Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

1,493 rows where has_cryoEM = 0, has_known_aptamer = 0 and tier = "Tier 1" sorted by priority_score descending

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in_cev_map 2

  • 1 830
  • 0 663

has_activation_state_pdb_pair 2

  • 0 1,492
  • 1 1

tier 1

  • Tier 1 · 1,493 ✖

has_known_aptamer 1

  • - · 1,493 ✖

has_cryoEM 1

  • - · 1,493 ✖
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
Q9UJA9 ENPP5 Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Tier 1 0.87 1 88.12 0 0       0 0   0 neurodegenerative disease 0.33211724272317855
P01911 HLA-DRB1 HLA class II histocompatibility antigen, DRB1 beta chain Tier 1 0.84 100 88.44 0 0       0 0   1 rheumatoid arthritis 0.40051584219092445
Q31135 H2-Ab1   Tier 1 0.83 12 85.12 0 0       0 0   0    
P35555 FBN1 Fibrillin-1 Tier 1 0.78 11   0 0       0 0   1 Marfan syndrome 0.8969300970597663
A6ND01 IZUMO1R Sperm-egg fusion protein Juno Tier 1 0.773 7 87.38 0 0       0 0   0 placental retention 0.23306495563589497
P02671 FGA Fibrinogen alpha chain Tier 1 0.77 40 60.34 0 0       0 0   1 familial dysfibrinogenemia 0.7947496460990987
P03951 F11 Coagulation factor XI Tier 1 0.77 100 86.88 0 0       0 0   1 factor XI deficiency 0.841884208404384
A0A5H2UYS3 HLA-A   Tier 1 0.77 20 85.25 0 0       0 0   0    
P16471 PRLR Prolactin receptor Tier 1 0.747 12 61.03 0 0       0 0   0 familial hyperprolactinemia 0.5718636087471152
P01563     Tier 1 0.744 13 85.06 0 0       0 0   0 renal cell carcinoma 0.3938654263610389
Q9BY67 CADM1 Cell adhesion molecule 1 Tier 1 0.734 2 80.56 0 0       0 0   1 Abnormality of the skeletal system 0.442731358018962
Q99497 PARK7 Parkinson disease protein 7 Tier 1 0.723 88 98.44 0 0       0 0   1 Young adult-onset Parkinsonism 0.7264878745993893
Q16878 CDO1 Cysteine dioxygenase type 1 Tier 1 0.72 17 93.62 0 0       0 0   0 adolescent idiopathic scoliosis 0.3105991982786747
Q12918 KLRB1 Killer cell lectin-like receptor subfamily B member 1 Tier 1 0.719 3 81.0 0 0       0 0   0 sensory perception of smell 0.287724180593876
Q99574 SERPINI1 Neuroserpin Tier 1 0.712 3 88.12 0 0       0 0   0 familial encephalopathy with neuroserpin inclusion bodies 0.7162803151916303
A0A583ZB34     Tier 1 0.71 9 84.38 0 0       0 0   0    
P01889 HLA-B HLA class I histocompatibility antigen, B alpha chain Tier 1 0.708 100 88.06 0 0       0 0   1 COVID-19 0.48417012135481613
P14555 PLA2G2A Phospholipase A2, membrane associated Tier 1 0.7 17 91.0 0 0       0 0   0 familial colorectal cancer 0.3326218692162316
Q5Y7D3 HLA-DQB1   Tier 1 0.7 6 85.31 0 0       0 0   0    
P08473 MME Neprilysin Tier 1 0.699 16 96.19 0 0       0 0   1 Charcot-Marie-Tooth disease axonal type 2T 0.7912653398252156
O43570 CA12 Carbonic anhydrase 12 Tier 1 0.695 40 87.81 0 0       0 0   0 isolated hyperchlorhidrosis 0.6794515382695604
Q96QV1 HHIP Hedgehog-interacting protein Tier 1 0.692 11 79.75 0 0       0 0   0 Abnormality of the skeletal system 0.5195282784554633
P04435 TRBV7-9 T cell receptor beta variable 7-9 Tier 1 0.691 2 90.06 0 0       0 0   0 neoplasm 0.11454334012562349
