{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where in_cev_map = 1, surface_class = \"A_assoc\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P02462", "COL4A1", "Collagen alpha-1(IV) chain", "Tier 1.5", 0.854, 1, "A_assoc", 4, 48.47, 0, 0, null, null, 0, 0, null, 1, "brain small vessel disease 1 with or without ocular anomalies", 0.84655287380359], ["P04180", "LCAT", "Phosphatidylcholine-sterol acyltransferase", "Tier 1.5", 0.848, 1, "A_assoc", 7, 86.75, 1, 0, null, null, 0, 0, null, 1, "Fish-eye disease", 0.8273460309828392], ["Q15582", "TGFBI", "Transforming growth factor-beta-induced protein ig-h3", "Tier 1.5", 0.847, 1, "A_assoc", 10, 90.25, 1, 0, null, null, 0, 0, null, 1, "lattice corneal dystrophy type I", 0.8242841141270143], ["P07225", "PROS1", "Vitamin K-dependent protein S", "Tier 1.5", 0.847, 1, "A_assoc", 3, 82.94, 1, 0, null, null, 1, 2, "36859809,33674695", 1, "thrombophilia due to protein S deficiency, autosomal dominant", 0.8240418292042652], ["P07942", "LAMB1", "Laminin subunit beta-1", "Tier 1.5", 0.84, 1, "A_assoc", 3, 76.69, 1, 0, null, null, 0, 0, null, 1, "cobblestone lissencephaly without muscular or ocular involvement", 0.8016665947624902], ["P22105", "TNXB", "Tenascin-X", "Tier 1.5", 0.837, 1, "A_assoc", 3, 87.81, 0, 0, null, null, 0, 0, null, 1, "Ehlers-Danlos syndrome due to tenascin-X deficiency", 0.7916412481554758], ["P39060", "COL18A1", "Collagen alpha-1(XVIII) chain", "Tier 1.5", 0.836, 1, "A_assoc", 9, 50.62, 1, 0, null, null, 1, 2, "36707842,23679916", 1, "Knobloch syndrome 1", 0.7867122552672962], ["P35858", "IGFALS", "Insulin-like growth factor-binding protein complex acid labile subunit", "Tier 1.5", 0.833, 1, "A_assoc", 1, 90.56, 1, 0, null, null, 0, 0, null, 1, "Reduced insulin like growth factor binding protein acid labile subunit concentration", 0.7760522769257892], ["P35625", "TIMP3", "Metalloproteinase inhibitor 3", "Tier 1.5", 0.831, 1, "A_assoc", 1, 87.0, 0, 0, null, null, 1, 3, "42105605,36768220", 1, "Sorsby fundus dystrophy", 0.7684253675298044], ["P02748", "C9", "Complement component C9", "Tier 1.5", 0.829, 1, "A_assoc", 9, 78.75, 1, 0, null, null, 1, 10, "41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383", 1, "Immunodeficiency due to a late component of complements deficiency", 0.761965409699055], ["O15230", "LAMA5", "Laminin subunit alpha-5", "Tier 1.5", 0.828, 1, "A_assoc", 2, 79.12, 1, 0, null, null, 0, 0, null, 1, "nephrotic syndrome, IIa 26", 0.7594872666460903], ["P08572", "COL4A2", "Collagen alpha-2(IV) chain", "Tier 1.5", 0.819, 1, "A_assoc", 4, 47.25, 0, 0, null, null, 0, 0, null, 1, "porencephaly 2", 0.7294975109351518], ["O60568", "PLOD3", "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "Tier 1.5", 0.815, 1, "A_assoc", 18, 91.38, 1, 0, null, null, 0, 0, null, 1, "bone fragility with contractures, arterial rupture, and deafness", 0.7159150369336311], ["P36955", "SERPINF1", "Pigment epithelium-derived factor", "Tier 1.5", 0.811, 1, "A_assoc", 3, 90.12, 0, 0, null, null, 1, 17, "41503480,40965986,24311895,21546514,19668729,17628122,16787141,16724865,16136393,15947805", 1, "osteogenesis imperfecta", 0.701995723393119], ["O00187", "MASP2", "Mannan-binding lectin serine protease 2", "Tier 1.5", 0.81, 1, "A_assoc", 10, 89.44, 0, 0, null, null, 1, 1, "40371468", 1, "immunodeficiency due to MASP-2 deficiency", 0.6996393077218865], ["Q9Y6C2", "EMILIN1", "EMILIN-1", "Tier 1.5", 0.786, 1, "A_assoc", 2, 62.91, 0, 0, null, null, 0, 0, null, 1, "arterial tortuosity-bone fragility syndrome", 0.6185329512431467], ["P49767", "VEGFC", "Vascular endothelial growth factor C", "Tier 1.5", 0.785, 1, "A_assoc", 4, 73.19, 0, 0, null, null, 0, 0, null, 1, "Milroy disease", 0.6170524106764851], ["Q16270", "IGFBP7", "Insulin-like growth factor-binding protein 7", "Tier 1.5", 0.785, 1, "A_assoc", 1, 84.44, 0, 0, null, null, 1, 4, "41192243,27679852,41280530", 1, "familial retinal arterial macroaneurysm", 0.6182241349863704], ["Q99988", "GDF15", "Growth/differentiation factor 15", "Tier 1.5", 0.775, 1, "A_assoc", 