Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

1,044 rows where has_cryoEM = 0 and has_known_aptamer = 1 sorted by priority_score descending

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tier 2

in_cev_map 2

  • 1 590
  • 0 454

has_activation_state_pdb_pair 2

  • 0 1,037
  • 1 7

has_known_aptamer 1

  • 1 · 1,044 ✖

has_cryoEM 1

  • - · 1,044 ✖
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P23946 CMA1 Chymase Tier 1 0.875 42 91.31 0 0       1 1 30572223 0 pernicious anemia 0.17348905136256007
P13747 HLA-E HLA class I histocompatibility antigen, alpha chain E Tier 1 0.865 34 87.0 0 0       1 1 38473398 1 COVID-19 0.4822929100647597
Q15848 ADIPOQ Adiponectin Tier 1 0.806 3 79.88 0 0       1 10 41636061, 38392020, 36508319, 35323639, 34796696, 34117903, 33535822, 31988066, 25105541 1 hearing loss 0.25844907375917336
P15260 IFNGR1 Interferon gamma receptor 1 Tier 1.5 0.804 5 66.0 0 0       1 2 33667716 1 disseminated atypical mycobacterial infection 0.5414012388034828
P01236 PRL Prolactin Tier 1 0.795 12 85.56 0 0       1 6 40327044, 30834248, 29277631, 28263753, 27679852, 16947086 0 AL amyloidosis 0.4619748183558772
O14788 TNFSF11 Tumor necrosis factor ligand superfamily member 11 Tier 1 0.79 2 79.19 0 0       1 2 15562003, 41226313 0 osteoporosis 0.6957850224892792
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Tier 1.5 0.788 11 75.94 0 0       1 6 41733039, 34364920, 31434881, 30237882, 29299123, 22411871 1 acute myeloid leukemia 0.8313389209288576
P01019 AGT Angiotensinogen Tier 1 0.779 22 86.44 0 0       1 16 35983901, 34936368, 34779902, 34248841, 32838280, 23766021, 17673982, 11419945, 38045440, 34619249, 29844151, 27530235 1 renal tubular dysgenesis 0.7354947364860083
P48023 FASLG Tumor necrosis factor ligand superfamily member 6 Tier 1.5 0.775 3 80.19 0 0       1 1 16581027 0 autoimmune lymphoproliferative syndrome type 1 0.6984292519156657
P61769 B2M Beta-2-microglobulin Tier 1 0.77 100 94.06 0 0       1 15 41850110, 40373155, 38904251, 40658810, 35026285, 32631049, 29281176, 28960840, 25100729, 20616783, 19137104, 17878167 1 Immunodeficiency by defective expression of HLA class 1 0.6180318849819645
P02776 PF4 Platelet factor 4 Tier 1.5 0.77 10 75.06 0 0       1 10 33859620, 32366845, 31967847, 23847186, 23673861, 34248840, 32022468 1 systemic scleroderma 0.11523541376593864
P26951 IL3RA Interleukin-3 receptor subunit alpha Tier 1 0.767 4 85.25 0 0       1 3 40931580, 36171541, 31323275 0 acute myeloid leukemia 0.46904332714118013
P05546 SERPIND1 Heparin cofactor 2 Tier 1 0.752 9 79.62 0 0       1 4 20062917, 20053992, 34248840, 31247951 1 heparin cofactor 2 deficiency 0.719744572767547
Q9GZU2 PEG3 Paternally-expressed gene 3 protein Tier 1.5 0.75 1 44.53 0 0       1 1 16595502 0 neurodegenerative disease 0.34815912577489827
P18075 BMP7 Bone morphogenetic protein 7 Tier 1.5 0.749 4 76.19 0 0       1 1 30537181 0 Inguinal hernia 0.4420059023371716
P05164 MPO Myeloperoxidase Tier 1 0.745 49 89.0 0 0       1 16 41629951, 41316897, 40501769, 38127443, 33534888, 33495506, 37991715, 37277648, 34183667, 34117903, 33869115, 31210423, 30431231 1 myeloperoxidase deficiency 0.7742533340195327
Q9Y5C1 ANGPTL3 Angiopoietin-related protein 3 Tier 1.5 0.727 1 79.62 0 0       1 1 23770039 0 familial hypobetalipoproteinemia 2 0.6739043862507132
