{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where surface_class = \"A_surface\" sorted by evidence_priority descending", "rows": [["P21359", "NF1", "Neurofibromin", "Tier 1.5", 0.965, 1, "A_surface", 26, 87.19, 1, 0, null, null, 1, 2, "32980430,22617876", 1, "neurofibromatosis type 1", 0.8844735398780649], ["P33897", "ABCD1", "ATP-binding cassette sub-family D member 1", "Tier 1", 0.96, 1, "A_surface", 14, 80.62, 1, 0, null, null, 0, 0, null, 1, "adrenoleukodystrophy", 0.8656366512509434], ["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.959, 1, "A_surface", 6, 90.25, 1, 0, null, null, 1, 2, "24635113", 1, "chronic granulomatous disease", 0.8633132852459866], ["P21802", "FGFR2", "Fibroblast growth factor receptor 2", "Tier 1", 0.959, 1, "A_surface", 62, 73.94, 0, 0, null, null, 1, 5, "41786503,39759879,31357131,24242861,19212647", 1, "Crouzon syndrome", 0.8637438969881663], ["P78504", "JAG1", "Protein jagged-1", "Tier 1", 0.958, 1, "A_surface", 7, 73.12, 0, 0, null, null, 1, 4, "37338014,37052638,23341879,18673242", 1, "Alagille syndrome due to a JAG1 point mutation", 0.8586542923232751], ["P00813", "ADA", "Adenosine deaminase", "Tier 1.5", 0.957, 1, "A_surface", 2, 96.56, 0, 0, null, null, 1, 72, "42012076,41877526,41762796,41635914,40403280,40189053,39856849,39847085,36796307,33998617,32043202,30876536,30060448,27589406,26606306,25597304,25521724,25360869,24976151,24893272,24682016,24035856,23462984,23202335,23037591,22944024,22613226,41910181,41791686,41267360,39673485,39396299,38583236,36855421,34241023,33147453,32546280,30926472,26605646,24624989,23373863,22543727,20345118,19381549,19378312,18293985,17440909,17000903,16856187,16619330", 1, "Severe combined immunodeficiency due to adenosine deaminase deficiency", 0.8556816060494579], ["P11166", "SLC2A1", "Solute carrier family 2, facilitated glucose transporter member 1", "Tier 1", 0.956, 1, "A_surface", 5, 90.25, 0, 0, null, null, 1, 2, "39627234,33184583", 1, "encephalopathy due to GLUT1 deficiency", 0.8521823225896756], ["P36021", "SLC16A2", "Monocarboxylate transporter 8", "Tier 1.5", 0.956, 1, "A_surface", 7, 79.56, 1, 0, null, null, 0, 0, null, 1, "Allan-Herndon-Dudley syndrome", 0.8533069932022032], ["P51795", "CLCN5", "H(+)/Cl(-) exchange transporter 5", "Tier 1.5", 0.955, 1, "A_surface", 2, 80.62, 0, 0, null, null, 0, 0, null, 1, "Dent disease type 1", 0.850724240157394], ["P29965", "CD40LG", "CD40 ligand", "Tier 1", 0.954, 1, "A_surface", 8, 82.62, 1, 0, null, null, 1, 6, "37331977,36203210,26504624", 1, "hyper-IgM syndrome type 1", 0.8451678829647167], ["P11362", "FGFR1", "Fibroblast growth factor receptor 1", "Tier 1", 0.954, 1, "A_surface", 82, 73.88, 0, 0, null, null, 1, 13, "41873087,41820318,40092750,39759879,39249203,37336759,33536494,31583159,31357131,30297602,28442904", 1, "hypogonadotropic hypogonadism 2 with or without anosmia", 0.8472925100660907], ["Q9NQ11", "ATP13A2", "Polyamine-transporting ATPase 13A2", "Tier 1", 0.953, 1, "A_surface", 25, 79.62, 1, 0, null, null, 0, 0, null, 1, "Kufor-Rakeb syndrome", 0.8439049037191295], ["P08581", "MET", "Hepatocyte growth factor receptor", "Tier 1", 0.953, 1, "A_surface", 100, 79.25, 0, 0, null, null, 1, 149, "42012469,41992303,41973478,41873087,41861669,41858296,41848278,41601428,41462891,41391726,41234744,41123956,41084363,41065179,41024479,40954195,40938088,40923343,40840349,40740738,40728393,40640119,40388621,40189053,40116812,40041032,39930702,39853766,39852082,39744222,39735310,39674868,39631842,39586988,39527480,39513807,39355222,39348183,39288204,39087949,38925633,38923378,38876234,38829176,38697444,38515622,38298092,38277932,38230289,38225704,30237882,29416033,26131766", 1, "papillary renal cell carcinoma", 0.84195976263742], ["P06213", "INSR", "Insulin receptor", "Tier 1", 0.953, 1, "A_surface", 87, 77.62, 0, 0, null, null, 1, 14, "33410883,24768638,40603733,37779149,36310231,35478209,29262294,27648925,26387957,26245346,19396447,17167487", 1, "Leprechaunism", 0.8448849372402896], ["Q8WZ42", "TTN", "Titin", "Tier 1", 0.953, 1, "A_surface", 64, null, 0, 0, null, null, 1, 1, "29952259", 1, "dilated cardiomyopathy", 0.8419847660466327], ["Q14524", "SCN5A", "Sodium channel protein type 5 subunit alpha", "Tier 1.5", 0.953, 1, "A_surface", 16, 67.25, 1, 0, null, null, 0, 0, null, 1, "long QT syndrome 3", 0.8448298602976083], ["Q969N2", "PIGT", "GPI-anchor transamidase component PIGT", "Tier 