4, 75.69, 1, 0, null, null, 1, 29, "41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547", 1, "hyperemesis gravidarum", 0.5821658682742563], ["P10451", "SPP1", "Osteopontin", "Tier 1.5", 0.772, 1, "A_assoc", 3, 53.41, 0, 0, null, null, 1, 62, "41690559,41223977,39422353,38600327,32943056,32042311,31603904,30307407,28916037,28453726,25278703,21147843,42136308,42108056,40845664,40479828,39677448,39340832,38834269,37162508,36508319,36284815,35433114,35190123,34420232,32166466,31987218,31879964,31806966,31301870,30135425,29441346,28988933,28706912,26529285,25949891,25930003,25713073,24902765,24491763,24438228,23889968,23619316,22880609,22241292,21962803,21801960,20967826,19570203,18985031", 1, "osteoporosis", 0.5729473764531288], ["P10646", "TFPI", "Tissue factor pathway inhibitor", "Tier 1.5", 0.768, 1, "A_assoc", 9, 73.62, 1, 0, null, null, 1, 28, "32366845,32224381,30994257,30302740,27563744,27196067,24263002,23528042,22951415,22658294,22632032,22239993,21696535,21389323,8578509,25521966,24319161", 1, "hemophilia A", 0.5591056672248635], ["P10909", "CLU", "Clusterin", "Tier 1.5", 0.766, 1, "A_assoc", 2, 77.31, 0, 0, null, null, 1, 5, "42041411,37179603,36980195,35383192,26061649", 1, "Alzheimer disease", 0.5545645077431476], ["P13497", "BMP1", "Bone morphogenetic protein 1", "Tier 1.5", 0.766, 1, "A_assoc", 8, 81.44, 0, 0, null, null, 1, 1, "39939919", 1, "osteogenesis imperfecta", 0.5547577676549571], ["O00622", "CCN1", "CCN family member 1", "Tier 1.5", 0.765, 1, "A_assoc", 2, 73.12, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.5505331194769112], ["P02771", "AFP", "Alpha-fetoprotein", "Tier 1.5", 0.765, 1, "A_assoc", 5, 88.94, 1, 0, null, null, 1, 195, "41849903,41732103,41688234,41327249,41051792,40839965,40750207,40684729,40578247,40383027,40381048,40347636,40262341,40216053,39982565,39942588,39890683,39771616,39479488,39383727,39305942,39167423,39140150,39082193,39067928,39007743,38904836,38852341,38356334,37836778,37709445,37606762,37366993,37303825,37295202,37284243,37228865,37104032,36989661,36979562,36842207,36693188,36512161,36389169,36290918,36240195,36130652,35969067,35793076,35747812,41637558,41575587,41123957,41103270,40349714,40286895,38899396,37325361", 1, "Congenital deficiency in alpha-fetoprotein", 0.5500580170557311], ["Q68CZ2", "TNS3", "Tensin-3", "Tier 1.5", 0.762, 1, "A_assoc", 1, 56.81, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.539772721274482], ["P55145", "MANF", "Mesencephalic astrocyte-derived neurotrophic factor", "Tier 1.5", 0.761, 1, "A_assoc", 3, 81.69, 0, 0, null, null, 1, 1, "12698297", 1, "diabetes, deafness, developmental delay, and short stature syndrome", 0.5377386885662411], ["Q9Y3B8", "REXO2", "Oligoribonuclease, mitochondrial", "Tier 1.5", 0.754, 1, "A_assoc", 10, 88.19, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5134178677464454], ["P36980", "CFHR2", "Complement factor H-related protein 2", "Tier 1.5", 0.753, 1, "A_assoc", 4, 90.62, 0, 0, null, null, 0, 0, null, 1, "age-related macular degeneration", 0.5100732932209376], ["Q13177", "PAK2", "Serine/threonine-protein kinase PAK 2", "Tier 1.5", 0.736, 1, "A_assoc", 5, 74.62, 0, 0, null, null, 0, 0, null, 1, "Knobloch syndrome", 0.45371318009439854], ["Q13625", "TP53BP2", "Apoptosis-stimulating of p53 protein 2", "Tier 1.5", 0.735, 1, "A_assoc", 6, 58.97, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4484066399496438], ["Q9UKU9", "ANGPTL2", "Angiopoietin-related protein 2", "Tier 1.5", 0.727, 1, "A_assoc", 1, 78.19, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.4235882639081519], ["Q96SL4", "GPX7", "Glutathione peroxidase 7", "Tier 1.5", 0.721, 1, "A_assoc", 1, 92.69, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.40349356855524837], ["Q16627", "CCL14", "C-C motif chemokine 14", "Tier 1.5", 0.711, 1, "A_assoc", 2, 85.38, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.37013422446672883], ["P24593", "IGFBP5", "Insulin-like growth factor-binding protein 5", "Tier 1.5", 0.711, 1, "A_assoc", 3, 76.06, 1, 0, null, null, 1, 