Targets — browse / sort / filter (view)

One row per human protein target with names + key evidence. Click column headers to SORT; use the facets to FILTER (tier, activation pair, known aptamer, EV-Map). UniProt IDs link to the source.

Data license: CC BY 4.0 · Data source: apt-scout automated curation pipeline (E. Dohi, NCNP) — values harvested from public databases; raw source stored per target

id
UniProt accession (human). Links to uniprot.org.
gene_symbol
Gene symbol (e.g. ITGB3).
protein_name
Protein name (UniProt).
tier
Tier 1 = PDB-anchored; Tier 1.5 = AlphaFold-confident.
priority_score
Composite prioritisation = 0.30*biology + 0.30*reagent-gap + 0.20*druggability + 0.10*disease + 0.10*novelty. Sub-scores are assigned during LLM-assisted curation — a heuristic ranking, NOT an experimental measurement.
has_activation_state_pdb_pair
1 if a curated ACTIVE/INACTIVE PDB pair exists (only 11 targets).
in_cev_map
1 if in the EV-Map circulating-EV proteome (Rai 2025); 3,422 targets.
has_known_aptamer
1 if aptamer evidence found in PubMed/Aptagen (1,472 targets).
opentargets_top_disease_score
Open Targets association score (0-1).
aptamer_count_pubmed
Number of PubMed hits for this protein AND (aptamer OR SELEX).
aptamer_pmids
The actual PubMed IDs behind the aptamer evidence — click each to read the paper. This is the source of the 'has aptamer' claim.

647 rows where has_cryoEM = 0, has_known_aptamer = 1 and tier = "Tier 1" sorted by priority_score descending

✎ View and edit SQL

This data as json, CSV (advanced)

