aptamer_costructures: 13

114 experimental aptamer-protein co-structures: demonstrated cases that an aptamer CAN bind a given protein (binding-site precedent). Empirical evidence of aptamer-amenability. Note: aptamers (anionic backbone) strongly favour basic/positive protein interfaces - of 111 computable co-structure interfaces ~103 positive / 5 neutral / 3 negative (preliminary analysis, E. Dohi 2026); acidic/negative epitopes have essentially no electrostatic precedent and are better addressed by small-molecule or modified-aptamer approaches.

This data as json

rowid	pdb_id	title	keywords	resolution_A	pmid	doi	experimental_method
13	9GXH	Nanobody bound to TBA G-quadruplex	G-quadruplex, DNA, thrombin, nanobody, thrombin-binding aptamer, TBA, IMMUNE SYSTEM	1.9			X-RAY DIFFRACTION