aptamer_costructures: 7

114 experimental aptamer-protein co-structures: demonstrated cases that an aptamer CAN bind a given protein (binding-site precedent). Empirical evidence of aptamer-amenability. Note: aptamers (anionic backbone) strongly favour basic/positive protein interfaces - of 111 computable co-structure interfaces ~103 positive / 5 neutral / 3 negative (preliminary analysis, E. Dohi 2026); acidic/negative epitopes have essentially no electrostatic precedent and are better addressed by small-molecule or modified-aptamer approaches.

This data as json

rowid	pdb_id	title	keywords	resolution_A	pmid	doi	experimental_method
7	3HXQ	Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding	ARC1779, VWF, Platelet Glycoprotein Ib, Aptamer, ARC1772, Blood coagulation, Cell adhesion, Cleavage on pair of basic residues, Disease mutation, Disulfide bond, Extracellular matrix, Glycoprotein, Hemostasis, Isopeptide bond, Secreted, von Willebrand disease, BLOOD CLOTTING-BLOOD CLOTTING REGULATOR COMPLEX	2.694			X-RAY DIFFRACTION