Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

498 rows where has_activation_state_pdb_pair = 0, has_known_aptamer = 1 and tier = "Tier 1.5" sorted by priority_score descending

✎ View and edit SQL

This data as json, CSV (advanced)

Suggested facets: pdb_count_total

in_cev_map 2

  • 0 261
  • 1 237

has_cryoEM 2

  • 0 396
  • 1 102

tier 1

  • Tier 1.5 · 498 ✖

has_known_aptamer 1

has_activation_state_pdb_pair 1

id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P25445 FAS Tumor necrosis factor receptor superfamily member 6 Tier 1.5 0.914 7 77.88 1 0       1 17 40784034, 39897575, 37458448, 36908619, 35402075, 32270033, 31436946, 30594071, 30417194, 30339905, 26318819, 23980164, 23511245, 18997060, 18956014, 16729304, 16581027 1 autoimmune lymphoproliferative syndrome type 1 0.7377210386590284
P21583 KITLG Kit ligand Tier 1.5 0.848 6 71.88 1 0       1 2 36579647, 23967247 0 hyperpigmentation with or without hypopigmentation, familial progressive 0.6756727302967072
Q00975 CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B Tier 1.5 0.807 7 59.91 1 0       1 2 31118475, 25782368 0 Seizure 0.7217241968702018
P15260 IFNGR1 Interferon gamma receptor 1 Tier 1.5 0.804 5 66.0 0 0       1 2 33667716 1 disseminated atypical mycobacterial infection 0.5414012388034828
P02748 C9 Complement component C9 Tier 1.5 0.796 9 78.75 1 0       1 10 41636061, 40411682, 36428893, 36290981, 35247355, 28794177, 27836219, 22678933, 19261617, 15687383 1 Immunodeficiency due to a late component of complements deficiency 0.761965409699055
Q13085 ACACA Acetyl-CoA carboxylase 1 Tier 1.5 0.79 10 82.81 1 0       1 1 41854184 1    
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Tier 1.5 0.788 11 75.94 0 0       1 6 41733039, 34364920, 31434881, 30237882, 29299123, 22411871 1 acute myeloid leukemia 0.8313389209288576
Q92633 LPAR1 Lysophosphatidic acid receptor 1 Tier 1.5 0.785 16 83.62 1 0       1 1 32065590 1 Epiretinal membrane 0.4757255248053499
P03971 AMH Anti-Muellerian hormone Tier 1.5 0.783 3 68.62 1 0       1 2 41101154, 27364573 0 persistent Mullerian duct syndrome 0.7847328444470535
P48023 FASLG Tumor necrosis factor ligand superfamily member 6 Tier 1.5 0.775 3 80.19 0 0       1 1 16581027 0 autoimmune lymphoproliferative syndrome type 1 0.6984292519156657
P02776 PF4 Platelet factor 4 Tier 1.5 0.77 10 75.06 0 0       1 10 33859620, 32366845, 31967847, 23847186, 23673861, 34248840, 32022468 1 systemic scleroderma 0.11523541376593864
P39060 COL18A1 Collagen alpha-1(XVIII) chain Tier 1.5 0.769 9 50.62 1 0       1 2 36707842, 23679916 1 Knobloch syndrome 1 0.7867122552672962
P43007 SLC1A4 Neutral amino acid transporter A Tier 1.5 0.75 1 80.56 1 0       1 6 36219068, 31989939, 27571928, 26811678, 19046328, 16139842 1 spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome 0.8025684205131692
Q9GZU2 PEG3 Paternally-expressed gene 3 protein Tier 1.5 0.75 1 44.53 0 0       1 1 16595502 0 neurodegenerative disease 0.34815912577489827
