Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

11 rows where has_activation_state_pdb_pair = 1 sorted by priority_score descending

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Suggested facets: priority_score, pdb_count_total, activation_state_pdb_active, activation_state_pdb_inactive, aptamer_count_pubmed, opentargets_top_disease_name

has_known_aptamer 2

has_cryoEM 2

in_cev_map 1

  • 1 11

has_activation_state_pdb_pair 1

id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P05106 ITGB3 Integrin beta-3 Positive Control 0.715 123 87.0 1 1 8T2U 8T2V   1 2 22133781, 23544955 1 Glanzmann thrombasthenia 1 0.8208115968652424
P11802 CDK4 Cyclin-dependent kinase 4 Tier 1 0.575 15 86.81 1 1 2W96 3G33   1 2 41535871, 21059336 1 melanoma, cutaneous malignant, susceptibility to, 3 0.7141203476842687
P06756 ITGAV Integrin alpha-V Tier 1.5 0.572 0 88.31 0 1 1L5G 1JV2   1 8 27693080, 31361124, 28191852, 21848510, 21136958, 21071077, 19235198 1 neurodegenerative disease 0.41990892731367724
P08514 ITGA2B Integrin alpha-IIb Positive Control 0.515 78 88.12 1 1 8T2U 8T2V   0 0   1 Glanzmann thrombasthenia 1 0.8224288672248264
P00519 ABL1 Tyrosine-protein kinase ABL1 Tier 1 0.0 85 63.38 0 1 2GQG 1OPL   1 5 31295447, 23836560, 22411871, 21810089, 21653319 1 chronic myelogenous leukemia 0.8219762968845584
P01112 HRAS GTPase HRas Tier 1 0.0 100 91.94 0 1 5P21 4Q21   0 0   1 Costello syndrome 0.8839339324666988
P01116 KRAS GTPase KRas Tier 1 0.0 100 91.5 0 1 6GOD 6MNX   1 21 41132421, 40824107, 40766128, 40148451, 39215101, 38784467, 38784452, 38604287, 37637206, 36229679, 35473857, 34097885, 32871244, 32370304, 32010971, 31583159, 28639199, 28514850, 27936442, 20565241, 17461759 1 Noonan syndrome 3 0.8263697027313498
P12931 SRC Proto-oncogene tyrosine-protein kinase Src Tier 1 0.0 78 83.44 0 1 1Y57 2SRC   1 19 40569566, 39664567, 38471488, 35928129, 35859339, 34757788, 34083659, 33530373, 32668060, 30970280, 28701145, 26458993, 25645980, 23842900, 22693611, 22323540, 18985031, 18682833, 12842895 1 cancer 0.6343904000453656
P24941 CDK2 Cyclin-dependent kinase 2 Tier 1 0.0 100 88.44 0 1 1QMZ 1HCK   1 24 33981223, 26972431, 21616931, 21059336, 20394401, 19320493, 18495468, 18186614, 11071782, 11106396, 9826690, 9826689, 8606778, 11566434 1 neurodegenerative disease 0.37316884263655814
P31749 AKT1 RAC-alpha serine/threonine-protein kinase Tier 1 0.0 43 83.06 0 1 4EJN 3O96   1 5 40487120, 33535960, 27907160, 27663888, 24242861 1 Proteus syndrome 0.7595350815691262
O14965 AURKA Aurora kinase A Tier 1   100 75.06 0 1 1OL5 1MUO   1 2 39776073 1 neurodegenerative disease 0.520933205943212

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;