aptamer_costructures: 11

114 experimental aptamer-protein co-structures: demonstrated cases that an aptamer CAN bind a given protein (binding-site precedent). Empirical evidence of aptamer-amenability. Note: aptamers (anionic backbone) strongly favour basic/positive protein interfaces - of 111 computable co-structure interfaces ~103 positive / 5 neutral / 3 negative (preliminary analysis, E. Dohi 2026); acidic/negative epitopes have essentially no electrostatic precedent and are better addressed by small-molecule or modified-aptamer approaches.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

This data as json

rowid	pdb_id	title	keywords	resolution_A	pmid	doi	experimental_method
11	2RSK	RNA aptamer against prion protein in complex with the partial binding peptide	Aptamer, Prion, RNA, Alzheimer's disease, Membrane Protein-RNA complex				SOLUTION NMR