1.5", 0.953, 1, "A_surface", 3, 87.25, 1, 0, null, null, 0, 0, null, 1, "multiple congenital anomalies-hypotonia-seizures syndrome 3", 0.8439030764005646], ["P13637", "ATP1A3", "Sodium/potassium-transporting ATPase subunit alpha-3", "Tier 1.5", 0.953, 1, "A_surface", 5, 88.81, 1, 0, null, null, 0, 0, null, 1, "alternating hemiplegia of childhood 2", 0.842328126568451], ["P37173", "TGFBR2", "TGF-beta receptor type-2", "Tier 1", 0.952, 1, "A_surface", 22, 81.0, 1, 0, null, null, 1, 8, "32452828,30595527,29522674,29375127,26284552,23999222,22899759,11856769", 1, "Loeys-Dietz syndrome", 0.8390072008866913], ["P35499", "SCN4A", "Sodium channel protein type 4 subunit alpha", "Tier 1", 0.952, 1, "A_surface", 3, 72.44, 1, 0, null, null, 0, 0, null, 1, "paramyotonia congenita of Von Eulenburg", 0.8401628899371881], ["Q99250", "SCN2A", "Sodium channel protein type 2 subunit alpha", "Tier 1.5", 0.952, 1, "A_surface", 5, 68.81, 1, 0, null, null, 0, 0, null, 1, "developmental and epileptic encephalopathy, 11", 0.8388748085806758], ["O00571", "DDX3X", "ATP-dependent RNA helicase DDX3X", "Tier 1", 0.951, 1, "A_surface", 17, 72.19, 0, 0, null, null, 0, 0, null, 1, "X-linked non-syndromic intellectual disability", 0.8362533125067105], ["P19438", "TNFRSF1A", "Tumor necrosis factor receptor superfamily member 1A", "Tier 1", 0.951, 1, "A_surface", 13, 71.38, 1, 0, null, null, 1, 1, "35197258", 1, "TNF receptor 1-associated periodic fever syndrome", 0.8352778213184682], ["P25189", "MPZ", "Myelin protein P0", "Tier 1.5", 0.951, 1, "A_surface", 2, 81.69, 0, 0, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease type 1B", 0.8377022197539885], ["P54760", "EPHB4", "Ephrin type-B receptor 4", "Tier 1", 0.95, 1, "A_surface", 23, 82.0, 0, 0, null, null, 0, 0, null, 1, "Capillary malformation - arteriovenous malformation", 0.8317426466005666], ["P07359", "GP1BA", "Platelet glycoprotein Ib alpha chain", "Tier 1", 0.95, 1, "A_surface", 22, 64.31, 1, 0, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8346884735388165], ["Q9HAB3", "SLC52A2", "Solute carrier family 52, riboflavin transporter, member 2", "Tier 1.5", 0.95, 1, "A_surface", 1, 84.12, 1, 0, null, null, 0, 0, null, 1, "riboflavin transporter deficiency", 0.8333271825486935], ["Q9Y653", "ADGRG1", "Adhesion G-protein coupled receptor G1", "Tier 1.5", 0.95, 1, "A_surface", 1, 77.88, 1, 0, null, null, 0, 0, null, 1, "bilateral frontoparietal polymicrogyria", 0.8322298896713178], ["P06744", "GPI", "Glucose-6-phosphate isomerase", "Tier 1", 0.949, 1, "A_surface", 13, 97.94, 1, 0, null, null, 1, 19, "41911185,41329468,41232387,35821507,34953205,32730952,29501157,27419372,25919296,25483705,24334484,23656757,23578283,23018995,22116094,20967861,17574575,27380815", 1, "hemolytic anemia due to glucophosphate isomerase deficiency", 0.8306909118751346], ["Q9NRA2", "SLC17A5", "Sialin", "Tier 1", 0.949, 1, "A_surface", 7, 84.12, 1, 0, null, null, 0, 0, null, 1, "free sialic acid storage disease, infantile form", 0.8292382821211967], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.949, 1, "A_surface", 11, 75.94, 0, 0, null, null, 1, 6, "41733039,34364920,31434881,30237882,29299123,22411871", 1, "acute myeloid leukemia", 0.8313389209288576], ["P63092", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms short", "Tier 1", 0.948, 1, "A_surface", 100, 91.31, 1, 0, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["Q8WZA1", "POMGNT1", "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "Tier 1", 0.948, 1, "A_surface", 10, 89.88, 0, 0, null, null, 0, 0, null, 1, "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3", 0.826104223872448], ["P36897", "TGFBR1", "TGF-beta receptor type-1", "Tier 1", 0.948, 1, "A_surface", 44, 84.19, 1, 0, null, null, 1, 1, "41089000", 1, "Loeys-Dietz syndrome 1", 0.8275292516338373], ["P36894", "BMPR1A", "Bone morphogenetic protein receptor type-1A", "Tier 1", 0.948, 1, "A_surface", 11, 82.62, 0, 0, null, null, 1, 1, "30537181", 1, "juvenile polyposis syndrome", 0.8278395086688584], ["P22607", "FGFR3", "Fibroblast growth factor receptor 3", "Tier 1", 0.948, 1, "A_surface", 13, 74.19, 1, 0, null, null, 1, 6, "38569854,37704353,34864168,33952673,31357131", 1, "achondroplasia", 0.8270702096931246], ["Q5JWF2", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas", "Tier 1", 0.948, 1, "A_surface", 9, 56.72, 1, 0, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["P13473", "LAMP2", "Lysosome-associated