{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where surface_class = \"A2_pm_peripheral\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P29400", "COL4A5", "Collagen alpha-5(IV) chain", "Tier 1.5", 0.794, 1, "A2_pm_peripheral", 2, 48.12, 0, 0, null, null, 0, 0, null, 1, "X-linked Alport syndrome", 0.8472963899466404], ["Q14315", "FLNC", "Filamin-C", "Tier 1.5", 0.791, 1, "A2_pm_peripheral", 14, 75.06, 0, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy 26", 0.8363192336142512], ["O60315", "ZEB2", "Zinc finger E-box-binding homeobox 2", "Tier 1.5", 0.789, 1, "A2_pm_peripheral", 1, 48.16, 0, 0, null, null, 1, 3, "27719642,24146916,18698484", 1, "Mowat-Wilson syndrome", 0.8313744323041312], ["P31040", "SDHA", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Tier 1.5", 0.785, 1, "A2_pm_peripheral", 4, 93.94, 1, 0, null, null, 0, 0, null, 1, "mitochondrial complex II deficiency, nuclear type 1", 0.815589203208636], ["P11274", "BCR", "Breakpoint cluster region protein", "Tier 1.5", 0.785, 1, "A2_pm_peripheral", 5, 64.81, 0, 0, null, null, 1, 20, "41951939,41535871,40882628,37937247,37103734,32929022,32507237,31825964,31650445,31295447,29299123,28686804,25809097,23836560,22411871,21810089,21653319,21030439,16990253,11713794", 1, "chronic myelogenous leukemia", 0.8183048540102864], ["O95630", "STAMBP", "STAM-binding protein", "Tier 1.5", 0.782, 1, "A2_pm_peripheral", 5, 84.0, 0, 0, null, null, 0, 0, null, 1, "microcephaly-capillary malformation syndrome", 0.8060251236043802], ["Q12840", "KIF5A", "Kinesin heavy chain isoform 5A", "Tier 1.5", 0.781, 1, "A2_pm_peripheral", 4, 75.31, 1, 0, null, null, 0, 0, null, 1, "hereditary spastic paraplegia 10", 0.8029405627392309], ["O00330", "PDHX", "Pyruvate dehydrogenase protein X component, mitochondrial", "Tier 1.5", 0.779, 1, "A2_pm_peripheral", 5, 77.31, 1, 0, null, null, 0, 0, null, 1, "pyruvate dehydrogenase E3-binding protein deficiency", 0.7957753555992844], ["Q9NQG7", "HPS4", "BLOC-3 complex member HPS4", "Tier 1.5", 0.779, 1, "A2_pm_peripheral", 1, 61.66, 1, 0, null, null, 0, 0, null, 1, "Hermansky-Pudlak syndrome with pulmonary fibrosis", 0.7967575753847002], ["P12814", "ACTN1", "Alpha-actinin-1", "Tier 1.5", 0.777, 1, "A2_pm_peripheral", 4, 85.25, 0, 0, null, null, 0, 0, null, 1, "platelet-type bleeding disorder 15", 0.7887662502912471], ["O00468", "AGRN", "Agrin", "Tier 1.5", 0.777, 1, "A2_pm_peripheral", 1, 68.81, 1, 0, null, null, 0, 0, null, 1, "congenital myasthenic syndrome 8", 0.7912009864338403], ["Q9ULC3", "RAB23", "Ras-related protein Rab-23", "Tier 1.5", 0.776, 1, "A2_pm_peripheral", 6, 79.56, 1, 0, null, null, 1, 1, "23618401", 1, "RAB23-related Carpenter syndrome", 0.7879955689930709], ["P55263", "ADK", "Adenosine kinase", "Tier 1.5", 0.769, 1, "A2_pm_peripheral", 4, 93.31, 0, 0, null, null, 1, 2, "26051465", 1, "adenosine kinase deficiency", 0.7617058236708037], ["Q9NZ09", "UBAP1", "Ubiquitin-associated protein 1", "Tier 1.5", 0.764, 1, "A2_pm_peripheral", 3, 62.5, 0, 0, null, null, 0, 0, null, 1, "spastic paraplegia 80, autosomal dominant", 0.7464670113492812], ["Q6NZI2", "CAVIN1", "Caveolae-associated protein 1", "Tier 1.5", 0.76, 1, "A2_pm_peripheral", 3, 67.38, 0, 0, null, null, 0, 0, null, 1, "congenital generalized lipodystrophy type 4", 0.7317728549444928], ["Q92997", "DVL3", "Segment polarity protein dishevelled homolog DVL-3", "Tier 1.5", 0.759, 1, "A2_pm_peripheral", 9, 58.91, 0, 0, null, null, 0, 0, null, 1, "autosomal dominant Robinow syndrome", 0.7284158836126389], ["P22735", "TGM1", "Protein-glutamine gamma-glutamyltransferase K", "Tier 1.5", 0.754, 1, "A2_pm_peripheral", 1, 84.12, 0, 0, null, null, 0, 0, null, 1, "autosomal recessive congenital ichthyosis", 0.714755023666953], ["P31939", "ATIC", "Bifunctional