Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

886 rows where has_activation_state_pdb_pair = 0, has_cryoEM = 1 and in_cev_map = 1 sorted by priority_score descending

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tier 3

has_known_aptamer 2

  • 0 635
  • 1 251

in_cev_map 1

has_cryoEM 1

has_activation_state_pdb_pair 1

id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P25445 FAS Tumor necrosis factor receptor superfamily member 6 Tier 1.5 0.914 7 77.88 1 0       1 17 40784034, 39897575, 37458448, 36908619, 35402075, 32270033, 31436946, 30594071, 30417194, 30339905, 26318819, 23980164, 23511245, 18997060, 18956014, 16729304, 16581027 1 autoimmune lymphoproliferative syndrome type 1 0.7377210386590284
O75581 LRP6 Low-density lipoprotein receptor-related protein 6 Tier 1 0.865 27 79.19 1 0       1 5 42031715, 37175248, 18673242 1 tooth agenesis, selective, 7 0.7022725510765017
Q02094 RHAG Ammonium transporter Rh type A Tier 1.5 0.841 8 95.62 1 0       0 0   1 Rh deficiency syndrome 0.764209214915708
Q14392 LRRC32 Transforming growth factor beta activator LRRC32 Tier 1.5 0.838 6 86.06 1 0       0 0   1 cleft palate, proliferative retinopathy, and developmental delay 0.5770707112957068
P12532 CKMT1A Creatine kinase U-type, mitochondrial Tier 1.5 0.83 9 89.31 1 0       0 0   1 neurodegenerative disease 0.5385822922582763
P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 Tier 1.5 0.81 7 89.69 1 0       0 0   1 congestive heart failure 0.5999952111132625
P43005 SLC1A1 Excitatory amino acid transporter 3 Tier 1 0.805 22 80.12 1 0       0 0   1 dicarboxylic aminoaciduria 0.6273449709512636
P51679 CCR4 C-C chemokine receptor type 4 Tier 1 0.804 7 80.75 1 0       1 3 41518674, 39071952, 29103909 1 mycosis fungoides 0.5404546856597274
P00488 F13A1 Coagulation factor XIII A chain Tier 1 0.799 15 90.88 1 0       0 0   1 Factor XIII subunit A deficiency 0.7939842013132387
P02748 C9 Complement component C9 Tier 1.5 0.796 9 78.75 1 0       1 10 41636061, 40411682, 36428893, 36290981, 35247355, 28794177, 27836219, 22678933, 19261617, 15687383 1 Immunodeficiency due to a late component of complements deficiency 0.761965409699055
P06731 CEACAM5 Cell adhesion molecule CEACAM5 Tier 1 0.795 6 87.12 1 0       0 0   1 neurodegenerative disease 0.45156128674958135
P13671 C6 Complement component C6 Tier 1 0.795 11 79.62 1 0       1 31 41255414, 39736202, 39680325, 38188151, 36290981, 36165950, 34535250, 33034309, 32414072, 32119944, 31819445, 30039760, 29594379, 29408200, 28024568, 27940247, 26588795, 26316749, 26107993, 24512500, 24309623, 23657986, 22973579, 22527269, 21944470, 21788069, 21645749, 21071077, 20008986, 19469583, 15473710 1 Immunodeficiency due to a late component of complements deficiency 0.75437296887129
Q13085 ACACA Acetyl-CoA carboxylase 1 Tier 1.5 0.79 10 82.81 1 0       1 1 41854184 1    
P04156 PRNP Major prion protein Tier 1 0.785 70 64.19 1 0       1 2 39556313, 34067472 1 Gerstmann-Straussler-Scheinker syndrome 0.8246149684620239
