aptamer_costructures: 26

114 experimental aptamer-protein co-structures: demonstrated cases that an aptamer CAN bind a given protein (binding-site precedent). Empirical evidence of aptamer-amenability. Note: aptamers (anionic backbone) strongly favour basic/positive protein interfaces - of 111 computable co-structure interfaces ~103 positive / 5 neutral / 3 negative (preliminary analysis, E. Dohi 2026); acidic/negative epitopes have essentially no electrostatic precedent and are better addressed by small-molecule or modified-aptamer approaches.

This data as json

rowid	pdb_id	title	keywords	resolution_A	pmid	doi	experimental_method
26	6SY6	TetR in complex with the TetR-binding RNA-aptamer K2	TetR, transcription regulator, aptamer, RNA, DNA BINDING PROTEIN	2.9			X-RAY DIFFRACTION