aptamer_costructures: 19

114 experimental aptamer-protein co-structures: demonstrated cases that an aptamer CAN bind a given protein (binding-site precedent). Empirical evidence of aptamer-amenability. Note: aptamers (anionic backbone) strongly favour basic/positive protein interfaces - of 111 computable co-structure interfaces ~103 positive / 5 neutral / 3 negative (preliminary analysis, E. Dohi 2026); acidic/negative epitopes have essentially no electrostatic precedent and are better addressed by small-molecule or modified-aptamer approaches.

This data as json

rowid	pdb_id	title	keywords	resolution_A	pmid	doi	experimental_method
19	4Q9Q	Crystal structure of an RNA aptamer bound to bromo-ligand analog in complex with Fab	G-quadruplex, Fluorescence, Fluorophore, RNA	2.45			X-RAY DIFFRACTION