Targets — browse / sort / filter (view)

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id

UniProt accession (human). Links to uniprot.org.

gene_symbol

Gene symbol (e.g. ITGB3).

protein_name

Protein name (UniProt).

tier

Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.

priority_score

Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.

has_activation_state_pdb_pair

1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).

in_cev_map

1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.

has_known_aptamer

1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).

opentargets_top_disease_score

Open Targets association score (0-1).

aptamer_count_pubmed

Number of PubMed hits for this protein AND (aptamer OR SELEX).

aptamer_pmids

The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

1,168 rows where has_activation_state_pdb_pair = 0, has_cryoEM = 1 and tier = "Tier 1" sorted by priority_score descending

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;