target_layer4_expression

Layer 4 EXPRESSION. Source: Human Protein Atlas (tissue) + Vesiclepedia/ExoCarta/EV-Map (EV proteome membership). raw_json = HPA record.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

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Suggested facets: in_cev_map, cev_map_in, cev_map_is_ev_hallmark, cev_map_is_nonev_hallmark, cev_map_conservation_pct, recorded_utc (date)

target_id ▼ hpa_tissue_count hpa_tissue_jsons gtex_protein_id ev_proteome_pride_id in_vesiclepedia in_exocarta in_cev_map raw_json recorded_utc cev_map_in cev_map_is_ev_hallmark cev_map_is_nonev_hallmark cev_map_conservation_pct cev_map_isolation cev_map_detection cev_map_n_samples cev_map_source_doi
A0A075B5G3 0 []         0 {"uniprot_id": "A0A075B5G3", "_note": "no gene symbol"} 2026-05-27T10:45:01.877716+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A075B6T6 0 []         0 {"Gene": "TRAV12-2", "Gene synonym": [], "Ensembl": "ENSG00000211789", "Uniprot": ["A0A075B6T6"], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Tissue enriched", "RNA tissue specificity score": "5", "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A075B6T6", "gene_symbol": "TRAV12-2"} 2026-05-27T10:45:01.499329+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A087X1C5 0 []         0 {"Gene": "CYP2D7", "Gene synonym": ["CYP2D", "CYP2D@", "CYP2D7P", "CYP2D7P1"], "Ensembl": "ENSG00000205702", "Uniprot": [], "Protein class": ["Predicted intracellular proteins"], "Disease involvement": null, "RNA tissue specificity": "Not detected", "RNA tissue specificity score": null, "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A087X1C5", "gene_symbol": "CYP2D7"} 2026-05-27T10:45:03.013413+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A087X2I1 0 []         1 {"Gene": "PSMC6", "Gene synonym": ["p42", "RPT5"], "Ensembl": "ENSG00000100519", "Uniprot": ["P62333"], "Protein class": ["Essential proteins", "Predicted intracellular proteins"], "Disease involvement": null, "RNA tissue specificity": "Low tissue specificity", "RNA tissue specificity score": null, "Antibody": ["HPA042823"], "Subcellular location": ["Nucleoplasm", "Plasma membrane", "Cytosol"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A087X2I1", "gene_symbol": "PSMC6"} 2026-05-27T10:45:01.919478+00:00 1 0 0 8.333333333333332 iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0A6YX08 0 []         0 {"Gene": "TRBJ2-2", "Gene synonym": ["TCRBJ2S2", "TRBJ22"], "Ensembl": "ENSG00000211765", "Uniprot": [], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Tissue enhanced", "RNA tissue specificity score": null, "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A0A6YX08", "gene_symbol": "Trbj2-2"} 2026-05-27T10:45:02.450636+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0B4J1J9 0 []         0 {"Gene": "TRAV1-1", "Gene synonym": ["TCRAV1S1", "TCRAV7S1", "TRAV11"], "Ensembl": "ENSG00000255569", "Uniprot": ["A0A0B4J248"], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Tissue enriched", "RNA tissue specificity score": "13", "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A0B4J1J9", "gene_symbol": "Trav11"} 2026-05-27T10:45:01.587608+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0B4J271 0 []         0 {"Gene": "TRAV12-3", "Gene synonym": ["TCRAV12S3", "TCRAV2S2", "TRAV123"], "Ensembl": "ENSG00000211794", "Uniprot": ["A0A0B4J271"], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Tissue enriched", "RNA tissue specificity score": "10", "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A0B4J271", "gene_symbol": "TRAV12-3"} 2026-05-27T10:45:01.537767+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0B4J2E0 0 []         0 {"Gene": "TRBV12-4", "Gene synonym": ["TCRBV12S4", "TCRBV8S2A1T", "TRBV124"], "Ensembl": "ENSG00000276953", "Uniprot": ["A0A0B4J2E0"], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Tissue enriched", "RNA tissue specificity score": "44", "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A0B4J2E0", "gene_symbol": "TRBV12-4"} 