aptamer_costructures: 10

114 experimental aptamer-protein co-structures: demonstrated cases that an aptamer CAN bind a given protein (binding-site precedent). Empirical evidence of aptamer-amenability. Note: aptamers (anionic backbone) strongly favour basic/positive protein interfaces - of 111 computable co-structure interfaces ~103 positive / 5 neutral / 3 negative (preliminary analysis, E. Dohi 2026); acidic/negative epitopes have essentially no electrostatic precedent and are better addressed by small-molecule or modified-aptamer approaches.

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rowid	pdb_id	title	keywords	resolution_A	pmid	doi	experimental_method
10	1ULL	RNA APTAMER COMPLEXED WITH HIV-1 REV PEPTIDE, NMR, 7 STRUCTURES	REV PEPTIDE-RNA RECOGNITION, ALPHA-HELIX IN WIDENED RNA MAJOR GROOVE, PURINE-PURINE MISMATCHES, UAU BASE TRIPLE, ADAPTIVE BINDING OF PEPTIDE AND RNA IN COMPLEX, COMPLEX (RNA APTAMER-REV PEPTIDE), Viral protein-RNA COMPLEX				SOLUTION NMR