{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where surface_class = \"A_surface\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P21359", "NF1", "Neurofibromin", "Tier 1.5", 0.965, 1, "A_surface", 26, 87.19, 1, 0, null, null, 1, 2, "32980430,22617876", 1, "neurofibromatosis type 1", 0.8844735398780649], ["P00813", "ADA", "Adenosine deaminase", "Tier 1.5", 0.957, 1, "A_surface", 2, 96.56, 0, 0, null, null, 1, 72, "42012076,41877526,41762796,41635914,40403280,40189053,39856849,39847085,36796307,33998617,32043202,30876536,30060448,27589406,26606306,25597304,25521724,25360869,24976151,24893272,24682016,24035856,23462984,23202335,23037591,22944024,22613226,41910181,41791686,41267360,39673485,39396299,38583236,36855421,34241023,33147453,32546280,30926472,26605646,24624989,23373863,22543727,20345118,19381549,19378312,18293985,17440909,17000903,16856187,16619330", 1, "Severe combined immunodeficiency due to adenosine deaminase deficiency", 0.8556816060494579], ["P36021", "SLC16A2", "Monocarboxylate transporter 8", "Tier 1.5", 0.956, 1, "A_surface", 7, 79.56, 1, 0, null, null, 0, 0, null, 1, "Allan-Herndon-Dudley syndrome", 0.8533069932022032], ["P51795", "CLCN5", "H(+)/Cl(-) exchange transporter 5", "Tier 1.5", 0.955, 1, "A_surface", 2, 80.62, 0, 0, null, null, 0, 0, null, 1, "Dent disease type 1", 0.850724240157394], ["Q14524", "SCN5A", "Sodium channel protein type 5 subunit alpha", "Tier 1.5", 0.953, 1, "A_surface", 16, 67.25, 1, 0, null, null, 0, 0, null, 1, "long QT syndrome 3", 0.8448298602976083], ["Q969N2", "PIGT", "GPI-anchor transamidase component PIGT", "Tier 1.5", 0.953, 1, "A_surface", 3, 87.25, 1, 0, null, null, 0, 0, null, 1, "multiple congenital anomalies-hypotonia-seizures syndrome 3", 0.8439030764005646], ["P13637", "ATP1A3", "Sodium/potassium-transporting ATPase subunit alpha-3", "Tier 1.5", 0.953, 1, "A_surface", 5, 88.81, 1, 0, null, null, 0, 0, null, 1, "alternating hemiplegia of childhood 2", 0.842328126568451], ["Q99250", "SCN2A", "Sodium channel protein type 2 subunit alpha", "Tier 1.5", 0.952, 1, "A_surface", 5, 68.81, 1, 0, null, null, 0, 0, null, 1, "developmental and epileptic encephalopathy, 11", 0.8388748085806758], ["P25189", "MPZ", "Myelin protein P0", "Tier 1.5", 0.951, 1, "A_surface", 2, 81.69, 0, 0, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease type 1B", 0.8377022197539885], ["Q9HAB3", "SLC52A2", "Solute carrier family 52, riboflavin transporter, member 2", "Tier 1.5", 0.95, 1, "A_surface", 1, 84.12, 1, 0, null, null, 0, 0, null, 1, "riboflavin transporter deficiency", 0.8333271825486935], ["Q9Y653", "ADGRG1", "Adhesion G-protein coupled receptor G1", "Tier 1.5", 0.95, 1, "A_surface", 1, 77.88, 1, 0, null, null, 0, 0, null, 1, "bilateral frontoparietal polymicrogyria", 0.8322298896713178], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.949, 1, "A_surface", 11, 75.94, 0, 0, null, null, 1, 6, "41733039,34364920,31434881,30237882,29299123,22411871", 1, "acute myeloid leukemia", 0.8313389209288576], ["P13473", "LAMP2", "Lysosome-associated membrane glycoprotein 2", "Tier 1.5", 0.948, 1, "A_surface", 2, 83.19, 0, 0, null, null, 0, 0, null, 1, "Glycogen Storage Disease Type 2b", 0.8273010649608126], ["P14770", "GP9", "Platelet glycoprotein IX", "Tier 1.5", 0.947, 1, "A_surface", 2, 84.69, 1, 0, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8233582238860002], ["P16234", "PDGFRA", "Platelet-derived growth factor receptor alpha", "Tier 1.5", 0.945, 1, "A_surface", 14, 72.69, 1, 0, null, null, 1, 4, "33334063,32127469,28010895,30594071", 1, "gastrointestinal stromal tumor", 0.8167494524079806], ["P51798", "CLCN7", "H(+)/Cl(-) exchange transporter 7", "Tier 1.5", 0.942, 1, "A_surface", 9, 80.94, 1, 0, null, null, 0, 0, null, 1, "Autosomal recessive malignant osteopetrosis", 0.8065499095904218], ["Q96JI7", "SPG11", "Spatacsin", "Tier 1.5", 0.937, 1, "A_surface", 3, 66.75, 1, 0, null, null, 0, 0, null, 1, "Autosomal recessive spastic paraplegia type 11", 0.7886006646085494], ["Q8TD43", "TRPM4", "Transient receptor potential cation channel subfamily M member 4", "Tier 1.5", 