Surface vs cargo — class counts (why the split matters)

How the human target universe splits by EV accessibility. Only A_surface (ecto) is reachable by an aptamer on an intact EV; A2 sits at the PM but faces the cytoplasm; B is luminal cargo.

Custom SQL query returning 5 rows (hide)

SELECT surface_class, COUNT(*) AS n, CASE surface_class WHEN 'A_surface' THEN 'integral/ecto cell-surface — EV-surface accessible' WHEN 'A2_pm_peripheral' THEN 'plasma-membrane but cytoplasmic leaflet — NOT accessible' WHEN 'A_assoc' THEN 'secreted / surface corona' WHEN 'B_cargo' THEN 'luminal cargo (inside EV)' ELSE 'no HPA localization' END AS meaning FROM membrane_surface_class GROUP BY surface_class ORDER BY n DESC

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This data as json, CSV

surface_class	n	meaning
B_cargo	4184	luminal cargo (inside EV)
A_surface	1136	integral/ecto cell-surface — EV-surface accessible
unknown	852	no HPA localization
A_assoc	539	secreted / surface corona
A2_pm_peripheral	486	plasma-membrane but cytoplasmic leaflet — NOT accessible