Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

454 rows where has_cryoEM = 0, has_known_aptamer = 1 and in_cev_map = 0 sorted by priority_score descending

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tier 2

in_cev_map 1

has_known_aptamer 1

has_cryoEM 1

has_activation_state_pdb_pair 1

  • 0 454
id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P23946 CMA1 Chymase Tier 1 0.875 42 91.31 0 0       1 1 30572223 0 pernicious anemia 0.17348905136256007
P01236 PRL Prolactin Tier 1 0.795 12 85.56 0 0       1 6 40327044, 30834248, 29277631, 28263753, 27679852, 16947086 0 AL amyloidosis 0.4619748183558772
O14788 TNFSF11 Tumor necrosis factor ligand superfamily member 11 Tier 1 0.79 2 79.19 0 0       1 2 15562003, 41226313 0 osteoporosis 0.6957850224892792
P48023 FASLG Tumor necrosis factor ligand superfamily member 6 Tier 1.5 0.775 3 80.19 0 0       1 1 16581027 0 autoimmune lymphoproliferative syndrome type 1 0.6984292519156657
P26951 IL3RA Interleukin-3 receptor subunit alpha Tier 1 0.767 4 85.25 0 0       1 3 40931580, 36171541, 31323275 0 acute myeloid leukemia 0.46904332714118013
Q9GZU2 PEG3 Paternally-expressed gene 3 protein Tier 1.5 0.75 1 44.53 0 0       1 1 16595502 0 neurodegenerative disease 0.34815912577489827
P18075 BMP7 Bone morphogenetic protein 7 Tier 1.5 0.749 4 76.19 0 0       1 1 30537181 0 Inguinal hernia 0.4420059023371716
Q9Y5C1 ANGPTL3 Angiopoietin-related protein 3 Tier 1.5 0.727 1 79.62 0 0       1 1 23770039 0 familial hypobetalipoproteinemia 2 0.6739043862507132
K7N5M4 B2M   Tier 1 0.72 24 90.94 0 0       1 3 41850110, 40373155, 38904251 0    
P42262 GRIA2 Glutamate receptor 2 Tier 1 0.715 16 84.94 0 0       1 4 28325839, 19417060, 17929944, 17024188 0 neurodevelopmental disorder with language impairment and behavioral abnormalities 0.8328652004757138
P14207 FOLR2 Folate receptor beta Tier 1 0.701 5 89.12 0 0       1 2 28686804 0 neoplasm 0.11545394821329319
P15248 IL9 Interleukin-9 Tier 1 0.7 5 84.06 0 0       1 1 40972397 0 neurodegenerative disease 0.40148548290272756
P01374 LTA Lymphotoxin-alpha Tier 1 0.7 3 83.44 0 0       1 3 41810142, 30576605 0    
A0A0C5B5G6 MT-RNR1 Mitochondrial-derived peptide MOTS-c Tier 1.5 0.7 0 72.06 0 0       1 1 35311942 0    
P08620 FGF4 Fibroblast growth factor 4 Tier 1.5 0.7 1 81.5 0 0       1 3 35415885, 33536494, 7547864 0 cancer 0.6026669167438079
P21781 FGF7 Fibroblast growth factor 7 Tier 1.5 0.695 0 82.44 0 0       1 5 35415885, 15719578, 7547864, 16462265 0 cancer 0.5963369026823151
Q95460 MR1 Major histocompatibility complex class I-related protein 1 Tier 1 0.693 79 87.5 0 0       1 2 41134135, 20000526 0 Immunodeficiency 0.3336382138166145
Q9NPF0 CD320 CD320 antigen Tier 1 0.69 6 63.81 0 0       1 1 39493449 0 Methylmalonic aciduria due to transcobalamin receptor defect 0.49918945650121177
P39900 MMP12 Macrophage metalloelastase Tier 1 0.68 86 86.94 0 0       1 8 41861669, 38477735, 38296402, 37015819, 35120890, 34183667, 27530235 0 atopic eczema 0.4795677061208266
