{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where surface_class = \"A_surface\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P33897", "ABCD1", "ATP-binding cassette sub-family D member 1", "Tier 1", 0.96, 1, "A_surface", 14, 80.62, 1, 0, null, null, 0, 0, null, 1, "adrenoleukodystrophy", 0.8656366512509434], ["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.959, 1, "A_surface", 6, 90.25, 1, 0, null, null, 1, 2, "24635113", 1, "chronic granulomatous disease", 0.8633132852459866], ["P21802", "FGFR2", "Fibroblast growth factor receptor 2", "Tier 1", 0.959, 1, "A_surface", 62, 73.94, 0, 0, null, null, 1, 5, "41786503,39759879,31357131,24242861,19212647", 1, "Crouzon syndrome", 0.8637438969881663], ["P78504", "JAG1", "Protein jagged-1", "Tier 1", 0.958, 1, "A_surface", 7, 73.12, 0, 0, null, null, 1, 4, "37338014,37052638,23341879,18673242", 1, "Alagille syndrome due to a JAG1 point mutation", 0.8586542923232751], ["P11166", "SLC2A1", "Solute carrier family 2, facilitated glucose transporter member 1", "Tier 1", 0.956, 1, "A_surface", 5, 90.25, 0, 0, null, null, 1, 2, "39627234,33184583", 1, "encephalopathy due to GLUT1 deficiency", 0.8521823225896756], ["P29965", "CD40LG", "CD40 ligand", "Tier 1", 0.954, 1, "A_surface", 8, 82.62, 1, 0, null, null, 1, 6, "37331977,36203210,26504624", 1, "hyper-IgM syndrome type 1", 0.8451678829647167], ["P11362", "FGFR1", "Fibroblast growth factor receptor 1", "Tier 1", 0.954, 1, "A_surface", 82, 73.88, 0, 0, null, null, 1, 13, "41873087,41820318,40092750,39759879,39249203,37336759,33536494,31583159,31357131,30297602,28442904", 1, "hypogonadotropic hypogonadism 2 with or without anosmia", 0.8472925100660907], ["Q9NQ11", "ATP13A2", "Polyamine-transporting ATPase 13A2", "Tier 1", 0.953, 1, "A_surface", 25, 79.62, 1, 0, null, null, 0, 0, null, 1, "Kufor-Rakeb syndrome", 0.8439049037191295], ["P08581", "MET", "Hepatocyte growth factor receptor", "Tier 1", 0.953, 1, "A_surface", 100, 79.25, 0, 0, null, null, 1, 149, "42012469,41992303,41973478,41873087,41861669,41858296,41848278,41601428,41462891,41391726,41234744,41123956,41084363,41065179,41024479,40954195,40938088,40923343,40840349,40740738,40728393,40640119,40388621,40189053,40116812,40041032,39930702,39853766,39852082,39744222,39735310,39674868,39631842,39586988,39527480,39513807,39355222,39348183,39288204,39087949,38925633,38923378,38876234,38829176,38697444,38515622,38298092,38277932,38230289,38225704,30237882,29416033,26131766", 1, "papillary renal cell carcinoma", 0.84195976263742], ["P06213", "INSR", "Insulin receptor", "Tier 1", 0.953, 1, "A_surface", 87, 77.62, 0, 0, null, null, 1, 14, "33410883,24768638,40603733,37779149,36310231,35478209,29262294,27648925,26387957,26245346,19396447,17167487", 1, "Leprechaunism", 0.8448849372402896], ["Q8WZ42", "TTN", "Titin", "Tier 1", 0.953, 1, "A_surface", 64, null, 0, 0, null, null, 1, 1, "29952259", 1, "dilated cardiomyopathy", 0.8419847660466327], ["P37173", "TGFBR2", "TGF-beta receptor type-2", "Tier 1", 0.952, 1, "A_surface", 22, 81.0, 1, 0, null, null, 1, 8, "32452828,30595527,29522674,29375127,26284552,23999222,22899759,11856769", 1, "Loeys-Dietz syndrome", 0.8390072008866913], ["P35499", "SCN4A", "Sodium channel protein type 4 subunit alpha", "Tier 1", 0.952, 1, "A_surface", 3, 72.44, 1, 0, null, null, 0, 0, null, 1, "paramyotonia congenita of Von Eulenburg", 0.8401628899371881], ["O00571", "DDX3X", "ATP-dependent RNA helicase DDX3X", "Tier 1", 0.951, 1, "A_surface", 17, 72.19, 0, 0, null, null, 0, 0, null, 1, "X-linked non-syndromic intellectual disability", 0.8362533125067105], ["P19438", "TNFRSF1A", "Tumor necrosis factor receptor superfamily member 1A", "Tier 1", 0.951, 1, "A_surface", 13, 71.38, 1, 0, null, null, 1, 1, "35197258", 1, "TNF receptor 1-associated periodic fever syndrome", 0.8352778213184682], ["P54760", "EPHB4", "Ephrin type-B receptor 4", "Tier 1", 0.95, 1, "A_surface", 23, 82.0, 0, 0, null, null, 0, 0, null, 1, "Capillary malformation - arteriovenous malformation", 0.8317426466005666], ["P07359", "GP1BA", "Platelet glycoprotein Ib alpha chain", "Tier 1", 0.95, 1, "A_surface", 22, 64.31, 1, 0, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8346884735388165], ["P06744", "GPI", "Glucose-6-phosphate isomerase", "Tier 1", 0.949, 1, "A_surface", 13, 97.94, 1, 0, null, null, 1, 19, "41911185,41329468,41232387,35821507,34953205,32730952,29501157,27419372,25919296,25483705,24334484,23656757,23578283,23018995,22116094,20967861,17574575,27380815", 1, "hemolytic anemia due to glucophosphate isomerase deficiency", 0.8306909118751346], ["Q9NRA2", "SLC17A5", "Sialin", "Tier 1", 0.949, 1, "A_surface", 7, 84.12, 1, 0, null, null, 0, 0, null, 1, "free sialic acid storage disease, infantile form", 0.8292382821211967], ["P63092", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms short", "Tier 1", 0.948, 1, "A_surface", 100, 91.31, 1, 0, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["Q8WZA1", "POMGNT1", "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "Tier 1", 0.948, 1, "A_surface", 10, 89.88, 0, 0, null, null, 0, 0, null, 1, "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3", 0.826104223872448], ["P36897", "TGFBR1", "TGF-beta receptor type-1", "Tier 1", 0.948, 1, "A_surface", 44, 84.19, 1, 0, null, null, 1, 1, "41089000", 1, "Loeys-Dietz syndrome 1", 0.8275292516338373], ["P36894", "BMPR1A", "Bone morphogenetic protein receptor type-1A", "Tier 1", 0.948, 1, "A_surface", 11, 82.62, 0, 0, null, null, 1, 1, "30537181", 1, "juvenile polyposis syndrome", 0.8278395086688584], ["P22607", "FGFR3", "Fibroblast growth factor receptor 3", "Tier 1", 0.948, 1, "A_surface", 13, 74.19, 1, 0, null, null, 1, 6, "38569854,37704353,34864168,33952673,31357131", 1, "achondroplasia", 0.8270702096931246], ["Q5JWF2", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas", "Tier 1", 0.948, 1, "A_surface", 9, 56.72, 1, 0, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["P16615", "ATP2A2", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Tier 1", 0.947, 1, "A_surface", 15, 85.44, 1, 0, null, null, 0, 0, null, 1, "Darier disease", 0.8223208039299769], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.947, 1, "A_surface", 70, 64.19, 1, 0, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["Q13936", "CACNA1C", "Voltage-dependent L-type calcium channel subunit alpha-1C", "Tier 1", 0.947, 1, "A_surface", 33, 61.94, 1, 0, null, null, 0, 0, null, 1, "Timothy syndrome", 0.8227725490420764], ["P02730", "SLC4A1", "Band 3 anion transport protein", "Tier 1", 0.946, 1, "A_surface", 54, 82.12, 1, 0, null, null, 0, 0, null, 1, "hereditary spherocytosis type 4", 0.820137113225454], ["P08069", "IGF1R", "Insulin-like growth factor 1 receptor", "Tier 1", 0.945, 1, "A_surface", 46, 78.0, 1, 0, null, null, 1, 10, "40997970,39263947,33410883,30041514,23373648,16019422,15231297", 1, "growth delay due to insulin-like growth factor I resistance", 0.8166352227841136], ["Q9H3H5", "DPAGT1", "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase", "Tier 1", 0.943, 1, "A_surface", 8, 94.69, 1, 0, null, null, 0, 0, null, 1, "DPAGT1-congenital disorder of glycosylation", 0.8101246300555436], ["Q13563", "PKD2", "Polycystin-2", "Tier 1", 0.943, 1, "A_surface", 31, 70.12, 1, 0, null, null, 1, 3, "41315228,36126144", 1, "polycystic kidney disease 2", 0.810960823768978], ["O75844", "ZMPSTE24", "CAAX prenyl protease 1 homolog", "Tier 1", 0.942, 1, "A_surface", 4, 89.44, 0, 0, null, null, 1, 1, "37565451", 1, "mandibuloacral dysplasia with type B lipodystrophy", 0.8071967390737101], ["P25942", "CD40", "Tumor necrosis factor receptor superfamily member 5", "Tier 1", 0.941, 1, "A_surface", 14, 81.19, 0, 0, null, null, 1, 8, "41982466,37331977,36203210,33335251,26504624,26231918,23460531,12828856", 1, "hyper-IgM syndrome type 3", 0.8038021669520221], ["P49810", "PSEN2", "Presenilin-2", "Tier 1", 0.941, 1, "A_surface", 2, 71.81, 1, 0, null, null, 0, 0, null, 1, "early-onset autosomal dominant Alzheimer disease", 0.8047686386596943], ["P58335", "ANTXR2", "Anthrax toxin receptor 2", "Tier 1", 0.941, 1, "A_surface", 14, 71.81, 1, 0, null, null, 1, 4, "41503480,41083485,41020397,40313273", 1, "hyaline fibromatosis syndrome", 0.8028849863986661], ["O94766", "B3GAT3", "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3", "Tier 1", 