aptamer_costructures: 2

114 experimental aptamer-protein co-structures: demonstrated cases that an aptamer CAN bind a given protein (binding-site precedent). Empirical evidence of aptamer-amenability. Note: aptamers (anionic backbone) strongly favour basic/positive protein interfaces - of 111 computable co-structure interfaces ~103 positive / 5 neutral / 3 negative (preliminary analysis, E. Dohi 2026); acidic/negative epitopes have essentially no electrostatic precedent and are better addressed by small-molecule or modified-aptamer approaches.

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rowid	pdb_id	title	keywords	resolution_A	pmid	doi	experimental_method
2	9I0V	Crystal structure of DasR in complex with a synthetic DasR-binding RNA aptamer	Bacterial repressor GntR-HutC family member Synthetic RNA aptamer SELEX-derived aptamer, RNA BINDING PROTEIN	2.02			X-RAY DIFFRACTION