P18075 BMP7 Bone morphogenetic protein 7 Tier 1.5 0.749 4 76.19 0 0       1 1 30537181 0 Inguinal hernia 0.4420059023371716
P08648 ITGA5 Integrin alpha-5 Tier 1.5 0.748 14 85.25 1 0       1 2 32174798, 38258032 1 skin disease 0.28465651599598124
O60884 DNAJA2 DnaJ homolog subfamily A member 2 Tier 1.5 0.73 1 83.38 1 0       1 2 41935727, 33879515 1 dengue disease 0.37068859424875583
Q9Y5C1 ANGPTL3 Angiopoietin-related protein 3 Tier 1.5 0.727 1 79.62 0 0       1 1 23770039 0 familial hypobetalipoproteinemia 2 0.6739043862507132
Q99988 GDF15 Growth/differentiation factor 15 Tier 1.5 0.718 4 75.69 1 0       1 29 41924874, 41862097, 38879214, 38477735, 37982669, 36927042, 36638554, 36508319, 36333824, 35762561, 33334063, 32527800, 31988066, 29992704, 39884764, 38497478, 38296402, 37162508, 32739349, 30335547 1 hyperemesis gravidarum 0.5821658682742563
Q00604 NDP Norrin Tier 1.5 0.716 11 83.56 1 0       1 2 39057719, 11352723 0 Norrie disease 0.8566451682188412
P46094 XCR1 Chemokine XC receptor 1 Tier 1.5 0.715 1 84.94 1 0       1 1 35212764 0 COVID-19 0.459103766220463
P32239 CCKBR Gastrin/cholecystokinin type B receptor Tier 1.5 0.713 5 75.75 1 0       1 2 33776434, 27754762 0 gastroesophageal reflux disease 0.4256110167566802
P25106 ACKR3 Atypical chemokine receptor 3 Tier 1.5 0.71 14 82.44 1 0       1 2 40401615, 28670693 0 oculomotor-abducens synkinesis 0.49893280382434735
P41221 WNT5A Protein Wnt-5a Tier 1.5 0.71 0 87.69 0 0       1 4 40855286, 32693649, 22363130, 18673242 1 Robinow syndrome 0.7220360983378594
A0A0C5B5G6 MT-RNR1 Mitochondrial-derived peptide MOTS-c Tier 1.5 0.7 0 72.06 0 0       1 1 35311942 0    
P07225 PROS1 Vitamin K-dependent protein S Tier 1.5 0.7 3 82.94 1 0       1 2 36859809, 33674695 1 thrombophilia due to protein S deficiency, autosomal dominant 0.8240418292042652
P08620 FGF4 Fibroblast growth factor 4 Tier 1.5 0.7 1 81.5 0 0       1 3 35415885, 33536494, 7547864 0 cancer 0.6026669167438079
P19021 PAM Peptidyl-glycine alpha-amidating monooxygenase Tier 1.5 0.695 0 71.69 0 0       1 25 41855944, 41500123, 41384307, 41285544, 41222440, 40607956, 39929897, 39472107, 38867016, 38846799, 37977804, 37977780, 37906116, 37127012, 36905684, 35478209, 33911033, 33516855, 32315032, 32307868, 30399413, 30124431, 26406332, 22954359, 14965210 1 type 2 diabetes mellitus 0.5754371880839976
P21359 NF1 Neurofibromin Tier 1.5 0.695 26 87.19 1 0       1 2 32980430, 22617876 1 neurofibromatosis type 1 0.8844735398780649
P21781 FGF7 Fibroblast growth factor 7 Tier 1.5 0.695 0 82.44 0 0       1 5 35415885, 15719578, 7547864, 16462265 0 cancer 0.5963369026823151
P10586 PTPRF Receptor-type tyrosine-protein phosphatase F Tier 1.5 0.69 13 82.0 0 0       1 4 42101929, 39087949, 36594741 1 smoking initiation 0.4641111755355386
O00501 CLDN5 Claudin-5 Tier 1.5 0.685 0 83.75 0 0       1 1 18951306 1 genetic disorder 0.40861362787778505
Q96RJ3 TNFRSF13C Tumor necrosis factor receptor superfamily member 13C Tier 1.5 0.681 8 63.03 1 0       1 1 23470998 0 immunodeficiency, common variable, 4 0.660711678987284
