Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

590 rows where has_cryoEM = 0, has_known_aptamer = 1 and in_cev_map = 1 sorted by priority_score descending

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tier 2

has_activation_state_pdb_pair 2

  • 0 583
  • 1 7

in_cev_map 1

has_known_aptamer 1

has_cryoEM 1

id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P13747 HLA-E HLA class I histocompatibility antigen, alpha chain E Tier 1 0.865 34 87.0 0 0       1 1 38473398 1 COVID-19 0.4822929100647597
Q15848 ADIPOQ Adiponectin Tier 1 0.806 3 79.88 0 0       1 10 41636061, 38392020, 36508319, 35323639, 34796696, 34117903, 33535822, 31988066, 25105541 1 hearing loss 0.25844907375917336
P15260 IFNGR1 Interferon gamma receptor 1 Tier 1.5 0.804 5 66.0 0 0       1 2 33667716 1 disseminated atypical mycobacterial infection 0.5414012388034828
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Tier 1.5 0.788 11 75.94 0 0       1 6 41733039, 34364920, 31434881, 30237882, 29299123, 22411871 1 acute myeloid leukemia 0.8313389209288576
P01019 AGT Angiotensinogen Tier 1 0.779 22 86.44 0 0       1 16 35983901, 34936368, 34779902, 34248841, 32838280, 23766021, 17673982, 11419945, 38045440, 34619249, 29844151, 27530235 1 renal tubular dysgenesis 0.7354947364860083
P61769 B2M Beta-2-microglobulin Tier 1 0.77 100 94.06 0 0       1 15 41850110, 40373155, 38904251, 40658810, 35026285, 32631049, 29281176, 28960840, 25100729, 20616783, 19137104, 17878167 1 Immunodeficiency by defective expression of HLA class 1 0.6180318849819645
P02776 PF4 Platelet factor 4 Tier 1.5 0.77 10 75.06 0 0       1 10 33859620, 32366845, 31967847, 23847186, 23673861, 34248840, 32022468 1 systemic scleroderma 0.11523541376593864
P05546 SERPIND1 Heparin cofactor 2 Tier 1 0.752 9 79.62 0 0       1 4 20062917, 20053992, 34248840, 31247951 1 heparin cofactor 2 deficiency 0.719744572767547
P05164 MPO Myeloperoxidase Tier 1 0.745 49 89.0 0 0       1 16 41629951, 41316897, 40501769, 38127443, 33534888, 33495506, 37991715, 37277648, 34183667, 34117903, 33869115, 31210423, 30431231 1 myeloperoxidase deficiency 0.7742533340195327
P05187 ALPP Alkaline phosphatase, placental type Tier 1 0.72 8 93.44 0 0       1 7 41329468, 38238732, 37425696, 37047289, 31687420, 25919296, 23467613 1 male reproductive organ cancer 0.16284411775950106
P29622 SERPINA4 Kallistatin Tier 1 0.719 3 86.69 0 0       1 4 38904251, 30297859, 37351609, 28794177 1 optic atrophy 0.28896631154492924
P41221 WNT5A Protein Wnt-5a Tier 1.5 0.71 0 87.69 0 0       1 4 40855286, 32693649, 22363130, 18673242 1 Robinow syndrome 0.7220360983378594
Q96IY4 CPB2 Carboxypeptidase B2 Tier 1 0.709 10 94.12 0 0       1 4 37329944, 36805075, 35861072, 30297859 1 type 2 diabetes mellitus 0.19338213943947646
P25311 AZGP1 Zinc-alpha-2-glycoprotein Tier 1 0.701 9 92.88 0 0       1 1 41325160 1 neoplasm 0.10887540652591159
P00746 CFD Complement factor D Tier 1 0.695 40 91.0 0 0       1 4 38057414, 38071633, 28972568, 25727321 1 recurrent Neisseria infections due to factor D deficiency 0.7726408204424132
P19021 PAM Peptidyl-glycine alpha-amidating monooxygenase Tier 1.5 0.695 0 71.69 0 0       1 25 41855944, 41500123, 41384307, 41285544, 41222440, 40607956, 39929897, 39472107, 38867016, 38846799, 37977804, 37977780, 37906116, 37127012, 36905684, 35478209, 33911033, 33516855, 32315032, 32307868, 30399413, 30124431, 26406332, 22954359, 14965210 1 type 2 diabetes mellitus 0.5754371880839976
P10586 PTPRF Receptor-type tyrosine-protein phosphatase F Tier 1.5 0.69 13 82.0 0 0       1 4 42101929, 39087949, 36594741 1 smoking initiation 0.4641111755355386
