aptamer_costructures: 4

114 experimental aptamer-protein co-structures: demonstrated cases that an aptamer CAN bind a given protein (binding-site precedent). Empirical evidence of aptamer-amenability. Note: aptamers (anionic backbone) strongly favour basic/positive protein interfaces - of 111 computable co-structure interfaces ~103 positive / 5 neutral / 3 negative (preliminary analysis, E. Dohi 2026); acidic/negative epitopes have essentially no electrostatic precedent and are better addressed by small-molecule or modified-aptamer approaches.

This data as json

rowid	pdb_id	title	keywords	resolution_A	pmid	doi	experimental_method
4	4PDB	CRYSTAL STRUCTURE OF BACILLUS ANTHRACIS RIBOSOMAL PROTEIN S8 IN COMPLEX WITH AN RNA APTAMER	PROTEIN-RNA COMPLEX SELEX BASE TRIPLE TRANSLATION, RIBOSOMAL PROTEIN-RNA complex	2.6			X-RAY DIFFRACTION