aptamer_costructures: 38

114 experimental aptamer-protein co-structures: demonstrated cases that an aptamer CAN bind a given protein (binding-site precedent). Empirical evidence of aptamer-amenability. Note: aptamers (anionic backbone) strongly favour basic/positive protein interfaces - of 111 computable co-structure interfaces ~103 positive / 5 neutral / 3 negative (preliminary analysis, E. Dohi 2026); acidic/negative epitopes have essentially no electrostatic precedent and are better addressed by small-molecule or modified-aptamer approaches.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

This data as json

rowid	pdb_id	title	keywords	resolution_A	pmid	doi	experimental_method
38	4WB2	Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a complement anaphylatoxin	protein-RNA complex, mirror-image aptamer, G-quadruplex, complement anaphylatoxin, DNA-RNA hybrid	1.8			X-RAY DIFFRACTION