purine biosynthesis protein ATIC", "Tier 1.5", 0.754, 1, "A2_pm_peripheral", 5, 97.38, 0, 0, null, null, 0, 0, null, 1, "AICA-ribosiduria", 0.7137167364484167], ["P35241", "RDX", "Radixin", "Tier 1.5", 0.749, 1, "A2_pm_peripheral", 2, 86.56, 0, 0, null, null, 1, 2, "33253235,30700648", 1, "hearing loss, autosomal recessive", 0.6973070672344621], ["Q8IXK2", "GALNT12", "Polypeptide N-acetylgalactosaminyltransferase 12", "Tier 1.5", 0.748, 1, "A2_pm_peripheral", 1, 93.5, 0, 0, null, null, 0, 0, null, 1, "colorectal cancer, susceptibility to, 1", 0.6932727729787528], ["O43516", "WIPF1", "WAS/WASL-interacting protein family member 1", "Tier 1.5", 0.737, 1, "A2_pm_peripheral", 4, 58.5, 0, 0, null, null, 0, 0, null, 1, "Wiskott-Aldrich syndrome", 0.6561328889736038], ["Q12929", "EPS8", "Epidermal growth factor receptor kinase substrate 8", "Tier 1.5", 0.731, 1, "A2_pm_peripheral", 2, 70.31, 0, 0, null, null, 0, 0, null, 1, "autosomal recessive nonsyndromic hearing loss 102", 0.6354471967036509], ["Q9NZ56", "FMN2", "Formin-2", "Tier 1.5", 0.729, 1, "A2_pm_peripheral", 2, 49.97, 0, 0, null, null, 0, 0, null, 1, "autosomal recessive non-syndromic intellectual disability", 0.6298956049368037], ["P32121", "ARRB2", "Beta-arrestin-2", "Tier 1.5", 0.719, 1, "A2_pm_peripheral", 1, 83.81, 1, 0, null, null, 1, 4, "24736311,40652239,29054528", 1, "cancer", 0.5962458729823639], ["O95425", "SVIL", "Supervillin", "Tier 1.5", 0.718, 1, "A2_pm_peripheral", 2, 53.44, 0, 0, null, null, 0, 0, null, 1, "myofibrillar myopathy 10", 0.5924877747412329], ["P09769", "FGR", "Tyrosine-protein kinase Fgr", "Tier 1.5", 0.716, 1, "A2_pm_peripheral", 3, 82.19, 0, 0, null, null, 1, 1, "39564692", 1, "chronic myelogenous leukemia", 0.5869168331059803], ["P10398", "ARAF", "Serine/threonine-protein kinase A-Raf", "Tier 1.5", 0.709, 1, "A2_pm_peripheral", 6, 70.06, 0, 0, null, null, 0, 0, null, 1, "cancer", 0.5616780822043126], ["Q01581", "HMGCS1", "Hydroxymethylglutaryl-CoA synthase, cytoplasmic", "Tier 1.5", 0.707, 1, "A2_pm_peripheral", 1, 91.31, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.55518193177393], ["Q9NT62", "ATG3", "Ubiquitin-like-conjugating enzyme ATG3", "Tier 1.5", 0.707, 1, "A2_pm_peripheral", 4, 73.38, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5571514462681344], ["Q02156", "PRKCE", "Protein kinase C epsilon type", "Tier 1.5", 0.706, 1, "A2_pm_peripheral", 2, 79.94, 0, 0, null, null, 0, 0, null, 1, "acute myeloid leukemia", 0.5549599198877609], ["P42680", "TEC", "Tyrosine-protein kinase Tec", "Tier 1.5", 0.705, 1, "A2_pm_peripheral", 1, 85.0, 0, 0, null, null, 1, 13, "39352470,39329798,36414190,36105684,35624657,35462326,35006795,30578658,30398689,27548775,26843427,25016253,24875764", 1, "alopecia areata", 0.5491699656070116], ["P17252", "PRKCA", "Protein kinase C alpha type", "Tier 1.5", 0.704, 1, "A2_pm_peripheral", 6, 86.38, 0, 0, null, null, 1, 1, "41505229", 1, "acute myeloid leukemia", 0.547429504944985], ["P00326", "ADH1C", "Alcohol dehydrogenase 1C", "Tier 1.5", 0.704, 1, "A2_pm_peripheral", 2, 98.12, 0, 0, null, null, 0, 0, null, 1, "alcohol drinking", 0.5465864505308649], ["Q99828", "CIB1", "Calcium and integrin-binding protein 1", "Tier 1.5", 0.701, 1, "A2_pm_peripheral", 9, 75.75, 0, 0, null, null, 0, 0, null, 1, "epidermodysplasia verruciformis", 0.5381616248572979], ["O15511", "ARPC5", "Actin-related protein 2/3 complex subunit 5", "Tier 1.5", 0.699, 1, "A2_pm_peripheral", 2, 92.19, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5305805352966168], ["P30154", "PPP2R1B", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Tier 1.5", 0.699, 1, "A2_pm_peripheral", 1, 92.81, 1, 0, null, null, 0, 0, null, 1, "cancer", 0.5305484520119053], ["Q16774", "GUK1", "Guanylate kinase", "Tier 1.5", 0.698, 