P05187 ALPP Alkaline phosphatase, placental type Tier 1 0.72 8 93.44 0 0       1 7 41329468, 38238732, 37425696, 37047289, 31687420, 25919296, 23467613 1 male reproductive organ cancer 0.16284411775950106
K7N5M4 B2M   Tier 1 0.72 24 90.94 0 0       1 3 41850110, 40373155, 38904251 0    
P29622 SERPINA4 Kallistatin Tier 1 0.719 3 86.69 0 0       1 4 38904251, 30297859, 37351609, 28794177 1 optic atrophy 0.28896631154492924
P42262 GRIA2 Glutamate receptor 2 Tier 1 0.715 16 84.94 0 0       1 4 28325839, 19417060, 17929944, 17024188 0 neurodevelopmental disorder with language impairment and behavioral abnormalities 0.8328652004757138
P41221 WNT5A Protein Wnt-5a Tier 1.5 0.71 0 87.69 0 0       1 4 40855286, 32693649, 22363130, 18673242 1 Robinow syndrome 0.7220360983378594
Q96IY4 CPB2 Carboxypeptidase B2 Tier 1 0.709 10 94.12 0 0       1 4 37329944, 36805075, 35861072, 30297859 1 type 2 diabetes mellitus 0.19338213943947646
P25311 AZGP1 Zinc-alpha-2-glycoprotein Tier 1 0.701 9 92.88 0 0       1 1 41325160 1 neoplasm 0.10887540652591159
P14207 FOLR2 Folate receptor beta Tier 1 0.701 5 89.12 0 0       1 2 28686804 0 neoplasm 0.11545394821329319
P15248 IL9 Interleukin-9 Tier 1 0.7 5 84.06 0 0       1 1 40972397 0 neurodegenerative disease 0.40148548290272756
P01374 LTA Lymphotoxin-alpha Tier 1 0.7 3 83.44 0 0       1 3 41810142, 30576605 0    
A0A0C5B5G6 MT-RNR1 Mitochondrial-derived peptide MOTS-c Tier 1.5 0.7 0 72.06 0 0       1 1 35311942 0    
P08620 FGF4 Fibroblast growth factor 4 Tier 1.5 0.7 1 81.5 0 0       1 3 35415885, 33536494, 7547864 0 cancer 0.6026669167438079
P00746 CFD Complement factor D Tier 1 0.695 40 91.0 0 0       1 4 38057414, 38071633, 28972568, 25727321 1 recurrent Neisseria infections due to factor D deficiency 0.7726408204424132
P19021 PAM Peptidyl-glycine alpha-amidating monooxygenase Tier 1.5 0.695 0 71.69 0 0       1 25 41855944, 41500123, 41384307, 41285544, 41222440, 40607956, 39929897, 39472107, 38867016, 38846799, 37977804, 37977780, 37906116, 37127012, 36905684, 35478209, 33911033, 33516855, 32315032, 32307868, 30399413, 30124431, 26406332, 22954359, 14965210 1 type 2 diabetes mellitus 0.5754371880839976
P21781 FGF7 Fibroblast growth factor 7 Tier 1.5 0.695 0 82.44 0 0       1 5 35415885, 15719578, 7547864, 16462265 0 cancer 0.5963369026823151
Q95460 MR1 Major histocompatibility complex class I-related protein 1 Tier 1 0.693 79 87.5 0 0       1 2 41134135, 20000526 0 Immunodeficiency 0.3336382138166145
Q9NPF0 CD320 CD320 antigen Tier 1 0.69 6 63.81 0 0       1 1 39493449 0 Methylmalonic aciduria due to transcobalamin receptor defect 0.49918945650121177
P10586 PTPRF Receptor-type tyrosine-protein phosphatase F Tier 1.5 0.69 13 82.0 0 0       1 4 42101929, 39087949, 36594741 1 smoking initiation 0.4641111755355386
P22303 ACHE Acetylcholinesterase Tier 1 0.685 78 92.94 0 0       1 135 41985393, 41898380, 41654945, 41639270, 41639254, 41565777, 41276911, 41237904, 41230502, 41086326, 41006757, 40855286, 40500390, 40487355, 40452137, 40444021, 40277325, 40262341, 40215752, 40154972, 40128122, 39834132, 39728786, 39689579, 39665919, 39282962, 39102642, 38996565, 38953438, 38949022, 38722683, 38569854, 38559166, 38544485, 38462144, 38410271, 38168820, 38026177, 37905115, 37759795, 37622311, 37506391, 37117194, 36741760, 36551106, 36368824, 36047811, 35842727, 35770801, 35439419, 36971430, 36375221, 36359944, 35479481, 35402070, 35235478, 35057959, 34509014, 33218485, 33096123, 32143069, 31748191, 31170561, 26003847, 25569873, 24756130, 24299064, 12852840 1 Alzheimer disease 0.628678841772617