0.936, 1, "A_surface", 25, 77.44, 1, 0, null, null, 0, 0, null, 1, "Familial progressive cardiac conduction defect", 0.7868180621357534], ["P05023", "ATP1A1", "Sodium/potassium-transporting ATPase subunit alpha-1", "Tier 1.5", 0.936, 1, "A_surface", 10, 88.69, 1, 0, null, null, 0, 0, null, 1, "Charcot-Marie-tooth disease, axonal, type 2DD", 0.7868851290226483], ["P04626", "ERBB2", "Receptor tyrosine-protein kinase erbB-2", "Tier 1.5", 0.934, 1, "A_surface", 63, 74.0, 0, 0, null, null, 1, 119, "41836728,41744190,41540559,41494763,41413339,41321156,41297941,40851486,40761795,40494827,40403699,40382399,40223744,40220375,40120226,40080161,40056884,39873777,39809083,39756158,39748051,39643321,39609809,39539244,39263860,39233482,39177424,38901393,38813974,38789508,38693181,38679242,38604040,38409854,38066021,37729138,37659641,37591183,37522239,37392577,37038354,36272296,36255496,36001395,35504229,34952586,34476602,34236165,33876310,33627408", 1, "non-small cell lung carcinoma", 0.7789523142843545], ["P15529", "CD46", "Membrane cofactor protein", "Tier 1.5", 0.934, 1, "A_surface", 7, 82.12, 1, 0, null, null, 1, 9, "35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032", 1, "atypical hemolytic-uremic syndrome with MCP/CD46 anomaly", 0.7798469882597787], ["O94856", "NFASC", "Neurofascin", "Tier 1.5", 0.933, 1, "A_surface", 2, 76.31, 0, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with central and peripheral motor dysfunction", 0.7782432580663833], ["Q15746", "MYLK", "Myosin light chain kinase, smooth muscle", "Tier 1.5", 0.93, 1, "A_surface", 7, 65.88, 0, 0, null, null, 0, 0, null, 1, "aortic aneurysm, familial thoracic 7", 0.7659842793171938], ["Q02094", "RHAG", "Ammonium transporter Rh type A", "Tier 1.5", 0.929, 1, "A_surface", 8, 95.62, 1, 0, null, null, 0, 0, null, 1, "Rh deficiency syndrome", 0.764209214915708], ["P00846", "MT-ATP6", "ATP synthase F(0) complex subunit a", "Tier 1.5", 0.928, 1, "A_surface", 10, 88.94, 1, 0, null, null, 0, 0, null, 1, "NARP syndrome", 0.760749518172638], ["P24394", "IL4R", "Interleukin-4 receptor subunit alpha", "Tier 1.5", 0.923, 1, "A_surface", 10, 54.75, 0, 0, null, null, 1, 3, "32751068,27819142,22282665", 1, "asthma", 0.742115080702623], ["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.921, 1, "A_surface", 7, 77.88, 1, 0, null, null, 1, 17, "40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027", 1, "autoimmune lymphoproliferative syndrome type 1", 0.7377210386590284], ["P16671", "CD36", "Platelet glycoprotein 4", "Tier 1.5", 0.921, 1, "A_surface", 1, 93.94, 0, 0, null, null, 1, 6, "41713143,41140242,39762152,33596054,33291667,31904170", 1, "platelet-type bleeding disorder 10", 0.7360571429413174], ["Q02413", "DSG1", "Desmoglein-1", "Tier 1.5", 0.92, 1, "A_surface", 1, 62.06, 0, 0, null, null, 0, 0, null, 1, "severe dermatitis-multiple allergies-metabolic wasting syndrome", 0.7335328506238418], ["P09758", "TACSTD2", "Tumor-associated calcium signal transducer 2", "Tier 1.5", 0.919, 1, "A_surface", 7, 82.69, 0, 0, null, null, 1, 4, "41384307,41241473,40050871,39250993", 1, "gelatinous drop-like corneal dystrophy", 0.7293087728162646], ["O15554", "KCNN4", "Intermediate conductance calcium-activated potassium channel protein 4", "Tier 1.5", 0.914, 1, "A_surface", 17, 84.19, 1, 0, null, null, 0, 0, null, 1, "dehydrated hereditary stomatocytosis", 0.7145864899974032], ["O75110", "ATP9A", "Probable phospholipid-transporting ATPase IIA", "Tier 1.5", 0.914, 1, "A_surface", 4, 84.19, 1, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with poor growth and behavioral abnormalities", 0.7120328673255018], ["Q9NR82", "KCNQ5", "Potassium voltage-gated channel subfamily KQT member 5", "Tier 1.5", 0.913, 1, "A_surface", 5, 56.41, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 46", 0.7086662845211597], ["P08637", "FCGR3A", "Low affinity immunoglobulin gamma Fc region receptor III-A", "Tier 1.5", 0.912, 1, "A_surface", 15, 85.69, 0, 0, null, null, 1, 2, "41249026,21531729", 1, "autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity", 0.7061437347032623], ["P51797", "CLCN6", "H(+)/Cl(-) exchange