Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

2,524 rows where has_activation_state_pdb_pair = 0, has_cryoEM = 0 and in_cev_map = 1 sorted by priority_score descending

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tier 2

has_known_aptamer 2

  • 0 1,941
  • 1 583

in_cev_map 1

  • 1 · 2,524 ✖

has_cryoEM 1

  • - · 2,524 ✖

has_activation_state_pdb_pair 1

  • - · 2,524 ✖
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P13747 HLA-E HLA class I histocompatibility antigen, alpha chain E Tier 1 0.865 34 87.0 0 0       1 1 38473398 1 COVID-19 0.4822929100647597
Q9NX14 NDUFB11 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Tier 1.5 0.86 0 77.56 0 0       0 0   1 Microphthalmia with linear skin defects syndrome 0.7364493324598024
P01911 HLA-DRB1 HLA class II histocompatibility antigen, DRB1 beta chain Tier 1 0.84 100 88.44 0 0       0 0   1 rheumatoid arthritis 0.40051584219092445
Q15848 ADIPOQ Adiponectin Tier 1 0.806 3 79.88 0 0       1 10 41636061, 38392020, 36508319, 35323639, 34796696, 34117903, 33535822, 31988066, 25105541 1 hearing loss 0.25844907375917336
P15260 IFNGR1 Interferon gamma receptor 1 Tier 1.5 0.804 5 66.0 0 0       1 2 33667716 1 disseminated atypical mycobacterial infection 0.5414012388034828
Q9UBT7 CTNNAL1 Alpha-catulin Tier 1.5 0.795 0 84.06 0 0       0 0   1 Abnormality of the skeletal system 0.31316995706583495
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Tier 1.5 0.788 11 75.94 0 0       1 6 41733039, 34364920, 31434881, 30237882, 29299123, 22411871 1 acute myeloid leukemia 0.8313389209288576
P35555 FBN1 Fibrillin-1 Tier 1 0.78 11   0 0       0 0   1 Marfan syndrome 0.8969300970597663
P01019 AGT Angiotensinogen Tier 1 0.779 22 86.44 0 0       1 16 35983901, 34936368, 34779902, 34248841, 32838280, 23766021, 17673982, 11419945, 38045440, 34619249, 29844151, 27530235 1 renal tubular dysgenesis 0.7354947364860083
P02671 FGA Fibrinogen alpha chain Tier 1 0.77 40 60.34 0 0       0 0   1 familial dysfibrinogenemia 0.7947496460990987
P02776 PF4 Platelet factor 4 Tier 1.5 0.77 10 75.06 0 0       1 10 33859620, 32366845, 31967847, 23847186, 23673861, 34248840, 32022468 1 systemic scleroderma 0.11523541376593864
P03951 F11 Coagulation factor XI Tier 1 0.77 100 86.88 0 0       0 0   1 factor XI deficiency 0.841884208404384
P61769 B2M Beta-2-microglobulin Tier 1 0.77 100 94.06 0 0       1 15 41850110, 40373155, 38904251, 40658810, 35026285, 32631049, 29281176, 28960840, 25100729, 20616783, 19137104, 17878167 1 Immunodeficiency by defective expression of HLA class 1 0.6180318849819645
P27037 ACVR2A Activin receptor type-2A Tier 1.5 0.769 5 83.56 0 0       0 0   1 hepatocellular carcinoma 0.4908023126074436
O14958 CASQ2 Calsequestrin-2 Tier 1.5 0.767 4 90.5 0 0       0 0   1 catecholaminergic polymorphic ventricular tachycardia 0.7718998507471558
Q9H3K6 BOLA2 BolA-like protein 2 Tier 1.5 0.765 0 92.69 0 0       0 0   1 hepatocellular carcinoma 0.08093942543094014
P05546 SERPIND1 Heparin cofactor 2 Tier 1 0.752 9 79.62 0 0       1 4 20062917, 20053992, 34248840, 31247951 1 heparin cofactor 2 deficiency 0.719744572767547
P05164 MPO Myeloperoxidase Tier 1 0.745 49 89.0 0 0       1 16 41629951, 41316897, 40501769, 38127443, 33534888, 33495506, 37991715, 37277648, 34183667, 34117903, 33869115, 31210423, 30431231 1 myeloperoxidase deficiency 0.7742533340195327
Q92956 TNFRSF14 Tumor necrosis factor receptor superfamily member 14 Tier 1.5 0.745 8 79.94 0 0       0 0   1 diffuse large B-cell lymphoma 0.5983171413833771
P16389 KCNA2 Potassium voltage-gated channel subfamily A member 2 Tier 1.5 0.735 0 77.38 0 0       0 0   1 genetic developmental and epileptic encephalopathy 0.7513374591580034
P98196 ATP11A Phospholipid-transporting ATPase IH Tier 1.5 0.735 0 82.94 0 0       0 0   1 hearing loss, autosomal dominant 84 0.5506821963658654
Q9BY67 CADM1 Cell adhesion molecule 1 Tier 1 0.734 2 80.56 0 0       0 0   1 Abnormality of the skeletal system 0.442731358018962
P20702 ITGAX Integrin alpha-X Tier 1.5 0.732 9 88.0 0 0       0 0   1 neurodegenerative disease 0.41708750879240836