1, "A2_pm_peripheral", 14, 93.94, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.526507567426656], ["Q96PY5", "FMNL2", "Formin-like protein 2", "Tier 1.5", 0.695, 1, "A2_pm_peripheral", 1, 76.44, 0, 0, null, null, 1, 1, "41149482", 1, "open-angle glaucoma", 0.5157968177633478], ["O60861", "GAS7", "Growth arrest-specific protein 7", "Tier 1.5", 0.694, 1, "A2_pm_peripheral", 2, 83.75, 0, 0, null, null, 0, 0, null, 1, "open-angle glaucoma", 0.5145811266752988], ["Q53QZ3", "ARHGAP15", "Rho GTPase-activating protein 15", "Tier 1.5", 0.691, 1, "A2_pm_peripheral", 1, 76.06, 0, 0, null, null, 0, 0, null, 1, "diverticular disease", 0.5042377909782373], ["O00762", "UBE2C", "Ubiquitin-conjugating enzyme E2 C", "Tier 1.5", 0.689, 1, "A2_pm_peripheral", 9, 88.56, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.49682303083942114], ["P09543", "CNP", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "Tier 1.5", 0.689, 1, "A2_pm_peripheral", 1, 87.25, 0, 0, null, null, 1, 9, "40034273,38569854,37704353,35528922,31171207,30089209,27192549,19021295", 1, "myopia 2, autosomal dominant", 0.49606855995054094], ["P31948", "STIP1", "Stress-induced-phosphoprotein 1", "Tier 1.5", 0.689, 1, "A2_pm_peripheral", 8, 89.75, 1, 0, null, null, 1, 7, "41406518,38012811,34831332,32614006,27681499,24654750,24013070", 1, "neurodegenerative disease", 0.4967711525222825], ["P21980", "TGM2", "Protein-glutamine gamma-glutamyltransferase 2", "Tier 1.5", 0.688, 1, "A2_pm_peripheral", 17, 92.88, 1, 0, null, null, 1, 1, "35980938", 1, "neurodegenerative disease", 0.49455272812698803], ["Q86SR1", "GALNT10", "Polypeptide N-acetylgalactosaminyltransferase 10", "Tier 1.5", 0.688, 1, "A2_pm_peripheral", 2, 90.75, 0, 0, null, null, 0, 0, null, 1, "obesity", 0.49376752835968046], ["O75815", "BCAR3", "Breast cancer anti-estrogen resistance protein 3", "Tier 1.5", 0.687, 1, "A2_pm_peripheral", 1, 65.69, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4887088231206927], ["Q96FQ6", "S100A16", "Protein S100-A16", "Tier 1.5", 0.687, 1, "A2_pm_peripheral", 3, 81.12, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4899214982350221], ["Q8TBX8", "PIP4K2C", "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "Tier 1.5", 0.684, 1, "A2_pm_peripheral", 5, 80.31, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.47990990136472794], ["O00194", "RAB27B", "Ras-related protein Rab-27B", "Tier 1.5", 0.684, 1, "A2_pm_peripheral", 1, 84.56, 0, 0, null, null, 0, 0, null, 1, "major depressive disorder", 0.4805047942947544], ["O15247", "CLIC2", "Chloride intracellular channel protein 2", "Tier 1.5", 0.682, 1, "A2_pm_peripheral", 3, 92.94, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.47298055353356755]], "truncated": false, "filtered_table_rows_count": 236, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"surface_class\" = :p0 and \"tier\" = :p1 order by evidence_priority desc limit 51", "params": {"p0": "A2_pm_peripheral", "p1": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 131, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 105, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 236, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 236, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 196, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 40, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 236, "toggle_url": "https://apt-scout.org/scout/v_targets.json?tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 132, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 104, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 205, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 31, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 314.50917199254036, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}