Targets with BOTH a measured Kd and an aptamer co-structure

Aptamer-amenability + design gold: targets where affinity (Kd) AND binding location (3D co-structure) are both known. For these you can map the epitope and place modifications/linkers. thrombin is the standout (24 aptamers x 24 structures). Source: corpus Kd x PDB crossmatch.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

33 rows sorted by n_kd_records descending

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Suggested facets: n_kd_records, n_structures, pdb_ids

Link rowid target n_kd_records ▲ n_structures pdb_ids
1 1 METH 32 2 3UZS;5I42
2 2 Tyrosine 28 1 9JF9
3 3 thrombin 24 24 9GXH;4DIH;4DII;4I7Y;3QLP;4LZ1;4LZ4;6EO6
4 4 TAR 15 1 1EXY
5 5 Thrombin 12 24 9GXH;4DIH;4DII;4I7Y;3QLP;4LZ1;4LZ4;6EO6
6 6 Theophylline 8 2 8DK7;8D29
7 7 Escherichia Coli (E.Coli) 8 1 8G8Z
8 8 Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C) (Allergen Gal d IV) (allergen Gal d 4) 6 2 4M6D;4M4O
9 9 Tetracycline 5 1 3EGZ
10 10 Glycoprotein 4 2 3HXO;3HXQ
11 11 Arginine 3 1 1EXY
12 12 Human Thrombin 3 6 4LZ1;4LZ4;3DD2;5EW1;5EW2;8TQS
13 13 Plasmodium falciparum 3 1 3ZH2
14 14 PDGF-BB 3 2 4HQU;4HQX
15 15 Glu 2 2 1EXD;6Z8W
16 16 dsDNA 2 1 7LRI
17 17 Hfq (host factor required for phage Qβ RNA replication) 2 2 3AHU;3HSB
18 18 Human thrombin 2 6 4LZ1;4LZ4;3DD2;5EW1;5EW2;8TQS
19 19 Coagulation Factor IXa (FIXa) 2 1 8EPK
20 20 prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) 1 2 2RSK;2RU7
21 21 Lysozyme 1 2 4M6D;4M4O
22 22 tetracycline 1 1 3EGZ
23 23 AGE 1 10 3HXO;3HXQ;6MSF;5MSF;7MSF;4WB2;4WB3;4R8I
24 24 Membrane protein (OmpC) (Outer membrane porin protein C) (Outer membrane protein C) (Outer membrane protein C protein-like protein) (Phosphoporin PhoE) (Porin) (Porin OmpC) 1 5 2RSK;2RU7;9JF9;9JHS;9JFD
25 25 Guanine 1 1 1EXY
26 26 Capsid protein (Coat protein) 1 5 8TFD;5MSF;7MSF;8ZBF;1U1Y
27 27 Sodium 1 1 4DIH
28 28 DIR 1 2 6DB9;6DB8
29 29 ACE 1 4 3HXO;3HXQ;6EO6;6EO7
30 30 Insulin receptor (glioma cells) 1 8 7YQ6;9JF9;7YQ3;7YQ5;9SA8;9JHS;7YQ4;9JFD
31 31 HBC 1 2 7SZU;7U0Y
32 32 Ribosomal protein S8 1 1 4PDB
33 33 Bacteriophage MS2 coat protein 1 1 1U1Y

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CREATE TABLE kd_structure_crossmatch (target TEXT, n_kd_records INTEGER, n_structures INTEGER, pdb_ids TEXT);