Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

1,254 rows where has_activation_state_pdb_pair = 0, has_cryoEM = 1 and has_known_aptamer = 0 sorted by priority_score descending

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tier 2

in_cev_map 2

  • 1 635
  • 0 619

has_known_aptamer 1

  • - · 1,254 ✖

has_cryoEM 1

  • 1 · 1,254 ✖

has_activation_state_pdb_pair 1

  • - · 1,254 ✖
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P12263     Tier 1 0.9 7 63.59 1 0       0 0   0    
Q12879 GRIN2A Glutamate receptor ionotropic, NMDA 2A Tier 1 0.88 37 60.84 1 0       0 0   0 Landau-Kleffner syndrome 0.8407159711916629
P35346 SSTR5 Somatostatin receptor type 5 Tier 1.5 0.841 7 81.25 1 0       0 0   0 acromegaly 0.6094707180356006
Q02094 RHAG Ammonium transporter Rh type A Tier 1.5 0.841 8 95.62 1 0       0 0   1 Rh deficiency syndrome 0.764209214915708
Q5T848 GPR158 Metabotropic glycine receptor Tier 1 0.839 6 58.03 1 0       0 0   0 diverticular disease 0.4384404783771627
Q14392 LRRC32 Transforming growth factor beta activator LRRC32 Tier 1.5 0.838 6 86.06 1 0       0 0   1 cleft palate, proliferative retinopathy, and developmental delay 0.5770707112957068
P21439 ABCB4 Phosphatidylcholine translocator ABCB4 Tier 1.5 0.835 4 83.25 1 0       0 0   0 progressive familial intrahepatic cholestasis type 3 0.851728159166962
P0DSE2 TRB M1-specific T cell receptor beta chain Tier 1 0.83 5 90.12 1 0       0 0   0    
P12532 CKMT1A Creatine kinase U-type, mitochondrial Tier 1.5 0.83 9 89.31 1 0       0 0   1 neurodegenerative disease 0.5385822922582763
O75899 GABBR2 Gamma-aminobutyric acid type B receptor subunit 2 Tier 1.5 0.824 26 77.75 1 0       0 0   0 developmental and epileptic encephalopathy, 59 0.7356789732167734
P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 Tier 1.5 0.81 7 89.69 1 0       0 0   1 congestive heart failure 0.5999952111132625
P43005 SLC1A1 Excitatory amino acid transporter 3 Tier 1 0.805 22 80.12 1 0       0 0   1 dicarboxylic aminoaciduria 0.6273449709512636
Q9NS82 SLC7A10 Asc-type amino acid transporter 1 Tier 1 0.803 4 83.38 1 0       0 0   0 asthma 0.5295411410172121
O60895 RAMP2 Receptor activity-modifying protein 2 Tier 1 0.802 10 80.94 1 0       0 0   0 diabetes mellitus 0.4219370007650345
Q04844 CHRNE Acetylcholine receptor subunit epsilon Tier 1.5 0.802 13 80.69 1 0       0 0   0 Congenital myasthenic syndromes 0.8223287249629152
P29275 ADORA2B Adenosine receptor A2b Tier 1.5 0.801 4 88.12 1 0       0 0   0 migraine disorder 0.6060142180667235
Q9H2X9 SLC12A5 Solute carrier family 12 member 5 Tier 1.5 0.8 2 78.44 1 0       0 0   0 genetic developmental and epileptic encephalopathy 0.6993945840545625
P00488 F13A1 Coagulation factor XIII A chain Tier 1 0.799 15 90.88 1 0       0 0   1 Factor XIII subunit A deficiency 0.7939842013132387
P06731 CEACAM5 Cell adhesion molecule CEACAM5 Tier 1 0.795 6 87.12 1 0       0 0   1 neurodegenerative disease 0.45156128674958135
P01909 HLA-DQA1 HLA class II histocompatibility antigen, DQ alpha 1 chain Tier 1 0.792 27 87.94 1 0       0 0   0 Pleural Mesothelioma 0.1228600330569846
Q13705 ACVR2B Activin receptor type-2B Tier 1.5 0.791 9 83.31 1 0       0 0   0 Heterotaxia 0.7109733260300651
Q96CS2 HAUS1 HAUS augmin-like complex subunit 1 Tier 1.5 0.79 1 88.62 1 0       0 0   0 device complication 0.27547205131467467
Q5JUK3 KCNT1 Potassium channel subfamily T member 1 Tier 1.5 0.782 6 73.88 1 0       0 0   0 developmental and epileptic encephalopathy, 14 0.8165232785825526