in_cev_map 2

  • 1 404
  • 0 243

has_activation_state_pdb_pair 2

  • 0 641
  • 1 6

tier 1

  • Tier 1 · 647 ✖

has_known_aptamer 1

has_cryoEM 1

id gene_symbol protein_name tier priority_score ▲ pdb_count_total alphafold_mean_pLDDT has_cryoEM has_activation_state_pdb_pair activation_state_pdb_active activation_state_pdb_inactive drug_count_approved has_known_aptamer aptamer_count_pubmed aptamer_pmids in_cev_map opentargets_top_disease_name opentargets_top_disease_score
P23946 CMA1 Chymase Tier 1 0.875 42 91.31 0 0       1 1 30572223 0 pernicious anemia 0.17348905136256007
P13747 HLA-E HLA class I histocompatibility antigen, alpha chain E Tier 1 0.865 34 87.0 0 0       1 1 38473398 1 COVID-19 0.4822929100647597
Q15848 ADIPOQ Adiponectin Tier 1 0.806 3 79.88 0 0       1 10 41636061, 38392020, 36508319, 35323639, 34796696, 34117903, 33535822, 31988066, 25105541 1 hearing loss 0.25844907375917336
P01236 PRL Prolactin Tier 1 0.795 12 85.56 0 0       1 6 40327044, 30834248, 29277631, 28263753, 27679852, 16947086 0 AL amyloidosis 0.4619748183558772
O14788 TNFSF11 Tumor necrosis factor ligand superfamily member 11 Tier 1 0.79 2 79.19 0 0       1 2 15562003, 41226313 0 osteoporosis 0.6957850224892792
P01019 AGT Angiotensinogen Tier 1 0.779 22 86.44 0 0       1 16 35983901, 34936368, 34779902, 34248841, 32838280, 23766021, 17673982, 11419945, 38045440, 34619249, 29844151, 27530235 1 renal tubular dysgenesis 0.7354947364860083
P61769 B2M Beta-2-microglobulin Tier 1 0.77 100 94.06 0 0       1 15 41850110, 40373155, 38904251, 40658810, 35026285, 32631049, 29281176, 28960840, 25100729, 20616783, 19137104, 17878167 1 Immunodeficiency by defective expression of HLA class 1 0.6180318849819645
P26951 IL3RA Interleukin-3 receptor subunit alpha Tier 1 0.767 4 85.25 0 0       1 3 40931580, 36171541, 31323275 0 acute myeloid leukemia 0.46904332714118013
P05546 SERPIND1 Heparin cofactor 2 Tier 1 0.752 9 79.62 0 0       1 4 20062917, 20053992, 34248840, 31247951 1 heparin cofactor 2 deficiency 0.719744572767547
P05164 MPO Myeloperoxidase Tier 1 0.745 49 89.0 0 0       1 16 41629951, 41316897, 40501769, 38127443, 33534888, 33495506, 37991715, 37277648, 34183667, 34117903, 33869115, 31210423, 30431231 1 myeloperoxidase deficiency 0.7742533340195327
P05187 ALPP Alkaline phosphatase, placental type Tier 1 0.72 8 93.44 0 0       1 7 41329468, 38238732, 37425696, 37047289, 31687420, 25919296, 23467613 1 male reproductive organ cancer 0.16284411775950106
K7N5M4 B2M   Tier 1 0.72 24 90.94 0 0       1 3 41850110, 40373155, 38904251 0    
P29622 SERPINA4 Kallistatin Tier 1 0.719 3 86.69 0 0       1 4 38904251, 30297859, 37351609, 28794177 1 optic atrophy 0.28896631154492924
P42262 GRIA2 Glutamate receptor 2 Tier 1 0.715 16 84.94 0 0       1 4 28325839, 19417060, 17929944, 17024188 0 neurodevelopmental disorder with language impairment and behavioral abnormalities 0.8328652004757138
Q96IY4 CPB2 Carboxypeptidase B2 Tier 1 0.709 10 94.12 0 0       1 4 37329944, 36805075, 35861072, 30297859 1 type 2 diabetes mellitus 0.19338213943947646
P25311 AZGP1 Zinc-alpha-2-glycoprotein Tier 1 0.701 9 92.88 0 0       1 1 41325160 1 neoplasm 0.10887540652591159
P14207 FOLR2 Folate receptor beta Tier 1 0.701 5 89.12 0 0       1 2 28686804 0 neoplasm 0.11545394821329319
P15248 IL9 Interleukin-9 Tier 1 0.7 5 84.06 0 0       1 1 40972397 0 neurodegenerative disease 0.40148548290272756
P01374 LTA Lymphotoxin-alpha Tier 1 0.7 3 83.44 0 0       1 3 41810142, 30576605 0    
P00746 CFD Complement factor D Tier 1 0.695 40 91.0 0 0       1 4 38057414, 38071633, 28972568, 25727321 1 recurrent Neisseria infections due to factor D deficiency 0.7726408204424132
Q95460 MR1 Major histocompatibility complex class I-related protein 1 Tier 1 0.693 79 87.5 0 0       1 2 41134135, 20000526 0 Immunodeficiency 0.3336382138166145