P22303 ACHE Acetylcholinesterase Tier 1 0.685 78 92.94 0 0       1 135 41985393, 41898380, 41654945, 41639270, 41639254, 41565777, 41276911, 41237904, 41230502, 41086326, 41006757, 40855286, 40500390, 40487355, 40452137, 40444021, 40277325, 40262341, 40215752, 40154972, 40128122, 39834132, 39728786, 39689579, 39665919, 39282962, 39102642, 38996565, 38953438, 38949022, 38722683, 38569854, 38559166, 38544485, 38462144, 38410271, 38168820, 38026177, 37905115, 37759795, 37622311, 37506391, 37117194, 36741760, 36551106, 36368824, 36047811, 35842727, 35770801, 35439419, 36971430, 36375221, 36359944, 35479481, 35402070, 35235478, 35057959, 34509014, 33218485, 33096123, 32143069, 31748191, 31170561, 26003847, 25569873, 24756130, 24299064, 12852840 1 Alzheimer disease 0.628678841772617
P03950 ANG Angiogenin Tier 1 0.685 56 89.81 0 0       1 99 41948065, 41736700, 41688234, 41686152, 41625383, 41551985, 41550856, 41338305, 41194434, 40839054, 40825091, 40233536, 40046817, 39891801, 39871473, 39727889, 39700796, 39226945, 39078660, 38458987, 38282417, 37683754, 37585601, 37556929, 37527337, 37367006, 37284580, 37185488, 37100807, 36520671, 36315359, 36291000, 36087171, 35731347, 35489276, 35408368, 35290881, 35218097, 35084794, 34987275, 34964948, 34902643, 34617153, 34523638, 34500620, 34474207, 34464491, 34439828, 34350496, 34232998, 27841380, 25461163, 25422408, 22018671, 21774079, 18585145, 18533682, 17260069, 9578572 1 amyotrophic lateral sclerosis 0.7865457274017922
P01008 SERPINC1 Antithrombin-III Tier 1 0.685 27 84.69 0 0       1 11 32199927, 31881749, 31747245, 25467079, 25186782, 24359968, 23637781, 18316185, 15741074, 10660541, 10457984 1 hereditary antithrombin deficiency 0.8494671886642873
O00501 CLDN5 Claudin-5 Tier 1.5 0.685 0 83.75 0 0       1 1 18951306 1 genetic disorder 0.40861362787778505
Q15485 FCN2 Ficolin-2 Tier 1 0.682 13 85.12 0 0       1 2 27490795 1 hypopituitarism 0.2753784074131916
Q07954 LRP1 Prolow-density lipoprotein receptor-related protein 1 Tier 1 0.682 7 79.19 0 0       1 3 41599761, 38996211, 25855589 1 developmental dysplasia of the hip 0.6197148309275711
P00918 CA2 Carbonic anhydrase 2 Tier 1 0.68 100 97.38 0 0       1 109 41955789, 41543229, 41513346, 40854266, 40783389, 40744710, 40660917, 40411663, 40380946, 40321028, 39978259, 39928524, 39716707, 39536855, 39515698, 38946763, 38693181, 38462338, 38409486, 37997814, 37726778, 37148800, 37103734, 36792529, 36410157, 36140102, 36107718, 35490167, 35344667, 35211356, 35194086, 35022247, 35006986, 34619285, 34607961, 34440571, 34399193, 34362425, 34166652, 33832411, 33479839, 33410656, 33230701, 33080851, 32991252, 35516485, 32700526, 32493583, 32331372, 32304233 1 Osteopetrosis with renal tubular acidosis 0.7929568656592082
P09958 FURIN Furin Tier 1 0.68 48 84.75 0 0       1 4 36291832, 24808863 1 coronary artery disease 0.5783535503692275
P14384 CPM Carboxypeptidase M Tier 1.5 0.68 1 90.31 0 0       1 3 38876068, 38060303, 36768220 1 hydronephrosis 0.3163273148871551
P09382 LGALS1 Galectin-1 Tier 1 0.675 41 96.5 0 0       1 6 37141264, 33006019, 31778957 1 glaucoma 0.2854257184852107
P09758 TACSTD2 Tumor-associated calcium signal transducer 2 Tier 1.5 0.673 7 82.69 0 0       1 4 41384307, 41241473, 40050871, 39250993 1 gelatinous drop-like corneal dystrophy 0.7293087728162646
P98066 TNFAIP6 Tumor necrosis factor-inducible gene 6 protein Tier 1.5 0.671 5 81.12 0 0       1 1 39263947 1 type 2 diabetes mellitus 0.30862220597837015
P25942 CD40 Tumor necrosis factor receptor superfamily member 5 Tier 1 0.67 14 81.19 0 0       1 8 41982466, 37331977, 36203210, 33335251, 26504624, 26231918, 23460531, 12828856 1 hyper-IgM syndrome type 3 0.8038021669520221