membrane glycoprotein 2", "Tier 1.5", 0.948, 1, "A_surface", 2, 83.19, 0, 0, null, null, 0, 0, null, 1, "Glycogen Storage Disease Type 2b", 0.8273010649608126], ["P16615", "ATP2A2", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Tier 1", 0.947, 1, "A_surface", 15, 85.44, 1, 0, null, null, 0, 0, null, 1, "Darier disease", 0.8223208039299769], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.947, 1, "A_surface", 70, 64.19, 1, 0, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["Q13936", "CACNA1C", "Voltage-dependent L-type calcium channel subunit alpha-1C", "Tier 1", 0.947, 1, "A_surface", 33, 61.94, 1, 0, null, null, 0, 0, null, 1, "Timothy syndrome", 0.8227725490420764], ["P08514", "ITGA2B", "Integrin alpha-IIb", "Positive Control", 0.947, 1, "A_surface", 78, 88.12, 1, 1, "8T2U", "8T2V", 0, 0, null, 1, "Glanzmann thrombasthenia 1", 0.8224288672248264], ["P14770", "GP9", "Platelet glycoprotein IX", "Tier 1.5", 0.947, 1, "A_surface", 2, 84.69, 1, 0, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8233582238860002], ["P02730", "SLC4A1", "Band 3 anion transport protein", "Tier 1", 0.946, 1, "A_surface", 54, 82.12, 1, 0, null, null, 0, 0, null, 1, "hereditary spherocytosis type 4", 0.820137113225454], ["P05106", "ITGB3", "Integrin beta-3", "Positive Control", 0.946, 1, "A_surface", 123, 87.0, 1, 1, "8T2U", "8T2V", 1, 2, "22133781,23544955", 1, "Glanzmann thrombasthenia 1", 0.8208115968652424], ["P08069", "IGF1R", "Insulin-like growth factor 1 receptor", "Tier 1", 0.945, 1, "A_surface", 46, 78.0, 1, 0, null, null, 1, 10, "40997970,39263947,33410883,30041514,23373648,16019422,15231297", 1, "growth delay due to insulin-like growth factor I resistance", 0.8166352227841136], ["P16234", "PDGFRA", "Platelet-derived growth factor receptor alpha", "Tier 1.5", 0.945, 1, "A_surface", 14, 72.69, 1, 0, null, null, 1, 4, "33334063,32127469,28010895,30594071", 1, "gastrointestinal stromal tumor", 0.8167494524079806], ["Q9H3H5", "DPAGT1", "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase", "Tier 1", 0.943, 1, "A_surface", 8, 94.69, 1, 0, null, null, 0, 0, null, 1, "DPAGT1-congenital disorder of glycosylation", 0.8101246300555436], ["Q13563", "PKD2", "Polycystin-2", "Tier 1", 0.943, 1, "A_surface", 31, 70.12, 1, 0, null, null, 1, 3, "41315228,36126144", 1, "polycystic kidney disease 2", 0.810960823768978], ["O75844", "ZMPSTE24", "CAAX prenyl protease 1 homolog", "Tier 1", 0.942, 1, "A_surface", 4, 89.44, 0, 0, null, null, 1, 1, "37565451", 1, "mandibuloacral dysplasia with type B lipodystrophy", 0.8071967390737101]], "truncated": false, "filtered_table_rows_count": 1136, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"surface_class\" = :p0 order by evidence_priority desc limit 51", "params": {"p0": "A_surface"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 799, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 337, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 615, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5", "selected": false}, {"value": "Tier 1", "label": "Tier 1", "count": 519, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "selected": false}, {"value": "Positive Control", "label": "Positive Control", "count": 2, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Positive+Control", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 1133, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 3, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 850, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 286, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface", "results": [{"value": "A_surface", "label": "A_surface", "count": 1136, "toggle_url": "https://apt-scout.org/scout/v_targets.json", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 708, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 428, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 694, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 442, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "activation_state_pdb_active", "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&_facet=activation_state_pdb_active"}, {"name": "activation_state_pdb_inactive", "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&_facet=activation_state_pdb_inactive"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 328.60069582238793, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}