P14384 CPM Carboxypeptidase M Tier 1.5 0.68 1 90.31 0 0       1 3 38876068, 38060303, 36768220 1 hydronephrosis 0.3163273148871551
P26718 KLRK1 NKG2-D type II integral membrane protein Tier 1.5 0.679 22 79.19 0 0       1 1 24629635 0 Behcet's syndrome 0.18614538678991077
P09758 TACSTD2 Tumor-associated calcium signal transducer 2 Tier 1.5 0.673 7 82.69 0 0       1 4 41384307, 41241473, 40050871, 39250993 1 gelatinous drop-like corneal dystrophy 0.7293087728162646
P98066 TNFAIP6 Tumor necrosis factor-inducible gene 6 protein Tier 1.5 0.671 5 81.12 0 0       1 1 39263947 1 type 2 diabetes mellitus 0.30862220597837015
O00744 WNT10B Protein Wnt-10b Tier 1.5 0.668 0 80.06 0 0       1 2 32810272, 18673242 0 Split hand-split foot malformation 0.7755225395358214
O95750 FGF19 Fibroblast growth factor 19 Tier 1.5 0.668 4 79.81 0 0       1 4 35415885, 31967847, 27679852 0 cancer 0.38540691230511315
Q9HCK4 ROBO2 Roundabout homolog 2 Tier 1.5 0.665 6 67.38 0 0       1 2 40616090, 31640794 0 familial vesicoureteral reflux 0.6460375744556555
Q6PCB0 VWA1 von Willebrand factor A domain-containing protein 1 Tier 1.5 0.664 0 78.38 0 0       1 4 41906877, 41693575, 38904251, 38299345 0 neuronopathy, distal hereditary motor, autosomal recessive 7 0.7420531156755253
A2RU14 TMEM218 Transmembrane protein 218 Tier 1.5 0.663 0 87.62 0 0       1 6 41360349, 34861273, 31349094, 29277631, 26580576, 26248137 0 Joubert syndrome 39 0.7308441626389979
P16870 CPE Carboxypeptidase E Tier 1.5 0.66 0 90.38 0 0       1 16 39863729, 39793371, 38861005, 36832010, 36773630, 27886773, 27219679, 25738486, 28706644, 24768847, 23875581, 22280349, 21419619, 20949139, 20491465, 19174227 1 BDV syndrome 0.7029731914682913
P18510 IL1RN Interleukin-1 receptor antagonist protein Tier 1.5 0.66 5 87.06 0 0       1 1 38928037 0 sterile multifocal osteomyelitis with periostitis and pustulosis 0.7734282711738736
P22692 IGFBP4 Insulin-like growth factor-binding protein 4 Tier 1.5 0.66 4 77.25 0 0       1 6 35323639, 32515246, 31930684 1 allergic rhinitis 0.35214760515440524
P98155 VLDLR Very low-density lipoprotein receptor Tier 1.5 0.66 27 75.69 1 0       1 1 19188685 1 Dysequilibrium syndrome 0.790164037509625
Q13433 SLC39A6 Zinc transporter ZIP6 Tier 1.5 0.66 0 60.44 0 0       1 1 40132409 1 breast cancer 0.11188167100061543
Q86YL7 PDPN Podoplanin Tier 1.5 0.66 6 57.97 0 0       1 4 41304780, 41292412, 39451677 0 Microscopic hematuria 0.41183796492083136
O15389 SIGLEC5 Sialic acid-binding Ig-like lectin 5 Tier 1.5 0.656 3 77.75 0 0       1 3 33584010, 27678199, 24405684 0 dentures 0.15815607474115415
P02766 TTR Transthyretin Tier 1.5 0.655 0 88.0 0 0       1 11 39737993, 32616928, 23770039, 21875107, 21314458, 39596348, 38399458, 36881759, 33572452 1 amyloidosis, hereditary systemic 1 0.846421986844374

Next page

Advanced export

JSON shape: default, array, newline-delimited

CSV options: 

CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;