P26718 KLRK1 NKG2-D type II integral membrane protein Tier 1.5 0.679 22 79.19 0 0       1 1 24629635 0 Behcet's syndrome 0.18614538678991077
Q86Z14 KLB Beta-klotho Tier 1 0.676 5 89.38 0 0       1 1 40514411 0 congenital hypogonadotropic hypogonadism 0.462898767992589
P62576 nanA Sialidase A Tier 1 0.67 5 81.19 0 0       1 4 37350189, 34976356, 34341854, 32034503 0    
Q9GZX9 TWSG1 Twisted gastrulation protein homolog 1 Tier 1 0.67 6 80.38 0 0       1 1 39299474 0 Abruptio Placentae 0.29495361755469174
O95750 FGF19 Fibroblast growth factor 19 Tier 1.5 0.668 4 79.81 0 0       1 4 35415885, 31967847, 27679852 0 cancer 0.38540691230511315
O00744 WNT10B Protein Wnt-10b Tier 1.5 0.668 0 80.06 0 0       1 2 32810272, 18673242 0 Split hand-split foot malformation 0.7755225395358214
Q9HCK4 ROBO2 Roundabout homolog 2 Tier 1.5 0.665 6 67.38 0 0       1 2 40616090, 31640794 0 familial vesicoureteral reflux 0.6460375744556555
O15169 AXIN1 Axin-1 Tier 1 0.664 22 61.09 0 0       1 2 28129128 0 hepatocellular carcinoma 0.7864172882686208
Q6PCB0 VWA1 von Willebrand factor A domain-containing protein 1 Tier 1.5 0.664 0 78.38 0 0       1 4 41906877, 41693575, 38904251, 38299345 0 neuronopathy, distal hereditary motor, autosomal recessive 7 0.7420531156755253
A2RU14 TMEM218 Transmembrane protein 218 Tier 1.5 0.663 0 87.62 0 0       1 6 41360349, 34861273, 31349094, 29277631, 26580576, 26248137 0 Joubert syndrome 39 0.7308441626389979
P15941 MUC1 Mucin-1 Tier 1 0.66 23 47.41 0 0       1 686 42025056, 41988862, 41954302, 41771296, 41744704, 41744190, 41657320, 41627316, 41621292, 41582516, 41535857, 41471303, 41362016, 41352919, 41346179, 41330302, 41243570, 41205458, 41185018, 41101154, 41047832, 41027169, 40682599, 40665615, 40627939, 40607530, 40590839, 40578633, 40568899, 40556592, 40504676, 40500890, 40499867, 40479828, 40432219, 40422041, 40360093, 40286646, 40274149, 40158809, 40119836, 39978149, 39910821, 39705316, 39679901, 39626346, 39579679, 39566700, 39552005, 39550818, 41997681, 41247195, 40813258, 39454542, 39454415, 39440615, 39421884, 39406784, 39256285, 39243449, 39154820, 39142532, 39136402, 39119745, 39118454, 38923850, 38912896 0 tubulointerstitial kidney disease, autosomal dominant, 2 0.7040398435219726
P18510 IL1RN Interleukin-1 receptor antagonist protein Tier 1.5 0.66 5 87.06 0 0       1 1 38928037 0 sterile multifocal osteomyelitis with periostitis and pustulosis 0.7734282711738736
Q86YL7 PDPN Podoplanin Tier 1.5 0.66 6 57.97 0 0       1 4 41304780, 41292412, 39451677 0 Microscopic hematuria 0.41183796492083136
Q92876 KLK6 Kallikrein-6 Tier 1 0.659 21 91.75 0 0       1 2 30114962, 22505517 0 neuroinflammatory disorder 0.1901077464611955
O15389 SIGLEC5 Sialic acid-binding Ig-like lectin 5 Tier 1.5 0.656 3 77.75 0 0       1 3 33584010, 27678199, 24405684 0 dentures 0.15815607474115415
P22894 MMP8 Neutrophil collagenase Tier 1 0.655 25 90.38 0 0       1 4 35821507, 34183667, 33534888, 30197987 0 acne 0.603247809982021