P03950 ANG Angiogenin Tier 1 0.685 56 89.81 0 0       1 99 41948065, 41736700, 41688234, 41686152, 41625383, 41551985, 41550856, 41338305, 41194434, 40839054, 40825091, 40233536, 40046817, 39891801, 39871473, 39727889, 39700796, 39226945, 39078660, 38458987, 38282417, 37683754, 37585601, 37556929, 37527337, 37367006, 37284580, 37185488, 37100807, 36520671, 36315359, 36291000, 36087171, 35731347, 35489276, 35408368, 35290881, 35218097, 35084794, 34987275, 34964948, 34902643, 34617153, 34523638, 34500620, 34474207, 34464491, 34439828, 34350496, 34232998, 27841380, 25461163, 25422408, 22018671, 21774079, 18585145, 18533682, 17260069, 9578572 1 amyotrophic lateral sclerosis 0.7865457274017922
P01008 SERPINC1 Antithrombin-III Tier 1 0.685 27 84.69 0 0       1 11 32199927, 31881749, 31747245, 25467079, 25186782, 24359968, 23637781, 18316185, 15741074, 10660541, 10457984 1 hereditary antithrombin deficiency 0.8494671886642873
O00501 CLDN5 Claudin-5 Tier 1.5 0.685 0 83.75 0 0       1 1 18951306 1 genetic disorder 0.40861362787778505
Q15485 FCN2 Ficolin-2 Tier 1 0.682 13 85.12 0 0       1 2 27490795 1 hypopituitarism 0.2753784074131916
Q07954 LRP1 Prolow-density lipoprotein receptor-related protein 1 Tier 1 0.682 7 79.19 0 0       1 3 41599761, 38996211, 25855589 1 developmental dysplasia of the hip 0.6197148309275711
P00918 CA2 Carbonic anhydrase 2 Tier 1 0.68 100 97.38 0 0       1 109 41955789, 41543229, 41513346, 40854266, 40783389, 40744710, 40660917, 40411663, 40380946, 40321028, 39978259, 39928524, 39716707, 39536855, 39515698, 38946763, 38693181, 38462338, 38409486, 37997814, 37726778, 37148800, 37103734, 36792529, 36410157, 36140102, 36107718, 35490167, 35344667, 35211356, 35194086, 35022247, 35006986, 34619285, 34607961, 34440571, 34399193, 34362425, 34166652, 33832411, 33479839, 33410656, 33230701, 33080851, 32991252, 35516485, 32700526, 32493583, 32331372, 32304233 1 Osteopetrosis with renal tubular acidosis 0.7929568656592082
P39900 MMP12 Macrophage metalloelastase Tier 1 0.68 86 86.94 0 0       1 8 41861669, 38477735, 38296402, 37015819, 35120890, 34183667, 27530235 0 atopic eczema 0.4795677061208266
P09958 FURIN Furin Tier 1 0.68 48 84.75 0 0       1 4 36291832, 24808863 1 coronary artery disease 0.5783535503692275
P14384 CPM Carboxypeptidase M Tier 1.5 0.68 1 90.31 0 0       1 3 38876068, 38060303, 36768220 1 hydronephrosis 0.3163273148871551
P26718 KLRK1 NKG2-D type II integral membrane protein Tier 1.5 0.679 22 79.19 0 0       1 1 24629635 0 Behcet's syndrome 0.18614538678991077
Q86Z14 KLB Beta-klotho Tier 1 0.676 5 89.38 0 0       1 1 40514411 0 congenital hypogonadotropic hypogonadism 0.462898767992589
P09382 LGALS1 Galectin-1 Tier 1 0.675 41 96.5 0 0       1 6 37141264, 33006019, 31778957 1 glaucoma 0.2854257184852107
P09758 TACSTD2 Tumor-associated calcium signal transducer 2 Tier 1.5 0.673 7 82.69 0 0       1 4 41384307, 41241473, 40050871, 39250993 1 gelatinous drop-like corneal dystrophy 0.7293087728162646
P98066 TNFAIP6 Tumor necrosis factor-inducible gene 6 protein Tier 1.5 0.671 5 81.12 0 0       1 1 39263947 1 type 2 diabetes mellitus 0.30862220597837015

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;