2026-05-27T10:45:01.641646+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0B4J2F0 0 []         0 {"Gene": "PIGBOS1", "Gene synonym": [], "Ensembl": "ENSG00000225973", "Uniprot": ["A0A0B4J2F0"], "Protein class": ["Predicted intracellular proteins"], "Disease involvement": null, "RNA tissue specificity": "Low tissue specificity", "RNA tissue specificity score": null, "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A0B4J2F0", "gene_symbol": "PIGBOS1"} 2026-05-27T10:45:03.013563+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0C4DH28 0 []         0 {"Gene": "TRGV4", "Gene synonym": ["TCRGV4", "V1S4"], "Ensembl": "ENSG00000211698", "Uniprot": ["A0A0C4DH28"], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Tissue enhanced", "RNA tissue specificity score": null, "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A0C4DH28", "gene_symbol": "TRGV4"} 2026-05-27T10:45:01.831304+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0C5B5G6 0 []         0 {"uniprot_id": "A0A0C5B5G6", "gene_symbol": "MT-RNR1"} 2026-05-27T10:45:02.465941+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0E3EAY4 0 []         0 {"Gene": "ERVW-1", "Gene synonym": ["envW", "ERVWE1", "HERV-7q", "HERV-W", "HERV-W-ENV", "HERVW"], "Ensembl": "ENSG00000242950", "Uniprot": ["Q9UQF0"], "Protein class": ["Essential proteins", "Predicted membrane proteins", "Transporters"], "Disease involvement": null, "RNA tissue specificity": "Tissue enriched", "RNA tissue specificity score": "8", "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A0E3EAY4", "gene_symbol": "env"} 2026-05-27T10:45:02.453631+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0G2JG46 0 []         0 {"Gene": "TRAJ18", "Gene synonym": [], "Ensembl": "ENSG00000211871", "Uniprot": [], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Group enriched", "RNA tissue specificity score": "5", "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A0G2JG46", "gene_symbol": "Traj18"} 2026-05-27T10:45:02.451754+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0G2LB96 0 []         0 {"Gene": "TRBV29-1", "Gene synonym": ["TCRBV29S1", "TCRBV4S1A1T", "TRBV291"], "Ensembl": "ENSG00000232869", "Uniprot": ["A0A5B7"], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Tissue enriched", "RNA tissue specificity score": "5", "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A0G2LB96", "gene_symbol": "Trbv29"} 2026-05-27T10:45:01.581162+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0J9YX06 0 []         0 {"Gene": "TRBJ1-2", "Gene synonym": ["TCRBJ1S2", "TRBJ12"], "Ensembl": "ENSG00000282420", "Uniprot": ["A0A0J9YX06"], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Tissue enriched", "RNA tissue specificity score": "11", "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A0J9YX06", "gene_symbol": "TRBJ1-2"} 2026-05-27T10:45:02.452292+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0K0K1A5 0 []         0 {"Gene": "TRBV6-5", "Gene synonym": ["TCRBV13S1", "TCRBV6S5", "TRBV65"], "Ensembl": "ENSG00000211721", "Uniprot": ["A0A0K0K1A5"], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Tissue enriched", "RNA tissue specificity score": "11", "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A0K0K1A5", "gene_symbol": "TRBV6-5"} 2026-05-27T10:45:01.545719+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0K2S4Q6 0 []         0 {"Gene": "CD300H", "Gene synonym": [], "Ensembl": "ENSG00000284690", "Uniprot": ["A0A0K2S4Q6"], "Protein class": ["Essential proteins", "Predicted membrane proteins", "Predicted secreted proteins"], "Disease involvement": null, "RNA tissue specificity": "Tissue enhanced", "RNA tissue specificity score": null, "Antibody": null, "Subcellular location": null, "Secretome location": "Secreted to blood", "Secretome function": "No annotated function", "uniprot_id": "A0A0K2S4Q6", "gene_symbol": "CD300H"} 2026-05-27T10:45:03.013734+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0L7RG06 0 []         0 {"uniprot_id": "A0A0L7RG06", "_note": "no gene symbol"} 