Q9NPF0 CD320 CD320 antigen Tier 1 0.69 6 63.81 0 0       1 1 39493449 0 Methylmalonic aciduria due to transcobalamin receptor defect 0.49918945650121177
P22303 ACHE Acetylcholinesterase Tier 1 0.685 78 92.94 0 0       1 135 41985393, 41898380, 41654945, 41639270, 41639254, 41565777, 41276911, 41237904, 41230502, 41086326, 41006757, 40855286, 40500390, 40487355, 40452137, 40444021, 40277325, 40262341, 40215752, 40154972, 40128122, 39834132, 39728786, 39689579, 39665919, 39282962, 39102642, 38996565, 38953438, 38949022, 38722683, 38569854, 38559166, 38544485, 38462144, 38410271, 38168820, 38026177, 37905115, 37759795, 37622311, 37506391, 37117194, 36741760, 36551106, 36368824, 36047811, 35842727, 35770801, 35439419, 36971430, 36375221, 36359944, 35479481, 35402070, 35235478, 35057959, 34509014, 33218485, 33096123, 32143069, 31748191, 31170561, 26003847, 25569873, 24756130, 24299064, 12852840 1 Alzheimer disease 0.628678841772617
P03950 ANG Angiogenin Tier 1 0.685 56 89.81 0 0       1 99 41948065, 41736700, 41688234, 41686152, 41625383, 41551985, 41550856, 41338305, 41194434, 40839054, 40825091, 40233536, 40046817, 39891801, 39871473, 39727889, 39700796, 39226945, 39078660, 38458987, 38282417, 37683754, 37585601, 37556929, 37527337, 37367006, 37284580, 37185488, 37100807, 36520671, 36315359, 36291000, 36087171, 35731347, 35489276, 35408368, 35290881, 35218097, 35084794, 34987275, 34964948, 34902643, 34617153, 34523638, 34500620, 34474207, 34464491, 34439828, 34350496, 34232998, 27841380, 25461163, 25422408, 22018671, 21774079, 18585145, 18533682, 17260069, 9578572 1 amyotrophic lateral sclerosis 0.7865457274017922
P01008 SERPINC1 Antithrombin-III Tier 1 0.685 27 84.69 0 0       1 11 32199927, 31881749, 31747245, 25467079, 25186782, 24359968, 23637781, 18316185, 15741074, 10660541, 10457984 1 hereditary antithrombin deficiency 0.8494671886642873
Q15485 FCN2 Ficolin-2 Tier 1 0.682 13 85.12 0 0       1 2 27490795 1 hypopituitarism 0.2753784074131916
Q07954 LRP1 Prolow-density lipoprotein receptor-related protein 1 Tier 1 0.682 7 79.19 0 0       1 3 41599761, 38996211, 25855589 1 developmental dysplasia of the hip 0.6197148309275711
P00918 CA2 Carbonic anhydrase 2 Tier 1 0.68 100 97.38 0 0       1 109 41955789, 41543229, 41513346, 40854266, 40783389, 40744710, 40660917, 40411663, 40380946, 40321028, 39978259, 39928524, 39716707, 39536855, 39515698, 38946763, 38693181, 38462338, 38409486, 37997814, 37726778, 37148800, 37103734, 36792529, 36410157, 36140102, 36107718, 35490167, 35344667, 35211356, 35194086, 35022247, 35006986, 34619285, 34607961, 34440571, 34399193, 34362425, 34166652, 33832411, 33479839, 33410656, 33230701, 33080851, 32991252, 35516485, 32700526, 32493583, 32331372, 32304233 1 Osteopetrosis with renal tubular acidosis 0.7929568656592082
P39900 MMP12 Macrophage metalloelastase Tier 1 0.68 86 86.94 0 0       1 8 41861669, 38477735, 38296402, 37015819, 35120890, 34183667, 27530235 0 atopic eczema 0.4795677061208266
P09958 FURIN Furin Tier 1 0.68 48 84.75 0 0       1 4 36291832, 24808863 1 coronary artery disease 0.5783535503692275
Q86Z14 KLB Beta-klotho Tier 1 0.676 5 89.38 0 0       1 1 40514411 0 congenital hypogonadotropic hypogonadism 0.462898767992589
P09382 LGALS1 Galectin-1 Tier 1 0.675 41 96.5 0 0       1 6 37141264, 33006019, 31778957 1 glaucoma 0.2854257184852107
P62576 nanA Sialidase A Tier 1 0.67 5 81.19 0 0       1 4 37350189, 34976356, 34341854, 32034503 0    
P25942 CD40 Tumor necrosis factor receptor superfamily member 5 Tier 1 0.67 14 81.19 0 0       1 8 41982466, 37331977, 36203210, 33335251, 26504624, 26231918, 23460531, 12828856 1 hyper-IgM syndrome type 3 0.8038021669520221
Q9GZX9 TWSG1 Twisted gastrulation protein homolog 1 Tier 1 0.67 6 80.38 0 0       1 1 39299474 0 Abruptio Placentae 0.29495361755469174