4, "39317671,31930684", 1, "hypothyroidism", 0.3702458751451027], ["O43866", "CD5L", "CD5 antigen-like", "Tier 1.5", 0.706, 1, "A_assoc", 4, 85.88, 1, 0, null, null, 1, 3, "40215752,37100807", 1, "functional neutrophil defect", 0.3529395470693119], ["P10145", "CXCL8", "Interleukin-8", "Tier 1.5", 0.706, 1, "A_assoc", 21, 88.06, 1, 0, null, null, 1, 15, "39564692,35821507,31985806,29268188,41866852,37732574,37016361,36037714,35197258,34884636,25998051,24129312", 1, "coronary artery disease", 0.35357870191996843], ["P22692", "IGFBP4", "Insulin-like growth factor-binding protein 4", "Tier 1.5", 0.706, 1, "A_assoc", 4, 77.25, 0, 0, null, null, 1, 6, "35323639,32515246,31930684", 1, "allergic rhinitis", 0.35214760515440524], ["P12273", "PIP", "Prolactin-inducible protein", "Tier 1.5", 0.701, 1, "A_assoc", 1, 89.69, 0, 0, null, null, 1, 7, "41440247,36179084,35726753,35336001,28107930,26297462,21559755", 1, "neurodegenerative disease", 0.3382059336442212], ["P80162", "CXCL6", "C-X-C motif chemokine 6", "Tier 1.5", 0.699, 1, "A_assoc", 2, 81.0, 1, 0, null, null, 1, 3, "40008515,36649818,32628701", 1, "neurodegenerative disease", 0.3309117033683961], ["P98066", "TNFAIP6", "Tumor necrosis factor-inducible gene 6 protein", "Tier 1.5", 0.693, 1, "A_assoc", 5, 81.12, 0, 0, null, null, 1, 1, "39263947", 1, "type 2 diabetes mellitus", 0.30862220597837015], ["Q8WUP2", "FBLIM1", "Filamin-binding LIM protein 1", "Tier 1.5", 0.687, 1, "A_assoc", 3, 66.44, 0, 0, null, null, 0, 0, null, 1, "COVID-19", 0.28975781420803737], ["P19876", "CXCL3", "C-X-C motif chemokine 3", "Tier 1.5", 0.679, 1, "A_assoc", 2, 81.88, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.26311734927710556], ["P19875", "CXCL2", "C-X-C motif chemokine 2", "Tier 1.5", 0.674, 1, "A_assoc", 4, 81.62, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.24624512698601778], ["O75594", "PGLYRP1", "Peptidoglycan recognition protein 1", "Tier 1.5", 0.649, 1, "A_assoc", 1, 91.0, 0, 0, null, null, 1, 2, "35821507,33534888", 1, "dementia", 0.16478389504231422], ["P02776", "PF4", "Platelet factor 4", "Tier 1.5", 0.635, 1, "A_assoc", 10, 75.06, 0, 0, null, null, 1, 10, "33859620,32366845,31967847,23847186,23673861,34248840,32022468", 1, "systemic scleroderma", 0.11523541376593864], ["Q9NWU2", "GID8", "Glucose-induced degradation protein 8 homolog", "Tier 1.5", 0.631, 1, "A_assoc", 1, 91.94, 1, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.10187555420552867], ["O95445", "APOM", "Apolipoprotein M", "Tier 1.5", 0.631, 1, "A_assoc", 3, 89.44, 0, 0, null, null, 1, 10, "38238732,36980195,35120890,32237898,30771967,37425696,37400771,34796696", 1, "type 2 diabetes mellitus", 0.10169659060091507], ["P35556", "FBN2", "Fibrillin-2", "Tier 1.5", 0.612, 0, "A_assoc", 0, 68.38, 0, 0, null, null, 0, 0, null, 1, "congenital contractural arachnodactyly", 0.8556257369085999], ["P02766", "TTR", "Transthyretin", "Tier 1.5", 0.609, 0, "A_assoc", 0, 88.0, 0, 0, null, null, 1, 11, "39737993,32616928,23770039,21875107,21314458,39596348,38399458,36881759,33572452", 1, "amyloidosis, hereditary systemic 1", 0.846421986844374]], "truncated": false, "filtered_table_rows_count": 89, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"in_cev_map\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A_assoc", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 49, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 40, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 89, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 89, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 53, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 36, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 89, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 89, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_assoc&tier=Tier+1.5", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 70, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 19, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 338.16159376874566, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}