2026-05-27T10:45:01.817476+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0U5IHY9 0 []         0 {"Gene": "HLA-DQB1", "Gene synonym": ["CELIAC1", "HLA-DQB", "IDDM1"], "Ensembl": "ENSG00000179344", "Uniprot": [], "Protein class": ["Human disease related genes", "Predicted intracellular proteins", "Predicted membrane proteins"], "Disease involvement": null, "RNA tissue specificity": "Tissue enhanced", "RNA tissue specificity score": null, "Antibody": ["HPA013667"], "Subcellular location": ["Golgi apparatus", "Rods & Rings"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A0U5IHY9", "gene_symbol": "HLA-DQB1"} 2026-05-27T10:45:01.768441+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A0U5Q247 0 []         0 {"uniprot_id": "A0A0U5Q247", "_note": "no gene symbol"} 2026-05-27T10:45:01.789528+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A140T913 0 []         1 {"Gene": "HLA-A", "Gene synonym": [], "Ensembl": "ENSG00000206503", "Uniprot": ["P04439"], "Protein class": ["Cancer-related genes", "Disease related genes", "Human disease related genes", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Transporters"], "Disease involvement": ["Cancer-related genes"], "RNA tissue specificity": "Low tissue specificity", "RNA tissue specificity score": null, "Antibody": ["CAB078470"], "Subcellular location": ["Golgi apparatus", "Plasma membrane"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A140T913", "gene_symbol": "HLA-A"} 2026-05-27T10:45:01.805581+00:00 1 0 0 100.0 iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A1B0GTW7 0 []         0 {"Gene": "CIROP", "Gene synonym": ["LMLN2"], "Ensembl": "ENSG00000283654", "Uniprot": ["A0A1B0GTW7"], "Protein class": ["Disease related genes", "Enzymes", "Human disease related genes", "Potential drug targets", "Predicted membrane proteins"], "Disease involvement": ["Disease variant", "Heterotaxy"], "RNA tissue specificity": "Not detected", "RNA tissue specificity score": null, "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A1B0GTW7", "gene_symbol": "CIROP"} 2026-05-27T10:45:02.466098+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A1B0GX56 0 []         0 {"Gene": "TRDV1", "Gene synonym": ["hDV101S1"], "Ensembl": "ENSG00000211804", "Uniprot": ["A0A1B0GX56"], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Tissue enriched", "RNA tissue specificity score": "16", "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A1B0GX56", "gene_symbol": "TRDV1"} 2026-05-27T10:45:01.590459+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A1B0GXE1 0 []         0 {"Gene": "TRBV6-4", "Gene synonym": ["TCRBV13S5", "TCRBV6S4", "TRBV64"], "Ensembl": "ENSG00000211713", "Uniprot": ["A0A1B0GX49"], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Tissue enhanced", "RNA tissue specificity score": null, "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A1B0GXE1", "gene_symbol": "TRBV6-4"} 2026-05-27T10:45:01.611471+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A2K6KCS5 0 []         0 {"Gene": "YTHDC1", "Gene synonym": ["KIAA1966", "YT521", "YT521-B"], "Ensembl": "ENSG00000083896", "Uniprot": ["Q96MU7"], "Protein class": ["Essential proteins", "Plasma proteins", "Predicted intracellular proteins"], "Disease involvement": null, "RNA tissue specificity": "Low tissue specificity", "RNA tissue specificity score": null, "Antibody": ["HPA036462"], "Subcellular location": ["Nucleoplasm", "Plasma membrane"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A2K6KCS5", "gene_symbol": "YTHDC1"} 2026-05-27T10:45:02.419405+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A2R7Z5J3 0 []         0 {"uniprot_id": "A0A2R7Z5J3", "_note": "no gene symbol"} 2026-05-27T10:45:01.722044+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A340WVW7 0 []         0 {"Gene": "RPS23", "Gene synonym": ["S23", "uS12"], "Ensembl": "ENSG00000186468", "Uniprot": ["P62266"], "Protein class": ["Disease related genes", "Essential proteins", "Predicted intracellular proteins", "Ribosomal proteins"], "Disease