apt‑scout

Which protein target should you raise an aptamer or antibody against — and can you hit a specific functional state? apt‑scout answers this for ~7,183 human proteins by pulling structure, modification, interaction, expression and disease evidence into one comparable, provenance‑tracked profile.

7,177targets profiled
5evidence layers
~330active/inactive structure pairs
1,472with known aptamers
Try: P05106 · integrin β3 P00519 · ABL1 P01112 · HRAS Browse all →

What can you do with apt-scout?

1 Target a specific functional state Find proteins with a curated ACTIVE vs INACTIVE PDB pair, so you can design a reagent that binds only one conformation. e.g. activated integrin αIIbβ3 — 8T2U (active) vs 8T2V (inactive). See state-selective targets → 2 Pick an EV / liquid-biopsy biomarker target Filter to extracellular-vesicle proteins (Vesiclepedia / ExoCarta / EV‑Map) that already have aptamer evidence — a shortlist for capture / depletion reagents. See EV targets with aptamers → 3 Prioritise a tractable target fast Rank by a composite score combining structural readiness, existing reagents and disease relevance — so you don't sink months into an intractable target. See top-priority targets →

Who it's for: aptamer / antibody engineers choosing a target · EV & liquid-biopsy biomarker researchers · structural biologists pursuing conformation-selective binders.

The five evidence layers (per target)

1 · StructurePDB count, resolution, AlphaFold pLDDT, cryo-EM, active/inactive pairs (PDB, AlphaFold, EMDB)
2 · ModificationPTM counts; activation-state structure pairs (UniProt; curated PDB list)
3 · InteractionInteractions, drugs, known aptamers & antibodies (Open Targets, ChEMBL, PubMed, Aptagen, HPA)
4 · ExpressionTissue expression; EV-proteome membership (Human Protein Atlas, Vesiclepedia, ExoCarta, EV-Map)
5 · DiseaseDisease associations & scores (Open Targets)

Trust & verify

Every value is mechanically harvested from a public database and the raw source record is stored per target. UniProt accessions and PDB IDs are clickable straight to the source — check anything in two clicks.

Open the human verification worksheet → CSV All tables & SQL / JSON API

Transparent limitations: ppi_count pending; OMIM/ClinVar blank in this snapshot; pLDDT missing for 653 targets; data-quality audit (incl. inter-rater verification) in progress. License CC BY 4.0 · E. Dohi, NCNP.