2_pm_peripheral", 5, 67.75, 1, 0, null, null, 0, 0, null, 1, "Hypomyelination - congenital cataract", 0.7528702184568328], ["P35221", "CTNNA1", "Catenin alpha-1", "Tier 1", 0.765, 1, "A2_pm_peripheral", 10, 82.94, 1, 0, null, null, 1, 2, "40265971", 1, "Butterfly-shaped pigment dystrophy", 0.7487735496199569], ["Q01484", "ANK2", "Ankyrin-2", "Tier 1", 0.762, 1, "A2_pm_peripheral", 11, 61.78, 0, 0, null, null, 0, 0, null, 1, "Romano-Ward syndrome", 0.7390647393986454], ["P13797", "PLS3", "Plastin-3", "Tier 1", 0.757, 1, "A2_pm_peripheral", 6, 88.75, 1, 0, null, null, 0, 0, null, 1, "X-linked osteoporosis with fractures", 0.721756781312783], ["P26038", "MSN", "Moesin", "Tier 1", 0.755, 1, "A2_pm_peripheral", 10, 86.38, 0, 0, null, null, 1, 65, "41813080,41784619,41611946,40904334,40886652,40258621,40222299,39454415,39053429,38856817,38759442,38687941,38561432,38446130,38349197,38295649,38266273,37869770,37806507,37423650,37353120,37062561,37058944,36982925,36843953,36700559,36562728,36179642,35026109,34893239,34538325,33960345,33727809,33528465,33149582,32882423,32291531,32170403,31872318,31792209,31213813,31072481,30985076,30865739,32254866,29955964,29568450,29136862,28917759,28832225", 1, "combined immunodeficiency due to moesin deficiency", 0.7157135146765757], ["P84077", "ARF1", "ADP-ribosylation factor 1", "Tier 1", 0.755, 1, "A2_pm_peripheral", 36, 85.94, 1, 0, null, null, 1, 3, "30965174,11320245", 1, "periventricular nodular heterotopia 8", 0.7173626622431929], ["P07948", "LYN", "Tyrosine-protein kinase Lyn", "Tier 1", 0.754, 1, "A2_pm_peripheral", 6, 83.12, 0, 0, null, null, 0, 0, null, 1, "autoinflammatory disease, systemic, with vasculitis", 0.7119500711989845], ["Q13153", "PAK1", "Serine/threonine-protein kinase PAK 1", "Tier 1", 0.753, 1, "A2_pm_peripheral", 41, 73.69, 0, 0, null, null, 1, 2, "32636813,20564698", 1, "intellectual developmental disorder with macrocephaly, seizures, and speech delay", 0.7110292416229067], ["O15117", "FYB1", "FYN-binding protein 1", "Tier 1", 0.752, 1, "A2_pm_peripheral", 3, 56.59, 0, 0, null, null, 0, 0, null, 1, "thrombocytopenia 3", 0.7067701415491194], ["P07357", "C8A", "Complement component C8 alpha chain", "Tier 1", 0.75, 1, "A2_pm_peripheral", 11, 78.69, 1, 0, null, null, 0, 0, null, 1, "Immunodeficiency due to a late component of complements deficiency", 0.700643416115894], ["Q13546", "RIPK1", "Receptor-interacting serine/threonine-protein kinase 1", "Tier 1", 0.749, 1, "A2_pm_peripheral", 39, 69.75, 1, 0, null, null, 1, 2, "41290466,35919280", 1, "immunodeficiency 57", 0.698121745966467], ["Q9Y5K6", "CD2AP", "CD2-associated protein", "Tier 1", 0.749, 1, "A2_pm_peripheral", 12, 62.22, 0, 0, null, null, 0, 0, null, 1, "focal segmental glomerulosclerosis", 0.6952333377860125], ["P50148", "GNAQ", "Guanine nucleotide-binding protein G(q) subunit alpha", "Tier 1", 0.748, 1, "A2_pm_peripheral", 30, 93.0, 1, 0, null, null, 1, 1, "40015005", 1, "Sturge-Weber syndrome", 0.6941111530708174], ["Q8IZQ1", "WDFY3", "WD repeat and FYVE domain-containing protein 3", "Tier 1", 0.748, 1, "A2_pm_peripheral", 2, null, 0, 0, null, null, 0, 0, null, 1, "Autosomal dominant microcephaly", 0.6934322596452817], ["P61586", "RHOA", "Transforming protein RhoA", "Tier 1", 0.744, 1, "A2_pm_peripheral", 100, 93.56, 0, 0, null, null, 1, 4, "25645980,19389625,12927206,12123800", 1, "ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies", 0.6804889074382072], ["Q00535", "CDK5", "Cyclin-dependent kinase 5", "Tier 1", 0.744, 1, "A2_pm_peripheral", 10, 91.56, 0, 0, null, null, 1, 4, "33291667,33200349", 1, "Alzheimer disease", 0.6800338890220147], ["Q96CW1", "AP2M1", "AP-2 complex subunit mu", "Tier 1", 0.741, 1, "A2_pm_peripheral", 4, 89.19, 0, 0, null, null, 0, 0, null, 1, "intellectual developmental disorder 60 with seizures", 0.6712897942723018], ["O95786", "RIGI", "Antiviral innate immune response receptor RIG-I", "Tier 1", 0.735, 1, "A2_pm_peripheral", 44, 85.19, 1, 0, null, null, 1, 6, "34487794,33253193,32946572,31600868,26018150,22127865", 1, "Singleton-Merten dysplasia", 0.6485708110478319], ["P26196", "DDX6", "Probable ATP-dependent RNA helicase DDX6", "Tier 1", 0.734, 1, "A2_pm_peripheral", 9, 84.06, 0, 0, null, null, 1, 2, "34132569", 1, "intellectual developmental disorder with impaired language and dysmorphic facies", 0.6482686715821397], ["P48730", "CSNK1D", "Casein kinase I isoform delta", "Tier 1", 0.732, 1, "A2_pm_peripheral", 46, 81.0, 0, 0, null, null, 0, 0, null, 1, "Familial advanced sleep-phase syndrome", 0.6394614732145313], ["P27815", "PDE4A", "3',5'-cyclic-AMP phosphodiesterase 4A", "Tier 1", 0.732, 1, "A2_pm_peripheral", 5, 64.5, 0, 0, null, null, 0, 0, null, 1, "psoriasis", 0.6394621747004946], ["P12931", "SRC", "Proto-oncogene tyrosine-protein kinase Src", "Tier 1", 0.73, 1, "A2_pm_peripheral", 78, 83.44, 0, 1, "1Y57", "2SRC", 1, 19, "40569566,39664567,38471488,35928129,35859339,34757788,34083659,33530373,32668060,30970280,28701145,26458993,25645980,23842900,22693611,22323540,18985031,18682833,12842895", 1, "cancer", 0.6343904000453656]], "truncated": false, "filtered_table_rows_count": 181, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"in_cev_map\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A2_pm_peripheral", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 170, "toggle_url": 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"surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 181, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 181, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 142, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A2_pm_peripheral&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 39, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A2_pm_peripheral&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A2_pm_peripheral&tier=Tier+1&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A2_pm_peripheral&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1057.327478658408, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}