EV-Map conserved proteome (Rai & Greening 2025)

The complete EV-Map conserved molecular signature (Rai & Greening 2025, Nat Cell Biol 10.1038/s41556-025-01795-7): 182 conserved EV-hallmark proteins + 42 non-EV (lipoprotein-network) proteins. in_apt_scout = 1 if the protein is an apt-scout target (104 of the 182 EV-hallmark + 25 of the 42 non-EV are; the rest are reference-only, outside apt-scout's target universe). Source: paper Supplementary Table 7.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

gene_name
Gene symbol.
feature
EV-hallmark (conserved EV) or non-EV (lipoprotein-network).
category
EV-Map conservation category (1/2/3/Rest).
in_apt_scout
1 if this protein is an apt-scout target.
apt_scout_uniprot
apt-scout target UniProt (if in_apt_scout=1).

104 rows where category = "Category 1", feature = "EV-hallmark" and in_apt_scout = 1

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in_apt_scout 1

feature 1

  • EV-hallmark · 104 ✖

category 1

  • Category 1 · 104 ✖
Link rowid ▼ gene_name feature category misev_marker entrezgene_id pevs_median in_apt_scout apt_scout_uniprot
1 1 YWHAZ EV-hallmark Category 1   7534 28.45468418 1 P63104
2 2 YWHAH EV-hallmark Category 1   7533 25.13893447 1 Q04917
3 3 YWHAE EV-hallmark Category 1   7531 25.27100806 1 P62258
6 6 VCP EV-hallmark Category 1   7415 25.33415684 1 P55072
7 7 VCL EV-hallmark Category 1   7414 28.01670384 1 P18206
8 8 VASP EV-hallmark Category 1   7408 24.67483149 1 P50552
9 9 TXN EV-hallmark Category 1   7295 23.66868868 1 P10599
10 10 TUBB1 EV-hallmark Category 1   81027 27.9398276 1 Q9H4B7
14 14 THBS1 EV-hallmark Category 1   7057 28.68547501 1 P07996
15 15 TFRC EV-hallmark Category 1   7037 26.00470107 1 P02786
17 17 TAGLN2 EV-hallmark Category 1   8407 25.91603631 1 P37802
18 18 STXBP2 EV-hallmark Category 1   6813 25.41292757 1 Q15833
19 19 STX7 EV-hallmark Category 1   8417 24.21802859 1 O15400
21 21 STEAP3 EV-hallmark Category 1   55240 23.91589282 1 Q658P3
22 22 SRC EV-hallmark Category 1   6714 24.88760814 1 P12931
23 23 SPTA1 EV-hallmark Category 1   6708 25.81147463 1 P02549
24 24 SOD2 EV-hallmark Category 1   6648 25.1545267 1 P04179
25 25 SNAP23 EV-hallmark Category 1   8773 23.74082625 1 O00161
26 26 SLC4A1 EV-hallmark Category 1   6521 29.41994604 1 P02730
28 28 SLC2A3 EV-hallmark Category 1   6515 25.62146728 1 P11169
29 29 SLC2A1 EV-hallmark Category 1   6513 26.64195033 1 P11166
38 38 SDCBP EV-hallmark Category 1   6386 23.05441285 1 O00560
39 39 S100A9 EV-hallmark Category 1   6280 24.30169775 1 P06702
40 40 S100A8 EV-hallmark Category 1   6279 23.74222506 1 P05109
41 41 RSU1 EV-hallmark Category 1   6251 26.07493689 1 Q15404
42 42 RPS27A EV-hallmark Category 1   6233 25.79577986 1 P62979
43 43 RHOA EV-hallmark Category 1   387 24.33077011 1 P61586
45 45 RAP1B EV-hallmark Category 1   5908 28.4733278 1 P61224
46 46 RAN EV-hallmark Category 1   5901 22.8753578 1 P62826
47 47 RAC1 EV-hallmark Category 1   5879 25.37625276 1 P63000
49 49 RAB27B EV-hallmark Category 1   5874 25.03630892 1 O00194
51 51 PTPRJ EV-hallmark Category 1   5795 24.26575206 1 Q12913
52 52 PTPRC EV-hallmark Category 1   5788 23.56840014 1 P08575
53 53 PSMA7 EV-hallmark Category 1   5688 23.19270288 1 O14818
54 54 PSMA5 EV-hallmark Category 1   5686 22.26214849 1 P28066
55 55 PSMA1 EV-hallmark Category 1   5682 22.52368987 1 P25786
56 56 PROS1 EV-hallmark Category 1   5627 28.6708111 1 P07225
59 59 PRDX2 EV-hallmark Category 1   7001 25.4300557 1 P32119
60 60 PPIA EV-hallmark Category 1   5478 27.02909784 1 P62937
61 61 PPBP EV-hallmark Category 1   5473 27.5329792 1 P02775
64 64 PKM EV-hallmark Category 1   5315 26.47931588 1 P14618
65 65 PIGR EV-hallmark Category 1   5284 27.55104355 1 P01833
67 67 PGK1 EV-hallmark Category 1   5230 25.27297175 1 P00558
68 68 PFN1 EV-hallmark Category 1   5216 27.19337044 1 P07737
69 69 PFKP EV-hallmark Category 1   5214 23.19368765 1 Q01813
72 72 PDCD6IP EV-hallmark Category 1   10015 23.48915388 1 Q8WUM4
73 73 PARVB EV-hallmark Category 1   29780 26.39690637 1 Q9HBI1
77 77 NAPA EV-hallmark Category 1   8775 24.00843077 1 P54920
80 80 MSN EV-hallmark Category 1   4478 25.66843079 1 P26038
82 82 MMRN1 EV-hallmark Category 1   22915 26.01260308 1 Q13201

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CREATE TABLE ev_map_conserved (gene_name TEXT, feature TEXT, category TEXT,
             misev_marker TEXT, entrezgene_id TEXT, pevs_median TEXT,
             in_apt_scout INTEGER, apt_scout_uniprot TEXT);