0.94, 1, "A_surface", 3, 92.56, 0, 0, null, null, 0, 0, null, 1, "Larsen-like syndrome, B3GAT3 type", 0.7995331164339264], ["P61073", "CXCR4", "C-X-C chemokine receptor type 4", "Tier 1", 0.94, 1, "A_surface", 33, 82.25, 1, 0, null, null, 1, 17, "40671676,40401615,39865939,39778270,37052638,35157940,33739080,31737891,31267721,31097627,28670693,26265085,25329893,22811524,22376154,12498773,41543187", 1, "WHIM syndrome", 0.8009225456235435], ["Q9H2M9", "RAB3GAP2", "Rab3 GTPase-activating protein non-catalytic subunit", "Tier 1", 0.939, 1, "A_surface", 1, 79.62, 1, 0, null, null, 0, 0, null, 1, "Cataract - intellectual disability - hypogonadism", 0.7977527040203786], ["Q9Y5Y0", "FLVCR1", "Choline/ethanolamine transporter FLVCR1", "Tier 1", 0.938, 1, "A_surface", 8, 77.56, 1, 0, null, null, 0, 0, null, 1, "Posterior column ataxia - retinitis pigmentosa", 0.7932113640677738], ["Q14118", "DAG1", "Dystroglycan 1", "Tier 1", 0.938, 1, "A_surface", 8, 68.19, 0, 0, null, null, 0, 0, null, 1, "autosomal recessive limb-girdle muscular dystrophy type 2P", 0.7935290060634741], ["Q9UPN3", "MACF1", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5", "Tier 1", 0.938, 1, "A_surface", 3, null, 0, 0, null, null, 0, 0, null, 1, "lissencephaly 9 with complex brainstem malformation", 0.7945569032416216], ["P08473", "MME", "Neprilysin", "Tier 1", 0.937, 1, "A_surface", 16, 96.19, 0, 0, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease axonal type 2T", 0.7912653398252156], ["Q9NW15", "ANO10", "Anoctamin-10", "Tier 1", 0.937, 1, "A_surface", 5, 86.12, 1, 0, null, null, 0, 0, null, 1, "autosomal recessive spinocerebellar ataxia 10", 0.7915327777093032], ["P35916", "FLT4", "Vascular endothelial growth factor receptor 3", "Tier 1", 0.937, 1, "A_surface", 2, 72.44, 0, 0, null, null, 0, 0, null, 1, "lymphatic malformation 1", 0.7904355931811005], ["Q16832", "DDR2", "Discoidin domain-containing receptor 2", "Tier 1", 0.936, 1, "A_surface", 5, 75.81, 0, 0, null, null, 1, 1, "26067556", 1, "spondyloepimetaphyseal dysplasia-short limb-abnormal calcification syndrome", 0.7854778386444168], ["Q6PJF5", "RHBDF2", "Inactive rhomboid protein 2", "Tier 1", 0.936, 1, "A_surface", 5, 67.38, 1, 0, null, null, 0, 0, null, 1, "palmoplantar keratoderma-esophageal carcinoma syndrome", 0.7882817956366938], ["O75880", "SCO1", "Cytochrome c oxidase assembly factor SCO1", "Tier 1", 0.935, 1, "A_surface", 10, 77.75, 0, 0, null, null, 0, 0, null, 1, "mitochondrial complex IV deficiency, nuclear type 4", 0.7827872588103603], ["Q9NP58", "ABCB6", "ATP-binding cassette sub-family B member 6", "Tier 1", 0.934, 1, "A_surface", 16, 83.06, 1, 0, null, null, 0, 0, null, 1, "dyschromatosis universalis hereditaria 3", 0.7783407126197405], ["P13987", "CD59", "CD59 glycoprotein", "Tier 1", 0.932, 1, "A_surface", 17, 79.31, 1, 0, null, null, 1, 1, "19915929", 1, "primary CD59 deficiency", 0.7738276843579196]], "truncated": false, "filtered_table_rows_count": 519, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"surface_class\" = :p0 and \"tier\" = :p1 order by evidence_priority desc limit 51", "params": {"p0": "A_surface", "p1": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 511, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 8, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 519, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 519, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 336, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 183, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "results": [{"value": "A_surface", "label": "A_surface", "count": 519, "toggle_url": "https://apt-scout.org/scout/v_targets.json?tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 291, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 228, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 280, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1&has_cryoEM=1", "selected": false}, {"value": 0, "label": 0, "count": 239, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1&has_cryoEM=0", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 397.3083491437137, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}