involvement": ["Deafness", "Disease variant", "Dwarfism"], "RNA tissue specificity": "Low tissue specificity", "RNA tissue specificity score": null, "Antibody": ["HPA054853", "HPA071639"], "Subcellular location": ["Endoplasmic reticulum", "Cytosol"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A340WVW7", "gene_symbol": "RPS23"} 2026-05-27T10:45:01.507487+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A3B3ITX3 0 []         0 {"Gene": "GNAI1", "Gene synonym": [], "Ensembl": "ENSG00000127955", "Uniprot": ["P63096"], "Protein class": ["Cancer-related genes", "Disease related genes", "Plasma proteins", "Predicted intracellular proteins"], "Disease involvement": ["Cancer-related genes", "Disease variant", "Epilepsy", "Intellectual disability"], "RNA tissue specificity": "Tissue enhanced", "RNA tissue specificity score": null, "Antibody": ["CAB022449", "HPA042141"], "Subcellular location": ["Nucleoplasm", "Nucleoli", "Golgi apparatus", "Centriolar satellite", "Centrosome", "Basal body", "Cytosol", "Principal piece"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A3B3ITX3", "gene_symbol": "GNAI1"} 2026-05-27T10:45:02.418712+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A583ZB34 0 []         0 {"uniprot_id": "A0A583ZB34", "_note": "no gene symbol"} 2026-05-27T10:45:01.824265+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A592 0 []         0 {"Gene": "TRBV7-3", "Gene synonym": ["TCRBV6S1A1N1", "TCRBV7S3", "TRBV73"], "Ensembl": "ENSG00000211714", "Uniprot": ["A0A075B6L6"], "Protein class": ["Predicted intracellular proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Tissue enhanced", "RNA tissue specificity score": null, "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A592", "gene_symbol": "TCRBV6S1A1N1"} 2026-05-27T10:45:01.675403+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A5B9 0 []         1 {"Gene": "TRBC2", "Gene synonym": ["TCRBC2"], "Ensembl": "ENSG00000211772", "Uniprot": ["A0A5B9"], "Protein class": ["Predicted membrane proteins", "T-cell receptor genes"], "Disease involvement": null, "RNA tissue specificity": "Group enriched", "RNA tissue specificity score": "5", "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A5B9", "gene_symbol": "TRBC2"} 2026-05-27T10:45:01.478532+00:00 1 0 0 25.0 iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A5C2GQT9 0 []         0 {"uniprot_id": "A0A5C2GQT9", "_note": "no gene symbol"} 2026-05-27T10:45:01.393836+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A5H2UYS3 0 []         0 {"Gene": "HLA-A", "Gene synonym": [], "Ensembl": "ENSG00000206503", "Uniprot": ["P04439"], "Protein class": ["Cancer-related genes", "Disease related genes", "Human disease related genes", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Transporters"], "Disease involvement": ["Cancer-related genes"], "RNA tissue specificity": "Low tissue specificity", "RNA tissue specificity score": null, "Antibody": ["CAB078470"], "Subcellular location": ["Golgi apparatus", "Plasma membrane"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A5H2UYS3", "gene_symbol": "HLA-A"} 2026-05-27T10:45:01.785270+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A5P9VSM6 0 []         0 {"uniprot_id": "A0A5P9VSM6", "_note": "no gene symbol"} 2026-05-27T10:45:02.455450+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A5P9VSM8 0 []         0 {"uniprot_id": "A0A5P9VSM8", "_note": "no gene symbol"} 2026-05-27T10:45:02.454149+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A678ZMW1 0 []         0 {"Gene": "HLA-B", "Gene synonym": ["AS"], "Ensembl": "ENSG00000234745", "Uniprot": ["P01889"], "Protein class": ["Cancer-related genes", "Disease related genes", "Human disease related genes", "Predicted intracellular proteins", "Predicted membrane proteins"], "Disease involvement": ["Cancer-related genes"], "RNA tissue specificity": "Tissue enhanced", "RNA tissue specificity score": null, "Antibody": ["CAB015418"], "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A678ZMW1", "gene_symbol": "HLA-B"} 