Q92633 LPAR1 Lysophosphatidic acid receptor 1 Tier 1.5 0.785 16 83.62 1 0       1 1 32065590 1 Epiretinal membrane 0.4757255248053499
P14210 HGF Hepatocyte growth factor Tier 1 0.78 36 83.5 1 0       1 64 41873087, 41601428, 41123956, 40189053, 40041032, 39853766, 39355222, 38963794, 38923378, 37965838, 37075136, 36935149, 36826373, 36477303, 36126144, 34424707, 34165951, 31967847, 31825565, 31595614, 30444610, 30353654, 30312735, 28627727, 26658271, 26592704, 25223895, 23615526, 21546514, 20594164, 16225393, 38925633, 38876234, 34142433, 31381313, 30237882, 29944203, 29416033, 27679852, 27363484, 26131766, 11753087 1 hearing loss, autosomal recessive 0.5910507391848663
P04839 CYBB NADPH oxidase 2 Tier 1 0.776 6 90.25 1 0       1 2 24635113 1 chronic granulomatous disease 0.8633132852459866
P39060 COL18A1 Collagen alpha-1(XVIII) chain Tier 1.5 0.769 9 50.62 1 0       1 2 36707842, 23679916 1 Knobloch syndrome 1 0.7867122552672962
O60568 PLOD3 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 Tier 1.5 0.762 18 91.38 1 0       0 0   1 bone fragility with contractures, arterial rupture, and deafness 0.7159150369336311
P02747 C1QC Complement C1q subcomponent subunit C Tier 1 0.762 11 80.56 1 0       0 0   1 C1Q deficiency 0.6233532074390745
P01189 POMC Pro-opiomelanocortin Tier 1 0.76 13 57.66 1 0       1 1 30161145 1 obesity due to pro-opiomelanocortin deficiency 0.6958797353500403
Q02817 MUC2 Mucin-2 Tier 1 0.76 12   1 0       0 0   1    
P07360     Tier 1 0.755 15 89.75 1 0       0 0   1 complement deficiency 0.3695798546847018
P41440 SLC19A1 Reduced folate transporter Tier 1.5 0.755 19 72.06 1 0       0 0   1 Knobloch syndrome 0.5526223217595396
P55899 FCGRT IgG receptor FcRn large subunit p51 Tier 1 0.752 31 85.0 1 0       0 0   1 Myasthenia gravis 0.5932721106551206
P26022 PTX3 Pentraxin-related protein PTX3 Tier 1.5 0.75 9 76.75 1 0       0 0   1 polycystic ovary syndrome 0.12287624125782433
P43007 SLC1A4 Neutral amino acid transporter A Tier 1.5 0.75 1 80.56 1 0       1 6 36219068, 31989939, 27571928, 26811678, 19046328, 16139842 1 spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome 0.8025684205131692
P08648 ITGA5 Integrin alpha-5 Tier 1.5 0.748 14 85.25 1 0       1 2 32174798, 38258032 1 skin disease 0.28465651599598124
Q9Y653 ADGRG1 Adhesion G-protein coupled receptor G1 Tier 1.5 0.743 1 77.88 1 0       0 0   1 bilateral frontoparietal polymicrogyria 0.8322298896713178
P0C0L4 C4A Complement C4-A Tier 1 0.74 12 83.44 1 0       1 4 37566081, 36619572, 34739903, 31019918 1    
P15144 ANPEP Aminopeptidase N Tier 1 0.74 15 93.06 1 0       1 1 33554306 1 cholelithiasis 0.5030146927270738
Q03405 PLAUR Urokinase plasminogen activator surface receptor Tier 1 0.738 13 81.44 1 0       1 2 37533140 1 Abdominal Aortic Aneurysm 0.4819526979346149
O60884 DNAJA2 DnaJ homolog subfamily A member 2 Tier 1.5 0.73 1 83.38 1 0       1 2 41935727, 33879515 1 dengue disease 0.37068859424875583