P08581 MET Hepatocyte growth factor receptor Tier 1 0.669 100 79.25 0 0       1 149 42012469, 41992303, 41973478, 41873087, 41861669, 41858296, 41848278, 41601428, 41462891, 41391726, 41234744, 41123956, 41084363, 41065179, 41024479, 40954195, 40938088, 40923343, 40840349, 40740738, 40728393, 40640119, 40388621, 40189053, 40116812, 40041032, 39930702, 39853766, 39852082, 39744222, 39735310, 39674868, 39631842, 39586988, 39527480, 39513807, 39355222, 39348183, 39288204, 39087949, 38925633, 38923378, 38876234, 38829176, 38697444, 38515622, 38298092, 38277932, 38230289, 38225704, 30237882, 29416033, 26131766 1 papillary renal cell carcinoma 0.84195976263742
P56817 BACE1 Beta-secretase 1 Tier 1 0.668 100 87.5 0 0       1 9 39241336, 36149663, 35402070, 31513457, 30959405, 29327496, 26473367, 23832586, 16888322 1 metabolic disease 0.42482013576989197
P08311 CTSG Cathepsin G Tier 1 0.667 16 91.38 0 0       1 6 41316897, 40501769, 9062133, 23598134, 19325843 1 tuberculosis 0.37188972877648113
Q9Y251 HPSE Heparanase Tier 1 0.66 58 94.69 0 0       1 7 41363219, 31252265, 30086306, 28150826, 25295847, 23968994, 22719856 1 Vitiligo 0.3120033501413742
Q13093 PLA2G7 Platelet-activating factor acetylhydrolase Tier 1 0.66 33 87.81 0 0       1 1 35187107 1 Platelet-activating factor acetylhydrolase deficiency 0.6405981442654826
P16870 CPE Carboxypeptidase E Tier 1.5 0.66 0 90.38 0 0       1 16 39863729, 39793371, 38861005, 36832010, 36773630, 27886773, 27219679, 25738486, 28706644, 24768847, 23875581, 22280349, 21419619, 20949139, 20491465, 19174227 1 BDV syndrome 0.7029731914682913
P22692 IGFBP4 Insulin-like growth factor-binding protein 4 Tier 1.5 0.66 4 77.25 0 0       1 6 35323639, 32515246, 31930684 1 allergic rhinitis 0.35214760515440524
Q13433 SLC39A6 Zinc transporter ZIP6 Tier 1.5 0.66 0 60.44 0 0       1 1 40132409 1 breast cancer 0.11188167100061543
P02461 COL3A1 Collagen alpha-1(III) chain Tier 1 0.656 11 53.25 0 0       1 1 28453726 1 Ehlers-Danlos syndrome, vascular type 0.8608667500207768
P15907 ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 Tier 1 0.655 4 88.12 0 0       1 1 41889102 1 COVID-19 0.5471103766359176
P08709 F7 Coagulation factor VII Tier 1 0.655 100 82.12 0 0       1 4 41980687, 32224381, 28496951, 11127866 1 factor VII deficiency 0.8542078994169972
Q9Y625 GPC6 Glypican-6 Tier 1.5 0.655 0 82.0 0 0       1 1 40093223 1 autosomal recessive omodysplasia 0.7503216726357611
P02766 TTR Transthyretin Tier 1.5 0.655 0 88.0 0 0       1 11 39737993, 32616928, 23770039, 21875107, 21314458, 39596348, 38399458, 36881759, 33572452 1 amyloidosis, hereditary systemic 1 0.846421986844374
Q9H0R3 TMEM222 Transmembrane protein 222 Tier 1.5 0.654 0 84.81 0 0       1 3 41643149, 36174865, 25998051 1 neurodevelopmental disorder with motor and speech delay and behavioral abnormalities 0.6449281600938256
P36894 BMPR1A Bone morphogenetic protein receptor type-1A Tier 1 0.653 11 82.62 0 0       1 1 30537181 1 juvenile polyposis syndrome 0.8278395086688584
P62937 PPIA Peptidyl-prolyl cis-trans isomerase A Tier 1 0.652 100 98.06 0 0       1 1 30121422 1 HIV infection 0.6219943433906236
P32942 ICAM3 Intercellular adhesion molecule 3 Tier 1.5 0.648 1 87.12 0 0       1 3 40650261, 34730968, 17660953 1 lymphatic system disease 0.28331776251399693
P09104 ENO2 Gamma-enolase Tier 1 0.645 16 97.06 0 0       1 1 36384120 1 neurodegenerative disease 0.4533558777394424
P29323 EPHB2 Ephrin type-B receptor 2 Tier 1 0.643 5 80.0 0 0       1 1 26824783 1 medullary thyroid gland carcinoma 0.5261243162992855
P48740 MASP1 Mannan-binding lectin serine protease 1 Tier 1 0.64 9 90.44 0 0       1 2 40371468, 41587892 1 3MC syndrome 1 0.8185972518103526

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CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;