transporter 6", "Tier 1.5", 0.897, 1, "A_surface", 3, 77.81, 1, 0, null, null, 0, 0, null, 1, "neurodegeneration, childhood-onset, with hypotonia, respiratory insufficiency, and brain imaging abnormalities", 0.6554030932062199], ["P21731", "TBXA2R", "Thromboxane A2 receptor", "Tier 1.5", 0.892, 1, "A_surface", 6, 86.25, 1, 0, null, null, 0, 0, null, 1, "bleeding diathesis due to thromboxane synthesis deficiency", 0.639967145559869], ["Q13555", "CAMK2G", "Calcium/calmodulin-dependent protein kinase type II subunit gamma", "Tier 1.5", 0.891, 1, "A_surface", 2, 78.38, 0, 0, null, null, 0, 0, null, 1, "intellectual developmental disorder 59", 0.6354497016986491], ["P02786", "TFRC", "Transferrin receptor protein 1", "Tier 1.5", 0.887, 1, "A_surface", 22, 86.69, 1, 0, null, null, 1, 3, "39831311,29046922,32527800", 1, "TFRC-related combined immunodeficiency", 0.623449899069336], ["P54709", "ATP1B3", "Sodium/potassium-transporting ATPase subunit beta-3", "Tier 1.5", 0.88, 1, "A_surface", 7, 89.69, 1, 0, null, null, 0, 0, null, 1, "congestive heart failure", 0.5999952111132625], ["Q92956", "TNFRSF14", "Tumor necrosis factor receptor superfamily member 14", "Tier 1.5", 0.879, 1, "A_surface", 8, 79.94, 0, 0, null, null, 0, 0, null, 1, "diffuse large B-cell lymphoma", 0.5983171413833771], ["P01597", "IGKV1-39", "Immunoglobulin kappa variable 1-39", "Tier 1.5", 0.876, 1, "A_surface", 2, 90.5, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P01764", "IGHV3-23", "Immunoglobulin heavy variable 3-23", "Tier 1.5", 0.876, 1, "A_surface", 6, 91.0, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P01825", "IGHV4-59", "Immunoglobulin heavy variable 4-59", "Tier 1.5", 0.876, 1, "A_surface", 3, 91.56, 1, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P23083", "IGHV1-2", "Immunoglobulin heavy variable 1-2", "Tier 1.5", 0.876, 1, "A_surface", 1, 91.75, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P01593", "IGKV1D-33", "Immunoglobulin kappa variable 1D-33", "Tier 1.5", 0.876, 1, "A_surface", 6, 90.88, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P06312", "IGKV4-1", "Immunoglobulin kappa variable 4-1", "Tier 1.5", 0.876, 1, "A_surface", 10, 90.62, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P15954", "COX7C", "Cytochrome c oxidase subunit 7C, mitochondrial", "Tier 1.5", 0.868, 1, "A_surface", 3, 91.38, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5589133210585959], ["P41440", "SLC19A1", "Reduced folate transporter", "Tier 1.5", 0.866, 1, "A_surface", 19, 72.06, 1, 0, null, null, 0, 0, null, 1, "Knobloch syndrome", 0.5526223217595396], ["Q96D96", "HVCN1", "Voltage-gated hydrogen channel 1", "Tier 1.5", 0.865, 1, "A_surface", 2, 69.75, 0, 0, null, null, 0, 0, null, 1, "Joubert syndrome", 0.5504227269701596], ["Q9P1W8", "SIRPG", "Signal-regulatory protein gamma", "Tier 1.5", 0.864, 1, "A_surface", 2, 85.5, 0, 0, null, null, 0, 0, null, 1, "type 1 diabetes mellitus", 0.5457344827318543]], "truncated": false, "filtered_table_rows_count": 615, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"surface_class\" = :p0 and \"tier\" = :p1 order by evidence_priority desc limit 51", "params": {"p0": "A_surface", "p1": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 329, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 286, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 615, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 614, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 513, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 102, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5", "results": [{"value": "A_surface", "label": "A_surface", "count": 615, "toggle_url": "https://apt-scout.org/scout/v_targets.json?tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 417, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 198, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 455, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 160, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 321.7052551917732, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}