P08581 MET Hepatocyte growth factor receptor Tier 1 0.669 100 79.25 0 0       1 149 42012469, 41992303, 41973478, 41873087, 41861669, 41858296, 41848278, 41601428, 41462891, 41391726, 41234744, 41123956, 41084363, 41065179, 41024479, 40954195, 40938088, 40923343, 40840349, 40740738, 40728393, 40640119, 40388621, 40189053, 40116812, 40041032, 39930702, 39853766, 39852082, 39744222, 39735310, 39674868, 39631842, 39586988, 39527480, 39513807, 39355222, 39348183, 39288204, 39087949, 38925633, 38923378, 38876234, 38829176, 38697444, 38515622, 38298092, 38277932, 38230289, 38225704, 30237882, 29416033, 26131766 1 papillary renal cell carcinoma 0.84195976263742
P56817 BACE1 Beta-secretase 1 Tier 1 0.668 100 87.5 0 0       1 9 39241336, 36149663, 35402070, 31513457, 30959405, 29327496, 26473367, 23832586, 16888322 1 metabolic disease 0.42482013576989197
P08311 CTSG Cathepsin G Tier 1 0.667 16 91.38 0 0       1 6 41316897, 40501769, 9062133, 23598134, 19325843 1 tuberculosis 0.37188972877648113
O15169 AXIN1 Axin-1 Tier 1 0.664 22 61.09 0 0       1 2 28129128 0 hepatocellular carcinoma 0.7864172882686208
Q9Y251 HPSE Heparanase Tier 1 0.66 58 94.69 0 0       1 7 41363219, 31252265, 30086306, 28150826, 25295847, 23968994, 22719856 1 Vitiligo 0.3120033501413742
Q13093 PLA2G7 Platelet-activating factor acetylhydrolase Tier 1 0.66 33 87.81 0 0       1 1 35187107 1 Platelet-activating factor acetylhydrolase deficiency 0.6405981442654826
P15941 MUC1 Mucin-1 Tier 1 0.66 23 47.41 0 0       1 686 42025056, 41988862, 41954302, 41771296, 41744704, 41744190, 41657320, 41627316, 41621292, 41582516, 41535857, 41471303, 41362016, 41352919, 41346179, 41330302, 41243570, 41205458, 41185018, 41101154, 41047832, 41027169, 40682599, 40665615, 40627939, 40607530, 40590839, 40578633, 40568899, 40556592, 40504676, 40500890, 40499867, 40479828, 40432219, 40422041, 40360093, 40286646, 40274149, 40158809, 40119836, 39978149, 39910821, 39705316, 39679901, 39626346, 39579679, 39566700, 39552005, 39550818, 41997681, 41247195, 40813258, 39454542, 39454415, 39440615, 39421884, 39406784, 39256285, 39243449, 39154820, 39142532, 39136402, 39119745, 39118454, 38923850, 38912896 0 tubulointerstitial kidney disease, autosomal dominant, 2 0.7040398435219726
Q92876 KLK6 Kallikrein-6 Tier 1 0.659 21 91.75 0 0       1 2 30114962, 22505517 0 neuroinflammatory disorder 0.1901077464611955
P02461 COL3A1 Collagen alpha-1(III) chain Tier 1 0.656 11 53.25 0 0       1 1 28453726 1 Ehlers-Danlos syndrome, vascular type 0.8608667500207768
P22894 MMP8 Neutrophil collagenase Tier 1 0.655 25 90.38 0 0       1 4 35821507, 34183667, 33534888, 30197987 0 acne 0.603247809982021
P15907 ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 Tier 1 0.655 4 88.12 0 0       1 1 41889102 1 COVID-19 0.5471103766359176
P08709 F7 Coagulation factor VII Tier 1 0.655 100 82.12 0 0       1 4 41980687, 32224381, 28496951, 11127866 1 factor VII deficiency 0.8542078994169972
P36894 BMPR1A Bone morphogenetic protein receptor type-1A Tier 1 0.653 11 82.62 0 0       1 1 30537181 1 juvenile polyposis syndrome 0.8278395086688584
P62937 PPIA Peptidyl-prolyl cis-trans isomerase A Tier 1 0.652 100 98.06 0 0       1 1 30121422 1 HIV infection 0.6219943433906236
P45452 MMP13 Collagenase 3 Tier 1 0.65 49 88.62 0 0       1 4 41754778, 40893365, 38471488, 38750696 0 spondyloepimetaphyseal dysplasia, Missouri type 0.8032079813035149

Next page

Advanced export

JSON shape: default, array, newline-delimited

CSV options: 

CREATE VIEW v_targets AS
SELECT f.id, n.gene_symbol, n.protein_name, tg.tier, f.priority_score,
 f.pdb_count_total, f.alphafold_mean_pLDDT, f.has_cryoEM,
 f.has_activation_state_pdb_pair, f.activation_state_pdb_active, f.activation_state_pdb_inactive,
 f.drug_count_approved, f.has_known_aptamer, f.aptamer_count_pubmed, ap.aptamer_pmids,
 f.in_cev_map, f.opentargets_top_disease_name, f.opentargets_top_disease_score
FROM v_target_full f
LEFT JOIN target_names n ON n.target_id=f.id
LEFT JOIN targets tg ON tg.id=f.id
LEFT JOIN target_aptamer_pmids ap ON ap.target_id=f.id;