Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

629 rows where has_activation_state_pdb_pair = 0, has_known_aptamer = 1 and in_cev_map = 0 sorted by priority_score descending

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tier 2

has_cryoEM 2

  • 0 454
  • 1 175

in_cev_map 1

has_known_aptamer 1

has_activation_state_pdb_pair 1

id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P23946 CMA1 Chymase Tier 1 0.875 42 91.31 0 0       1 1 30572223 0 pernicious anemia 0.17348905136256007
P21583 KITLG Kit ligand Tier 1.5 0.848 6 71.88 1 0       1 2 36579647, 23967247 0 hyperpigmentation with or without hypopigmentation, familial progressive 0.6756727302967072
A0A0E3EAY4 env Envelope glycoprotein gp160 Tier 1 0.82 2   1 0       1 12 36576612, 29464116, 29217761, 22379083, 18776229, 18569791, 16146716, 16043495, 16013840, 12498773, 11024283, 9713975 0    
Q00975 CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B Tier 1.5 0.807 7 59.91 1 0       1 2 31118475, 25782368 0 Seizure 0.7217241968702018
P35414 APLNR Apelin receptor Tier 1 0.8 37 81.69 1 0       1 1 36126144 0 essential hypertension 0.2159614840844307
P01236 PRL Prolactin Tier 1 0.795 12 85.56 0 0       1 6 40327044, 30834248, 29277631, 28263753, 27679852, 16947086 0 AL amyloidosis 0.4619748183558772
O14788 TNFSF11 Tumor necrosis factor ligand superfamily member 11 Tier 1 0.79 2 79.19 0 0       1 2 15562003, 41226313 0 osteoporosis 0.6957850224892792
P03971 AMH Anti-Muellerian hormone Tier 1.5 0.783 3 68.62 1 0       1 2 41101154, 27364573 0 persistent Mullerian duct syndrome 0.7847328444470535
P48023 FASLG Tumor necrosis factor ligand superfamily member 6 Tier 1.5 0.775 3 80.19 0 0       1 1 16581027 0 autoimmune lymphoproliferative syndrome type 1 0.6984292519156657
P07911 UMOD Uromodulin Tier 1 0.774 10 82.94 1 0       1 4 37533140, 35446786 0 familial juvenile hyperuricemic nephropathy type 1 0.8446536377993564
P26951 IL3RA Interleukin-3 receptor subunit alpha Tier 1 0.767 4 85.25 0 0       1 3 40931580, 36171541, 31323275 0 acute myeloid leukemia 0.46904332714118013
P40225 THPO Thrombopoietin Tier 1 0.76 3 61.44 1 0       1 2 38928037, 30312735 0 thrombocythemia 1 0.7027329039559379
Q9GZU2 PEG3 Paternally-expressed gene 3 protein Tier 1.5 0.75 1 44.53 0 0       1 1 16595502 0 neurodegenerative disease 0.34815912577489827
P18075 BMP7 Bone morphogenetic protein 7 Tier 1.5 0.749 4 76.19 0 0       1 1 30537181 0 Inguinal hernia 0.4420059023371716
Q9ULV1 FZD4 Frizzled-4 Tier 1 0.745 11 84.31 1 0       1 1 18673242 0 Familial exudative vitreoretinopathy 0.8152111103672746
P21730 C5AR1 C5a anaphylatoxin chemotactic receptor 1 Tier 1 0.741 19 85.75 1 0       1 5 33495506, 29981048, 29327939, 28288993, 25901944 0 anti-neutrophil cytoplasmic antibody-associated vasculitis 0.5076734733894334
Q9Y5C1 ANGPTL3 Angiopoietin-related protein 3 Tier 1.5 0.727 1 79.62 0 0       1 1 23770039 0 familial hypobetalipoproteinemia 2 0.6739043862507132
K7N5M4 B2M   Tier 1 0.72 24 90.94 0 0       1 3 41850110, 40373155, 38904251 0    
Q00604 NDP Norrin Tier 1.5 0.716 11 83.56 1 0       1 2 39057719, 11352723 0 Norrie disease 0.8566451682188412
P42262 GRIA2 Glutamate receptor 2 Tier 1 0.715 16 84.94 0 0       1 4 28325839, 19417060, 17929944, 17024188 0 neurodevelopmental disorder with language impairment and behavioral abnormalities 0.8328652004757138
P46094 XCR1 Chemokine XC receptor 1 Tier 1.5 0.715 1 84.94 1 0       1 1 35212764 0 COVID-19 0.459103766220463
P32239 CCKBR Gastrin/cholecystokinin type B receptor Tier 1.5 0.713 5 75.75 1 0       1 2 33776434, 27754762 0 gastroesophageal reflux disease 0.4256110167566802
P20809 IL11 Interleukin-11 Tier 1 0.712 8 82.62 1 0       1 8 39408993, 39263947, 28791655, 27878687, 25696907, 24629635 0 osteoarthritis, hip 0.31754029889853136
P25106 ACKR3 Atypical chemokine receptor 3 Tier 1.5 0.71 14 82.44 1 0       1 2 40401615, 28670693 0 oculomotor-abducens synkinesis 0.49893280382434735
P14207 FOLR2 Folate receptor beta Tier 1 0.701 5 89.12 0 0       1 2 28686804 0 neoplasm 0.11545394821329319