P45452 MMP13 Collagenase 3 Tier 1 0.65 49 88.62 0 0       1 4 41754778, 40893365, 38471488, 38750696 0 spondyloepimetaphyseal dysplasia, Missouri type 0.8032079813035149
O15263 DEFB4A Defensin beta 4A Tier 1.5 0.65 6 78.0 0 0       1 2 40362575, 32067984 0 ulcerative colitis 0.09865892368546408
P84996 GNAS Protein ALEX Tier 1.5 0.65 0 43.59 0 0       1 9 39154820, 37963924, 36037714, 34488577, 31129134, 30979095, 30682825, 29146902, 28626560 0    
P01138 NGF Beta-nerve growth factor Tier 1.5 0.648 8 73.25 0 0       1 6 42015870, 38780008, 32982626, 21216401, 7545283, 29754498 0 hereditary sensory and autonomic neuropathy type 5 0.7785402119369383
Q2I0M5 RSPO4 R-spondin-4 Tier 1.5 0.646 0 78.56 0 0       1 3 38238732, 37425696 0 nonsyndromic congenital nail disorder 4 0.7604902779349189
Q9BQ51 PDCD1LG2 Programmed cell death 1 ligand 2 Tier 1.5 0.645 2 86.38 0 0       1 1 38928037 0 melanoma 0.42716921377769757
Q9UKP5 ADAMTS6 A disintegrin and metalloproteinase with thrombospondin motifs 6 Tier 1.5 0.644 0 77.5 0 0       1 1 35700850 0 Abnormality of the skeletal system 0.5444162515485208
P10747 CD28 T-cell-specific surface glycoprotein CD28 Tier 1 0.641 10 81.31 0 0       1 12 40702285, 40479828, 36979667, 36126113, 32584540, 32280743, 32024070, 26999456, 26992239, 26320067, 23756353, 10435754 0 HIV infection 0.5105949023227331
Q04609 FOLH1 Glutamate carboxypeptidase 2 Tier 1 0.64 88 93.81 0 0       1 47 41855944, 41683470, 41548790, 41478044, 41126016, 40684732, 39388218, 39187748, 38769597, 34341883, 33794195, 33061374, 33025277, 32721116, 32611993, 32525981, 32208602, 29313393, 28794625, 28746182, 27574424, 27456457, 27228412, 27077564, 26985893, 26472453, 26438155, 25938427, 25620467, 25620167, 25473281, 24954476, 24337602, 24321253, 23590171, 21980237, 21641946, 21555850, 21147500, 20550178, 20407731, 19701187, 19514954, 19488725, 18776550, 15520166, 12124337 0 prostate cancer 0.5500818985644047
P07202 TPO Thyroid peroxidase Tier 1.5 0.64 0 83.44 0 0       1 1 29881374 0 familial thyroid dyshormonogenesis 0.6710562308468054
P31994 FCGR2B Low affinity immunoglobulin gamma Fc region receptor II-b Tier 1.5 0.636 5 78.44 0 0       1 1 38928037 0 systemic lupus erythematosus 0.460465747544726
Q16674 MIA Melanoma-derived growth regulatory protein Tier 1.5 0.636 4 86.38 0 0       1 15 41768714, 40943389, 40444021, 38899488, 37853818, 35842727, 35593028, 35061691, 34038704, 32957732, 31878307, 31289496, 29499935, 28059418, 26840019 0 neurodegenerative disease 0.36367051545295126
Q92563 SPOCK2 Testican-2 Tier 1.5 0.627 0 66.94 0 0       1 8 39695715, 35474272, 32958645, 28794177, 38656806, 36288905 0 Back pain 0.3687304175767662
P34810 CD68 Macrosialin Tier 1.5 0.627 0 73.19 0 0       1 4 37422510, 33321636, 28315675, 27940247 0 neurodegenerative disease 0.3710186480081222
Q96NZ8 WFIKKN1 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 Tier 1.5 0.621 2 78.06 0 0       1 1 33591955 0 neurodegenerative disease 0.3060887002952384

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;