2026-05-27T10:45:01.738488+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A6B7FTL9 0 []         0 {"Gene": "HLA-B", "Gene synonym": ["AS"], "Ensembl": "ENSG00000234745", "Uniprot": ["P01889"], "Protein class": ["Cancer-related genes", "Disease related genes", "Human disease related genes", "Predicted intracellular proteins", "Predicted membrane proteins"], "Disease involvement": ["Cancer-related genes"], "RNA tissue specificity": "Tissue enhanced", "RNA tissue specificity score": null, "Antibody": ["CAB015418"], "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A6B7FTL9", "gene_symbol": "HLA-B"} 2026-05-27T10:45:01.750661+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A6B7HFJ9 0 []         0 {"Gene": "HLA-B", "Gene synonym": ["AS"], "Ensembl": "ENSG00000234745", "Uniprot": ["P01889"], "Protein class": ["Cancer-related genes", "Disease related genes", "Human disease related genes", "Predicted intracellular proteins", "Predicted membrane proteins"], "Disease involvement": ["Cancer-related genes"], "RNA tissue specificity": "Tissue enhanced", "RNA tissue specificity score": null, "Antibody": ["CAB015418"], "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A6B7HFJ9", "gene_symbol": "HLA-B"} 2026-05-27T10:45:01.741682+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A6I9HGD1 0 []         0 {"Gene": "ACTB", "Gene synonym": [], "Ensembl": "ENSG00000075624", "Uniprot": ["P60709"], "Protein class": ["Disease related genes", "Essential proteins", "Human disease related genes", "Plasma proteins", "Predicted intracellular proteins"], "Disease involvement": ["Deafness", "Disease variant", "Dystonia", "Intellectual disability"], "RNA tissue specificity": "Low tissue specificity", "RNA tissue specificity score": null, "Antibody": ["CAB002621", "HPA041264", "HPA041271"], "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A6I9HGD1", "gene_symbol": "ACTB"} 2026-05-27T10:45:01.531885+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A6J0Y1Z7 0 []         0 {"uniprot_id": "A0A6J0Y1Z7", "_note": "no gene symbol"} 2026-05-27T10:45:01.656376+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A6S7XV52 0 []         0 {"Gene": "HLA-A", "Gene synonym": [], "Ensembl": "ENSG00000206503", "Uniprot": ["P04439"], "Protein class": ["Cancer-related genes", "Disease related genes", "Human disease related genes", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Transporters"], "Disease involvement": ["Cancer-related genes"], "RNA tissue specificity": "Low tissue specificity", "RNA tissue specificity score": null, "Antibody": ["CAB078470"], "Subcellular location": ["Golgi apparatus", "Plasma membrane"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0A6S7XV52", "gene_symbol": "HLA-A"} 2026-05-27T10:45:01.784036+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0A9P1NJI6 0 []         0 {"uniprot_id": "A0A9P1NJI6", "_note": "no gene symbol"} 2026-05-27T10:45:02.454581+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0AVK6 0 []         0 {"Gene": "E2F8", "Gene synonym": ["FLJ23311"], "Ensembl": "ENSG00000129173", "Uniprot": ["A0AVK6"], "Protein class": ["Predicted intracellular proteins", "Transcription factors"], "Disease involvement": null, "RNA tissue specificity": "Tissue enhanced", "RNA tissue specificity score": null, "Antibody": ["HPA064882", "HPA076614"], "Subcellular location": ["Nucleoplasm", "Nucleoli", "Cytosol"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0AVK6", "gene_symbol": "E2F8"} 2026-05-27T10:45:03.013911+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0AVT1 0 []         1 {"Gene": "UBA6", "Gene synonym": ["FLJ10808", "UBE1L2"], "Ensembl": "ENSG00000033178", "Uniprot": ["A0AVT1"], "Protein class": ["Enzymes", "Essential proteins", "Metabolic proteins", "Predicted intracellular proteins"], "Disease involvement": null, "RNA tissue specificity": "Low tissue specificity", "RNA tissue specificity score": null, "Antibody": ["HPA037001"], "Subcellular