aptamer_costructures: 17

114 experimental aptamer-protein co-structures: demonstrated cases that an aptamer CAN bind a given protein (binding-site precedent). Empirical evidence of aptamer-amenability. Note: aptamers (anionic backbone) strongly favour basic/positive protein interfaces - of 111 computable co-structure interfaces ~103 positive / 5 neutral / 3 negative (preliminary analysis, E. Dohi 2026); acidic/negative epitopes have essentially no electrostatic precedent and are better addressed by small-molecule or modified-aptamer approaches.

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rowid	pdb_id	title	keywords	resolution_A	pmid	doi	experimental_method
17	5HTO	Crystal structure of Plasmodium Vivax LDH in complex with a DNA aptamer called pL1 (tetrameric LDH in an asymmetric unit)	LDH, malaria, DNA aptamer, aptamer, structural element, OXIDOREDUCTASE-DNA complex	1.9			X-RAY DIFFRACTION