A0A0C5B5G6 MT-RNR1 Mitochondrial-derived peptide MOTS-c Tier 1.5 0.7 0 72.06 0 0       1 1 35311942 0    
P01374 LTA Lymphotoxin-alpha Tier 1 0.7 3 83.44 0 0       1 3 41810142, 30576605 0    
P08620 FGF4 Fibroblast growth factor 4 Tier 1.5 0.7 1 81.5 0 0       1 3 35415885, 33536494, 7547864 0 cancer 0.6026669167438079
P15248 IL9 Interleukin-9 Tier 1 0.7 5 84.06 0 0       1 1 40972397 0 neurodegenerative disease 0.40148548290272756
P15309 ACP3 Prostatic acid phosphatase Tier 1 0.695 17 92.25 1 0       1 3 41890985, 25591398 0 prostate cancer 0.5521391557206573
P21781 FGF7 Fibroblast growth factor 7 Tier 1.5 0.695 0 82.44 0 0       1 5 35415885, 15719578, 7547864, 16462265 0 cancer 0.5963369026823151
Q95460 MR1 Major histocompatibility complex class I-related protein 1 Tier 1 0.693 79 87.5 0 0       1 2 41134135, 20000526 0 Immunodeficiency 0.3336382138166145
Q9NPF0 CD320 CD320 antigen Tier 1 0.69 6 63.81 0 0       1 1 39493449 0 Methylmalonic aciduria due to transcobalamin receptor defect 0.49918945650121177
P48061 CXCL12 Stromal cell-derived factor 1 Tier 1 0.685 34 83.25 1 0       1 36 41951573, 41931849, 41907643, 41527798, 40401615, 40008515, 39865939, 39263947, 38806504, 38477735, 32784904, 31267721, 31097627, 30465210, 30385042, 29111236, 28963140, 28670693, 27940247, 27924617, 27392463, 26265085, 25560701, 25236655, 24526776, 24277076, 23615526, 22376154, 21147843, 41963275 0 HIV-1 infection 0.3675509850165065
Q6NW40 RGMB Repulsive guidance molecule B Tier 1 0.683 11 79.44 1 0       1 1 39263947 0 Abnormality of the skeletal system 0.42535629367019584
Q96RJ3 TNFRSF13C Tumor necrosis factor receptor superfamily member 13C Tier 1.5 0.681 8 63.03 1 0       1 1 23470998 0 immunodeficiency, common variable, 4 0.660711678987284
P39900 MMP12 Macrophage metalloelastase Tier 1 0.68 86 86.94 0 0       1 8 41861669, 38477735, 38296402, 37015819, 35120890, 34183667, 27530235 0 atopic eczema 0.4795677061208266
P26718 KLRK1 NKG2-D type II integral membrane protein Tier 1.5 0.679 22 79.19 0 0       1 1 24629635 0 Behcet's syndrome 0.18614538678991077
Q86Z14 KLB Beta-klotho Tier 1 0.676 5 89.38 0 0       1 1 40514411 0 congenital hypogonadotropic hypogonadism 0.462898767992589
Q9UEF7 KL Klotho Tier 1 0.676 6 89.06 1 0       1 19 41978019, 41851110, 41038766, 40370992, 39975897, 39909827, 38500260, 38233588, 37584531, 36891771, 36535944, 35770801, 35360393, 34375633, 33536505, 31511614, 25325398, 18569791, 40514411 0 type 2 diabetes mellitus 0.5587488336100863
P51681 CCR5 C-C chemokine receptor type 5 Tier 1 0.674 25 85.38 1 0       1 23 36576612, 33981364, 29678881, 29556342, 29301363, 27807347, 27652575, 26965267, 25794434, 25754473, 25329893, 23629001, 22811524, 21576818, 18799178, 16631118, 16227301, 15813986, 14610191, 12498773 0 HIV infection 0.7442590579227027
P62576 nanA Sialidase A Tier 1 0.67 5 81.19 0 0       1 4 37350189, 34976356, 34341854, 32034503 0    
Q9GZX9 TWSG1 Twisted gastrulation protein homolog 1 Tier 1 0.67 6 80.38 0 0       1 1 39299474 0 Abruptio Placentae 0.29495361755469174
O00744 WNT10B Protein Wnt-10b Tier 1.5 0.668 0 80.06 0 0       1 2 32810272, 18673242 0 Split hand-split foot malformation 0.7755225395358214
O95750 FGF19 Fibroblast growth factor 19 Tier 1.5 0.668 4 79.81 0 0       1 4 35415885, 31967847, 27679852 0 cancer 0.38540691230511315
P56704 WNT3A Protein Wnt-3a Tier 1 0.665 4 88.31 1 0       1 1 37231925 0 neurodegenerative disease 0.5271953966006525
Q9HCK4 ROBO2 Roundabout homolog 2 Tier 1.5 0.665 6 67.38 0 0       1 2 40616090, 31640794 0 familial vesicoureteral reflux 0.6460375744556555
O15169 AXIN1 Axin-1 Tier 1 0.664 22 61.09 0 0       1 2 28129128 0 hepatocellular carcinoma 0.7864172882686208
P05113 IL5 Interleukin-5 Tier 1 0.664 5 86.69 1 0       1 12 40972397, 35487180, 35356877, 34831332, 32784904, 32038731, 29881374, 28062796, 26048585 0 asthma 0.6399821251487101
Q6PCB0 VWA1 von Willebrand factor A domain-containing protein 1 Tier 1.5 0.664 0 78.38 0 0       1 4 41906877, 41693575, 38904251, 38299345 0 neuronopathy, distal hereditary motor, autosomal recessive 7 0.7420531156755253

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;