location": ["Nucleoplasm", "Cytosol"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0AVT1", "gene_symbol": "UBA6"} 2026-05-27T10:45:01.558263+00:00 1 0 0 0.0 iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0FGR8 0 []         1 {"Gene": "ESYT2", "Gene synonym": ["CHR2SYT", "FAM62B", "KIAA1228"], "Ensembl": "ENSG00000117868", "Uniprot": ["A0FGR8"], "Protein class": ["Plasma proteins", "Predicted membrane proteins", "Transporters"], "Disease involvement": null, "RNA tissue specificity": "Low tissue specificity", "RNA tissue specificity score": null, "Antibody": ["HPA002132", "HPA070823"], "Subcellular location": ["Plasma membrane", "Cytosol"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0FGR8", "gene_symbol": "ESYT2"} 2026-05-27T10:45:02.153105+00:00 1 0 0 8.333333333333332 iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0JLT2 0 []         0 {"Gene": "MED19", "Gene synonym": ["LCMR1"], "Ensembl": "ENSG00000156603", "Uniprot": ["A0JLT2"], "Protein class": ["Predicted intracellular proteins"], "Disease involvement": null, "RNA tissue specificity": "Low tissue specificity", "RNA tissue specificity score": null, "Antibody": ["HPA039912", "HPA040860"], "Subcellular location": ["Nucleoplasm", "Nuclear bodies"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0JLT2", "gene_symbol": "MED19"} 2026-05-27T10:45:02.316896+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0JNW5 0 []         1 {"Gene": "BLTP3B", "Gene synonym": ["KIAA0701", "SHIP164", "UHRF1BP1L"], "Ensembl": "ENSG00000111647", "Uniprot": ["A0JNW5"], "Protein class": ["Predicted intracellular proteins"], "Disease involvement": null, "RNA tissue specificity": "Low tissue specificity", "RNA tissue specificity score": null, "Antibody": ["HPA039671", "HPA075150"], "Subcellular location": ["Nucleoplasm", "Vesicles", "Cytosol"], "Secretome location": null, "Secretome function": null, "uniprot_id": "A0JNW5", "gene_symbol": "BLTP3B"} 2026-05-27T10:45:02.466286+00:00 1 0 0 0.0 iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0JP26 0 []         0 {"Gene": "POTEB3", "Gene synonym": [], "Ensembl": "ENSG00000278522", "Uniprot": ["A0JP26"], "Protein class": ["Predicted intracellular proteins"], "Disease involvement": null, "RNA tissue specificity": "Tissue enriched", "RNA tissue specificity score": "19", "Antibody": null, "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0JP26", "gene_symbol": "POTEB3"} 2026-05-27T10:45:02.466474+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0N8J3 0 []         0 {"uniprot_id": "A0N8J3", "_note": "no gene symbol"} 2026-05-27T10:45:01.584690+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7
A0PJK1 0 []         0 {"Gene": "SLC5A10", "Gene synonym": ["SGLT5"], "Ensembl": "ENSG00000154025", "Uniprot": ["A0PJK1"], "Protein class": ["Metabolic proteins", "Predicted membrane proteins", "Transporters"], "Disease involvement": null, "RNA tissue specificity": "Tissue enriched", "RNA tissue specificity score": "13", "Antibody": ["HPA052014"], "Subcellular location": null, "Secretome location": null, "Secretome function": null, "uniprot_id": "A0PJK1", "gene_symbol": "SLC5A10"} 2026-05-27T10:45:03.014124+00:00 0       iodixanol_DGS_top_down_fraction6-8 LC-MS/MS_label_free 38 10.1038/s41556-025-01795-7

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CREATE TABLE target_layer4_expression (
  target_id              TEXT PRIMARY KEY,
  hpa_tissue_count       INTEGER,
  hpa_tissue_jsons       TEXT,
  gtex_protein_id        TEXT,
  ev_proteome_pride_id   TEXT,
  in_vesiclepedia        INTEGER,  -- 0 / 1 ★
  in_exocarta            INTEGER,  -- 0 / 1 ★
  in_cev_map             INTEGER,  -- 0 / 1 ★ (Shaw 2025)
  raw_json               TEXT,
  recorded_utc           TEXT
, cev_map_in INTEGER, cev_map_is_ev_hallmark INTEGER, cev_map_is_nonev_hallmark INTEGER, cev_map_conservation_pct REAL, cev_map_isolation TEXT, cev_map_detection TEXT, cev_map_n_samples INTEGER, cev_map_source_doi TEXT);
CREATE INDEX idx_l4_evproteome ON target_layer4_expression(in_vesiclepedia, in_exocarta, in_cev_map);