Q02083 NAAA N-acylethanolamine-hydrolyzing acid amidase Tier 1 0.69 2 92.25 0 0       0 0   0 abscess 0.2726858643799341
Q92187 ST8SIA4 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase Tier 1 0.69 3 86.44 0 0       0 0   1 systemic lupus erythematosus 0.43832763677821385
Q15788 NCOA1 Nuclear receptor coactivator 1 Tier 1 0.69 100 46.72 0 0       0 0   0 neurodegenerative disease 0.48697450901885614
A0A9P1NJI6     Tier 1 0.69 6   0 0       0 0   0    
Q9UBH0 IL36RN Interleukin-36 receptor antagonist protein Tier 1 0.687 3 92.44 0 0       0 0   0 psoriasis 14, pustular 0.8155144873787125
O95399 UTS2 Urotensin-2 Tier 1 0.685 2 58.44 0 0       0 0   1 hair color 0.35316475479030335
A0A0C4DH28 TRGV4 T cell receptor gamma variable 4 Tier 1 0.681 4 84.06 0 0       0 0   0 Townes-Brocks syndrome 0.006652437384324632
Q99584 S100A13 Protein S100-A13 Tier 1 0.681 12 80.81 0 0       0 0   1 neurodegenerative disease 0.41302685279153983
U5YJJ6 HLA-A   Tier 1 0.68 3 89.0 0 0       0 0   0    
Q16651 PRSS8 Prostasin Tier 1 0.68 9 83.75 0 0       0 0   0 Alzheimer disease 0.4223067864061274
Q9HBI1 PARVB Beta-parvin Tier 1 0.68 3 81.75 0 0       0 0   1 thyroiditis 0.28021156500366357
O00602 FCN1 Ficolin-1 Tier 1 0.675 7 84.94 0 0       0 0   1 neurodegenerative disease 0.351581018821974
Q9UK55 SERPINA10 Protein Z-dependent protease inhibitor Tier 1 0.672 4 86.75 0 0       0 0   1 macular degeneration 0.3247169581531489
P02749 APOH Beta-2-glycoprotein 1 Tier 1 0.67 14 93.12 0 0       0 0   1 atrial fibrillation 0.5456247991985232
P06703 S100A6 Protein S100-A6 Tier 1 0.67 6 87.19 0 0       0 0   1 neoplasm 0.10449825238323361
P78552 IL13RA1 Interleukin-13 receptor subunit alpha-1 Tier 1 0.67 4 81.56 0 0       0 0   1 type 2 diabetes mellitus 0.48627783096767857
P14867 GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 Tier 1 0.667 0 81.69 0 0       0 0   0 developmental and epileptic encephalopathy, 19 0.7734302780200346
P54762 EPHB1 Ephrin type-B receptor 1 Tier 1 0.665 8 83.62 0 0       0 0   1 medullary thyroid gland carcinoma 0.5204553830376101
Q9UHV8 LGALS13 Galactoside-binding soluble lectin 13 Tier 1 0.66 11 97.5 0 0       0 0   0 preeclampsia 0.11027592759014439
Q6IQ20 NAPEPLD N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D Tier 1 0.66 4 87.25 0 0       0 0   0 reticular dystrophy of the retinal pigment epithelium 0.3695798546847018
A0A0U5Q247     Tier 1 0.66 3 85.12 0 0       0 0   0    
Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M Tier 1 0.66 0 55.28 0 0       0 0   1 Hernia 0.2963310523049043
Q8IYV9 IZUMO1 Izumo sperm-egg fusion protein 1 Tier 1 0.659 7 81.06 0 0       0 0   0 cholelithiasis 0.18873738346588434
P48552 NRIP1 Nuclear receptor-interacting protein 1 Tier 1 0.657 17 45.91 0 0       0 0   0 neurodegenerative disease 0.5654759320154787
P05543 SERPINA7 Thyroxine-binding globulin Tier 1 0.655 9 87.06 0 0       0 0   1 neoplasm 0.09631257418600654
P20701 ITGAL Integrin alpha-L Tier 1 0.655 41 82.62 0 0       0 0   1 psoriasis 0.5899795223699872
A8MUM7 LGALS16 Galectin-16 Tier 1 0.654 3 94.62 0 0       0 0   0 neurodegenerative disease 0.536067027639694

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;