apt-scout — Human Verification Worksheet

45 targets (stratified: controls + activation pairs + Tier 1 + Tier 1.5). Click each source link, confirm the value matches, mark ✔/✗.
How to use: For each row, open the source links (UniProt / AlphaFold / PDB / PubMed / HPA / OpenTargets) and confirm apt-scout's value matches the source. Mark the ✔ columns OK or WRONG. Focus on activation pair: open both PDB structures and confirm one is the ACTIVE and the other the INACTIVE conformation. Two reviewers on a shared subset → compute inter-rater κ for the paper.
#UniProtTier#PDB→verifypLDDTActivePDB→verifyInactivePDB→verifyAptamer PubMed→PMIDsTopDisease (score)→verify✔ structure?✔ activation pair?✔ disease?note
1P08514Positive Control78   AlphaFold88.18T2U8T2V0   Glanzmann thrombasthenia 1 (0.82)   OpenTargets
2P05106Positive Control123   AlphaFold87.08T2U8T2V2   22133781, 23544955Glanzmann thrombasthenia 1 (0.82)   OpenTargets
3P60709Negative Control30   AlphaFold95.2——3   40413753, 38783134, 34598060Baraitser-Winter syndrome 1 (0.82)   OpenTargets
4O14965Tier 1100   AlphaFold75.11OL51MUO2   39776073, 39776073neurodegenerative disease (0.52)   OpenTargets
5P00519Tier 185   AlphaFold63.42GQG1OPL5   31295447, 23836560, 22411871, 21810089chronic myelogenous leukemia (0.82)   OpenTargets
6P01112Tier 1100   AlphaFold91.95P214Q210   Costello syndrome (0.88)   OpenTargets
7P01116Tier 1100   AlphaFold91.56GOD6MNX21   41132421, 40824107, 40766128, 40148451Noonan syndrome 3 (0.83)   OpenTargets
8P06756Tier 1.50   AlphaFold88.31L5G1JV28   27693080, 31361124, 28191852, 27693080neurodegenerative disease (0.42)   OpenTargets
9P11802Tier 115   AlphaFold86.82W963G332   41535871, 21059336melanoma, cutaneous malignant, susceptibility to, 3 (0.71)   OpenTargets
10A0A075B5G3Tier 11   AlphaFold82.8——0   (—)  
11O15382Tier 130   AlphaFold93.1——1   41255424hypervalinemia and hyperleucine-isoleucinemia (0.68)   OpenTargets
12O94760Tier 114   AlphaFold95.6——0   seborrheic keratosis (0.33)   OpenTargets
13P04075Tier 18   AlphaFold96.4——0   glycogen storage disease due to aldolase A deficiency (0.83)   OpenTargets
14P0CG48Tier 1100   AlphaFold88.6——9   35120890, 34469713, 31451750, 31261719HIV infection (0.57)   OpenTargets
15P17947Tier 135   AlphaFold65.5——0   agammaglobulinemia 10, autosomal dominant (0.72)   OpenTargets
16P28161Tier 111   AlphaFold98.5——0   neurodegenerative disease (0.37)   OpenTargets
17P41235Tier 18   AlphaFold73.9——1   37016361MODY (0.83)   OpenTargets
18P51681Tier 125   AlphaFold85.4——23   36576612, 33981364, 29678881, 29556342HIV infection (0.74)   OpenTargets
19P62841Tier 10   AlphaFold86.4——0   influenza (0.46)   OpenTargets
20Q08AG7Tier 126   AlphaFold92.2——0   frozen shoulder (0.28)   OpenTargets
21Q15047Tier 126   AlphaFold65.1——1   41498743acute myeloid leukemia (0.25)   OpenTargets
22Q63ZY3Tier 13   AlphaFold60.1——0   nephrotic syndrome 16 (0.61)   OpenTargets
23Q8IZD2Tier 13   AlphaFold44.0——0   O'Donnell-Luria-Rodan syndrome (0.79)   OpenTargets
24Q969U7Tier 113   AlphaFold92.5——0   proteasome-associated autoinflammatory syndrome 4 (0.51)   OpenTargets
25Q9BSE4Tier 11   AlphaFold60.6——0   hidradenitis (0.33)   OpenTargets
26Q9HD40Tier 17   AlphaFold92.8——0   pontocerebellar hypoplasia type 2D (0.76)   OpenTargets
27Q9UI09Tier 17   AlphaFold95.9——0   mitochondrial complex I deficiency, nuclear type 23 (0.75)   OpenTargets
28A0A087X1C5Tier 1.50   AlphaFold91.0——0   (—)   OpenTargets
29O15259Tier 1.52   AlphaFold75.9——0   nephronophthisis 1 (0.81)   OpenTargets
30O75677Tier 1.50   AlphaFold84.6——0   coronary atherosclerosis (0.31)   OpenTargets
31P04628Tier 1.50   AlphaFold85.9——0   osteogenesis imperfecta (0.69)   OpenTargets
32P17096Tier 1.55   AlphaFold65.0——4   41871245, 31538905, 20961861, 19956671HIV infection (0.58)   OpenTargets
33P35573Tier 1.51   AlphaFold92.8——0   glycogen storage disease III (0.83)   OpenTargets
34P53701Tier 1.50   AlphaFold77.3——3   35429769, 30122918, 29675356Microphthalmia with linear skin defects syndrome (0.80)   OpenTargets
35Q02985Tier 1.50   AlphaFold91.8——0   macular degeneration (0.45)   OpenTargets
36Q14CN4Tier 1.50   AlphaFold70.6——0   neurodegenerative disease (0.28)   OpenTargets
37Q53RT3Tier 1.50   AlphaFold69.7——0   ichthyosis, lamellar, autosomal dominant (0.62)   OpenTargets
38Q6P3W7Tier 1.50   AlphaFold———0   (—)  
39Q7Z5W3Tier 1.50   AlphaFold———0   (—)  
40Q8IYX4Tier 1.50   AlphaFold———0   (—)  
41Q8NHH9Tier 1.50   AlphaFold84.1——0   neurodegenerative disease (0.53)   OpenTargets
42Q92796Tier 1.50   AlphaFold———0   (—)  
43Q96LA8Tier 1.50   AlphaFold———0   (—)  
44Q9GZX6Tier 1.56   AlphaFold88.1——7   34208021, 33869115, 28942363, 26792955atopic eczema (0.56)   OpenTargets
45Q9P003Tier 1.50   AlphaFold92.9——0   smoking initiation (0.35)   OpenTargets

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