P07942 LAMB1 Laminin subunit beta-1 Tier 1.5 0.72 3 76.69 1 0       0 0   1 cobblestone lissencephaly without muscular or ocular involvement 0.8016665947624902
P11215 ITGAM Integrin alpha-M Tier 1 0.72 30 86.25 1 0       0 0   1 systemic lupus erythematosus 0.30502849242596436
Q99988 GDF15 Growth/differentiation factor 15 Tier 1.5 0.718 4 75.69 1 0       1 29 41924874, 41862097, 38879214, 38477735, 37982669, 36927042, 36638554, 36508319, 36333824, 35762561, 33334063, 32527800, 31988066, 29992704, 39884764, 38497478, 38296402, 37162508, 32739349, 30335547 1 hyperemesis gravidarum 0.5821658682742563
Q9NR82 KCNQ5 Potassium voltage-gated channel subfamily KQT member 5 Tier 1.5 0.711 5 56.41 1 0       0 0   1 intellectual disability, autosomal dominant 46 0.7086662845211597
Q9NV96 TMEM30A Cell cycle control protein 50A Tier 1 0.71 33 89.5 1 0       0 0   1 atrial fibrillation 0.31177132249681394
P13987 CD59 CD59 glycoprotein Tier 1 0.705 17 79.31 1 0       1 1 19915929 1 primary CD59 deficiency 0.7738276843579196
O60486 PLXNC1 Plexin-C1 Tier 1 0.703 4 79.06 1 0       0 0   1 asthma 0.532656225351722
P14770 GP9 Platelet glycoprotein IX Tier 1.5 0.702 2 84.69 1 0       0 0   1 Bernard-Soulier syndrome 0.8233582238860002
P07225 PROS1 Vitamin K-dependent protein S Tier 1.5 0.7 3 82.94 1 0       1 2 36859809, 33674695 1 thrombophilia due to protein S deficiency, autosomal dominant 0.8240418292042652
Q12884 FAP Prolyl endopeptidase FAP Tier 1 0.7 4 95.62 1 0       1 7 40046817, 39710916, 39026723, 37192373, 36838669, 36494579, 35879297 1 psoriasis 0.40173767366839236
P00738 HP Haptoglobin Tier 1 0.695 15 84.81 1 0       1 76 41855944, 41638958, 40968672, 40231802, 39880691, 39880501, 39835381, 39804483, 39788927, 39613489, 39435559, 38585969, 38545293, 38218089, 38185050, 38047083, 38039678, 37879039, 37701520, 37696275, 37560929, 37104434, 36863194, 36564526, 36291832, 36201958, 35868696, 35686646, 35439614, 35394406, 35195734, 35081018, 34647930, 34556234, 34520834, 34064911, 34038999, 33896635, 33534888, 33404555, 33395442, 33234387, 33214769, 33131243, 31892078, 31820139, 31665673, 31655906, 31655383, 31494507, 38916796, 34183667, 34117903 1 Hypercholesterolemia 0.5684135700226365
P21359 NF1 Neurofibromin Tier 1.5 0.695 26 87.19 1 0       1 2 32980430, 22617876 1 neurofibromatosis type 1 0.8844735398780649
O95858 TSPAN15 Tetraspanin-15 Tier 1 0.692 3 87.56 1 0       1 1 37047289 1 venous thromboembolism 0.5182425801223098
P00451 F8 Coagulation factor VIII Tier 1 0.691 25 60.75 1 0       1 13 40727755, 40266188, 28791655, 21144556, 41587892, 40009491, 38992298, 38752747, 31493779, 29609491, 28979328, 21389323, 20589313 1 hemophilia A 0.9108044347811838
P01825 IGHV4-59 Immunoglobulin heavy variable 4-59 Tier 1.5 0.69 3 91.56 1 0       0 0   1 cutaneous Leishmaniasis 0.5868213846274001
Q6NT16 SLC18B1 MFS-type transporter SLC18B1 Tier 1.5 0.688 4 84.62 1 0       0 0   1 Parkinson disease 0.276931649354752
Q8NBJ9     Tier 1 0.688 7 80.25 1 0       0 0   1 hypothyroidism 0.32686531914177924

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;