Activation-state-selective targets

Targets with a curated ACTIVE vs INACTIVE PDB pair. Click the PDB IDs to verify at RCSB.

Custom SQL query returning 11 rows (hide) 

SELECT id, gene_symbol, protein_name, activation_state_pdb_active, activation_state_pdb_inactive, opentargets_top_disease_name, priority_score FROM v_targets WHERE has_activation_state_pdb_pair=1 ORDER BY priority_score DESC

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idgene_symbolprotein_nameactivation_state_pdb_activeactivation_state_pdb_inactiveopentargets_top_disease_namepriority_score
P05106 ITGB3 Integrin beta-3 8T2U 8T2V Glanzmann thrombasthenia 1 0.715
P11802 CDK4 Cyclin-dependent kinase 4 2W96 3G33 melanoma, cutaneous malignant, susceptibility to, 3 0.575
P06756 ITGAV Integrin alpha-V 1L5G 1JV2 neurodegenerative disease 0.572
P08514 ITGA2B Integrin alpha-IIb 8T2U 8T2V Glanzmann thrombasthenia 1 0.515
P00519 ABL1 Tyrosine-protein kinase ABL1 2GQG 1OPL chronic myelogenous leukemia 0.0
P01112 HRAS GTPase HRas 5P21 4Q21 Costello syndrome 0.0
P01116 KRAS GTPase KRas 6GOD 6MNX Noonan syndrome 3 0.0
P12931 SRC Proto-oncogene tyrosine-protein kinase Src 1Y57 2SRC cancer 0.0
P24941 CDK2 Cyclin-dependent kinase 2 1QMZ 1HCK neurodegenerative disease 0.0
P31749 AKT1 RAC-alpha serine/threonine-protein kinase 4EJN 3O96 Proteus syndrome 0.0
O14965 AURKA Aurora kinase A 1OL5 1MUO neurodegenerative disease