P09603     Tier 1.5 0.729 8 57.41 0 0       0 0   1 type 2 diabetes mellitus 0.39219340856589974
P22732 SLC2A5 Solute carrier family 2, facilitated glucose transporter member 5 Tier 1.5 0.728 0 90.56 0 0       0 0   1 Prolonged QT interval 0.3326218692162316
Q9P2B2 PTGFRN Prostaglandin F2 receptor negative regulator Tier 1.5 0.728 0 84.12 0 0       0 0   1 type 2 diabetes mellitus 0.48052208463481294
Q92636 NSMAF Protein FAN Tier 1.5 0.725 0 88.31 0 0       0 0   1 placental retention 0.36802220150078147
Q99497 PARK7 Parkinson disease protein 7 Tier 1 0.723 88 98.44 0 0       0 0   1 Young adult-onset Parkinsonism 0.7264878745993893
P05187 ALPP Alkaline phosphatase, placental type Tier 1 0.72 8 93.44 0 0       1 7 41329468, 38238732, 37425696, 37047289, 31687420, 25919296, 23467613 1 male reproductive organ cancer 0.16284411775950106
P29622 SERPINA4 Kallistatin Tier 1 0.719 3 86.69 0 0       1 4 38904251, 30297859, 37351609, 28794177 1 optic atrophy 0.28896631154492924
O95562 SFT2D2 Vesicle transport protein SFT2B Tier 1.5 0.71 0 78.5 0 0       0 0   1 neurodegenerative disease 0.38598268164814226
P41221 WNT5A Protein Wnt-5a Tier 1.5 0.71 0 87.69 0 0       1 4 40855286, 32693649, 22363130, 18673242 1 Robinow syndrome 0.7220360983378594
P79483 HLA-DRB3 HLA class II histocompatibility antigen, DR beta 3 chain Tier 1.5 0.71 2 88.38 0 0       0 0   1    
Q96IY4 CPB2 Carboxypeptidase B2 Tier 1 0.709 10 94.12 0 0       1 4 37329944, 36805075, 35861072, 30297859 1 type 2 diabetes mellitus 0.19338213943947646
P01889 HLA-B HLA class I histocompatibility antigen, B alpha chain Tier 1 0.708 100 88.06 0 0       0 0   1 COVID-19 0.48417012135481613
P03905 MT-ND4 NADH-ubiquinone oxidoreductase chain 4 Tier 1.5 0.705 0 93.94 0 0       0 0   1 Leber hereditary optic neuropathy 0.7517935125709835
P25311 AZGP1 Zinc-alpha-2-glycoprotein Tier 1 0.701 9 92.88 0 0       1 1 41325160 1 neoplasm 0.10887540652591159
P08473 MME Neprilysin Tier 1 0.699 16 96.19 0 0       0 0   1 Charcot-Marie-Tooth disease axonal type 2T 0.7912653398252156
P00746 CFD Complement factor D Tier 1 0.695 40 91.0 0 0       1 4 38057414, 38071633, 28972568, 25727321 1 recurrent Neisseria infections due to factor D deficiency 0.7726408204424132
P01615 IGKV2D-28 Immunoglobulin kappa variable 2D-28 Tier 1.5 0.695 0 91.0 0 0       0 0   1 cutaneous Leishmaniasis 0.5868213846274001
P19021 PAM Peptidyl-glycine alpha-amidating monooxygenase Tier 1.5 0.695 0 71.69 0 0       1 25 41855944, 41500123, 41384307, 41285544, 41222440, 40607956, 39929897, 39472107, 38867016, 38846799, 37977804, 37977780, 37906116, 37127012, 36905684, 35478209, 33911033, 33516855, 32315032, 32307868, 30399413, 30124431, 26406332, 22954359, 14965210 1 type 2 diabetes mellitus 0.5754371880839976
Q30154 HLA-DRB5 HLA class II histocompatibility antigen, DR beta 5 chain Tier 1.5 0.694 4 86.75 0 0       0 0   1 seasonal allergic rhinitis 0.19424611770933498
Q9Y678 COPG1 Coatomer subunit gamma-1 Tier 1.5 0.692 1 87.88 0 0       0 0   1 neurodegenerative disease 0.4905625531390244
P36980 CFHR2 Complement factor H-related protein 2 Tier 1.5 0.691 4 90.62 0 0       0 0   1 age-related macular degeneration 0.5100732932209376
P10586 PTPRF Receptor-type tyrosine-protein phosphatase F Tier 1.5 0.69 13 82.0 0 0       1 4 42101929, 39087949, 36594741 1 smoking initiation 0.4641111755355386
Q8IUH8 SPPL2C Signal peptide peptidase-like 2C Tier 1.5 0.69 0 67.06 0 0       0 0   1 osteoarthritis, hip 0.35379836590273994
Q92187 ST8SIA4 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase Tier 1 0.69 3 86.44 0 0       0 0   1 systemic lupus erythematosus 0.43832763677821385
Q14520 HABP2 Factor VII-activating protease Tier 1.5 0.686 0 77.62 0 0       0 0   1 follicular thyroid carcinoma 0.46213907606907034
O00501 CLDN5 Claudin-5 Tier 1.5 0.685 0 83.75 0 0       1 1 18951306 1 genetic disorder 0.40861362787778505
O95399 UTS2 Urotensin-2 Tier 1 0.685 2 58.44 0 0       0 0   1 hair color 0.35316475479030335

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;