Q13639     Tier 1 0.781 3 80.88 1 0       0 0   0 schizophrenia 0.6060830827022777
P13866 SLC5A1 Sodium/glucose cotransporter 1 Tier 1.5 0.777 4 84.38 1 0       0 0   0 glucose-galactose malabsorption 0.8220991027793896
P30542 ADORA1 Adenosine receptor A1 Tier 1.5 0.777 5 92.44 1 0       0 0   0 asthma 0.7232344154541454
O15393     Tier 1 0.775 31 79.38 1 0       0 0   0 COVID-19 0.6157541390484623
P29460 IL12B Interleukin-12 subunit beta Tier 1 0.769 20 91.12 1 0       0 0   0 psoriasis 0.7914863943708039
P43004 SLC1A2 Excitatory amino acid transporter 2 Tier 1.5 0.768 7 77.75 1 0       0 0   0 developmental and epileptic encephalopathy, 41 0.7772658651722512
O60931 CTNS Cystinosin Tier 1.5 0.764 6 89.44 1 0       0 0   0 nephropathic cystinosis 0.841818398377195
O60568 PLOD3 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 Tier 1.5 0.762 18 91.38 1 0       0 0   1 bone fragility with contractures, arterial rupture, and deafness 0.7159150369336311
P02747 C1QC Complement C1q subcomponent subunit C Tier 1 0.762 11 80.56 1 0       0 0   1 C1Q deficiency 0.6233532074390745
P98073     Tier 1 0.761 14 81.5 1 0       0 0   0 congenital enteropathy due to enteropeptidase deficiency 0.7102613227574134
Q9Y5Y9 SCN10A Sodium channel protein type 10 subunit alpha Tier 1.5 0.761 8 67.31 1 0       0 0   0 atrial fibrillation 0.7126293968222049
O75762 TRPA1 Transient receptor potential cation channel subfamily A member 1 Tier 1 0.76 17 81.94 1 0       0 0   0 familial episodic pain syndrome with predominantly upper body involvement 0.6615353934604322
Q02817 MUC2 Mucin-2 Tier 1 0.76 12   1 0       0 0   1    
O15552 FFAR2 Free fatty acid receptor 2 Tier 1.5 0.759 11 88.06 1 0       0 0   0 type 1 diabetes mellitus 0.09182737097469269
P35462 DRD3 D(3) dopamine receptor Tier 1.5 0.757 6 75.38 1 0       0 0   0 schizophrenia 0.6687268941647396
P07360     Tier 1 0.755 15 89.75 1 0       0 0   1 complement deficiency 0.3695798546847018
P41440 SLC19A1 Reduced folate transporter Tier 1.5 0.755 19 72.06 1 0       0 0   1 Knobloch syndrome 0.5526223217595396
O00591 GABRP Gamma-aminobutyric acid receptor subunit pi Tier 1.5 0.752 2 79.12 1 0       0 0   0 migraine disorder 0.6191855696357259
P55899 FCGRT IgG receptor FcRn large subunit p51 Tier 1 0.752 31 85.0 1 0       0 0   1 Myasthenia gravis 0.5932721106551206
P0DMS8 ADORA3 Adenosine receptor A3 Tier 1.5 0.751 5 91.31 1 0       0 0   0 migraine disorder 0.6052134617149065
P26022 PTX3 Pentraxin-related protein PTX3 Tier 1.5 0.75 9 76.75 1 0       0 0   1 polycystic ovary syndrome 0.12287624125782433
O43614     Tier 1 0.75 11 78.94 1 0       0 0   0 insomnia 0.5988748728311054
P46089 GPR3 G-protein coupled receptor 3 Tier 1.5 0.748 8 81.81 1 0       0 0   0 hypertension 0.18488148594282316
O15245 SLC22A1 Solute carrier family 22 member 1 Tier 1 0.744 16 84.25 1 0       0 0   0 coronary artery disease 0.5384890077265535
O43526 KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 Tier 1 0.744 24 58.19 1 0       0 0   0 Benign familial neonatal seizures 0.8423358217314708
Q8N158 GPC2 Glypican-2 Tier 1 0.744 2 79.06 1 0       0 0   0 COVID-19 0.5409211817593593
Q9Y653 ADGRG1 Adhesion G-protein coupled receptor G1 Tier 1.5 0.743 1 77.88 1 0       0 0   1 bilateral frontoparietal polymicrogyria 0.8322298896713178

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;